Details for: IGHV3 52

Gene ID: 28421

Symbol: IGHV3 52

Ensembl ID: ENSG00000253545

Description: immunoglobulin heavy variable 3-52 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.1431
    Cell Significance Index: 1.4500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0765
    Cell Significance Index: 0.9700
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.0021
    Cell Significance Index: 0.0200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0054
    Cell Significance Index: -0.0700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0091
    Cell Significance Index: -0.1300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0093
    Cell Significance Index: -0.1000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0194
    Cell Significance Index: -0.2900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0328
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0347
    Cell Significance Index: -0.3600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0412
    Cell Significance Index: -0.5600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0542
    Cell Significance Index: -1.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0572
    Cell Significance Index: -1.4600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0617
    Cell Significance Index: -0.7300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0625
    Cell Significance Index: -0.7700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0662
    Cell Significance Index: -1.0100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0664
    Cell Significance Index: -0.7000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0699
    Cell Significance Index: -0.9600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0721
    Cell Significance Index: -1.1600
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0736
    Cell Significance Index: -0.4900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0752
    Cell Significance Index: -0.9200
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0796
    Cell Significance Index: -0.7300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0829
    Cell Significance Index: -0.5400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0864
    Cell Significance Index: -1.2600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0942
    Cell Significance Index: -1.2100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0942
    Cell Significance Index: -1.3200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0994
    Cell Significance Index: -1.1100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1003
    Cell Significance Index: -1.3200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1034
    Cell Significance Index: -1.2300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1039
    Cell Significance Index: -0.8300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1042
    Cell Significance Index: -1.2500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1053
    Cell Significance Index: -1.2500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1074
    Cell Significance Index: -1.1900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1074
    Cell Significance Index: -1.4100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1076
    Cell Significance Index: -1.0100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1100
    Cell Significance Index: -1.3900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1143
    Cell Significance Index: -1.3800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1159
    Cell Significance Index: -1.3700
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1171
    Cell Significance Index: -1.3500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1184
    Cell Significance Index: -1.2600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1185
    Cell Significance Index: -1.4000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1189
    Cell Significance Index: -1.3400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1199
    Cell Significance Index: -1.3800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1208
    Cell Significance Index: -1.3900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1209
    Cell Significance Index: -1.3000
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1231
    Cell Significance Index: -1.3200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1262
    Cell Significance Index: -1.3400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1271
    Cell Significance Index: -1.2900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1317
    Cell Significance Index: -1.3500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1326
    Cell Significance Index: -1.4300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1330
    Cell Significance Index: -1.4000
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1359
    Cell Significance Index: -1.3800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1368
    Cell Significance Index: -1.4500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1374
    Cell Significance Index: -0.7400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1379
    Cell Significance Index: -1.2800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1413
    Cell Significance Index: -1.3400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1458
    Cell Significance Index: -1.4600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1458
    Cell Significance Index: -1.4000
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.1465
    Cell Significance Index: -0.6700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1475
    Cell Significance Index: -1.3800
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1480
    Cell Significance Index: -1.4000
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1487
    Cell Significance Index: -1.3600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1493
    Cell Significance Index: -1.3900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1538
    Cell Significance Index: -1.3100
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1545
    Cell Significance Index: -1.3800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1578
    Cell Significance Index: -1.3300
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1584
    Cell Significance Index: -1.3500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1589
    Cell Significance Index: -1.3900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1599
    Cell Significance Index: -1.3800
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1613
    Cell Significance Index: -1.3900
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1626
    Cell Significance Index: -1.4500
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1629
    Cell Significance Index: -1.4200
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1636
    Cell Significance Index: -1.4500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1637
    Cell Significance Index: -1.4400
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1671
    Cell Significance Index: -1.4500
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1817
    Cell Significance Index: -1.4600
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1901
    Cell Significance Index: -1.4600
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.1989
    Cell Significance Index: -1.4600
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.2052
    Cell Significance Index: -1.4500
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.2212
    Cell Significance Index: -1.4400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2232
    Cell Significance Index: -1.3900
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: -0.2824
    Cell Significance Index: -1.4400
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.2909
    Cell Significance Index: -1.4600
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.3435
    Cell Significance Index: -1.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV3-52 is a member of the immunoglobulin heavy chain gene family, which encodes the heavy chains of antibodies. The variable region of an antibody determines its specificity and affinity for antigens. In the case of IGHV3-52, the pseudogene has undergone extensive mutations, resulting in a non-functional product. Despite this, the gene remains expressed in various immune cells, suggesting that it may play a role in regulating immune responses or influencing the development of these cells. **Pathways and Functions:** The expression of IGHV3-52 in different immune cells suggests that it may be involved in various cellular processes. Some possible pathways and functions of IGHV3-52 include: * **Immune cell development:** IGHV3-52 may play a role in the development of precursor B cells and the transition from a double-negative thymocyte to a mature B cell. * **Immune cell activation:** The expression of IGHV3-52 in lymphocytes and plasmablasts may be involved in the activation and differentiation of these cells in response to antigens. * **Regulation of immune responses:** IGHV3-52 may modulate immune responses by influencing the expression of other genes involved in immune cell function. **Clinical Significance:** The expression of IGHV3-52 in various immune cells has implications for our understanding of immune function and disease. Some potential clinical implications of IGHV3-52 include: * **Autoimmune diseases:** The expression of IGHV3-52 in certain immune cells may contribute to the development of autoimmune diseases, such as rheumatoid arthritis or lupus. * **Cancer:** The expression of IGHV3-52 in plasma cells may be involved in the development of certain types of cancer, such as multiple myeloma. * **Immunodeficiency disorders:** The expression of IGHV3-52 in precursor B cells may be involved in the development of immunodeficiency disorders, such as X-linked agammaglobulinemia. In conclusion, the immunoglobulin heavy variable 3-52 gene is a pseudogene with significant implications for our understanding of immune function and disease. Further research is needed to fully elucidate the role of IGHV3-52 in immune cell development, activation, and regulation, as well as its potential involvement in various clinical disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.