Details for: HPCA

Gene ID: 3208

Symbol: HPCA

Ensembl ID: ENSG00000121905

Description: hippocalcin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 6.4518
    Cell Significance Index: 49.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.7739
    Cell Significance Index: 250.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.7815
    Cell Significance Index: -10.1300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.2463
    Cell Significance Index: 92.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.9465
    Cell Significance Index: 86.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.6286
    Cell Significance Index: 61.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.4805
    Cell Significance Index: 99.5500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.4230
    Cell Significance Index: 12.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1595
    Cell Significance Index: 232.5900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.1248
    Cell Significance Index: 13.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5308
    Cell Significance Index: 57.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4962
    Cell Significance Index: 80.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4567
    Cell Significance Index: 20.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4467
    Cell Significance Index: 26.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3807
    Cell Significance Index: 136.5700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3410
    Cell Significance Index: 4.2300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3280
    Cell Significance Index: 7.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3148
    Cell Significance Index: 59.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2848
    Cell Significance Index: 19.7000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.2653
    Cell Significance Index: 3.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2476
    Cell Significance Index: 15.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2425
    Cell Significance Index: 5.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1885
    Cell Significance Index: 3.2300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1450
    Cell Significance Index: 1.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0944
    Cell Significance Index: 9.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0503
    Cell Significance Index: 1.4500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0499
    Cell Significance Index: 0.6300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0389
    Cell Significance Index: 0.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0259
    Cell Significance Index: 0.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0111
    Cell Significance Index: 0.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0097
    Cell Significance Index: 0.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0085
    Cell Significance Index: 0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0047
    Cell Significance Index: -8.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0052
    Cell Significance Index: -9.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0061
    Cell Significance Index: -9.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0092
    Cell Significance Index: -5.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0133
    Cell Significance Index: -10.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0158
    Cell Significance Index: -10.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0162
    Cell Significance Index: -8.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0170
    Cell Significance Index: -10.6100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0172
    Cell Significance Index: -0.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0175
    Cell Significance Index: -2.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0185
    Cell Significance Index: -8.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0208
    Cell Significance Index: -0.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0223
    Cell Significance Index: -10.1400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0287
    Cell Significance Index: -0.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0290
    Cell Significance Index: -8.3300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0343
    Cell Significance Index: -0.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0382
    Cell Significance Index: -2.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0386
    Cell Significance Index: -1.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0407
    Cell Significance Index: -7.3400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0412
    Cell Significance Index: -0.4700
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.0422
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0480
    Cell Significance Index: -10.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0484
    Cell Significance Index: -9.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0503
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0598
    Cell Significance Index: -10.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0621
    Cell Significance Index: -7.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0648
    Cell Significance Index: -7.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0658
    Cell Significance Index: -9.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0689
    Cell Significance Index: -8.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0707
    Cell Significance Index: -8.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0772
    Cell Significance Index: -7.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0772
    Cell Significance Index: -9.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0838
    Cell Significance Index: -1.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0987
    Cell Significance Index: -10.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1011
    Cell Significance Index: -5.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1021
    Cell Significance Index: -2.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1076
    Cell Significance Index: -6.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1231
    Cell Significance Index: -4.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1269
    Cell Significance Index: -9.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1332
    Cell Significance Index: -3.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1363
    Cell Significance Index: -7.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1497
    Cell Significance Index: -6.9800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1535
    Cell Significance Index: -1.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1542
    Cell Significance Index: -2.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1766
    Cell Significance Index: -2.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1833
    Cell Significance Index: -9.5500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1916
    Cell Significance Index: -4.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2060
    Cell Significance Index: -6.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2111
    Cell Significance Index: -9.9200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2114
    Cell Significance Index: -3.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2203
    Cell Significance Index: -2.4000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2263
    Cell Significance Index: -3.4100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2405
    Cell Significance Index: -1.9900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2562
    Cell Significance Index: -6.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2572
    Cell Significance Index: -9.0100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2603
    Cell Significance Index: -3.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2686
    Cell Significance Index: -9.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2737
    Cell Significance Index: -5.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2738
    Cell Significance Index: -7.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2754
    Cell Significance Index: -9.5700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3221
    Cell Significance Index: -14.0100
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.3228
    Cell Significance Index: -3.4700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3287
    Cell Significance Index: -6.5000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3345
    Cell Significance Index: -10.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3377
    Cell Significance Index: -9.6800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3379
    Cell Significance Index: -6.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium-binding protein:** Hippocalcin is a calcium-binding protein, which suggests its involvement in calcium-mediated signaling pathways. 2. **Neuronal expression:** Significantly expressed in glycinergic neurons, GABAergic interneurons, and L2/3-6 intratelencephalic projecting glutamatergic neurons, indicating its role in neuronal function. 3. **Intestinal expression:** Also expressed in intestinal crypt stem cells, suggesting its involvement in intestinal cell differentiation and homeostasis. 4. **Dendritic spine head localization:** Hippocalcin is localized to the dendritic spine head, a region critical for synaptic plasticity and neuronal excitability. **Pathways and Functions:** 1. **Calcium-mediated signaling:** Hippocalcin is involved in calcium-mediated signaling pathways, influencing neuronal excitability and synaptic transmission. 2. **Regulation of postsynaptic neurotransmitter receptor internalization:** Hippocalcin regulates the internalization of postsynaptic neurotransmitter receptors, modulating synaptic plasticity and neuronal excitability. 3. **Regulation of voltage-gated calcium channel activity:** Hippocalcin regulates voltage-gated calcium channel activity, influencing neuronal excitability and synaptic transmission. 4. **Inner ear development:** Hippocalcin is involved in the development of the inner ear, highlighting its importance in auditory function. 5. **Regulation of glutamatergic synapse:** Hippocalcin regulates glutamatergic synapse formation and function, influencing neuronal excitability and synaptic transmission. **Clinical Significance:** 1. **Neurological disorders:** Alterations in hippocalcin expression or function may contribute to neurological disorders, such as epilepsy, anxiety, or depression. 2. **Intestinal disorders:** Changes in hippocalcin expression or function may influence intestinal health, potentially contributing to disorders such as inflammatory bowel disease or cancer. 3. **Neurodevelopmental disorders:** Hippocalcin's role in neuronal development and synaptic plasticity suggests its involvement in neurodevelopmental disorders, such as autism spectrum disorder or schizophrenia. 4. **Cancer:** Hippocalcin's expression in intestinal crypt stem cells and its role in cellular differentiation and homeostasis suggest its potential involvement in cancer development and progression. In conclusion, hippocalcin is a calcium-binding protein with significant implications in neuronal and intestinal cell function. Its involvement in calcium-mediated signaling pathways, regulation of postsynaptic neurotransmitter receptor internalization, and voltage-gated calcium channel activity highlights its importance in neuronal excitability and synaptic transmission. Further research is necessary to fully elucidate hippocalcin's role in various diseases and disorders, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 1632553970

Symbol: HPCA_HUMAN

Name: Calcium-binding protein BDR-2

UniProtKB Accession Codes:

P84074 B2R9T3 D3DPQ7 P32076 P41211 P70510

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8166736

Title: Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene.

PubMed ID: 8166736

DOI: 10.1006/bbrc.1994.1491

PubMed ID: 9931466

Title: Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes.

PubMed ID: 9931466

DOI: 10.1016/s0378-1119(98)00526-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28398555

Title: Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia.

PubMed ID: 28398555

DOI: 10.1093/hmg/ddx133

PubMed ID: 25799108

Title: Mutations in HPCA cause autosomal-recessive primary isolated dystonia.

PubMed ID: 25799108

DOI: 10.1016/j.ajhg.2015.02.007

Sequence Information:

  • Length: 193
  • Mass: 22427
  • Checksum: 3DBEA176AC945DB1
  • Sequence:
    • MGKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK IYANFFPYGD 
ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK LMWAFSMYDL DGNGYISREE 
MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 
RLLQCDPSSA SQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.