Details for: GUCY1A1

Gene ID: 2982

Symbol: GUCY1A1

Ensembl ID: ENSG00000164116

Description: guanylate cyclase 1 soluble subunit alpha 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 10.75
    Marker Score: 11261.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 4.76
    Marker Score: 6566
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.66
    Marker Score: 48659.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.28
    Marker Score: 7203.5
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.97
    Marker Score: 1611
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.59
    Marker Score: 2469
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.56
    Marker Score: 1337.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.05
    Marker Score: 8495
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.89
    Marker Score: 2602
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.81
    Marker Score: 686
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.79
    Marker Score: 16869
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.75
    Marker Score: 1242
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.65
    Marker Score: 3169
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.61
    Marker Score: 59299
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.6
    Marker Score: 3010
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1154
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.57
    Marker Score: 15920
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.48
    Marker Score: 90928.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.46
    Marker Score: 55274
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.4
    Marker Score: 5695.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.39
    Marker Score: 807
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.35
    Marker Score: 1398
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.32
    Marker Score: 732
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.29
    Marker Score: 931
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.28
    Marker Score: 16890
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.26
    Marker Score: 283
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2
    Marker Score: 4649
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.18
    Marker Score: 4840
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.17
    Marker Score: 773
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.17
    Marker Score: 5431
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.15
    Marker Score: 2343
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.14
    Marker Score: 775
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.12
    Marker Score: 591.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17460
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.09
    Marker Score: 24320
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.06
    Marker Score: 734
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251764.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.02
    Marker Score: 2407
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1
    Marker Score: 489
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71784
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48008.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1
    Marker Score: 2670
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.96
    Marker Score: 471
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.96
    Marker Score: 562
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.96
    Marker Score: 966
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.96
    Marker Score: 14290
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.95
    Marker Score: 1099
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5244
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.88
    Marker Score: 1359
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.88
    Marker Score: 404.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5274
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.86
    Marker Score: 5147
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.85
    Marker Score: 911.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.84
    Marker Score: 247.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.84
    Marker Score: 1983
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.84
    Marker Score: 1701
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.84
    Marker Score: 350
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.83
    Marker Score: 2176
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.82
    Marker Score: 5325
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0.8
    Marker Score: 92179
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.8
    Marker Score: 178
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 596
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.78
    Marker Score: 372
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.78
    Marker Score: 272
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.77
    Marker Score: 5893
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.77
    Marker Score: 289
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.76
    Marker Score: 421
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.75
    Marker Score: 373
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.73
    Marker Score: 6967
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3012
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.71
    Marker Score: 2022
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.7
    Marker Score: 441
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.68
    Marker Score: 655
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.68
    Marker Score: 192
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.67
    Marker Score: 2379
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 215
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.66
    Marker Score: 398
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.64
    Marker Score: 722
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.62
    Marker Score: 159
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.62
    Marker Score: 176
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.62
    Marker Score: 6229
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.62
    Marker Score: 214
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.62
    Marker Score: 214
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.61
    Marker Score: 977
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.6
    Marker Score: 923
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.59
    Marker Score: 909.5
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.59
    Marker Score: 270
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.58
    Marker Score: 239
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.57
    Marker Score: 184

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * GUCY1A1 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including thymocytes, cardiac muscle cells, ciliary muscle cells, contractile cells, renal interstitial pericytes, rod bipolar cells, and chandelier pvalb GABAergic cortical interneurons. * GUCY1A1 is a highly regulated protein. Its expression is controlled by a variety of factors, including calcium, potassium, and nitric oxide levels. * GUCY1A1 is a key regulator of blood pressure. It does this by regulating the activity of the guanylate cyclase, which is an enzyme that converts GTP to cyclic GMP. Cyclic GMP is a second messenger that can activate a variety of downstream targets, including the vasodilator protein vasopressin. By regulating the activity of the guanylate cyclase, GUCY1A1 can control the blood pressure of the body. **Pathways and functions:** * GUCY1A1 is involved in a variety of cellular processes, including blood pressure regulation, vascular function, and inflammation. * In blood pressure regulation, GUCY1A1 helps to control the release of vasodilators from blood vessels. This helps to lower blood pressure. * In vascular function, GUCY1A1 helps to regulate the dilation and contraction of blood vessels. This helps to maintain blood flow and oxygenation of tissues. * In inflammation, GUCY1A1 is involved in the regulation of inflammation. It helps to control the production of inflammatory cytokines and chemokines. **Clinical significance:** GUCY1A1 is a key gene in blood pressure regulation. Mutations in the GUCY1A1 gene have been linked to a number of human diseases, including hypertension and heart failure. These diseases are caused by abnormal blood pressure levels and vascular dysfunction. GUCY1A1 inhibitors are being investigated as a treatment for these diseases.

Genular Protein ID: 4003239014

Symbol: GCYA1_HUMAN

Name: Soluble guanylate cyclase large subunit

UniProtKB Accession Codes:

Q02108 D3DP19 D6RDW3 O43843 Q8TAH3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 10 EMDB 10 Ensembl 6 ExpressionAtlas 1 GO 18 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 12 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 9 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1352257

Title: Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain.

PubMed ID: 1352257

DOI: 10.1016/0014-5793(92)80594-7

PubMed ID: 9742212

Title: Human soluble guanylate cyclase: functional expression and revised isoenzyme family.

PubMed ID: 9742212

DOI: 10.1042/bj3350051

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23505436

Title: Crystal structures of the catalytic domain of human soluble guanylate cyclase.

PubMed ID: 23505436

DOI: 10.1371/journal.pone.0057644

PubMed ID: 24581742

Title: Loss of alpha1beta1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia.

PubMed ID: 24581742

DOI: 10.1016/j.ajhg.2014.01.018

PubMed ID: 24669844

Title: Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.

PubMed ID: 24669844

DOI: 10.1021/bi500129k

Sequence Information:

  • Length: 690
  • Mass: 77452
  • Checksum: DA1E14A5E11451CF
  • Sequence:
    • MFCTKLKDLK ITGECPFSLL APGQVPNESS EEAAGSSESC KATVPICQDI PEKNIQESLP 
QRKTSRSRVY LHTLAESICK LIFPEFERLN VALQRTLAKH KIKESRKSLE REDFEKTIAE 
QAVAAGVPVE VIKESLGEEV FKICYEEDEN ILGVVGGTLK DFLNSFSTLL KQSSHCQEAG 
KRGRLEDASI LCLDKEDDFL HVYYFFPKRT TSLILPGIIK AAAHVLYETE VEVSLMPPCF 
HNDCSEFVNQ PYLLYSVHMK STKPSLSPSK PQSSLVIPTS LFCKTFPFHF MFDKDMTILQ 
FGNGIRRLMN RRDFQGKPNF EEYFEILTPK INQTFSGIMT MLNMQFVVRV RRWDNSVKKS 
SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR 
AQDGLKKRLG KLKATLEQAH QALEEEKKKT VDLLCSIFPC EVAQQLWQGQ VVQAKKFSNV 
TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHK 
ESDTHAVQIA LMALKMMELS DEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN 
VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSEI PGICHFLDAY 
QQGTNSKPCF QKKDVEDGNA NFLGKASGID

Genular Protein ID: 4103408465

Symbol: B3KU69_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KU69

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 4 GenomeRNAi 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 690
  • Mass: 77353
  • Checksum: D11EA6D5586454CE
  • Sequence:
    • MFCTKLKDLK ITGECPFSLL APGQVPNESS EEAAGSSESC KATVPICQDI PEKNIQESLP 
QRKTSRSRVY LHTLAESICK LIFPEFERLN VALQRTLAKH KIKESRKSLE REDFEKTIAE 
QAVAAGVPVE VIKESLGEEV FKICYEEDEN ILGVVGGTLK DFLNSFSTLL KQSSHCQEAG 
KRGRLEDASI LCLDKEDDFL HVYYFFPKRT TSLILPGIIK AAAHVLYETE VEVSLMPPCF 
HNDCSEFVNQ PYLLYSVHMK STKPSLSPSK PQSSLVIPTS LFCKTFPFHF MFDKDMTILQ 
FGNGIRRLMN RGDFQGKPNF EEYFEILTPK INQTFSGIMT MLNMQFVVRV RRWDNSVKKS 
SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR 
AQDGLKKRLG KLKATLEQAH QALEEEKKKT VDLLCSIFPC EVAQQLWQGQ VVQAKKFSNV 
TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHK 
ESDTHAVQIA LMALKMMELS DEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN 
VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSEI PGICHFLDAY 
QQGTNSKPCF QKKDVEDGNA NFLGKASGID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.