Details for: HLA DOB

Gene ID: 3112

Symbol: HLA DOB

Ensembl ID: ENSG00000241106

Description: major histocompatibility complex, class II, DO beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1990
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.69
    Marker Score: 1664
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1165
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.49
    Marker Score: 4432
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.4
    Marker Score: 1317
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.39
    Marker Score: 847
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.33
    Marker Score: 801
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.28
    Marker Score: 630
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.21
    Marker Score: 429
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.18
    Marker Score: 272
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4810
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.14
    Marker Score: 1993
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.09
    Marker Score: 2280
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.07
    Marker Score: 954
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.05
    Marker Score: 1133
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.02
    Marker Score: 6789
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.95
    Marker Score: 226.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5319
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.89
    Marker Score: 650.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.87
    Marker Score: 400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.85
    Marker Score: 644
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.81
    Marker Score: 491
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 596
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.72
    Marker Score: 613
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.53
    Marker Score: 126
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.52
    Marker Score: 305
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.48
    Marker Score: 460
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 197
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.44
    Marker Score: 1080
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.36
    Marker Score: 127
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.36
    Marker Score: 238
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.36
    Marker Score: 247
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.35
    Marker Score: 4040
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.31
    Marker Score: 645.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.3
    Marker Score: 332
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.29
    Marker Score: 423.5
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.27
    Marker Score: 324
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.25
    Marker Score: 651.5
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.24
    Marker Score: 241
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.24
    Marker Score: 227
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.23
    Marker Score: 384
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.22
    Marker Score: 296
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.22
    Marker Score: 124
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.22
    Marker Score: 95
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2
    Marker Score: 214
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.17
    Marker Score: 114
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.17
    Marker Score: 111
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.17
    Marker Score: 114
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.17
    Marker Score: 95
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.16
    Marker Score: 48
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.16
    Marker Score: 390
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.16
    Marker Score: 84
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.15
    Marker Score: 814
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 49
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.15
    Marker Score: 414
  • Cell Name: myeloid dendritic cell, human (CL0001057)
    Fold Change: 0.15
    Marker Score: 52
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.14
    Marker Score: 93.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.14
    Marker Score: 220
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.13
    Marker Score: 877.5
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.13
    Marker Score: 103.5
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.13
    Marker Score: 60
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.13
    Marker Score: 132
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.13
    Marker Score: 130
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.13
    Marker Score: 126
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.12
    Marker Score: 192
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.12
    Marker Score: 41
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.12
    Marker Score: 74
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.12
    Marker Score: 143
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.11
    Marker Score: 490
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.11
    Marker Score: 42
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.11
    Marker Score: 29

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Other Information

**Key characteristics:** * The HLA-DOB gene is located on chromosome 15q21.1. * It is a member of the MHC class II family of MHC genes. * The DO beta chain is a glycoprotein that is expressed in the endoplasmic reticulum of antigen-presenting cells. * The DO beta chain is a heterodimeric protein, meaning that it consists of two polypeptide chains that are held together by disulfide bonds. * The DO beta chain is responsible for the recognition of certain glycoproteins, including those derived from dietary antigens. **Pathways and functions:** * The HLA-DOB gene is involved in the adaptive immune response by encoding a protein that is expressed on the surface of antigen-presenting cells. * The DO beta chain is a key component of the MHC class II complex, which is responsible for the processing and presentation of peptide antigens to T cells. * The MHC class II complex is expressed on the surface of professional antigen-presenting cells, such as macrophages and dendritic cells. * When a peptide antigen is presented by the MHC class II complex, it binds to MHC class II receptors on the surface of T cells. * This binding triggers a cascade of events that leads to the activation of the T cell. **Clinical significance:** * Mutations in the HLA-DOB gene have been linked to several autoimmune diseases, including Crohn's disease and ulcerative colitis. * These diseases are characterized by inflammation of the digestive tract, and the HLA-DOB gene is expressed in cells that are involved in the immune response to antigens. * By understanding the role of the HLA-DOB gene in autoimmune diseases, it may be possible to develop new treatments that can prevent or cure these diseases.

Genular Protein ID: 563821240

Symbol: DOB_HUMAN

Name: HLA class II histocompatibility antigen, DO beta chain

UniProtKB Accession Codes:

P13765 B0V0Y0 Q29746 Q29825 Q6FHC2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 7 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2998758

Title: DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.

PubMed ID: 2998758

DOI: 10.1002/j.1460-2075.1985.tb04012.x

PubMed ID: 2499532

Title: Human class II DNA and DOB genes display low sequence variability.

PubMed ID: 2499532

DOI: 10.1007/bf00375872

PubMed ID: 1453454

Title: DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing.

PubMed ID: 1453454

DOI: 10.1016/0022-2836(92)90832-5

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3036827

Title: Class II genes of the human major histocompatibility complex. The DO beta gene is a divergent member of the class II beta gene family.

PubMed ID: 3036827

DOI: 10.1016/s0021-9258(18)47481-9

PubMed ID: 8568858

Title: Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.

PubMed ID: 8568858

DOI: 10.1006/jmbi.1996.0001

PubMed ID: 12445321

Title: The HLA-DOB gene displays limited polymorphism with only one amino acid substitution.

PubMed ID: 12445321

DOI: 10.1034/j.1399-0039.2002.590608.x

PubMed ID: 10837054

Title: Nonclassical MHC class II molecules.

PubMed ID: 10837054

DOI: 10.1146/annurev.immunol.18.1.113

Sequence Information:

  • Length: 273
  • Mass: 30822
  • Checksum: C06A1360DCC4AD26
  • Sequence:
    • MGSGWVPWVV ALLVNLTRLD SSMTQGTDSP EDFVIQAKAD CYFTNGTEKV QFVVRFIFNL 
EEYVRFDSDV GMFVALTKLG QPDAEQWNSR LDLLERSRQA VDGVCRHNYR LGAPFTVGRK 
VQPEVTVYPE RTPLLHQHNL LHCSVTGFYP GDIKIKWFLN GQEERAGVMS TGPIRNGDWT 
FQTVVMLEMT PELGHVYTCL VDHSSLLSPV SVEWRAQSEY SWRKMLSGIA AFLLGLIFLL 
VGIVIQLRAQ KGYVRTQMSG NEVSRAVLLP QSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.