Details for: TRAV4

Gene ID: 28689

Symbol: TRAV4

Ensembl ID: ENSG00000211778

Description: T cell receptor alpha variable 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.0105
    Cell Significance Index: 5.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.7163
    Cell Significance Index: -2.2000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.5765
    Cell Significance Index: 5.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.4927
    Cell Significance Index: -1.3200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3100
    Cell Significance Index: 3.4700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.2068
    Cell Significance Index: 3.5700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.0897
    Cell Significance Index: 0.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0202
    Cell Significance Index: 0.9500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0028
    Cell Significance Index: 0.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0016
    Cell Significance Index: -0.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0043
    Cell Significance Index: -3.2300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0054
    Cell Significance Index: -0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0090
    Cell Significance Index: -1.8000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0218
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0264
    Cell Significance Index: -4.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0278
    Cell Significance Index: -3.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0322
    Cell Significance Index: -3.2900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0448
    Cell Significance Index: -0.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0555
    Cell Significance Index: -1.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0570
    Cell Significance Index: -3.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0642
    Cell Significance Index: -2.9100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0678
    Cell Significance Index: -0.8000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0716
    Cell Significance Index: -0.6100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0750
    Cell Significance Index: -1.0200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0765
    Cell Significance Index: -1.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0912
    Cell Significance Index: -2.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0924
    Cell Significance Index: -4.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0951
    Cell Significance Index: -3.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1030
    Cell Significance Index: -3.3000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1108
    Cell Significance Index: -1.4000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1203
    Cell Significance Index: -1.1300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1222
    Cell Significance Index: -1.8900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1241
    Cell Significance Index: -1.8200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1321
    Cell Significance Index: -1.3400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1331
    Cell Significance Index: -3.3900
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1381
    Cell Significance Index: -1.4600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1407
    Cell Significance Index: -1.9300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1441
    Cell Significance Index: -3.3300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1624
    Cell Significance Index: -1.5400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1729
    Cell Significance Index: -3.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1758
    Cell Significance Index: -1.6900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1779
    Cell Significance Index: -1.1600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1823
    Cell Significance Index: -3.3700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1854
    Cell Significance Index: -3.1700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1872
    Cell Significance Index: -2.3200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1889
    Cell Significance Index: -3.0600
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1894
    Cell Significance Index: -1.8600
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1896
    Cell Significance Index: -2.0600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1918
    Cell Significance Index: -1.8700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1944
    Cell Significance Index: -2.8700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1960
    Cell Significance Index: -1.9800
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2015
    Cell Significance Index: -1.6700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2038
    Cell Significance Index: -2.4300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2083
    Cell Significance Index: -2.1600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2086
    Cell Significance Index: -1.8000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2115
    Cell Significance Index: -1.8500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2125
    Cell Significance Index: -3.5800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2141
    Cell Significance Index: -2.2700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2159
    Cell Significance Index: -2.1800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2172
    Cell Significance Index: -1.6900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2223
    Cell Significance Index: -2.3900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2246
    Cell Significance Index: -2.6100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2260
    Cell Significance Index: -2.9500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2272
    Cell Significance Index: -3.4500
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.2293
    Cell Significance Index: -1.7500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2296
    Cell Significance Index: -2.9500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2319
    Cell Significance Index: -3.3800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2333
    Cell Significance Index: -2.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2347
    Cell Significance Index: -6.3900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2394
    Cell Significance Index: -2.7600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2406
    Cell Significance Index: -2.0300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2409
    Cell Significance Index: -3.1500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2415
    Cell Significance Index: -3.0600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2417
    Cell Significance Index: -2.3200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2419
    Cell Significance Index: -3.1300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2423
    Cell Significance Index: -2.7300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2423
    Cell Significance Index: -3.2300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2425
    Cell Significance Index: -3.3300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.2448
    Cell Significance Index: -2.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2453
    Cell Significance Index: -3.6200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2469
    Cell Significance Index: -3.2400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2501
    Cell Significance Index: -3.0400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2518
    Cell Significance Index: -2.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2526
    Cell Significance Index: -4.9300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2562
    Cell Significance Index: -3.2000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2573
    Cell Significance Index: -3.0900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2578
    Cell Significance Index: -2.3900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2581
    Cell Significance Index: -3.5800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2601
    Cell Significance Index: -3.1400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2612
    Cell Significance Index: -4.2000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2614
    Cell Significance Index: -3.4400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2645
    Cell Significance Index: -3.1900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.2651
    Cell Significance Index: -2.2800
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2656
    Cell Significance Index: -2.2200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2664
    Cell Significance Index: -3.7900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.2665
    Cell Significance Index: -2.1300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2689
    Cell Significance Index: -3.5100
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2712
    Cell Significance Index: -2.4400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2717
    Cell Significance Index: -3.3400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2751
    Cell Significance Index: -3.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Variable region:** TRAV4 encodes a variable region of the TCR alpha chain, which is essential for antigen recognition and binding. 2. **Adaptive immune response:** TRAV4 is involved in the adaptive immune response, where T cells recognize and respond to specific antigens. 3. **T cell receptor complex:** TRAV4 is part of the TCR complex, which is a critical component of the adaptive immune response. 4. **Diversity:** TRAV4 contributes to the diversity of the TCR, allowing for the recognition of a wide range of antigens. 5. **Expression:** TRAV4 is expressed in various cell types, including goblet cells, granulocyte-monocyte progenitor cells, and neoplastic cells. **Pathways and Functions:** 1. **Adaptive immune response:** TRAV4 plays a crucial role in the adaptive immune response by recognizing and binding to specific antigens. 2. **T cell activation:** The recognition of antigens by TRAV4 on the surface of T cells leads to T cell activation and the initiation of an immune response. 3. **Antigen presentation:** TRAV4 is involved in the presentation of antigens to T cells, which is essential for the activation of T cells. 4. **Immune regulation:** TRAV4 may also play a role in regulating the immune response, including the modulation of T cell activity and the prevention of autoimmune diseases. **Clinical Significance:** 1. **Autoimmune diseases:** Alterations in TRAV4 expression or function may contribute to the development of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer:** TRAV4 is expressed in neoplastic cells, suggesting its potential role in cancer development and progression. 3. **Immunodeficiency:** Mutations in TRAV4 may lead to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 4. **Transplant rejection:** TRAV4 may play a role in transplant rejection, as it is involved in the recognition and response to antigens presented by transplanted tissues. 5. **Vaccine development:** Understanding the function and clinical significance of TRAV4 may lead to the development of new vaccines and immunotherapies. In conclusion, TRAV4 is a critical gene that contributes to the diversity of the TCR and plays a crucial role in the adaptive immune response. Its expression in various cell types and involvement in antigen recognition and presentation highlight its potential role in immune regulation and disease. Further research is necessary to fully elucidate the function and clinical significance of TRAV4.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.