Details for: IGKV1 13

Gene ID: 28939

Symbol: IGKV1 13

Ensembl ID: ENSG00000253497

Description: immunoglobulin kappa variable 1-13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.3534
    Cell Significance Index: 3.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0016
    Cell Significance Index: 0.0800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0054
    Cell Significance Index: -0.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0076
    Cell Significance Index: -0.2800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0103
    Cell Significance Index: -0.1400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0255
    Cell Significance Index: -0.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0275
    Cell Significance Index: -0.6400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0304
    Cell Significance Index: -0.3400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0369
    Cell Significance Index: -0.9400
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0409
    Cell Significance Index: -0.3700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0430
    Cell Significance Index: -0.5100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0517
    Cell Significance Index: -1.0100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0537
    Cell Significance Index: -0.3500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0551
    Cell Significance Index: -0.6500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0609
    Cell Significance Index: -0.7300
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0612
    Cell Significance Index: -0.5600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0643
    Cell Significance Index: -0.7900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0649
    Cell Significance Index: -0.6900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0667
    Cell Significance Index: -0.7100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0669
    Cell Significance Index: -0.9500
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0685
    Cell Significance Index: -0.7100
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0689
    Cell Significance Index: -0.6800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0694
    Cell Significance Index: -0.7200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0695
    Cell Significance Index: -0.7100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0712
    Cell Significance Index: -0.9300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0722
    Cell Significance Index: -0.6700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0730
    Cell Significance Index: -0.7400
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0736
    Cell Significance Index: -0.7200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0737
    Cell Significance Index: -1.1200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0739
    Cell Significance Index: -0.9700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0744
    Cell Significance Index: -0.9300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0749
    Cell Significance Index: -0.7600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0762
    Cell Significance Index: -0.9000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0763
    Cell Significance Index: -0.6100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0767
    Cell Significance Index: -1.0100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0770
    Cell Significance Index: -0.9100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0778
    Cell Significance Index: -1.0000
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0779
    Cell Significance Index: -0.6900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0789
    Cell Significance Index: -1.1500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0790
    Cell Significance Index: -1.0500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0792
    Cell Significance Index: -1.1100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0793
    Cell Significance Index: -0.9200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0807
    Cell Significance Index: -0.8500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0808
    Cell Significance Index: -0.9300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0810
    Cell Significance Index: -0.7900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0812
    Cell Significance Index: -0.9600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0813
    Cell Significance Index: -0.9000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0839
    Cell Significance Index: -0.8900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0840
    Cell Significance Index: -1.0000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0865
    Cell Significance Index: -0.9300
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0867
    Cell Significance Index: -0.7900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0886
    Cell Significance Index: -1.0200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0894
    Cell Significance Index: -0.9900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0898
    Cell Significance Index: -0.8400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0902
    Cell Significance Index: -0.9000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0907
    Cell Significance Index: -0.8600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0913
    Cell Significance Index: -0.9900
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0915
    Cell Significance Index: -0.7800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0916
    Cell Significance Index: -0.7900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0921
    Cell Significance Index: -0.9300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0936
    Cell Significance Index: -0.6800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0960
    Cell Significance Index: -0.9800
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0964
    Cell Significance Index: -0.8400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0988
    Cell Significance Index: -0.9200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0998
    Cell Significance Index: -1.3700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1005
    Cell Significance Index: -0.9300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1009
    Cell Significance Index: -1.0600
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1010
    Cell Significance Index: -0.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1020
    Cell Significance Index: -0.9800
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1036
    Cell Significance Index: -0.9800
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1041
    Cell Significance Index: -0.9300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1042
    Cell Significance Index: -1.0500
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1049
    Cell Significance Index: -0.9100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1096
    Cell Significance Index: -0.6800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1140
    Cell Significance Index: -1.0700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1144
    Cell Significance Index: -1.0200
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1146
    Cell Significance Index: -1.0200
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.1172
    Cell Significance Index: -1.0300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1200
    Cell Significance Index: -1.0500
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.1267
    Cell Significance Index: -0.9300
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1269
    Cell Significance Index: -1.0200
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1295
    Cell Significance Index: -0.9200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1335
    Cell Significance Index: -1.1800
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1341
    Cell Significance Index: -1.0300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1350
    Cell Significance Index: -1.0500
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1383
    Cell Significance Index: -0.9000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1408
    Cell Significance Index: -1.1900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1501
    Cell Significance Index: -2.0800
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1507
    Cell Significance Index: -1.1500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1806
    Cell Significance Index: -0.9700
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.2082
    Cell Significance Index: -2.1200
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2244
    Cell Significance Index: -1.9600
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.2507
    Cell Significance Index: -1.3300
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.2676
    Cell Significance Index: -1.3400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.2797
    Cell Significance Index: -2.5700
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.3051
    Cell Significance Index: -0.9300
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: -0.3352
    Cell Significance Index: -1.0900
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.3759
    Cell Significance Index: -1.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV1 13 is a gene located on the X chromosome, which is one of the two sex chromosomes in humans. The gene is part of the immunoglobulin kappa (IgK) family, which consists of genes that encode the kappa light chains of antibodies. The IgK family is responsible for producing a diverse repertoire of antibodies, allowing the immune system to respond to a wide range of pathogens. IGKV1 13 is specifically involved in the production of kappa light chains, which are essential for the assembly and secretion of functional antibodies. **Pathways and Functions:** IGKV1 13 is involved in several key pathways that regulate the adaptive immune response. These pathways include: 1. **Immunoglobulin production:** IGKV1 13 is essential for the production of kappa light chains, which are the building blocks of antibodies. The gene is activated during B-cell development, and its expression is tightly regulated to ensure the correct assembly and secretion of functional antibodies. 2. **Adaptive immune response:** IGKV1 13 plays a critical role in the adaptive immune response by producing antibodies that recognize and neutralize pathogens. The gene is involved in the activation of B cells, which then differentiate into antibody-producing plasma cells. 3. **B-cell development:** IGKV1 13 is also involved in the development of B cells, which are the cells responsible for producing antibodies. The gene is expressed during the transition from the pro-B cell stage to the mature B cell stage. **Clinical Significance:** IGKV1 13 has significant clinical implications in the context of immune responses. Dysregulation of the gene has been implicated in various immune-related disorders, including: 1. **Immunodeficiency diseases:** IGKV1 13 mutations have been associated with primary immunodeficiency diseases, such as X-linked agammaglobulinemia, which is characterized by a lack of antibodies and impaired immune function. 2. **Autoimmune diseases:** IGKV1 13 has also been implicated in autoimmune diseases, such as rheumatoid arthritis, where the immune system mistakenly attacks healthy tissues. 3. **Cancer:** IGKV1 13 mutations have been found in certain types of cancer, such as lymphoma, where the gene is involved in the development and progression of the disease. In conclusion, IGKV1 13 is a critical gene that plays a vital role in the adaptive immune response. Its dysregulation has significant clinical implications, and further research is needed to fully understand the mechanisms underlying its function and the consequences of its dysregulation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.