Details for: GRM4

Gene ID: 2914

Symbol: GRM4

Ensembl ID: ENSG00000124493

Description: glutamate metabotropic receptor 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.38
    Marker Score: 2393
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.13
    Marker Score: 4041
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.93
    Marker Score: 18166
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.75
    Marker Score: 1205
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.71
    Marker Score: 3534
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.64
    Marker Score: 8787
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.53
    Marker Score: 14579
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.47
    Marker Score: 2980
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.34
    Marker Score: 20043
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.32
    Marker Score: 962
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.28
    Marker Score: 9847
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.19
    Marker Score: 1838
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4820
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.15
    Marker Score: 1261.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.15
    Marker Score: 689
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.13
    Marker Score: 17622
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.1
    Marker Score: 4470
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.05
    Marker Score: 481
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.02
    Marker Score: 424
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.02
    Marker Score: 426
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.93
    Marker Score: 254
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.92
    Marker Score: 4805
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.84
    Marker Score: 443
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.83
    Marker Score: 27928
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.82
    Marker Score: 31030
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.78
    Marker Score: 3033
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.76
    Marker Score: 5735
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.74
    Marker Score: 352
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.74
    Marker Score: 14630
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.72
    Marker Score: 1033
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.69
    Marker Score: 220
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 437
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.66
    Marker Score: 5660
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.66
    Marker Score: 339
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.63
    Marker Score: 5290
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.61
    Marker Score: 4023
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 480
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.59
    Marker Score: 36212
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.59
    Marker Score: 236
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.58
    Marker Score: 327
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.58
    Marker Score: 1323
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.56
    Marker Score: 322
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.54
    Marker Score: 239
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.52
    Marker Score: 399
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 206.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.48
    Marker Score: 482
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.46
    Marker Score: 148
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.45
    Marker Score: 1070
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 444
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.43
    Marker Score: 1977
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 412
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.41
    Marker Score: 4274
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.36
    Marker Score: 352
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.35
    Marker Score: 122
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.35
    Marker Score: 168
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.34
    Marker Score: 12620
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.34
    Marker Score: 88
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.34
    Marker Score: 688
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.33
    Marker Score: 103
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.32
    Marker Score: 537
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.31
    Marker Score: 1031
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.3
    Marker Score: 1245
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.28
    Marker Score: 114
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.28
    Marker Score: 124
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.25
    Marker Score: 2530
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.22
    Marker Score: 96
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.22
    Marker Score: 80
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.21
    Marker Score: 267
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.2
    Marker Score: 74
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2
    Marker Score: 69
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.2
    Marker Score: 370
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.19
    Marker Score: 238
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.19
    Marker Score: 336
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 114
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.19
    Marker Score: 74

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Other Information

**Key characteristics:** * GRM4 is a member of the G protein-coupled glutamate receptor (GPCR) family. * It is a transmembrane protein with seven transmembrane domains. * It is expressed in high levels in the central nervous system and the periphery. * It is a ligand for the G protein-coupled receptor Gα(i). * It is a negative regulator of the adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway. **Pathways and functions:** * GRM4 is a negative regulator of the adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway. * It is involved in synaptic transmission by interacting with the Gα(i) subunit of G proteins. * It modulates the activity of the GPCR, which is expressed on the plasma membrane of neurons. * It is involved in the regulation of neuronal apoptosis, synaptic transmission, and taste perception. **Clinical significance:** * Mutations in GRM4 have been linked to several neurological disorders, including amyotrophic lateral sclerosis, schizophrenia, and depression. * GRM4 is a potential target for therapeutic intervention in these disorders. **Additional information:** * GRM4 is a highly conserved protein, with a similar sequence in rodents and humans. * It is a promising target for the development of new drugs for neurological disorders.

Genular Protein ID: 2348027017

Symbol: GRM4_HUMAN

Name: Metabotropic glutamate receptor 4

UniProtKB Accession Codes:

Q14833 B3KVL9 B7Z1T9 B7Z1U6 F5GXM5 Q5SZ84 Q6ZMQ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 8 EMDB 2 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 3 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 3 RefSeq 9 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8738157

Title: Molecular characterization and localization of human metabotropic glutamate receptor type 4.

PubMed ID: 8738157

DOI: 10.1016/0169-328x(95)00321-i

PubMed ID: 9473604

Title: Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.

PubMed ID: 9473604

DOI: 10.1016/s0169-328x(97)00277-5

PubMed ID: 7617140

Title: Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4.

PubMed ID: 7617140

DOI: 10.1016/0028-3908(94)00149-m

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 11525421

Title: Mutation screening of the metabotropic glutamate receptor mGluR4 (GRM4) gene in patients with schizophrenia.

PubMed ID: 11525421

DOI: 10.1097/00041444-200106000-00004

Sequence Information:

  • Length: 912
  • Mass: 101868
  • Checksum: 4A2F36E63A2EAF5A
  • Sequence:
    • MPGKRGLGWW WARLPLCLLL SLYGPWMPSS LGKPKGHPHM NSIRIDGDIT LGGLFPVHGR 
GSEGKPCGEL KKEKGIHRLE AMLFALDRIN NDPDLLPNIT LGARILDTCS RDTHALEQSL 
TFVQALIEKD GTEVRCGSGG PPIITKPERV VGVIGASGSS VSIMVANILR LFKIPQISYA 
STAPDLSDNS RYDFFSRVVP SDTYQAQAMV DIVRALKWNY VSTVASEGSY GESGVEAFIQ 
KSREDGGVCI AQSVKIPREP KAGEFDKIIR RLLETSNARA VIIFANEDDI RRVLEAARRA 
NQTGHFFWMG SDSWGSKIAP VLHLEEVAEG AVTILPKRMS VRGFDRYFSS RTLDNNRRNI 
WFAEFWEDNF HCKLSRHALK KGSHVKKCTN RERIGQDSAY EQEGKVQFVI DAVYAMGHAL 
HAMHRDLCPG RVGLCPRMDP VDGTQLLKYI RNVNFSGIAG NPVTFNENGD APGRYDIYQY 
QLRNDSAEYK VIGSWTDHLH LRIERMHWPG SGQQLPRSIC SLPCQPGERK KTVKGMPCCW 
HCEPCTGYQY QVDRYTCKTC PYDMRPTENR TGCRPIPIIK LEWGSPWAVL PLFLAVVGIA 
ATLFVVITFV RYNDTPIVKA SGRELSYVLL AGIFLCYATT FLMIAEPDLG TCSLRRIFLG 
LGMSISYAAL LTKTNRIYRI FEQGKRSVSA PRFISPASQL AITFSLISLQ LLGICVWFVV 
DPSHSVVDFQ DQRTLDPRFA RGVLKCDISD LSLICLLGYS MLLMVTCTVY AIKTRGVPET 
FNEAKPIGFT MYTTCIVWLA FIPIFFGTSQ SADKLYIQTT TLTVSVSLSA SVSLGMLYMP 
KVYIILFHPE QNVPKRKRSL KAVVTAATMS NKFTQKGNFR PNGEAKSELC ENLEAPALAT 
KQTYVTYTNH AI

Genular Protein ID: 1651099849

Symbol: A8K0J8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K0J8

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 4 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 4 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 604
  • Mass: 67999
  • Checksum: B99356631C935F16
  • Sequence:
    • MGSDSWGSKI APVLHLEEVA EGAVTILPKR MSVRGFDRYF SSRTLDNNRR NIWFAEFWED 
NFHCKLSRHA LKKGSHVKKC TNRERIGQDS AYEQEGKVQF VIDAVYAMGH ALHAMHRDLC 
PGRVGLCPRM DPVDGTQLLK YIRNVNFSGI AGNPVTFNEN GDAPGRYDIY QYQLRNDSAE 
YKVIGSWTDH LHLRIERMHW PGSGQQLPRS ICSLPCQPGE RKKTVKGMPC CWHCEPCTGY 
QYQVDRYTCK TCPYDMRPTE NRTGCRPIPI IKLEWGSPWA VLPLFLAVVG IAATLFVVIT 
FVRYNDTPIV KASGRELSYV LLAGIFLCYA TTFLMIAEPD LGTCSLRRIF LGLGMSISYA 
ALLTKTNRIY RIFEQGKRSV SAPRFISPAS QLAITFSLIS LQLLGICVWF VVDPSHSVVD 
FQDQRTLDPR FARGVLKCDI SDLSLICLLG YSMLLMVTCT VYAIKTRGVP ETFNEAKPIG 
FTMYTTCIVW LAFIPIFFGT SQSADKLYIQ TTTLTVSVSL SASVSLGMLY MPKVYIILFH 
PEQNVPKRKR SLKAVVTAAT MSNKFTQKGN FRPNGEAKSE LCENLEAPAL ATKQTYVTYT 
NHAI

Genular Protein ID: 3990698199

Symbol: B7ZLU9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLU9

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 9 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 PeptideAtlas 1 Pfam 3 Proteomes 2 RefSeq 1 SAM 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 865
  • Mass: 96139
  • Checksum: 6166A86C8E3865A0
  • Sequence:
    • MPGKRGLGWW WARLPLCLLL SLYGPWMPSS LGKPKGHPHM NSIRIDGDIT LGGLFPVHGR 
GSEGKPCGEL KKEKGIHRLE AMLFALDRIN NDPDLLPNIT LGARILDTCS RDTHALEQSL 
TFVQALIEKD GTEVRCGSGG PPIITKPERV VGVIGASGSS VSIMVANILR LFKIPQISYA 
STAPDLSDNS RYDFFSRVVP SDTYQAQAMV DIVRALKWNY VSTVASEGSY GESGVEAFIQ 
KSREDGGVCI AQSVKIPREP KAGEFDKIIR RLLETSNARA VIIFANEDDI RRVLEAARRA 
NQTGHFFWMG SDSWGSKIAP VLHLEEVAEG AVTILPKRMS VRDRERIGQD SAYEQEGKVQ 
FVIDAVYAMG HALHAMHRDL CPGRVGLCPR MDPVDGTQLL KYIRNVNFSG IAGNPVTFNE 
NGDAPGRYDI YQYQLRNDSA EYKVIGSWTD HLHLRIERMH WPGSGQQLPR SICSLPCQPG 
ERKKTVKGMP CCWHCEPCTG YQYQVDRYTC KTCPYDMRPT ENRTGCRPIP IIKLEWGSPW 
AVLPLFLAVV GIAATLFVVI TFVRYNDTPI VKASGRELSY VLLAGIFLCY ATTFLMIAEP 
DLGTCSLRRI FLGLGMSISY AALLTKTNRI YRIFEQGKRS VSAPRFISPA SQLAITFSLI 
SLQLLGICVW FVVDPSHSVV DFQDQRTLDP RFARGVLKCD ISDLSLICLL GYSMLLMVTC 
TVYAIKTRGV PETFNEAKPI GFTMYTTCIV WLAFIPIFFG TSQSADKLYI QTTTLTVSVS 
LSASVSLGML YMPKVYIILF HPEQNVPKRK RSLKAVVTAA TMSNKFTQKG NFRPNGEAKS 
ELCENLEAPA LATKQTYVTY TNHAI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.