Details for: HCK

Gene ID: 3055

Symbol: HCK

Ensembl ID: ENSG00000101336

Description: HCK proto-oncogene, Src family tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 78.1766
    Cell Significance Index: -12.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.8374
    Cell Significance Index: -11.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.6979
    Cell Significance Index: -13.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 28.5972
    Cell Significance Index: -14.7100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.3808
    Cell Significance Index: -13.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.8868
    Cell Significance Index: -12.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.5641
    Cell Significance Index: 102.8400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 4.8404
    Cell Significance Index: 48.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.5379
    Cell Significance Index: 673.2800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 3.1642
    Cell Significance Index: 39.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.8756
    Cell Significance Index: 44.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.7963
    Cell Significance Index: -6.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.4320
    Cell Significance Index: 240.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2731
    Cell Significance Index: 207.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1501
    Cell Significance Index: 125.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7103
    Cell Significance Index: 49.1200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.6722
    Cell Significance Index: 5.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6693
    Cell Significance Index: 43.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6414
    Cell Significance Index: 13.6600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.6042
    Cell Significance Index: 10.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5345
    Cell Significance Index: 32.0900
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3472
    Cell Significance Index: 1.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1400
    Cell Significance Index: 3.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0528
    Cell Significance Index: 10.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0517
    Cell Significance Index: 32.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0464
    Cell Significance Index: 1.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0227
    Cell Significance Index: 8.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0219
    Cell Significance Index: 0.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0066
    Cell Significance Index: 0.1900
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0014
    Cell Significance Index: -0.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0014
    Cell Significance Index: -0.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0018
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -6.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0074
    Cell Significance Index: -13.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0076
    Cell Significance Index: -4.3000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0090
    Cell Significance Index: -0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0090
    Cell Significance Index: -13.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0093
    Cell Significance Index: -1.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0112
    Cell Significance Index: -7.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0121
    Cell Significance Index: -0.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0132
    Cell Significance Index: -17.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0136
    Cell Significance Index: -2.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0146
    Cell Significance Index: -11.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0186
    Cell Significance Index: -1.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0194
    Cell Significance Index: -12.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0211
    Cell Significance Index: -11.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0230
    Cell Significance Index: -6.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0270
    Cell Significance Index: -3.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0309
    Cell Significance Index: -14.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0339
    Cell Significance Index: -4.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0400
    Cell Significance Index: -6.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0443
    Cell Significance Index: -7.9800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0467
    Cell Significance Index: -0.4000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0615
    Cell Significance Index: -0.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0739
    Cell Significance Index: -10.7500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0883
    Cell Significance Index: -10.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0930
    Cell Significance Index: -12.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0961
    Cell Significance Index: -11.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1095
    Cell Significance Index: -14.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1123
    Cell Significance Index: -11.6900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1275
    Cell Significance Index: -2.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1316
    Cell Significance Index: -10.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1343
    Cell Significance Index: -17.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1383
    Cell Significance Index: -2.3700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1484
    Cell Significance Index: -1.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1489
    Cell Significance Index: -4.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1517
    Cell Significance Index: -17.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1676
    Cell Significance Index: -11.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1726
    Cell Significance Index: -8.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1802
    Cell Significance Index: -14.2700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1812
    Cell Significance Index: -7.8800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1839
    Cell Significance Index: -1.2200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1841
    Cell Significance Index: -1.8800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1861
    Cell Significance Index: -3.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1897
    Cell Significance Index: -14.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1964
    Cell Significance Index: -10.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1996
    Cell Significance Index: -12.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2027
    Cell Significance Index: -5.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2221
    Cell Significance Index: -13.6500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2305
    Cell Significance Index: -5.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2387
    Cell Significance Index: -10.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2438
    Cell Significance Index: -12.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2457
    Cell Significance Index: -13.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2501
    Cell Significance Index: -15.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2575
    Cell Significance Index: -9.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2589
    Cell Significance Index: -13.4500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2747
    Cell Significance Index: -2.4200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2802
    Cell Significance Index: -3.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2807
    Cell Significance Index: -10.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2842
    Cell Significance Index: -14.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2973
    Cell Significance Index: -9.4700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2975
    Cell Significance Index: -2.7700
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.3160
    Cell Significance Index: -3.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3161
    Cell Significance Index: -10.3500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3345
    Cell Significance Index: -4.7900
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.3551
    Cell Significance Index: -3.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3612
    Cell Significance Index: -7.0500
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.3649
    Cell Significance Index: -3.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3827
    Cell Significance Index: -10.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proto-oncogene:** HCK is classified as a proto-oncogene, which means it has the potential to become an oncogene due to mutations or aberrant expression. 2. **Src family tyrosine kinase:** HCK belongs to the Src family of tyrosine kinases, which are known for their involvement in signaling pathways regulating cell growth, differentiation, and survival. 3. **Non-membrane spanning protein tyrosine kinase:** HCK lacks a transmembrane domain, allowing it to interact with the cytoskeleton and regulate the activity of downstream targets. **Pathways and Functions:** 1. **Cytokine-mediated signaling pathway:** HCK is involved in the signaling pathways of various cytokines, including interleukins, which play a crucial role in the regulation of immune responses. 2. **Fc-gamma receptor signaling pathway:** HCK is activated by Fc-gamma receptors, which are essential for the phagocytosis of pathogens and the regulation of the immune response. 3. **Actin filament polymerization:** HCK regulates the polymerization of actin filaments, which is crucial for cell shape, motility, and adhesion. 4. **Inflammatory response:** HCK modulates the inflammatory response by regulating the activity of transcription factors and the production of pro-inflammatory cytokines. 5. **Phagocytosis:** HCK is involved in the regulation of phagocytosis, a critical process for the elimination of pathogens and the clearance of dead cells. **Clinical Significance:** 1. **Leishmania infection:** HCK has been implicated in the pathogenesis of Leishmania infections, where it regulates the growth and survival of the parasite. 2. **HIV infection:** HCK is involved in the replication of HIV-1 and the modulation of the host immune response. 3. **Cancer:** Mutations or aberrant expression of HCK have been associated with various types of cancer, including leukemia and lymphoma. 4. **Autoimmune diseases:** HCK has been implicated in the regulation of the immune response in autoimmune diseases, such as rheumatoid arthritis and lupus. In conclusion, HCK plays a critical role in regulating various cellular processes, including cell adhesion, differentiation, and signaling pathways. Its involvement in the regulation of the immune response and disease pathogenesis highlights its importance as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 93804301

Symbol: HCK_HUMAN

Name: Tyrosine-protein kinase HCK

UniProtKB Accession Codes:

P08631 A8K1I1 B4DQB6 E1P5M2 Q29RX1 Q2VPE2 Q504R5 Q5T7K1 Q5T7K2 Q96CC0 Q9H5Y5 Q9NUA4 Q9UMJ5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 5 DrugCentral 1 EC 2 ELM 1 EMBL 24 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 39 PDBsum 39 PIR 2 PRINTS 3 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 9 RefSeq 5 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3496523

Title: Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.

PubMed ID: 3496523

DOI: 10.1128/mcb.7.6.2267-2275.1987

PubMed ID: 3453117

Title: Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin.

PubMed ID: 3453117

DOI: 10.1128/mcb.7.6.2276-2285.1987

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1875927

Title: Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization.

PubMed ID: 1875927

DOI: 10.1128/mcb.11.9.4363-4370.1991

PubMed ID: 1572549

Title: The genomic locus of the human hemopoietic-specific cell protein tyrosine kinase (PTK)-encoding gene (HCK) confirms conservation of exon-intron structure among human PTKs of the src family.

PubMed ID: 1572549

DOI: 10.1016/0378-1119(92)90407-g

PubMed ID: 8132624

Title: Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells.

PubMed ID: 8132624

DOI: 10.1016/s0021-9258(17)37050-3

PubMed ID: 8064233

Title: Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn.

PubMed ID: 8064233

DOI: 10.1084/jem.180.3.1165

PubMed ID: 7535819

Title: The Fc gamma RI receptor signals through the activation of hck and MAP kinase.

PubMed ID: 7535819

PubMed ID: 7791757

Title: Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae.

PubMed ID: 7791757

DOI: 10.1128/mcb.15.7.3507

PubMed ID: 9406996

Title: Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines.

PubMed ID: 9406996

PubMed ID: 8995234

Title: Hck is activated by opsonized zymosan and A23187 in distinct subcellular fractions of human granulocytes.

PubMed ID: 8995234

DOI: 10.1074/jbc.272.1.102

PubMed ID: 9218412

Title: SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.

PubMed ID: 9218412

DOI: 10.1074/jbc.272.29.17899

PubMed ID: 9407116

Title: The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.

PubMed ID: 9407116

DOI: 10.1074/jbc.272.52.33260

PubMed ID: 10092522

Title: The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.

PubMed ID: 10092522

DOI: 10.1006/bbrc.1999.0427

PubMed ID: 10779760

Title: IL-2 signaling in human monocytes involves the phosphorylation and activation of p59hck.

PubMed ID: 10779760

DOI: 10.4049/jimmunol.164.9.4575

PubMed ID: 10644735

Title: Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand.

PubMed ID: 10644735

DOI: 10.1074/jbc.275.4.2721

PubMed ID: 10973280

Title: Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI.

PubMed ID: 10973280

DOI: 10.1038/79767

PubMed ID: 11278465

Title: The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein.

PubMed ID: 11278465

DOI: 10.1074/jbc.m009076200

PubMed ID: 11518702

Title: The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.

PubMed ID: 11518702

DOI: 10.1074/jbc.m101546200

PubMed ID: 12411494

Title: The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.

PubMed ID: 12411494

DOI: 10.1093/emboj/cdf562

PubMed ID: 11741929

Title: Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.

PubMed ID: 11741929

DOI: 10.1074/jbc.m107430200

PubMed ID: 11904303

Title: p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner.

PubMed ID: 11904303

DOI: 10.1074/jbc.m201212200

PubMed ID: 11896602

Title: Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation.

PubMed ID: 11896602

DOI: 10.1038/sj.onc.1205228

PubMed ID: 15010462

Title: Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.

PubMed ID: 15010462

DOI: 10.1074/jbc.m305783200

PubMed ID: 15952790

Title: Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck.

PubMed ID: 15952790

DOI: 10.1021/bi0500832

PubMed ID: 15998323

Title: Activation of the lysosome-associated p61Hck isoform triggers the biogenesis of podosomes.

PubMed ID: 15998323

DOI: 10.1111/j.1600-0854.2005.00307.x

PubMed ID: 16849330

Title: HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.

PubMed ID: 16849330

DOI: 10.1074/jbc.m601128200

PubMed ID: 17535448

Title: Regulation of p73 by Hck through kinase-dependent and independent mechanisms.

PubMed ID: 17535448

DOI: 10.1186/1471-2199-8-45

PubMed ID: 17310994

Title: Inhibition of IL-6-dependent growth of myeloma cells by an acidic peptide repressing the gp130-mediated activation of Src family kinases.

PubMed ID: 17310994

DOI: 10.1038/sj.onc.1210306

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19114024

Title: The oncogenic activity of the Src family kinase Hck requires the cooperative action of the plasma membrane- and lysosome-associated isoforms.

PubMed ID: 19114024

DOI: 10.1016/j.ejca.2008.11.020

PubMed ID: 19718658

Title: Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins.

PubMed ID: 19718658

DOI: 10.1002/jcb.22317

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19903482

Title: c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration.

PubMed ID: 19903482

DOI: 10.1016/j.febslet.2009.11.009

PubMed ID: 20452982

Title: Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner.

PubMed ID: 20452982

DOI: 10.1074/jbc.m109.090043

PubMed ID: 18538446

Title: Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis.

PubMed ID: 18538446

DOI: 10.1016/j.ejcb.2008.03.008

PubMed ID: 21338576

Title: Protein tyrosine kinases in neutrophil activation and recruitment.

PubMed ID: 21338576

DOI: 10.1016/j.abb.2011.02.009

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25469238

Title: Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK.

PubMed ID: 25469238

DOI: 10.3892/br.2014.374

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9109402

Title: Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase.

PubMed ID: 9109402

DOI: 10.1016/s0014-5793(97)00255-x

PubMed ID: 9024658

Title: Crystal structure of the Src family tyrosine kinase Hck.

PubMed ID: 9024658

DOI: 10.1038/385602a0

PubMed ID: 9778343

Title: RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef.

PubMed ID: 9778343

DOI: 10.1021/bi980989q

PubMed ID: 9571048

Title: Solution structure of the human Hck SH3 domain and identification of its ligand binding site.

PubMed ID: 9571048

DOI: 10.1006/jmbi.1998.1690

PubMed ID: 10360180

Title: Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor.

PubMed ID: 10360180

DOI: 10.1016/s1097-2765(00)80357-3

PubMed ID: 16216497

Title: Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.

PubMed ID: 16216497

DOI: 10.1016/j.bmcl.2005.09.039

PubMed ID: 16997556

Title: The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck).

PubMed ID: 16997556

DOI: 10.1016/j.bmcl.2006.08.132

PubMed ID: 17141806

Title: Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes.

PubMed ID: 17141806

DOI: 10.1016/j.jmb.2006.11.013

PubMed ID: 20810664

Title: Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism.

PubMed ID: 20810664

DOI: 10.1074/jbc.m110.145102

PubMed ID: 21625496

Title: Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.

PubMed ID: 21625496

DOI: 10.1371/journal.pone.0020033

PubMed ID: 21477083

Title: Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly.

PubMed ID: 21477083

DOI: 10.1111/j.1600-0854.2011.01205.x

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 34536415

Title: Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK.

PubMed ID: 34536415

DOI: 10.1016/j.jaci.2021.07.046

Sequence Information:

  • Length: 526
  • Mass: 59600
  • Checksum: 847E877A0A641725
  • Sequence:
    • MGGRSSCEDP GCPRDEERAP RMGCMKSKFL QVGGNTFSKT ETSASPHCPV YVPDPTSTIK 
PGPNSHNSNT PGIREAGSED IIVVALYDYE AIHHEDLSFQ KGDQMVVLEE SGEWWKARSL 
ATRKEGYIPS NYVARVDSLE TEEWFFKGIS RKDAERQLLA PGNMLGSFMI RDSETTKGSY 
SLSVRDYDPR QGDTVKHYKI RTLDNGGFYI SPRSTFSTLQ ELVDHYKKGN DGLCQKLSVP 
CMSSKPQKPW EKDAWEIPRE SLKLEKKLGA GQFGEVWMAT YNKHTKVAVK TMKPGSMSVE 
AFLAEANVMK TLQHDKLVKL HAVVTKEPIY IITEFMAKGS LLDFLKSDEG SKQPLPKLID 
FSAQIAEGMA FIEQRNYIHR DLRAANILVS ASLVCKIADF GLARVIEDNE YTAREGAKFP 
IKWTAPEAIN FGSFTIKSDV WSFGILLMEI VTYGRIPYPG MSNPEVIRAL ERGYRMPRPE 
NCPEELYNIM MRCWKNRPEE RPTFEYIQSV LDDFYTATES QYQQQP

Genular Protein ID: 3717895784

Symbol: A8K4G3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K4G3

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 8 Gene3D 3 InterPro 12 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 8 PROSITE-ProRule 3 PeptideAtlas 1 Pfam 3 PharmGKB 1 ProteomicsDB 1 RefSeq 1 Rhea 3 RuleBase 1 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 506
  • Mass: 57444
  • Checksum: 4F025445F3EDF9CA
  • Sequence:
    • MMGCMKSKFL QVGGNTFSKT ETSASPHCPV YVPDPTSTIK PGPNSHNSNT PGIREAGSED 
IIVVALYDYE AIHHEDLSFQ KGDQMVVLEE SGEWWKARSL ATRKEGYIPS NYVARVDSLE 
TEEWFFKGIS RKDAERQLLA PGNMLGSFMI RDSETTKGSY SLSVRDYDPR QGDTVKHYKI 
RTLDNGGFYI SPRSTFSTLQ ELVDHYKKGN DGLCQKLSVP CMSSKPQKPW EKDAWEIPRE 
SLKLEKKLGA GQFGEVWMAT YNKHTKVAVK TMKPGSMSVE AFLAEANVMK TLQHDKLVKL 
HAVVTKEPIY IITEFMAKGS LLDFLKSDEG SKQPLPKLID FSAQIAEGMA FIEQRNYIHR 
DLRAANILVS ASLVCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGSFTIKSDV 
WSFGILLMEI VTYGRIPYPG MSNPEVIRAL ERGYRMPRPE NCPEELYNIM MRCWKNRPEE 
RPTFEYIQSV LDDFYTATES QYQQQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.