Gene HPCA - ENSG00000121905 | NCBI Gene ID: 3208

Details for: HPCA

Gene ID: 3208

Symbol: HPCA

Ensembl ID: ENSG00000121905

Description: hippocalcin

Associated with

Actin binding
(GO:0003779)
Axon
(GO:0030424)
Calcium-mediated signaling
(GO:0019722)
Calcium ion binding
(GO:0005509)
Cellular response to calcium ion
(GO:0071277)
Cellular response to electrical stimulus
(GO:0071257)
Cellular response to l-glutamate
(GO:1905232)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendrite cytoplasm
(GO:0032839)
Dendrite membrane
(GO:0032590)
Dendritic spine head
(GO:0044327)
Glutamatergic synapse
(GO:0098978)
Identical protein binding
(GO:0042802)
Inner ear development
(GO:0048839)
Kinase binding
(GO:0019900)
Membrane
(GO:0016020)
Neuronal cell body membrane
(GO:0032809)
Perikaryon
(GO:0043204)
Positive regulation of protein targeting to membrane
(GO:0090314)
Protein binding
(GO:0005515)
Regulation of postsynaptic neurotransmitter receptor internalization
(GO:0099149)
Regulation of voltage-gated calcium channel activity
(GO:1901385)
Response to aroclor 1254
(GO:1904010)
Response to ketamine
(GO:1901986)
Retina development in camera-type eye
(GO:0060041)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.38
Marker Score: 4082
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.06
Marker Score: 2889
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.32
Marker Score: 2339
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 2.19
Marker Score: 1512
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.66
Marker Score: 3383
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 870
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.27
Marker Score: 78190
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 855
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71824
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48048
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 507
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 461
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.96
Marker Score: 1985
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.96
Marker Score: 8219
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5336
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 373
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2739
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5286
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.86
Marker Score: 657
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.85
Marker Score: 442
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.84
Marker Score: 6403
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.77
Marker Score: 29199
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.77
Marker Score: 3221.5
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 696
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.76
Marker Score: 2927.5
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7
Marker Score: 10987
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.67
Marker Score: 713
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.64
Marker Score: 1866
Cell Name: B cell (CL0000236)
Fold Change: 0.64
Marker Score: 608
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.61
Marker Score: 393
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.61
Marker Score: 5746
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.58
Marker Score: 2410
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.55
Marker Score: 8276
Cell Name: mast cell (CL0000097)
Fold Change: 0.55
Marker Score: 320
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.53
Marker Score: 600
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.52
Marker Score: 1481
Cell Name: neuron (CL0000540)
Fold Change: 0.5
Marker Score: 2045
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.49
Marker Score: 826
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 473
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.48
Marker Score: 200
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.48
Marker Score: 762
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.47
Marker Score: 148
Cell Name: germ cell (CL0000586)
Fold Change: 0.44
Marker Score: 761
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.43
Marker Score: 809
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.4
Marker Score: 200
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.39
Marker Score: 131
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.37
Marker Score: 210
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 371
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.35
Marker Score: 1051
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.35
Marker Score: 146
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.32
Marker Score: 2996.5
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.31
Marker Score: 532
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.3
Marker Score: 1121
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.3
Marker Score: 157
Cell Name: male germ cell (CL0000015)
Fold Change: 0.3
Marker Score: 86
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.3
Marker Score: 196
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.29
Marker Score: 420
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.27
Marker Score: 393
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.27
Marker Score: 141
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.26
Marker Score: 105
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.26
Marker Score: 103
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.25
Marker Score: 508
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.24
Marker Score: 368
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.23
Marker Score: 86
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.23
Marker Score: 2336
Cell Name: retinal cone cell (CL0000573)
Fold Change: 0.23
Marker Score: 660.5
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.23
Marker Score: 67
Cell Name: motor neuron (CL0000100)
Fold Change: 0.23
Marker Score: 135
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.23
Marker Score: 108
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.22
Marker Score: 145
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.22
Marker Score: 907
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.22
Marker Score: 116
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.21
Marker Score: 107
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.2
Marker Score: 473.5
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.2
Marker Score: 62
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.19
Marker Score: 66
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.19
Marker Score: 69
Cell Name: astrocyte (CL0000127)
Fold Change: 0.18
Marker Score: 155
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.17
Marker Score: 217
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.17
Marker Score: 6197
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.17
Marker Score: 3321
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.17
Marker Score: 128
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.16
Marker Score: 204
Cell Name: PP cell (CL0000696)
Fold Change: 0.16
Marker Score: 36
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.16
Marker Score: 96
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.16
Marker Score: 83
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.15
Marker Score: 38
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.15
Marker Score: 91
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.15
Marker Score: 1567
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.15
Marker Score: 92
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.15
Marker Score: 80.5

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**Key characteristics:** - HPCA is a calcium-binding protein that is localized to the plasma membrane. - It is a member of the HSP70 family of calcium chaperones. - HPCA is involved in the regulation of calcium-mediated signaling by binding to the cytoplasmic face of calcium channels and modulating their activity. - It also binds to the cytoplasmic face of other calcium-binding proteins, such as calmodulin and calcineurin, and regulates their activity. **Pathways and functions:** - HPCA is involved in the regulation of calcium-mediated signaling in the central nervous system. - It is expressed in neurons and astrocytes, which are the two main cell types that are affected by calcium signaling. - HPCA is thought to regulate calcium signaling by binding to the cytoplasmic face of calcium channels and modulating their activity. - This binding event prevents the opening of calcium channels, which leads to a decrease in calcium signaling. - In addition, HPCA also binds to other calcium-binding proteins, such as calmodulin and calcineurin, and regulates their activity. - This binding event allows these proteins to interact with other signaling molecules, which can then initiate downstream signaling pathways. **Clinical significance:** - Mutations in the HPCA gene have been linked to a number of neurological disorders, including Alzheimer's disease, autism, and epilepsy. - These disorders are characterized by abnormal calcium signaling, which is thought to be caused by mutations in genes that regulate calcium homeostasis. - Therefore, HPCA is a promising target for the treatment of these diseases. **Conclusion:** HPCA is a key regulator of calcium signaling in the central nervous system. Its dysfunction has been linked to a number of neurological disorders, highlighting its importance in maintaining calcium homeostasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Calcium-binding protein BDR-2

Genular Protein ID: 1632553970

Symbol: HPCA_HUMAN

Name: Calcium-binding protein BDR-2

UniProtKB Accession Codes:

P84074 B2R9T3 D3DPQ7 P32076 P41211 P70510

Database IDs:

Citations:

PubMed ID: 8166736

Title: Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene.

PubMed ID: 8166736

DOI: 10.1006/bbrc.1994.1491

PubMed ID: 9931466

Title: Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes.

PubMed ID: 9931466

DOI: 10.1016/s0378-1119(98)00526-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28398555

Title: Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia.

PubMed ID: 28398555

DOI: 10.1093/hmg/ddx133

PubMed ID: 25799108

Title: Mutations in HPCA cause autosomal-recessive primary isolated dystonia.

PubMed ID: 25799108

DOI: 10.1016/j.ajhg.2015.02.007

Sequence Information:

Length: 193
Mass: 22427
Checksum: 3DBEA176AC945DB1
Sequence:

MGKQNSKLRP EMLQDLRENT EFSELELQEW YKGFLKDCPT GILNVDEFKK IYANFFPYGD 
ASKFAEHVFR TFDTNSDGTI DFREFIIALS VTSRGRLEQK LMWAFSMYDL DGNGYISREE 
MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV 
RLLQCDPSSA SQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: HPCA

Associated with

Cells (max top 100)

Other Information

Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene. PubMed ID: 8166736

Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes. PubMed ID: 9931466

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia. PubMed ID: 28398555