Details for: KCNIP1

Gene ID: 30820

Symbol: KCNIP1

Ensembl ID: ENSG00000182132

Description: potassium voltage-gated channel interacting protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.2817
    Cell Significance Index: 115.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.0682
    Cell Significance Index: 1459.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.8477
    Cell Significance Index: 175.0400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 2.6025
    Cell Significance Index: 33.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.0194
    Cell Significance Index: 48.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1713
    Cell Significance Index: 810.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8581
    Cell Significance Index: 37.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4600
    Cell Significance Index: 17.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1990
    Cell Significance Index: 39.9200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1391
    Cell Significance Index: 2.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0183
    Cell Significance Index: 24.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0146
    Cell Significance Index: 1.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0079
    Cell Significance Index: -14.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0122
    Cell Significance Index: -22.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0158
    Cell Significance Index: -24.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0400
    Cell Significance Index: -29.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0454
    Cell Significance Index: -0.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0463
    Cell Significance Index: -0.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0481
    Cell Significance Index: -35.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0499
    Cell Significance Index: -31.6800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0503
    Cell Significance Index: -1.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0551
    Cell Significance Index: -25.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0607
    Cell Significance Index: -26.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0613
    Cell Significance Index: -34.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0614
    Cell Significance Index: -38.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0616
    Cell Significance Index: -33.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0954
    Cell Significance Index: -18.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1025
    Cell Significance Index: -29.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1167
    Cell Significance Index: -16.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1593
    Cell Significance Index: -28.7200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1652
    Cell Significance Index: -2.3100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1653
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1808
    Cell Significance Index: -38.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2008
    Cell Significance Index: -27.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2023
    Cell Significance Index: -4.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2083
    Cell Significance Index: -35.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2323
    Cell Significance Index: -23.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2407
    Cell Significance Index: -29.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2638
    Cell Significance Index: -30.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2670
    Cell Significance Index: -34.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2984
    Cell Significance Index: -31.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3139
    Cell Significance Index: -35.9600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3339
    Cell Significance Index: -8.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4061
    Cell Significance Index: -11.3500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4398
    Cell Significance Index: -5.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4432
    Cell Significance Index: -24.8700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4563
    Cell Significance Index: -7.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4642
    Cell Significance Index: -34.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4686
    Cell Significance Index: -31.5100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4972
    Cell Significance Index: -5.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4982
    Cell Significance Index: -13.1000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5032
    Cell Significance Index: -6.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5400
    Cell Significance Index: -10.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5440
    Cell Significance Index: -17.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5701
    Cell Significance Index: -19.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5861
    Cell Significance Index: -30.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5871
    Cell Significance Index: -30.8300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6018
    Cell Significance Index: -8.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6129
    Cell Significance Index: -21.4700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.6138
    Cell Significance Index: -12.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6331
    Cell Significance Index: -10.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6342
    Cell Significance Index: -13.4600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6461
    Cell Significance Index: -13.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6518
    Cell Significance Index: -30.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6777
    Cell Significance Index: -31.8500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7143
    Cell Significance Index: -31.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7262
    Cell Significance Index: -23.1300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.7364
    Cell Significance Index: -14.6900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.7492
    Cell Significance Index: -8.9600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.7565
    Cell Significance Index: -7.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7737
    Cell Significance Index: -35.0700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8036
    Cell Significance Index: -20.0400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.8250
    Cell Significance Index: -7.8200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.8938
    Cell Significance Index: -21.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.9411
    Cell Significance Index: -33.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9861
    Cell Significance Index: -36.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.0212
    Cell Significance Index: -26.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0313
    Cell Significance Index: -29.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0545
    Cell Significance Index: -31.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0575
    Cell Significance Index: -30.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0615
    Cell Significance Index: -17.7700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.1322
    Cell Significance Index: -35.8100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -1.1424
    Cell Significance Index: -14.9100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.1427
    Cell Significance Index: -17.6800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.1481
    Cell Significance Index: -13.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1596
    Cell Significance Index: -33.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.2009
    Cell Significance Index: -30.0200
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -1.2289
    Cell Significance Index: -14.7600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.2437
    Cell Significance Index: -17.8600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -1.2596
    Cell Significance Index: -14.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3015
    Cell Significance Index: -34.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.3233
    Cell Significance Index: -36.0200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.3264
    Cell Significance Index: -26.9900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.3274
    Cell Significance Index: -33.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.3314
    Cell Significance Index: -35.5500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.3605
    Cell Significance Index: -33.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.4037
    Cell Significance Index: -34.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.4812
    Cell Significance Index: -39.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.4959
    Cell Significance Index: -34.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.5238
    Cell Significance Index: -31.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** KCNIP1 is predominantly expressed in epithelial cells of the alveolus, Purkinje cells, cardiac muscle cells, and specific types of neurons, including GABAergic interneurons and retinal bipolar neurons. 2. **Protein Structure:** KCNIP1 is a small protein with a single transmembrane domain, allowing it to interact with potassium voltage-gated channels. 3. **Function:** KCNIP1 regulates the inactivation properties of potassium channels, modulating neuronal excitability and cardiac conduction. 4. **Interactions:** KCNIP1 interacts with Kv channels, influencing their biophysical properties and, consequently, the overall excitability of neurons and the heart. **Pathways and Functions:** 1. **Calcium Ion Binding:** KCNIP1 interacts with calcium ions, influencing the modulation of potassium channel activity. 2. **Cardiac Conduction:** KCNIP1 plays a crucial role in regulating cardiac conduction by modulating the inactivation properties of potassium channels in cardiac muscle cells. 3. **Muscle Contraction:** KCNIP1 also regulates muscle contraction by modulating potassium channel activity in smooth muscle cells. 4. **Potassium Channel Activity:** KCNIP1 interacts with Kv channels, influencing their biophysical properties and, consequently, the overall excitability of neurons and the heart. 5. **Regulation of Potassium Ion Transmembrane Transport:** KCNIP1 regulates the transmembrane transport of potassium ions, influencing the overall excitability of neurons and the heart. **Clinical Significance:** 1. **Neurological Disorders:** Mutations in KCNIP1 have been associated with various neurological disorders, including epilepsy and intellectual disability. 2. **Cardiac Arrhythmias:** KCNIP1 dysfunction has been implicated in the development of cardiac arrhythmias, including long QT syndrome. 3. **Respiratory Disease:** KCNIP1 expression has been altered in respiratory diseases, such as chronic obstructive pulmonary disease (COPD). 4. **Neurodegenerative Diseases:** KCNIP1 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, KCNIP1 is a critical regulator of potassium channel activity in various cell types, with significant implications for neuronal and cardiac function. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining normal physiological function. Further research is necessary to fully understand the mechanisms by which KCNIP1 regulates potassium channel activity and its implications for human disease.

Genular Protein ID: 3218479130

Symbol: KCIP1_HUMAN

Name: Kv channel-interacting protein 1

UniProtKB Accession Codes:

Q9NZI2 A0A0C4DFQ7 B7Z7B4 Q3YAD0 Q3YAD1 Q3YAD2 Q3YAD3 Q5U822

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 EMDB 7 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 neXtProt 1

Citations:

PubMed ID: 10676964

Title: Modulation of A-type potassium channels by a family of calcium sensors.

PubMed ID: 10676964

DOI: 10.1038/35000592

PubMed ID: 16112838

Title: Structure, alternative splicing, and expression of the human and mouse KCNIP gene family.

PubMed ID: 16112838

DOI: 10.1016/j.ygeno.2005.07.001

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14572458

Title: Differential modulation of Kv4 kinetics by KCHIP1 splice variants.

PubMed ID: 14572458

DOI: 10.1016/s1044-7431(03)00174-x

PubMed ID: 11423117

Title: Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2.

PubMed ID: 11423117

DOI: 10.1016/s0014-5793(01)02560-1

PubMed ID: 12829703

Title: A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.

PubMed ID: 12829703

DOI: 10.1074/jbc.m306142200

PubMed ID: 15184042

Title: Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins.

PubMed ID: 15184042

DOI: 10.1016/j.bbrc.2004.05.064

PubMed ID: 15358149

Title: Protein-protein interactions of KChIP proteins and Kv4.2.

PubMed ID: 15358149

DOI: 10.1016/j.bbrc.2004.07.006

PubMed ID: 14980207

Title: Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.

PubMed ID: 14980207

DOI: 10.1016/s0896-6273(04)00049-2

PubMed ID: 17057713

Title: Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer.

PubMed ID: 17057713

DOI: 10.1038/nsmb1164

PubMed ID: 17187064

Title: Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits.

PubMed ID: 17187064

DOI: 10.1038/nn1822

PubMed ID: 34552243

Title: Structural basis of gating modulation of Kv4 channel complexes.

PubMed ID: 34552243

DOI: 10.1038/s41586-021-03935-z

PubMed ID: 34997220

Title: Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.

PubMed ID: 34997220

DOI: 10.1038/s41422-021-00608-4

Sequence Information:

  • Length: 227
  • Mass: 26817
  • Checksum: D39DD5F8EA13B0FD
  • Sequence:
    • MGAVMGTFSS LQTKQRRPSK DIAWWYYQYQ RDKIEDELEM TMVCHRPEGL EQLEAQTNFT 
KRELQVLYRG FKNECPSGVV NEDTFKQIYA QFFPHGDAST YAHYLFNAFD TTQTGSVKFE 
DFVTALSILL RGTVHEKLRW TFNLYDINKD GYINKEEMMD IVKAIYDMMG KYTYPVLKED 
TPRQHVDVFF QKMDKNKDGI VTLDEFLESC QEDDNIMRSL QLFQNVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.