Details for: IGHV3 16

Gene ID: 28447

Symbol: IGHV3 16

Ensembl ID: ENSG00000211944

Description: immunoglobulin heavy variable 3-16 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.5442
    Cell Significance Index: 5.5600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0228
    Cell Significance Index: -0.3100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0407
    Cell Significance Index: -1.0400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0439
    Cell Significance Index: -0.4900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0518
    Cell Significance Index: -0.6700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0549
    Cell Significance Index: -0.7800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0571
    Cell Significance Index: -0.3800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0579
    Cell Significance Index: -0.8800
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0621
    Cell Significance Index: -0.5500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0641
    Cell Significance Index: -1.0300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0652
    Cell Significance Index: -0.9500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0671
    Cell Significance Index: -0.6300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0703
    Cell Significance Index: -1.7900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0712
    Cell Significance Index: -0.7500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0721
    Cell Significance Index: -0.9900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0731
    Cell Significance Index: -1.4300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0748
    Cell Significance Index: -0.9100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0751
    Cell Significance Index: -0.9000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0756
    Cell Significance Index: -0.9300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0759
    Cell Significance Index: -0.8800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0784
    Cell Significance Index: -1.2700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0793
    Cell Significance Index: -1.0400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0803
    Cell Significance Index: -1.0200
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0803
    Cell Significance Index: -0.7000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0817
    Cell Significance Index: -1.0500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0822
    Cell Significance Index: -0.9700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0837
    Cell Significance Index: -0.8900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0868
    Cell Significance Index: -1.0300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0877
    Cell Significance Index: -0.9100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0889
    Cell Significance Index: -1.0500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0889
    Cell Significance Index: -1.0500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0892
    Cell Significance Index: -0.8700
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0900
    Cell Significance Index: -0.8400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0904
    Cell Significance Index: -1.0400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0919
    Cell Significance Index: -0.8400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0955
    Cell Significance Index: -1.0300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0965
    Cell Significance Index: -1.1100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1009
    Cell Significance Index: -1.0300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1016
    Cell Significance Index: -1.0300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1020
    Cell Significance Index: -1.1300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1029
    Cell Significance Index: -1.0400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1037
    Cell Significance Index: -1.1000
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1052
    Cell Significance Index: -1.0100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1064
    Cell Significance Index: -1.1200
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1074
    Cell Significance Index: -1.2400
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1141
    Cell Significance Index: -1.0800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1148
    Cell Significance Index: -1.1700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1172
    Cell Significance Index: -1.0500
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1199
    Cell Significance Index: -1.0400
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.1260
    Cell Significance Index: -1.0400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1267
    Cell Significance Index: -1.1800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1270
    Cell Significance Index: -0.6800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1272
    Cell Significance Index: -1.2700
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.1282
    Cell Significance Index: -1.0300
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1294
    Cell Significance Index: -1.0400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1322
    Cell Significance Index: -1.1200
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1323
    Cell Significance Index: -1.3700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1329
    Cell Significance Index: -1.2600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1370
    Cell Significance Index: -1.2400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1372
    Cell Significance Index: -1.3800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1379
    Cell Significance Index: -1.2900
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1383
    Cell Significance Index: -0.9000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1391
    Cell Significance Index: -1.2000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1448
    Cell Significance Index: -1.4900
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1449
    Cell Significance Index: -1.2900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1454
    Cell Significance Index: -1.3500
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1478
    Cell Significance Index: -1.2600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1568
    Cell Significance Index: -1.3300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1633
    Cell Significance Index: -1.7000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.1638
    Cell Significance Index: -1.0300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1644
    Cell Significance Index: -1.8200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1673
    Cell Significance Index: -1.5200
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1960
    Cell Significance Index: -1.3800
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.2079
    Cell Significance Index: -1.0400
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.2299
    Cell Significance Index: -1.2200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2929
    Cell Significance Index: -2.5800
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.3659
    Cell Significance Index: -1.8400
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.4609
    Cell Significance Index: -2.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV3-16 is a member of the immunoglobulin heavy chain gene family, which encodes the alpha subunit of antibodies. However, unlike other immunoglobulin genes, IGHV3-16 is non-functional and does not encode a functional antibody. Despite this, IGHV3-16 is expressed in a wide range of cell types, including lymphocytes, goblet cells, and intestinal epithelial cells. This expression is not limited to the immune system, as IGHV3-16 is also found in non-immune cells, such as goblet cells and intestinal epithelial cells. **Pathways and Functions:** IGHV3-16 is involved in various cellular pathways, including antigen binding, extracellular region, immunoglobulin complex, immunoglobulin-mediated immune response, and plasma membrane. While its non-functional status suggests that IGHV3-16 may not be involved in traditional antibody production, its expression in various cell types suggests that it may play a role in other cellular processes. One possible function of IGHV3-16 is its involvement in the regulation of immune responses. As a non-functional gene, IGHV3-16 may serve as a regulatory element that modulates the expression of other genes involved in immune responses. Additionally, IGHV3-16 may play a role in the development and differentiation of immune cells, such as lymphocytes. **Clinical Significance:** The expression of IGHV3-16 in various cell types has significant clinical implications. For example, the presence of IGHV3-16 in goblet cells and intestinal epithelial cells may contribute to the development of gastrointestinal diseases, such as inflammatory bowel disease (IBD). Furthermore, the expression of IGHV3-16 in lymphocytes may be associated with autoimmune diseases, such as rheumatoid arthritis and lupus. The non-functional status of IGHV3-16 also raises questions about its potential role in cancer. As a non-functional gene, IGHV3-16 may serve as a tumor suppressor gene that is silenced in cancer cells. The expression of IGHV3-16 in neoplastic cells may indicate a loss of function, which could contribute to tumorigenesis. In conclusion, the IGHV3-16 gene is a non-functional gene with widespread expression in the immune system and beyond. Its complex and multifaceted function suggests that IGHV3-16 plays a crucial role in regulating immune responses, cell development, and differentiation. Further research is needed to fully understand the clinical significance of IGHV3-16 and its potential role in various diseases, including IBD, autoimmune diseases, and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.