Details for: HPD
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hepatoblast (CL0005026)
Fold Change: 11.6877
Cell Significance Index: 196.5800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 4.9878
Cell Significance Index: 84.0200 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 1.2841
Cell Significance Index: 3.4400 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.1487
Cell Significance Index: 6.6200 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 1.0727
Cell Significance Index: 4.0400 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 0.7240
Cell Significance Index: 1.9100 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 0.7032
Cell Significance Index: 2.6900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.6502
Cell Significance Index: 94.5100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6073
Cell Significance Index: 120.5200 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.4963
Cell Significance Index: 7.2100 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.4878
Cell Significance Index: 7.2000 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.4868
Cell Significance Index: 12.1400 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.4095
Cell Significance Index: 4.0400 - Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 0.4078
Cell Significance Index: 1.5200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.3376
Cell Significance Index: 4.8400 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.2903
Cell Significance Index: 1.0100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.2775
Cell Significance Index: 21.9800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.2305
Cell Significance Index: 3.9500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1320
Cell Significance Index: 179.5400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1183
Cell Significance Index: 3.1700 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.1026
Cell Significance Index: 0.8100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0726
Cell Significance Index: 46.1400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0526
Cell Significance Index: 9.4800 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.0458
Cell Significance Index: 0.3500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0324
Cell Significance Index: 59.6700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0241
Cell Significance Index: 37.0600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0202
Cell Significance Index: 4.0600 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.0126
Cell Significance Index: 0.1200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0110
Cell Significance Index: 8.0400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0110
Cell Significance Index: 20.6600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0090
Cell Significance Index: 3.2200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0040
Cell Significance Index: 0.4600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0040
Cell Significance Index: 0.6800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0021
Cell Significance Index: 0.1600 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.0006
Cell Significance Index: -0.0100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0013
Cell Significance Index: -0.6000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0021
Cell Significance Index: -0.5900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0034
Cell Significance Index: -2.5400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0038
Cell Significance Index: -2.8800 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0039
Cell Significance Index: -2.1100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0047
Cell Significance Index: -2.6700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0048
Cell Significance Index: -3.0200 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: -0.0099
Cell Significance Index: -0.1000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0107
Cell Significance Index: -1.0900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0112
Cell Significance Index: -1.3800 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0133
Cell Significance Index: -0.1900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0137
Cell Significance Index: -2.8900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0139
Cell Significance Index: -0.3700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0146
Cell Significance Index: -0.9200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0159
Cell Significance Index: -2.1800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0161
Cell Significance Index: -0.4500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0164
Cell Significance Index: -1.0100 - Cell Name: Kupffer cell (CL0000091)
Fold Change: -0.0175
Cell Significance Index: -0.1600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0227
Cell Significance Index: -2.9300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0237
Cell Significance Index: -0.7600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0248
Cell Significance Index: -2.5800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0257
Cell Significance Index: -1.7300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0269
Cell Significance Index: -3.1300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0277
Cell Significance Index: -0.3300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0312
Cell Significance Index: -1.3800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0362
Cell Significance Index: -2.7000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0364
Cell Significance Index: -2.0500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0382
Cell Significance Index: -1.2500 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0389
Cell Significance Index: -0.7600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0391
Cell Significance Index: -1.4800 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0414
Cell Significance Index: -0.9000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0433
Cell Significance Index: -0.9200 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: -0.0446
Cell Significance Index: -0.4800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0452
Cell Significance Index: -2.3500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0462
Cell Significance Index: -2.1700 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0471
Cell Significance Index: -0.6700 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0482
Cell Significance Index: -1.1800 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0497
Cell Significance Index: -1.2400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0517
Cell Significance Index: -1.8100 - Cell Name: mature B cell (CL0000785)
Fold Change: -0.0568
Cell Significance Index: -0.3700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0577
Cell Significance Index: -3.0300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0634
Cell Significance Index: -3.3000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0640
Cell Significance Index: -2.9000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0663
Cell Significance Index: -1.9100 - Cell Name: primordial germ cell (CL0000670)
Fold Change: -0.0680
Cell Significance Index: -0.4200 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0682
Cell Significance Index: -1.3700 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.0693
Cell Significance Index: -0.5900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0704
Cell Significance Index: -2.0100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0714
Cell Significance Index: -3.3300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0718
Cell Significance Index: -1.4900 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0727
Cell Significance Index: -2.3000 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: -0.0735
Cell Significance Index: -0.6200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0747
Cell Significance Index: -1.9200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0790
Cell Significance Index: -1.7300 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0813
Cell Significance Index: -0.9200 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0820
Cell Significance Index: -1.2100 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0839
Cell Significance Index: -3.6500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0842
Cell Significance Index: -0.7800 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0848
Cell Significance Index: -1.1900 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.0849
Cell Significance Index: -0.7700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0860
Cell Significance Index: -1.7000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0864
Cell Significance Index: -3.1700 - Cell Name: germ cell (CL0000586)
Fold Change: -0.0867
Cell Significance Index: -0.6600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0871
Cell Significance Index: -3.0600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0910
Cell Significance Index: -2.6800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1738342095
Symbol: HPPD_HUMAN
Name: 4-hydroxyphenylpyruvate dioxygenase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7851880
Title: Structure of the human 4-hydroxyphenylpyruvic acid dioxygenase gene (HPD).
PubMed ID: 7851880
PubMed ID: 8521727
Title: Regional assignment of the human 4-hydroxyphenylpyruvate dioxygenase gene (HPD) to 12q24-->qter by fluorescence in situ hybridization.
PubMed ID: 8521727
DOI: 10.1159/000134142
PubMed ID: 9325050
Title: Human 4-hydroxyphenylpyruvate dioxygenase gene (HPD).
PubMed ID: 9325050
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1339442
Title: Primary structure deduced from complementary DNA sequence and expression in cultured cells of mammalian 4-hydroxyphenylpyruvic acid dioxygenase. Evidence that the enzyme is a homodimer of identical subunits homologous to rat liver-specific alloantigen F.
PubMed ID: 1339442
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 10942115
Title: Mutations in the 4-hydroxyphenylpyruvate dioxygenase gene (HPD) in patients with tyrosinemia type III.
PubMed ID: 10942115
PubMed ID: 11073718
Title: Mutations in the 4-hydroxyphenylpyruvic acid dioxygenase gene are responsible for tyrosinemia type III and hawkinsinuria.
PubMed ID: 11073718
Sequence Information:
- Length: 393
- Mass: 44964
- Checksum: 5B75BBCF9C788E3E
- Sequence:
MTTYSDKGAK PERGRFLHFH SVTFWVGNAK QATSFYCSKM GFEPLAYRGL ETGSREVVSH VIKQGKIVFV LSSALNPWNK EMGDHLVKHG DGVKDIAFEV EDCDYIVQKA RERGAKIMRE PWVEQDKFGK VKFAVLQTYG DTTHTLVEKM NYIGQFLPGY EAPAFMDPLL PKLPKCSLEM IDHIVGNQPD QEMVSASEWY LKNLQFHRFW SVDDTQVHTE YSSLRSIVVA NYEESIKMPI NEPAPGKKKS QIQEYVDYNG GAGVQHIALK TEDIITAIRH LRERGLEFLS VPSTYYKQLR EKLKTAKIKV KENIDALEEL KILVDYDEKG YLLQIFTKPV QDRPTLFLEV IQRHNHQGFG AGNFNSLFKA FEEEQNLRGN LTNMETNGVV PGM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.