Details for: HLA DOB

Gene ID: 3112

Symbol: HLA DOB

Ensembl ID: ENSG00000241106

Description: major histocompatibility complex, class II, DO beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 16.9083
    Cell Significance Index: -2.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 10.6449
    Cell Significance Index: -2.7000
  • Cell Name: centroblast (CL0009112)
    Fold Change: 8.2381
    Cell Significance Index: 19.2200
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.4016
    Cell Significance Index: 10.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.1331
    Cell Significance Index: -2.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.7024
    Cell Significance Index: 104.3800
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.4887
    Cell Significance Index: 4.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4660
    Cell Significance Index: 172.8900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.0408
    Cell Significance Index: 17.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.7020
    Cell Significance Index: -2.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6099
    Cell Significance Index: 27.6500
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.4752
    Cell Significance Index: 2.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4636
    Cell Significance Index: 88.2400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4282
    Cell Significance Index: 6.8700
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.3778
    Cell Significance Index: 1.8900
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.3399
    Cell Significance Index: 1.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3185
    Cell Significance Index: 31.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2753
    Cell Significance Index: 248.5400
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.2288
    Cell Significance Index: 2.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2035
    Cell Significance Index: 4.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1702
    Cell Significance Index: 27.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1625
    Cell Significance Index: 3.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.1554
    Cell Significance Index: -0.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1495
    Cell Significance Index: 16.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1136
    Cell Significance Index: 3.0400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0818
    Cell Significance Index: 1.8900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0815
    Cell Significance Index: 4.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0814
    Cell Significance Index: 5.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0270
    Cell Significance Index: 0.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0168
    Cell Significance Index: 6.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0122
    Cell Significance Index: 5.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0119
    Cell Significance Index: 2.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0113
    Cell Significance Index: 1.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0034
    Cell Significance Index: 0.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0034
    Cell Significance Index: 0.4000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.0028
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0017
    Cell Significance Index: -1.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0018
    Cell Significance Index: -1.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0031
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0037
    Cell Significance Index: -2.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0041
    Cell Significance Index: -0.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0050
    Cell Significance Index: -2.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0050
    Cell Significance Index: -3.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0058
    Cell Significance Index: -3.6800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0060
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0078
    Cell Significance Index: -3.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0084
    Cell Significance Index: -0.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0092
    Cell Significance Index: -0.2300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0106
    Cell Significance Index: -0.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0116
    Cell Significance Index: -2.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0116
    Cell Significance Index: -2.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0118
    Cell Significance Index: -1.2100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0127
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0141
    Cell Significance Index: -2.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0156
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0170
    Cell Significance Index: -2.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0192
    Cell Significance Index: -2.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0194
    Cell Significance Index: -0.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0225
    Cell Significance Index: -3.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0225
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0233
    Cell Significance Index: -2.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0242
    Cell Significance Index: -1.5600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0253
    Cell Significance Index: -0.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0259
    Cell Significance Index: -2.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0272
    Cell Significance Index: -0.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0274
    Cell Significance Index: -0.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0309
    Cell Significance Index: -1.9500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0322
    Cell Significance Index: -0.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0340
    Cell Significance Index: -2.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0366
    Cell Significance Index: -0.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0394
    Cell Significance Index: -1.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0400
    Cell Significance Index: -0.8500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0428
    Cell Significance Index: -0.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0462
    Cell Significance Index: -2.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0470
    Cell Significance Index: -2.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0472
    Cell Significance Index: -3.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0494
    Cell Significance Index: -1.2700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0504
    Cell Significance Index: -0.7800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0508
    Cell Significance Index: -0.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0510
    Cell Significance Index: -2.6800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0517
    Cell Significance Index: -1.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0518
    Cell Significance Index: -1.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0553
    Cell Significance Index: -1.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0564
    Cell Significance Index: -2.5000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0570
    Cell Significance Index: -1.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0581
    Cell Significance Index: -0.6600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0609
    Cell Significance Index: -0.7200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0635
    Cell Significance Index: -1.2500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0648
    Cell Significance Index: -0.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0654
    Cell Significance Index: -2.4000
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.0665
    Cell Significance Index: -0.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0684
    Cell Significance Index: -2.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0693
    Cell Significance Index: -1.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0700
    Cell Significance Index: -2.6500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0708
    Cell Significance Index: -1.4400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0728
    Cell Significance Index: -1.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0748
    Cell Significance Index: -1.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0753
    Cell Significance Index: -2.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HLA-DOB is a member of the MHC class II family, which is essential for the presentation of antigens to T-cells. This gene is characterized by its ability to assemble with peptide antigens and present them to T-cells, thereby regulating immune responses. HLA-DOB is specifically expressed in cells of the immune system, including B cells, T cells, and dendritic cells, and is involved in the regulation of immune responses, including positive and negative regulation of T-cell activation. **Pathways and Functions:** HLA-DOB is involved in several key pathways, including: 1. **Antigen processing and presentation**: HLA-DOB assembles with peptide antigens and presents them to T-cells via MHC class II molecules, thereby regulating immune responses. 2. **Adaptive immune response**: HLA-DOB plays a crucial role in the adaptive immune response by presenting antigens to T-cells, thereby regulating immune responses and maintaining immune homeostasis. 3. **Immune system regulation**: HLA-DOB is involved in the regulation of immune responses, including positive and negative regulation of T-cell activation. 4. **Peptide antigen assembly**: HLA-DOB assembles with peptide antigens and presents them to T-cells via MHC class II molecules. 5. **MHC class II protein complex binding**: HLA-DOB binds to MHC class II molecules, facilitating the presentation of antigens to T-cells. **Signaling pathways:** HLA-DOB is involved in several signaling pathways, including: 1. **T-cell activation**: HLA-DOB presents antigens to T-cells, thereby regulating T-cell activation and immune responses. 2. **Immune response regulation**: HLA-DOB regulates immune responses, including positive and negative regulation of T-cell activation. 3. **Antigen presentation**: HLA-DOB presents antigens to T-cells via MHC class II molecules, thereby regulating immune responses. **Significantly expressed cells:** HLA-DOB is significantly expressed in various immune cells, including: 1. **B cells**: HLA-DOB is expressed on B cells, including class-switched memory B cells, germinal center B cells, and IgG memory B cells. 2. **T cells**: HLA-DOB is expressed on T cells, including class-switched memory T cells and germinal center T cells. 3. **Dendritic cells**: HLA-DOB is expressed on dendritic cells, which are involved in the presentation of antigens to T-cells. 4. **Enterocytes**: HLA-DOB is expressed on enterocytes, which are involved in the presentation of antigens to T-cells in the gut. 5. **Colon goblet cells**: HLA-DOB is expressed on colon goblet cells, which are involved in the presentation of antigens to T-cells in the gut. **Clinical Significance:** HLA-DOB has significant clinical implications, including: 1. **Autoimmune diseases**: HLA-DOB has been associated with several autoimmune diseases, including multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. 2. **Cancer**: HLA-DOB has been implicated in cancer, including breast cancer and lung cancer. 3. **Transplantation**: HLA-DOB is involved in the rejection of transplanted organs and tissues. 4. **Infectious diseases**: HLA-DOB is involved in the presentation of antigens to T-cells, thereby regulating immune responses to infectious diseases. In conclusion, HLA-DOB is a critical component of the adaptive immune response, regulating immune responses and maintaining immune homeostasis. Understanding the functions and clinical significance of HLA-DOB is essential for appreciating its role in immune regulation and disease.

Genular Protein ID: 563821240

Symbol: DOB_HUMAN

Name: HLA class II histocompatibility antigen, DO beta chain

UniProtKB Accession Codes:

P13765 B0V0Y0 Q29746 Q29825 Q6FHC2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2998758

Title: DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.

PubMed ID: 2998758

DOI: 10.1002/j.1460-2075.1985.tb04012.x

PubMed ID: 2499532

Title: Human class II DNA and DOB genes display low sequence variability.

PubMed ID: 2499532

DOI: 10.1007/bf00375872

PubMed ID: 1453454

Title: DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing.

PubMed ID: 1453454

DOI: 10.1016/0022-2836(92)90832-5

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3036827

Title: Class II genes of the human major histocompatibility complex. The DO beta gene is a divergent member of the class II beta gene family.

PubMed ID: 3036827

DOI: 10.1016/s0021-9258(18)47481-9

PubMed ID: 8568858

Title: Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.

PubMed ID: 8568858

DOI: 10.1006/jmbi.1996.0001

PubMed ID: 12445321

Title: The HLA-DOB gene displays limited polymorphism with only one amino acid substitution.

PubMed ID: 12445321

DOI: 10.1034/j.1399-0039.2002.590608.x

PubMed ID: 10837054

Title: Nonclassical MHC class II molecules.

PubMed ID: 10837054

DOI: 10.1146/annurev.immunol.18.1.113

Sequence Information:

  • Length: 273
  • Mass: 30822
  • Checksum: C06A1360DCC4AD26
  • Sequence:
    • MGSGWVPWVV ALLVNLTRLD SSMTQGTDSP EDFVIQAKAD CYFTNGTEKV QFVVRFIFNL 
EEYVRFDSDV GMFVALTKLG QPDAEQWNSR LDLLERSRQA VDGVCRHNYR LGAPFTVGRK 
VQPEVTVYPE RTPLLHQHNL LHCSVTGFYP GDIKIKWFLN GQEERAGVMS TGPIRNGDWT 
FQTVVMLEMT PELGHVYTCL VDHSSLLSPV SVEWRAQSEY SWRKMLSGIA AFLLGLIFLL 
VGIVIQLRAQ KGYVRTQMSG NEVSRAVLLP QSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.