Details for: IGHV3 21

Gene ID: 28444

Symbol: IGHV3 21

Ensembl ID: ENSG00000211947

Description: immunoglobulin heavy variable 3-21

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5701
    Cell Significance Index: 8.8200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2101
    Cell Significance Index: 3.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0141
    Cell Significance Index: -1.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0451
    Cell Significance Index: -4.6100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0453
    Cell Significance Index: -1.1300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0756
    Cell Significance Index: -1.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0952
    Cell Significance Index: -12.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1064
    Cell Significance Index: -18.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1067
    Cell Significance Index: -6.5400
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.1304
    Cell Significance Index: -1.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1360
    Cell Significance Index: -3.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1653
    Cell Significance Index: -18.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1670
    Cell Significance Index: -4.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1729
    Cell Significance Index: -4.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1758
    Cell Significance Index: -13.1000
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2142
    Cell Significance Index: -2.4300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2385
    Cell Significance Index: -4.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2484
    Cell Significance Index: -11.5800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2652
    Cell Significance Index: -3.8700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2729
    Cell Significance Index: -3.0500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2891
    Cell Significance Index: -7.2100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3148
    Cell Significance Index: -3.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3216
    Cell Significance Index: -7.7900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3282
    Cell Significance Index: -4.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3300
    Cell Significance Index: -8.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3364
    Cell Significance Index: -11.8200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3634
    Cell Significance Index: -4.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3670
    Cell Significance Index: -4.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3847
    Cell Significance Index: -7.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3897
    Cell Significance Index: -9.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4061
    Cell Significance Index: -11.7000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4063
    Cell Significance Index: -6.5800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4163
    Cell Significance Index: -8.1400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.4169
    Cell Significance Index: -4.2600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.4179
    Cell Significance Index: -4.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4357
    Cell Significance Index: -12.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4362
    Cell Significance Index: -7.3000
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.4524
    Cell Significance Index: -4.6800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4651
    Cell Significance Index: -7.9500
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.4655
    Cell Significance Index: -3.1000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.4734
    Cell Significance Index: -6.4400
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -0.4793
    Cell Significance Index: -4.9000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.4817
    Cell Significance Index: -6.0500
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.4968
    Cell Significance Index: -4.9300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.5008
    Cell Significance Index: -6.4800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.5077
    Cell Significance Index: -6.0000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.5168
    Cell Significance Index: -6.0800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.5190
    Cell Significance Index: -7.5900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.5213
    Cell Significance Index: -5.6800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.5256
    Cell Significance Index: -6.6600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.5262
    Cell Significance Index: -5.5400
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.5335
    Cell Significance Index: -3.7700
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.5378
    Cell Significance Index: -4.9900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.5400
    Cell Significance Index: -7.4100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.5458
    Cell Significance Index: -6.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5530
    Cell Significance Index: -25.9900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5568
    Cell Significance Index: -11.5500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.5616
    Cell Significance Index: -4.0300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.5678
    Cell Significance Index: -6.0300
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.5719
    Cell Significance Index: -5.9800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.5820
    Cell Significance Index: -7.2700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.5829
    Cell Significance Index: -7.6500
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.5865
    Cell Significance Index: -5.6300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.5906
    Cell Significance Index: -7.0200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.5953
    Cell Significance Index: -7.0400
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.5960
    Cell Significance Index: -4.9200
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.5964
    Cell Significance Index: -6.3700
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.5981
    Cell Significance Index: -6.1100
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.6019
    Cell Significance Index: -6.3700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.6095
    Cell Significance Index: -7.8300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.6112
    Cell Significance Index: -6.8000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6114
    Cell Significance Index: -8.1300
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.6127
    Cell Significance Index: -5.4200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.6143
    Cell Significance Index: -6.0600
  • Cell Name: airway submucosal gland duct basal cell (CL4033024)
    Fold Change: -0.6180
    Cell Significance Index: -5.4200
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.6185
    Cell Significance Index: -6.8700
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.6197
    Cell Significance Index: -4.9800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.6201
    Cell Significance Index: -8.1600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.6268
    Cell Significance Index: -6.8800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.6275
    Cell Significance Index: -7.2900
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: -0.6289
    Cell Significance Index: -5.4500
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.6338
    Cell Significance Index: -6.6600
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.6360
    Cell Significance Index: -7.2300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.6385
    Cell Significance Index: -7.5800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.6397
    Cell Significance Index: -6.5300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.6398
    Cell Significance Index: -7.0100
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.6402
    Cell Significance Index: -6.3500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.6408
    Cell Significance Index: -7.7300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.6410
    Cell Significance Index: -4.9000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.6430
    Cell Significance Index: -6.6600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.6453
    Cell Significance Index: -7.8500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.6495
    Cell Significance Index: -7.0300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.6512
    Cell Significance Index: -7.2100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.6521
    Cell Significance Index: -8.2400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.6534
    Cell Significance Index: -8.5300
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.6550
    Cell Significance Index: -5.9700
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.6605
    Cell Significance Index: -6.6100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.6618
    Cell Significance Index: -7.8200
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.6626
    Cell Significance Index: -7.0800
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.6646
    Cell Significance Index: -6.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHV3-21 gene exhibits several key characteristics that enable it to perform its immunoglobulin function. These include: 1. **Variable region:** The IGHV3-21 gene encodes for the variable region of the heavy chain, which is responsible for antigen recognition and binding. 2. **High expression levels:** The IGHV3-21 gene is highly expressed in various cell types, including granulocyte-monocyte progenitor cells, goblet cells, and intestinal epithelial cells. 3. **Widespread expression:** The IGHV3-21 gene is expressed in multiple tissues, including the gut, where it plays a crucial role in mucosal immunity. 4. **Antigen-binding capacity:** The IGHV3-21 gene has been shown to have high antigen-binding capacity, making it an important component of the immune system. **Pathways and Functions:** The IGHV3-21 gene is involved in several key pathways and functions, including: 1. **Antigen binding:** The IGHV3-21 gene plays a crucial role in the recognition and binding of antigens, which is essential for the activation of the immune response. 2. **Immunoglobulin complex formation:** The IGHV3-21 gene is part of the Ig complex, which is formed by the combination of heavy and light chains. This complex is responsible for the binding of antigens. 3. **Immunoglobulin-mediated immune response:** The IGHV3-21 gene is involved in the regulation of the immune response through the production of antibodies. 4. **Plasma membrane localization:** The IGHV3-21 gene is localized to the plasma membrane, where it can interact with antigens and other immune cells. **Clinical Significance:** The IGHV3-21 gene has significant clinical implications, including: 1. **Cancer association:** Abnormal expression of the IGHV3-21 gene has been associated with various types of cancer, including lymphoma and leukemia. 2. **Autoimmune diseases:** The IGHV3-21 gene has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Infectious diseases:** The IGHV3-21 gene plays a crucial role in the recognition and binding of pathogens, making it an important component of the immune response to infections. 4. **Immunodeficiency disorders:** Mutations in the IGHV3-21 gene can lead to immunodeficiency disorders, such as X-linked lymphoproliferative disease. In conclusion, the IGHV3-21 gene is a critical component of the human immune system, playing a pivotal role in antigen recognition, binding, and regulation of the immune response. Its widespread expression across various cell types and tissues highlights its importance in maintaining immune homeostasis. Further research is needed to fully elucidate the clinical significance of the IGHV3-21 gene and its role in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.