Details for: GUCY1A1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 66.5929
Cell Significance Index: -31.4400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 65.4512
Cell Significance Index: -26.5900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 63.6488
Cell Significance Index: -32.7400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 27.8923
Cell Significance Index: -26.6300 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 3.2175
Cell Significance Index: 49.7800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 2.7995
Cell Significance Index: 89.6700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.6650
Cell Significance Index: 117.8800 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 1.7489
Cell Significance Index: 13.4800 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.6802
Cell Significance Index: 10.4000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.6565
Cell Significance Index: 106.8700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.5045
Cell Significance Index: 56.9700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.1233
Cell Significance Index: 509.8200 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.1207
Cell Significance Index: 13.9000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0891
Cell Significance Index: 218.4700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7635
Cell Significance Index: 145.3100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7348
Cell Significance Index: 263.5700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.7095
Cell Significance Index: 47.7100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7011
Cell Significance Index: 53.8000 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.5608
Cell Significance Index: 4.9400 - Cell Name: perivascular cell (CL4033054)
Fold Change: 0.4700
Cell Significance Index: 2.1700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3782
Cell Significance Index: 37.4200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3316
Cell Significance Index: 20.3800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3239
Cell Significance Index: 224.0000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3018
Cell Significance Index: 14.1900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2730
Cell Significance Index: 246.5000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2682
Cell Significance Index: 13.9700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2015
Cell Significance Index: 32.7700 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.2012
Cell Significance Index: 2.9700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1808
Cell Significance Index: 98.7400 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.1778
Cell Significance Index: 2.1600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1673
Cell Significance Index: 4.8200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1530
Cell Significance Index: 16.6400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1089
Cell Significance Index: 6.5400 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.0595
Cell Significance Index: 0.5000 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0340
Cell Significance Index: 4.3900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0147
Cell Significance Index: 10.7700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0066
Cell Significance Index: 12.4800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0037
Cell Significance Index: 2.3500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0134
Cell Significance Index: -10.1300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0168
Cell Significance Index: -30.9800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0188
Cell Significance Index: -0.6600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0198
Cell Significance Index: -30.5500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0233
Cell Significance Index: -31.6300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0248
Cell Significance Index: -10.9600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0281
Cell Significance Index: -1.7200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0296
Cell Significance Index: -21.9500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0460
Cell Significance Index: -25.9600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0471
Cell Significance Index: -6.8400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0513
Cell Significance Index: -3.5500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0556
Cell Significance Index: -34.7100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0615
Cell Significance Index: -1.5700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0664
Cell Significance Index: -11.9700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0668
Cell Significance Index: -1.6700 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0702
Cell Significance Index: -0.9000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0879
Cell Significance Index: -25.3000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0945
Cell Significance Index: -12.9800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1054
Cell Significance Index: -12.0800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1057
Cell Significance Index: -4.7900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1088
Cell Significance Index: -2.6100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1182
Cell Significance Index: -2.5600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1189
Cell Significance Index: -1.9900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1238
Cell Significance Index: -6.5000 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1249
Cell Significance Index: -16.0100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1345
Cell Significance Index: -26.6900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1412
Cell Significance Index: -17.3600 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: -0.1443
Cell Significance Index: -0.8900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1452
Cell Significance Index: -30.5800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1470
Cell Significance Index: -3.1200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1582
Cell Significance Index: -27.0100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2165
Cell Significance Index: -12.1500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2341
Cell Significance Index: -23.9100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2357
Cell Significance Index: -24.5400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2561
Cell Significance Index: -29.8500 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2660
Cell Significance Index: -5.3400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2794
Cell Significance Index: -4.2100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2861
Cell Significance Index: -33.7400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2865
Cell Significance Index: -13.3600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2876
Cell Significance Index: -22.7800 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.3801
Cell Significance Index: -5.0700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3914
Cell Significance Index: -29.1700 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: -0.4021
Cell Significance Index: -4.6100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4171
Cell Significance Index: -26.2900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.4331
Cell Significance Index: -21.8900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4428
Cell Significance Index: -11.8500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4544
Cell Significance Index: -12.9700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4822
Cell Significance Index: -25.0500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4841
Cell Significance Index: -10.3100 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.4854
Cell Significance Index: -6.9700 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.4913
Cell Significance Index: -5.5500 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4978
Cell Significance Index: -13.0900 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.4983
Cell Significance Index: -10.4000 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.5092
Cell Significance Index: -5.2700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.5536
Cell Significance Index: -17.6300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.5915
Cell Significance Index: -16.5300 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.5920
Cell Significance Index: -12.7900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6126
Cell Significance Index: -21.4600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6333
Cell Significance Index: -16.2800 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.6343
Cell Significance Index: -7.9100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6347
Cell Significance Index: -20.7800 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.6410
Cell Significance Index: -10.1700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4003239014
Symbol: GCYA1_HUMAN
Name: Soluble guanylate cyclase large subunit
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1352257
Title: Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain.
PubMed ID: 1352257
PubMed ID: 9742212
Title: Human soluble guanylate cyclase: functional expression and revised isoenzyme family.
PubMed ID: 9742212
DOI: 10.1042/bj3350051
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 23505436
Title: Crystal structures of the catalytic domain of human soluble guanylate cyclase.
PubMed ID: 23505436
PubMed ID: 24581742
Title: Loss of alpha1beta1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia.
PubMed ID: 24581742
PubMed ID: 24669844
Title: Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.
PubMed ID: 24669844
DOI: 10.1021/bi500129k
Sequence Information:
- Length: 690
- Mass: 77452
- Checksum: DA1E14A5E11451CF
- Sequence:
MFCTKLKDLK ITGECPFSLL APGQVPNESS EEAAGSSESC KATVPICQDI PEKNIQESLP QRKTSRSRVY LHTLAESICK LIFPEFERLN VALQRTLAKH KIKESRKSLE REDFEKTIAE QAVAAGVPVE VIKESLGEEV FKICYEEDEN ILGVVGGTLK DFLNSFSTLL KQSSHCQEAG KRGRLEDASI LCLDKEDDFL HVYYFFPKRT TSLILPGIIK AAAHVLYETE VEVSLMPPCF HNDCSEFVNQ PYLLYSVHMK STKPSLSPSK PQSSLVIPTS LFCKTFPFHF MFDKDMTILQ FGNGIRRLMN RRDFQGKPNF EEYFEILTPK INQTFSGIMT MLNMQFVVRV RRWDNSVKKS SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR AQDGLKKRLG KLKATLEQAH QALEEEKKKT VDLLCSIFPC EVAQQLWQGQ VVQAKKFSNV TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHK ESDTHAVQIA LMALKMMELS DEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSEI PGICHFLDAY QQGTNSKPCF QKKDVEDGNA NFLGKASGID
Genular Protein ID: 4103408465
Symbol: B3KU69_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 690
- Mass: 77353
- Checksum: D11EA6D5586454CE
- Sequence:
MFCTKLKDLK ITGECPFSLL APGQVPNESS EEAAGSSESC KATVPICQDI PEKNIQESLP QRKTSRSRVY LHTLAESICK LIFPEFERLN VALQRTLAKH KIKESRKSLE REDFEKTIAE QAVAAGVPVE VIKESLGEEV FKICYEEDEN ILGVVGGTLK DFLNSFSTLL KQSSHCQEAG KRGRLEDASI LCLDKEDDFL HVYYFFPKRT TSLILPGIIK AAAHVLYETE VEVSLMPPCF HNDCSEFVNQ PYLLYSVHMK STKPSLSPSK PQSSLVIPTS LFCKTFPFHF MFDKDMTILQ FGNGIRRLMN RGDFQGKPNF EEYFEILTPK INQTFSGIMT MLNMQFVVRV RRWDNSVKKS SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR AQDGLKKRLG KLKATLEQAH QALEEEKKKT VDLLCSIFPC EVAQQLWQGQ VVQAKKFSNV TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHK ESDTHAVQIA LMALKMMELS DEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSEI PGICHFLDAY QQGTNSKPCF QKKDVEDGNA NFLGKASGID
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.