Details for: IGHV3 52

Gene ID: 28421

Symbol: IGHV3 52

Ensembl ID: ENSG00000253545

Description: immunoglobulin heavy variable 3-52 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.07
    Marker Score: 88
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.05
    Marker Score: 64
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.03
    Marker Score: 37
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.02
    Marker Score: 51
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.01
    Marker Score: 3
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0
    Marker Score: 52
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 3

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV3-52 is a member of the immunoglobulin heavy chain gene family, which encodes the heavy chains of antibodies. The variable region of an antibody determines its specificity and affinity for antigens. In the case of IGHV3-52, the pseudogene has undergone extensive mutations, resulting in a non-functional product. Despite this, the gene remains expressed in various immune cells, suggesting that it may play a role in regulating immune responses or influencing the development of these cells. **Pathways and Functions:** The expression of IGHV3-52 in different immune cells suggests that it may be involved in various cellular processes. Some possible pathways and functions of IGHV3-52 include: * **Immune cell development:** IGHV3-52 may play a role in the development of precursor B cells and the transition from a double-negative thymocyte to a mature B cell. * **Immune cell activation:** The expression of IGHV3-52 in lymphocytes and plasmablasts may be involved in the activation and differentiation of these cells in response to antigens. * **Regulation of immune responses:** IGHV3-52 may modulate immune responses by influencing the expression of other genes involved in immune cell function. **Clinical Significance:** The expression of IGHV3-52 in various immune cells has implications for our understanding of immune function and disease. Some potential clinical implications of IGHV3-52 include: * **Autoimmune diseases:** The expression of IGHV3-52 in certain immune cells may contribute to the development of autoimmune diseases, such as rheumatoid arthritis or lupus. * **Cancer:** The expression of IGHV3-52 in plasma cells may be involved in the development of certain types of cancer, such as multiple myeloma. * **Immunodeficiency disorders:** The expression of IGHV3-52 in precursor B cells may be involved in the development of immunodeficiency disorders, such as X-linked agammaglobulinemia. In conclusion, the immunoglobulin heavy variable 3-52 gene is a pseudogene with significant implications for our understanding of immune function and disease. Further research is needed to fully elucidate the role of IGHV3-52 in immune cell development, activation, and regulation, as well as its potential involvement in various clinical disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.