Details for: HCK
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: amacrine cell (CL0000561)
Fold Change: 3.64
Marker Score: 11659.5 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 3.13
Marker Score: 3777 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.06
Marker Score: 5954 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.98
Marker Score: 166876 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.85
Marker Score: 6870 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 2.75
Marker Score: 2526 - Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 2.48
Marker Score: 2979.5 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.37
Marker Score: 5913.5 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.08
Marker Score: 753 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.85
Marker Score: 922 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.8
Marker Score: 994 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.74
Marker Score: 709 - Cell Name: blood cell (CL0000081)
Fold Change: 1.69
Marker Score: 19621 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.65
Marker Score: 42320 - Cell Name: lung macrophage (CL1001603)
Fold Change: 1.65
Marker Score: 1889 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.61
Marker Score: 1615 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.59
Marker Score: 1156 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 1.58
Marker Score: 813 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.47
Marker Score: 2994 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168795 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.44
Marker Score: 3742 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.4
Marker Score: 8477 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.36
Marker Score: 924 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.27
Marker Score: 530 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 1.26
Marker Score: 10669 - Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 1.2
Marker Score: 829 - Cell Name: pre-B-I cell (CL0000956)
Fold Change: 1.17
Marker Score: 298 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.1
Marker Score: 355 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251779 - Cell Name: microglial cell (CL0000129)
Fold Change: 1.01
Marker Score: 1839 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71798 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48023 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1
Marker Score: 675 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.99
Marker Score: 351 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 500 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.97
Marker Score: 401.5 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 454 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411 - Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.93
Marker Score: 947 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5285 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 367 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2735 - Cell Name: immature B cell (CL0000816)
Fold Change: 0.89
Marker Score: 592 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 321 - Cell Name: macrophage (CL0000235)
Fold Change: 0.89
Marker Score: 990 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5279 - Cell Name: classical monocyte (CL0000860)
Fold Change: 0.86
Marker Score: 3562 - Cell Name: dendritic cell (CL0000451)
Fold Change: 0.85
Marker Score: 586 - Cell Name: monocyte (CL0000576)
Fold Change: 0.82
Marker Score: 1068 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.82
Marker Score: 624 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.81
Marker Score: 486 - Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.79
Marker Score: 2146 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.79
Marker Score: 3299 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.78
Marker Score: 547 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1254 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.76
Marker Score: 7668 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 390 - Cell Name: Langerhans cell (CL0000453)
Fold Change: 0.75
Marker Score: 225 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.75
Marker Score: 1200 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.72
Marker Score: 229.5 - Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.72
Marker Score: 423 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.71
Marker Score: 455 - Cell Name: brush cell (CL0002204)
Fold Change: 0.69
Marker Score: 631 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176 - Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.64
Marker Score: 221 - Cell Name: promyelocyte (CL0000836)
Fold Change: 0.61
Marker Score: 302 - Cell Name: osteoclast (CL0000092)
Fold Change: 0.6
Marker Score: 299 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.6
Marker Score: 598 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.58
Marker Score: 385 - Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.58
Marker Score: 134 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.58
Marker Score: 1008 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.58
Marker Score: 1090 - Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.56
Marker Score: 525 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.53
Marker Score: 1552 - Cell Name: neutrophil (CL0000775)
Fold Change: 0.53
Marker Score: 323 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.49
Marker Score: 124 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.48
Marker Score: 222 - Cell Name: colon macrophage (CL0009038)
Fold Change: 0.48
Marker Score: 132 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.48
Marker Score: 7472 - Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.47
Marker Score: 106 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.46
Marker Score: 455 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.46
Marker Score: 146 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.46
Marker Score: 291 - Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.45
Marker Score: 273 - Cell Name: natural killer cell (CL0000623)
Fold Change: 0.45
Marker Score: 580 - Cell Name: granulocyte (CL0000094)
Fold Change: 0.44
Marker Score: 199 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.44
Marker Score: 152 - Cell Name: promonocyte (CL0000559)
Fold Change: 0.42
Marker Score: 273 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.42
Marker Score: 130 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.42
Marker Score: 276 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.41
Marker Score: 180 - Cell Name: myelocyte (CL0002193)
Fold Change: 0.41
Marker Score: 177 - Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.4
Marker Score: 106 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.38
Marker Score: 187 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.36
Marker Score: 215 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.35
Marker Score: 93 - Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.34
Marker Score: 966 - Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.34
Marker Score: 403
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Other Information
Genular Protein ID: 93804301
Symbol: HCK_HUMAN
Name: Tyrosine-protein kinase HCK
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3496523
Title: Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.
PubMed ID: 3496523
PubMed ID: 3453117
Title: Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin.
PubMed ID: 3453117
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1875927
Title: Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization.
PubMed ID: 1875927
PubMed ID: 1572549
Title: The genomic locus of the human hemopoietic-specific cell protein tyrosine kinase (PTK)-encoding gene (HCK) confirms conservation of exon-intron structure among human PTKs of the src family.
PubMed ID: 1572549
PubMed ID: 8132624
Title: Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells.
PubMed ID: 8132624
PubMed ID: 8064233
Title: Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn.
PubMed ID: 8064233
PubMed ID: 7535819
Title: The Fc gamma RI receptor signals through the activation of hck and MAP kinase.
PubMed ID: 7535819
PubMed ID: 7791757
Title: Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae.
PubMed ID: 7791757
PubMed ID: 9406996
Title: Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines.
PubMed ID: 9406996
PubMed ID: 8995234
Title: Hck is activated by opsonized zymosan and A23187 in distinct subcellular fractions of human granulocytes.
PubMed ID: 8995234
PubMed ID: 9218412
Title: SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.
PubMed ID: 9218412
PubMed ID: 9407116
Title: The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.
PubMed ID: 9407116
PubMed ID: 10092522
Title: The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.
PubMed ID: 10092522
PubMed ID: 10779760
Title: IL-2 signaling in human monocytes involves the phosphorylation and activation of p59hck.
PubMed ID: 10779760
PubMed ID: 10644735
Title: Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand.
PubMed ID: 10644735
PubMed ID: 10973280
Title: Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI.
PubMed ID: 10973280
DOI: 10.1038/79767
PubMed ID: 11278465
Title: The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein.
PubMed ID: 11278465
PubMed ID: 11518702
Title: The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.
PubMed ID: 11518702
PubMed ID: 12411494
Title: The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.
PubMed ID: 12411494
DOI: 10.1093/emboj/cdf562
PubMed ID: 11741929
Title: Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.
PubMed ID: 11741929
PubMed ID: 11904303
Title: p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner.
PubMed ID: 11904303
PubMed ID: 11896602
Title: Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation.
PubMed ID: 11896602
PubMed ID: 15010462
Title: Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.
PubMed ID: 15010462
PubMed ID: 15952790
Title: Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck.
PubMed ID: 15952790
DOI: 10.1021/bi0500832
PubMed ID: 15998323
Title: Activation of the lysosome-associated p61Hck isoform triggers the biogenesis of podosomes.
PubMed ID: 15998323
PubMed ID: 16849330
Title: HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.
PubMed ID: 16849330
PubMed ID: 17535448
Title: Regulation of p73 by Hck through kinase-dependent and independent mechanisms.
PubMed ID: 17535448
PubMed ID: 17310994
Title: Inhibition of IL-6-dependent growth of myeloma cells by an acidic peptide repressing the gp130-mediated activation of Src family kinases.
PubMed ID: 17310994
PubMed ID: 19807924
Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
PubMed ID: 19807924
PubMed ID: 19114024
Title: The oncogenic activity of the Src family kinase Hck requires the cooperative action of the plasma membrane- and lysosome-associated isoforms.
PubMed ID: 19114024
PubMed ID: 19718658
Title: Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins.
PubMed ID: 19718658
DOI: 10.1002/jcb.22317
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19903482
Title: c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration.
PubMed ID: 19903482
PubMed ID: 20452982
Title: Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner.
PubMed ID: 20452982
PubMed ID: 18538446
Title: Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis.
PubMed ID: 18538446
PubMed ID: 21338576
Title: Protein tyrosine kinases in neutrophil activation and recruitment.
PubMed ID: 21338576
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25469238
Title: Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK.
PubMed ID: 25469238
DOI: 10.3892/br.2014.374
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 9109402
Title: Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase.
PubMed ID: 9109402
PubMed ID: 9024658
Title: Crystal structure of the Src family tyrosine kinase Hck.
PubMed ID: 9024658
DOI: 10.1038/385602a0
PubMed ID: 9778343
Title: RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef.
PubMed ID: 9778343
DOI: 10.1021/bi980989q
PubMed ID: 9571048
Title: Solution structure of the human Hck SH3 domain and identification of its ligand binding site.
PubMed ID: 9571048
PubMed ID: 10360180
Title: Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor.
PubMed ID: 10360180
PubMed ID: 16216497
Title: Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.
PubMed ID: 16216497
PubMed ID: 16997556
Title: The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck).
PubMed ID: 16997556
PubMed ID: 17141806
Title: Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes.
PubMed ID: 17141806
PubMed ID: 20810664
Title: Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism.
PubMed ID: 20810664
PubMed ID: 21625496
Title: Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.
PubMed ID: 21625496
PubMed ID: 21477083
Title: Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly.
PubMed ID: 21477083
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
PubMed ID: 34536415
Title: Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK.
PubMed ID: 34536415
Sequence Information:
- Length: 526
- Mass: 59600
- Checksum: 847E877A0A641725
- Sequence:
MGGRSSCEDP GCPRDEERAP RMGCMKSKFL QVGGNTFSKT ETSASPHCPV YVPDPTSTIK PGPNSHNSNT PGIREAGSED IIVVALYDYE AIHHEDLSFQ KGDQMVVLEE SGEWWKARSL ATRKEGYIPS NYVARVDSLE TEEWFFKGIS RKDAERQLLA PGNMLGSFMI RDSETTKGSY SLSVRDYDPR QGDTVKHYKI RTLDNGGFYI SPRSTFSTLQ ELVDHYKKGN DGLCQKLSVP CMSSKPQKPW EKDAWEIPRE SLKLEKKLGA GQFGEVWMAT YNKHTKVAVK TMKPGSMSVE AFLAEANVMK TLQHDKLVKL HAVVTKEPIY IITEFMAKGS LLDFLKSDEG SKQPLPKLID FSAQIAEGMA FIEQRNYIHR DLRAANILVS ASLVCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGSFTIKSDV WSFGILLMEI VTYGRIPYPG MSNPEVIRAL ERGYRMPRPE NCPEELYNIM MRCWKNRPEE RPTFEYIQSV LDDFYTATES QYQQQP
Genular Protein ID: 3717895784
Symbol: A8K4G3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 506
- Mass: 57444
- Checksum: 4F025445F3EDF9CA
- Sequence:
MMGCMKSKFL QVGGNTFSKT ETSASPHCPV YVPDPTSTIK PGPNSHNSNT PGIREAGSED IIVVALYDYE AIHHEDLSFQ KGDQMVVLEE SGEWWKARSL ATRKEGYIPS NYVARVDSLE TEEWFFKGIS RKDAERQLLA PGNMLGSFMI RDSETTKGSY SLSVRDYDPR QGDTVKHYKI RTLDNGGFYI SPRSTFSTLQ ELVDHYKKGN DGLCQKLSVP CMSSKPQKPW EKDAWEIPRE SLKLEKKLGA GQFGEVWMAT YNKHTKVAVK TMKPGSMSVE AFLAEANVMK TLQHDKLVKL HAVVTKEPIY IITEFMAKGS LLDFLKSDEG SKQPLPKLID FSAQIAEGMA FIEQRNYIHR DLRAANILVS ASLVCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGSFTIKSDV WSFGILLMEI VTYGRIPYPG MSNPEVIRAL ERGYRMPRPE NCPEELYNIM MRCWKNRPEE RPTFEYIQSV LDDFYTATES QYQQQP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.