Details for: IGLV2 8

Gene ID: 28817

Symbol: IGLV2 8

Ensembl ID: ENSG00000278196

Description: immunoglobulin lambda variable 2-8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3833
    Cell Significance Index: 5.9300
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.1657
    Cell Significance Index: 1.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0888
    Cell Significance Index: 9.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0830
    Cell Significance Index: 10.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0046
    Cell Significance Index: -3.4800
  • Cell Name: smooth muscle cell of the pulmonary artery (CL0002591)
    Fold Change: -0.0170
    Cell Significance Index: -0.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0243
    Cell Significance Index: -4.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0348
    Cell Significance Index: -4.2800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0384
    Cell Significance Index: -0.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0399
    Cell Significance Index: -3.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0509
    Cell Significance Index: -6.5700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0551
    Cell Significance Index: -0.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0564
    Cell Significance Index: -1.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0639
    Cell Significance Index: -3.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0713
    Cell Significance Index: -4.6000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0854
    Cell Significance Index: -0.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0879
    Cell Significance Index: -6.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1042
    Cell Significance Index: -1.1800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1065
    Cell Significance Index: -1.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1072
    Cell Significance Index: -5.0000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1081
    Cell Significance Index: -1.5700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1141
    Cell Significance Index: -1.2800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1141
    Cell Significance Index: -4.1900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1147
    Cell Significance Index: -1.5600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1200
    Cell Significance Index: -1.2900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1248
    Cell Significance Index: -1.4000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1428
    Cell Significance Index: -1.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1538
    Cell Significance Index: -3.1900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1572
    Cell Significance Index: -2.6700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1597
    Cell Significance Index: -4.0700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1607
    Cell Significance Index: -1.3500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1632
    Cell Significance Index: -2.2900
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1649
    Cell Significance Index: -1.5500
  • Cell Name: collagen secreting cell (CL0000667)
    Fold Change: -0.1669
    Cell Significance Index: -0.9300
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1697
    Cell Significance Index: -1.1300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1850
    Cell Significance Index: -4.4800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1857
    Cell Significance Index: -3.6300
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.1894
    Cell Significance Index: -1.8800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1908
    Cell Significance Index: -2.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1910
    Cell Significance Index: -2.8200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1987
    Cell Significance Index: -2.0300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2029
    Cell Significance Index: -2.5100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2040
    Cell Significance Index: -2.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2050
    Cell Significance Index: -10.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2078
    Cell Significance Index: -3.8400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2121
    Cell Significance Index: -3.0500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2124
    Cell Significance Index: -3.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2198
    Cell Significance Index: -6.3000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2213
    Cell Significance Index: -2.3500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2268
    Cell Significance Index: -2.6800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2291
    Cell Significance Index: -2.9700
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2301
    Cell Significance Index: -2.6100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2329
    Cell Significance Index: -2.7400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2340
    Cell Significance Index: -3.0000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.2356
    Cell Significance Index: -3.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2359
    Cell Significance Index: -5.4500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2399
    Cell Significance Index: -2.7600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2425
    Cell Significance Index: -4.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2445
    Cell Significance Index: -11.4900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2457
    Cell Significance Index: -2.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2470
    Cell Significance Index: -4.1600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2657
    Cell Significance Index: -3.1400
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.2691
    Cell Significance Index: -2.9100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2694
    Cell Significance Index: -3.0500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2718
    Cell Significance Index: -3.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2785
    Cell Significance Index: -4.1100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2793
    Cell Significance Index: -3.8300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2845
    Cell Significance Index: -3.7200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.2865
    Cell Significance Index: -3.0600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2886
    Cell Significance Index: -3.9900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2896
    Cell Significance Index: -3.7200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2924
    Cell Significance Index: -3.7000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2940
    Cell Significance Index: -2.7600
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.2968
    Cell Significance Index: -3.0300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2986
    Cell Significance Index: -3.7500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.2990
    Cell Significance Index: -3.2700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3009
    Cell Significance Index: -3.9600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.3039
    Cell Significance Index: -3.2000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3045
    Cell Significance Index: -2.6000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3106
    Cell Significance Index: -3.8800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.3112
    Cell Significance Index: -2.1900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3114
    Cell Significance Index: -3.1600
  • Cell Name: lung interstitial macrophage (CL4033043)
    Fold Change: -0.3160
    Cell Significance Index: -3.0500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.3162
    Cell Significance Index: -2.8200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.3181
    Cell Significance Index: -3.8400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.3204
    Cell Significance Index: -2.9300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.3260
    Cell Significance Index: -3.0500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3266
    Cell Significance Index: -4.0200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.3267
    Cell Significance Index: -3.3700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3284
    Cell Significance Index: -4.3100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.3326
    Cell Significance Index: -3.9300
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.3328
    Cell Significance Index: -3.0100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.3329
    Cell Significance Index: -3.5300
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: -0.3335
    Cell Significance Index: -2.8900
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.3341
    Cell Significance Index: -3.1000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.3389
    Cell Significance Index: -2.8600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.3393
    Cell Significance Index: -3.4400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3394
    Cell Significance Index: -4.5100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.3398
    Cell Significance Index: -3.1100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.3402
    Cell Significance Index: -4.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Immunoglobulin structure**: IGLV2-8 is a part of the lambda light chain, which is one of the two chains that make up an antibody. The lambda light chain is responsible for the unique specificity of the antibody. 2. **Variable region**: The IGLV2-8 gene encodes the variable region of the lambda light chain, which determines the antibody's specificity and affinity for antigens. 3. **Expression in immune cells**: IGLV2-8 is expressed in various immune cells, including B cells, natural killer cells, and monocytes, which are all involved in the adaptive immune response. 4. **Leishmania parasite infection**: The IGLV2-8 gene is significantly upregulated in response to Leishmania parasite infection, suggesting a crucial role in the immune response against this pathogen. **Pathways and Functions** 1. **Adaptive immune response**: IGLV2-8 plays a crucial role in the adaptive immune response, particularly in the context of Leishmania parasite infection. 2. **Antigen binding**: The IGLV2-8 gene is involved in the binding of antigens to the antibody, which triggers an immune response. 3. **Complement cascade**: IGLV2-8 is involved in the activation of the complement cascade, a series of reactions that help eliminate pathogens from the body. 4. **Antigen presentation**: The IGLV2-8 gene is involved in the presentation of antigens to T cells, which is crucial for the activation of the adaptive immune response. 5. **Regulation of immune responses**: IGLV2-8 is involved in the regulation of immune responses, particularly in the context of Leishmania parasite infection. **Clinical Significance** 1. **Leishmania parasite infection**: The IGLV2-8 gene is significantly upregulated in response to Leishmania parasite infection, suggesting a crucial role in the immune response against this pathogen. 2. **Immunodeficiency diseases**: Mutations in the IGLV2-8 gene have been associated with immunodeficiency diseases, such as X-linked agammaglobulinemia. 3. **Cancer therapy**: IGLV2-8 has been identified as a potential target for cancer therapy, particularly in the context of B cell lymphomas. 4. **Vaccine development**: The IGLV2-8 gene has been identified as a potential target for vaccine development, particularly in the context of Leishmania parasite infection. In conclusion, the IGLV2-8 gene is a crucial component of the adaptive immune system, particularly in the context of Leishmania parasite infection. Further research is needed to fully understand the role of IGLV2-8 in the immune response and its potential applications in immunotherapy and vaccine development.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.