Details for: GUCY1A1

Gene ID: 2982

Symbol: GUCY1A1

Ensembl ID: ENSG00000164116

Description: guanylate cyclase 1 soluble subunit alpha 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 66.5929
    Cell Significance Index: -31.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.4512
    Cell Significance Index: -26.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 63.6488
    Cell Significance Index: -32.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.8923
    Cell Significance Index: -26.6300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.2175
    Cell Significance Index: 49.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.7995
    Cell Significance Index: 89.6700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.6650
    Cell Significance Index: 117.8800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.7489
    Cell Significance Index: 13.4800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.6802
    Cell Significance Index: 10.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6565
    Cell Significance Index: 106.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.5045
    Cell Significance Index: 56.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.1233
    Cell Significance Index: 509.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.1207
    Cell Significance Index: 13.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0891
    Cell Significance Index: 218.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7635
    Cell Significance Index: 145.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7348
    Cell Significance Index: 263.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7095
    Cell Significance Index: 47.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7011
    Cell Significance Index: 53.8000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.5608
    Cell Significance Index: 4.9400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.4700
    Cell Significance Index: 2.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3782
    Cell Significance Index: 37.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3316
    Cell Significance Index: 20.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3239
    Cell Significance Index: 224.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3018
    Cell Significance Index: 14.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2730
    Cell Significance Index: 246.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2682
    Cell Significance Index: 13.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2015
    Cell Significance Index: 32.7700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2012
    Cell Significance Index: 2.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1808
    Cell Significance Index: 98.7400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1778
    Cell Significance Index: 2.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1673
    Cell Significance Index: 4.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1530
    Cell Significance Index: 16.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1089
    Cell Significance Index: 6.5400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0595
    Cell Significance Index: 0.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0340
    Cell Significance Index: 4.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0147
    Cell Significance Index: 10.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0066
    Cell Significance Index: 12.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0037
    Cell Significance Index: 2.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0134
    Cell Significance Index: -10.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0168
    Cell Significance Index: -30.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0188
    Cell Significance Index: -0.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0198
    Cell Significance Index: -30.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0233
    Cell Significance Index: -31.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0248
    Cell Significance Index: -10.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0281
    Cell Significance Index: -1.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0296
    Cell Significance Index: -21.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0460
    Cell Significance Index: -25.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0471
    Cell Significance Index: -6.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0513
    Cell Significance Index: -3.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0556
    Cell Significance Index: -34.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0615
    Cell Significance Index: -1.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0664
    Cell Significance Index: -11.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0668
    Cell Significance Index: -1.6700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0702
    Cell Significance Index: -0.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0879
    Cell Significance Index: -25.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0945
    Cell Significance Index: -12.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1054
    Cell Significance Index: -12.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1057
    Cell Significance Index: -4.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1088
    Cell Significance Index: -2.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1182
    Cell Significance Index: -2.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1189
    Cell Significance Index: -1.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1238
    Cell Significance Index: -6.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1249
    Cell Significance Index: -16.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1345
    Cell Significance Index: -26.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1412
    Cell Significance Index: -17.3600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.1443
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1452
    Cell Significance Index: -30.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1470
    Cell Significance Index: -3.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1582
    Cell Significance Index: -27.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2165
    Cell Significance Index: -12.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2341
    Cell Significance Index: -23.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2357
    Cell Significance Index: -24.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2561
    Cell Significance Index: -29.8500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2660
    Cell Significance Index: -5.3400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2794
    Cell Significance Index: -4.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2861
    Cell Significance Index: -33.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2865
    Cell Significance Index: -13.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2876
    Cell Significance Index: -22.7800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.3801
    Cell Significance Index: -5.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3914
    Cell Significance Index: -29.1700
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.4021
    Cell Significance Index: -4.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4171
    Cell Significance Index: -26.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4331
    Cell Significance Index: -21.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4428
    Cell Significance Index: -11.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4544
    Cell Significance Index: -12.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4822
    Cell Significance Index: -25.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4841
    Cell Significance Index: -10.3100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4854
    Cell Significance Index: -6.9700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.4913
    Cell Significance Index: -5.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4978
    Cell Significance Index: -13.0900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4983
    Cell Significance Index: -10.4000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.5092
    Cell Significance Index: -5.2700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5536
    Cell Significance Index: -17.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5915
    Cell Significance Index: -16.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5920
    Cell Significance Index: -12.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6126
    Cell Significance Index: -21.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6333
    Cell Significance Index: -16.2800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6343
    Cell Significance Index: -7.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6347
    Cell Significance Index: -20.7800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.6410
    Cell Significance Index: -10.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Soluble subunit of guanylate cyclase complex**: GUCY1A1 is a non-catalytic subunit of the guanylate cyclase complex, which is responsible for converting guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP). 2. **Nitric oxide-mediated signaling**: GUCY1A1 is a key player in the nitric oxide-cGMP signaling pathway, which is crucial for regulating vascular tone, platelet aggregation, and blood pressure. 3. **Expression in various tissues**: GUCY1A1 is widely expressed in thymocytes, cardiac muscle cells, ciliary muscle cells, and smooth muscle cells, among others. 4. **Heme binding**: GUCY1A1 contains a heme-binding domain, which is essential for its interaction with nitric oxide and the regulation of the guanylate cyclase complex. **Pathways and Functions:** 1. **Nitric oxide-cGMP signaling pathway**: GUCY1A1 is involved in the regulation of this pathway, which is essential for maintaining vascular tone, platelet homeostasis, and blood pressure regulation. 2. **Blood circulation**: GUCY1A1 plays a crucial role in regulating blood pressure and vascular tone, which is essential for maintaining proper blood circulation. 3. **Muscle contraction**: GUCY1A1 is involved in the regulation of muscle contraction, particularly in smooth muscle cells, which is essential for maintaining proper blood pressure and vascular tone. 4. **Synaptic transmission**: GUCY1A1 is involved in the regulation of synaptic transmission, particularly in GABAergic and glutamatergic synapses, which is essential for maintaining proper neuronal function. **Clinical Significance:** 1. **Hypertension**: Abnormalities in GUCY1A1 have been linked to hypertension, which is a major risk factor for cardiovascular disease. 2. **Cardiovascular disease**: GUCY1A1 dysfunction has been implicated in the development of cardiovascular disease, including heart failure and coronary artery disease. 3. **Neurological disorders**: GUCY1A1 has been linked to various neurological disorders, including Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). 4. **Cancer**: GUCY1A1 has been implicated in the development and progression of various cancers, including colorectal cancer and breast cancer. In conclusion, GUCY1A1 is a crucial gene involved in the regulation of various physiological processes, including blood circulation, muscle contraction, and synaptic transmission. Its dysregulation has been linked to various diseases, including hypertension, cardiovascular disease, neurological disorders, and cancer. Further research is necessary to fully understand the mechanisms underlying GUCY1A1 function and its implications in human disease.

Genular Protein ID: 4003239014

Symbol: GCYA1_HUMAN

Name: Soluble guanylate cyclase large subunit

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1352257

Title: Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain.

PubMed ID: 1352257

DOI: 10.1016/0014-5793(92)80594-7

PubMed ID: 9742212

Title: Human soluble guanylate cyclase: functional expression and revised isoenzyme family.

PubMed ID: 9742212

DOI: 10.1042/bj3350051

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23505436

Title: Crystal structures of the catalytic domain of human soluble guanylate cyclase.

PubMed ID: 23505436

DOI: 10.1371/journal.pone.0057644

PubMed ID: 24581742

Title: Loss of alpha1beta1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia.

PubMed ID: 24581742

DOI: 10.1016/j.ajhg.2014.01.018

PubMed ID: 24669844

Title: Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.

PubMed ID: 24669844

DOI: 10.1021/bi500129k

Sequence Information:

  • Length: 690
  • Mass: 77452
  • Checksum: DA1E14A5E11451CF
  • Sequence:
  • MFCTKLKDLK ITGECPFSLL APGQVPNESS EEAAGSSESC KATVPICQDI PEKNIQESLP 
    QRKTSRSRVY LHTLAESICK LIFPEFERLN VALQRTLAKH KIKESRKSLE REDFEKTIAE 
    QAVAAGVPVE VIKESLGEEV FKICYEEDEN ILGVVGGTLK DFLNSFSTLL KQSSHCQEAG 
    KRGRLEDASI LCLDKEDDFL HVYYFFPKRT TSLILPGIIK AAAHVLYETE VEVSLMPPCF 
    HNDCSEFVNQ PYLLYSVHMK STKPSLSPSK PQSSLVIPTS LFCKTFPFHF MFDKDMTILQ 
    FGNGIRRLMN RRDFQGKPNF EEYFEILTPK INQTFSGIMT MLNMQFVVRV RRWDNSVKKS 
    SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR 
    AQDGLKKRLG KLKATLEQAH QALEEEKKKT VDLLCSIFPC EVAQQLWQGQ VVQAKKFSNV 
    TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHK 
    ESDTHAVQIA LMALKMMELS DEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN 
    VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSEI PGICHFLDAY 
    QQGTNSKPCF QKKDVEDGNA NFLGKASGID

Genular Protein ID: 4103408465

Symbol: B3KU69_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 690
  • Mass: 77353
  • Checksum: D11EA6D5586454CE
  • Sequence:
  • MFCTKLKDLK ITGECPFSLL APGQVPNESS EEAAGSSESC KATVPICQDI PEKNIQESLP 
    QRKTSRSRVY LHTLAESICK LIFPEFERLN VALQRTLAKH KIKESRKSLE REDFEKTIAE 
    QAVAAGVPVE VIKESLGEEV FKICYEEDEN ILGVVGGTLK DFLNSFSTLL KQSSHCQEAG 
    KRGRLEDASI LCLDKEDDFL HVYYFFPKRT TSLILPGIIK AAAHVLYETE VEVSLMPPCF 
    HNDCSEFVNQ PYLLYSVHMK STKPSLSPSK PQSSLVIPTS LFCKTFPFHF MFDKDMTILQ 
    FGNGIRRLMN RGDFQGKPNF EEYFEILTPK INQTFSGIMT MLNMQFVVRV RRWDNSVKKS 
    SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR 
    AQDGLKKRLG KLKATLEQAH QALEEEKKKT VDLLCSIFPC EVAQQLWQGQ VVQAKKFSNV 
    TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHK 
    ESDTHAVQIA LMALKMMELS DEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN 
    VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSEI PGICHFLDAY 
    QQGTNSKPCF QKKDVEDGNA NFLGKASGID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.