Details for: TRAV3

Gene ID: 28690

Symbol: TRAV3

Ensembl ID: ENSG00000211777

Description: T cell receptor alpha variable 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.7281
    Cell Significance Index: 3.9700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1109
    Cell Significance Index: 1.2400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0698
    Cell Significance Index: 0.7000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0012
    Cell Significance Index: 0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0027
    Cell Significance Index: -2.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0135
    Cell Significance Index: -2.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0260
    Cell Significance Index: -2.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0268
    Cell Significance Index: -3.6800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0328
    Cell Significance Index: -0.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0357
    Cell Significance Index: -4.3900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0417
    Cell Significance Index: -1.0100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0434
    Cell Significance Index: -0.3600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0553
    Cell Significance Index: -0.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0557
    Cell Significance Index: -1.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0574
    Cell Significance Index: -1.6900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0603
    Cell Significance Index: -0.8200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0720
    Cell Significance Index: -0.8500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0738
    Cell Significance Index: -1.0800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0744
    Cell Significance Index: -1.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0789
    Cell Significance Index: -3.6800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0930
    Cell Significance Index: -2.3700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1057
    Cell Significance Index: -0.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1079
    Cell Significance Index: -5.0700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1082
    Cell Significance Index: -1.0100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1104
    Cell Significance Index: -1.3700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1109
    Cell Significance Index: -1.1200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1118
    Cell Significance Index: -1.6300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1167
    Cell Significance Index: -1.8900
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1192
    Cell Significance Index: -0.8200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1207
    Cell Significance Index: -2.3600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1217
    Cell Significance Index: -1.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1236
    Cell Significance Index: -2.2900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1244
    Cell Significance Index: -1.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1249
    Cell Significance Index: -1.2000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1260
    Cell Significance Index: -1.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1314
    Cell Significance Index: -1.9400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1345
    Cell Significance Index: -1.7000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1376
    Cell Significance Index: -1.7800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1392
    Cell Significance Index: -2.4000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1402
    Cell Significance Index: -1.2100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1445
    Cell Significance Index: -1.1700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1470
    Cell Significance Index: -1.7300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1486
    Cell Significance Index: -2.5400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1495
    Cell Significance Index: -1.5500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1532
    Cell Significance Index: -1.9000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1551
    Cell Significance Index: -1.8600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1578
    Cell Significance Index: -1.8300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1590
    Cell Significance Index: -1.7100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1598
    Cell Significance Index: -1.6100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1600
    Cell Significance Index: -1.5600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1615
    Cell Significance Index: -2.1200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1620
    Cell Significance Index: -1.6800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1622
    Cell Significance Index: -1.7200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1633
    Cell Significance Index: -1.8400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1643
    Cell Significance Index: -1.8900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1646
    Cell Significance Index: -1.4400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1649
    Cell Significance Index: -2.1700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1675
    Cell Significance Index: -2.3800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1686
    Cell Significance Index: -2.5600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1698
    Cell Significance Index: -2.2200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1698
    Cell Significance Index: -2.8600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1701
    Cell Significance Index: -2.2200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1708
    Cell Significance Index: -2.0300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1708
    Cell Significance Index: -2.2000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1753
    Cell Significance Index: -1.8900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1762
    Cell Significance Index: -1.9200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1764
    Cell Significance Index: -1.9300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1765
    Cell Significance Index: -2.1700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1782
    Cell Significance Index: -2.0700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1790
    Cell Significance Index: -2.0600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1792
    Cell Significance Index: -2.1800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1793
    Cell Significance Index: -2.1800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1796
    Cell Significance Index: -2.0400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1798
    Cell Significance Index: -2.3100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1809
    Cell Significance Index: -2.2600
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1814
    Cell Significance Index: -1.5600
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1823
    Cell Significance Index: -2.0100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1835
    Cell Significance Index: -2.9500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1837
    Cell Significance Index: -1.5500
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1838
    Cell Significance Index: -1.7000
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1845
    Cell Significance Index: -1.6600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1853
    Cell Significance Index: -2.0300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1854
    Cell Significance Index: -2.0100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1863
    Cell Significance Index: -1.9000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1869
    Cell Significance Index: -2.4400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1877
    Cell Significance Index: -1.4600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1884
    Cell Significance Index: -2.0200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1921
    Cell Significance Index: -2.2700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1922
    Cell Significance Index: -2.6400
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1938
    Cell Significance Index: -1.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1938
    Cell Significance Index: -2.8600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1948
    Cell Significance Index: -2.2300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1963
    Cell Significance Index: -2.3200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1978
    Cell Significance Index: -2.0700
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1980
    Cell Significance Index: -2.3500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1997
    Cell Significance Index: -2.0400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1997
    Cell Significance Index: -1.9700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2005
    Cell Significance Index: -2.8100
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.2010
    Cell Significance Index: -1.9900
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.2015
    Cell Significance Index: -1.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV3 is a member of the TRAV family, which consists of 78 variable (V) genes that encode the alpha chain of the T cell receptor (TCR) complex. These V genes undergo somatic recombination during T cell development, resulting in a diverse repertoire of TCRs that enable the immune system to recognize a wide range of antigens. TRAV3 is one of the 27 TRAV genes that have been identified, and its expression is restricted to a subset of T cells, including early T lineage precursors and mature T cells. **Pathways and Functions:** TRAV3 plays a critical role in the adaptive immune response by participating in the recognition and binding of antigens to the TCR complex. The TCR complex, comprising TRAV3 and other TRAV and TRVC genes, recognizes specific major histocompatibility complex (MHC) molecules presented on antigen-presenting cells. This recognition triggers a signaling cascade that leads to the activation of T cells, proliferation, and differentiation into effector cells that can eliminate infected cells or produce cytokines to coordinate an immune response. In addition to its role in antigen recognition, TRAV3 is also involved in the regulation of T cell development and function. Studies have shown that TRAV3 is required for the proper development and maturation of T cells, including the early T lineage precursors and mature T cells. Furthermore, TRAV3 has been implicated in the regulation of T cell activation, proliferation, and cytokine production. **Clinical Significance:** The TRAV3 gene has been associated with several autoimmune and inflammatory diseases, including multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. These diseases are characterized by an abnormal immune response to self-antigens, leading to tissue damage and inflammation. Studies have shown that TRAV3 is overexpressed in these diseases, suggesting that it plays a critical role in the pathogenesis of these conditions. Moreover, TRAV3 has been identified as a potential therapeutic target for the treatment of autoimmune diseases. Research has shown that TRAV3 is involved in the regulation of T cell activation and cytokine production, making it a potential target for the development of novel immunotherapies. In conclusion, the TRAV3 gene plays a critical role in the adaptive immune response, and its dysregulation has been implicated in several autoimmune and inflammatory diseases. Further research is needed to fully understand the mechanisms by which TRAV3 regulates T cell development and function, as well as its potential as a therapeutic target for the treatment of autoimmune diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.