Details for: HPD
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 3.98
Marker Score: 11,597 - Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 3.64
Marker Score: 10,783 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.58
Marker Score: 30,248 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 3.38
Marker Score: 9,640 - Cell Name: retina horizontal cell (CL0000745)
Fold Change: 2.52
Marker Score: 2,414 - Cell Name: retinal cone cell (CL0000573)
Fold Change: 2.33
Marker Score: 6,692 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.26
Marker Score: 12,168 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.01
Marker Score: 7,137 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.89
Marker Score: 12,136 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.87
Marker Score: 8,073 - Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 170,059 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.44
Marker Score: 4,713 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.44
Marker Score: 841 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.26
Marker Score: 567 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.14
Marker Score: 1,224 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.12
Marker Score: 2,117 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 796 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,823 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,047 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.96
Marker Score: 2,264 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.96
Marker Score: 2,427 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,337 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.92
Marker Score: 348 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.92
Marker Score: 284 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,739 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.91
Marker Score: 1,856 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,296 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.86
Marker Score: 588 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.83
Marker Score: 12,937 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,259 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.76
Marker Score: 500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.62
Marker Score: 171 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.62
Marker Score: 199 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.61
Marker Score: 178 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.58
Marker Score: 350 - Cell Name: germ cell (CL0000586)
Fold Change: 0.57
Marker Score: 1,001 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.54
Marker Score: 564 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.54
Marker Score: 536 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.53
Marker Score: 490 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.53
Marker Score: 167 - Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.53
Marker Score: 123 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.5
Marker Score: 678 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.45
Marker Score: 141 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.44
Marker Score: 148 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.38
Marker Score: 479 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.37
Marker Score: 453 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.37
Marker Score: 360 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.37
Marker Score: 176 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 370 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.37
Marker Score: 97 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.37
Marker Score: 80 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.32
Marker Score: 140 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.31
Marker Score: 312 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.3
Marker Score: 78 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.3
Marker Score: 111 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.28
Marker Score: 117 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.26
Marker Score: 651 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.26
Marker Score: 163 - Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.24
Marker Score: 61 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.24
Marker Score: 458 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.23
Marker Score: 177 - Cell Name: goblet cell (CL0000160)
Fold Change: 0.23
Marker Score: 1,545 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.23
Marker Score: 321 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.22
Marker Score: 236 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.21
Marker Score: 126 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.21
Marker Score: 160 - Cell Name: leukocyte (CL0000738)
Fold Change: 0.2
Marker Score: 116 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.2
Marker Score: 190 - Cell Name: erythroblast (CL0000765)
Fold Change: 0.2
Marker Score: 122 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.19
Marker Score: 315 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.19
Marker Score: 76 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.19
Marker Score: 55 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.18
Marker Score: 164 - Cell Name: male germ cell (CL0000015)
Fold Change: 0.18
Marker Score: 53 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.18
Marker Score: 488 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.18
Marker Score: 160 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.17
Marker Score: 269 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.17
Marker Score: 731 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.17
Marker Score: 213 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.17
Marker Score: 181 - Cell Name: podocyte (CL0000653)
Fold Change: 0.17
Marker Score: 62 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.17
Marker Score: 994 - Cell Name: mast cell (CL0000097)
Fold Change: 0.15
Marker Score: 88 - Cell Name: adventitial cell (CL0002503)
Fold Change: 0.15
Marker Score: 37 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.15
Marker Score: 157 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.14
Marker Score: 76 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.14
Marker Score: 52 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.14
Marker Score: 123 - Cell Name: B cell (CL0000236)
Fold Change: 0.14
Marker Score: 135 - Cell Name: promonocyte (CL0000559)
Fold Change: 0.14
Marker Score: 90 - Cell Name: T cell (CL0000084)
Fold Change: 0.14
Marker Score: 234 - Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.14
Marker Score: 56 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.13
Marker Score: 353 - Cell Name: fibroblast (CL0000057)
Fold Change: 0.13
Marker Score: 130 - Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.13
Marker Score: 62
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2631948398
Symbol: HPPD_HUMAN
Name: 4-hydroxyphenylpyruvate dioxygenase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7851880
Title: Structure of the human 4-hydroxyphenylpyruvic acid dioxygenase gene (HPD).
PubMed ID: 7851880
PubMed ID: 8521727
Title: Regional assignment of the human 4-hydroxyphenylpyruvate dioxygenase gene (HPD) to 12q24-->qter by fluorescence in situ hybridization.
PubMed ID: 8521727
DOI: 10.1159/000134142
PubMed ID: 9325050
Title: Human 4-hydroxyphenylpyruvate dioxygenase gene (HPD).
PubMed ID: 9325050
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1339442
Title: Primary structure deduced from complementary DNA sequence and expression in cultured cells of mammalian 4-hydroxyphenylpyruvic acid dioxygenase. Evidence that the enzyme is a homodimer of identical subunits homologous to rat liver-specific alloantigen F.
PubMed ID: 1339442
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 10942115
Title: Mutations in the 4-hydroxyphenylpyruvate dioxygenase gene (HPD) in patients with tyrosinemia type III.
PubMed ID: 10942115
PubMed ID: 11073718
Title: Mutations in the 4-hydroxyphenylpyruvic acid dioxygenase gene are responsible for tyrosinemia type III and hawkinsinuria.
PubMed ID: 11073718
Sequence Information:
- Length: 393
- Mass: 44934
- Checksum: 4314A16532C33A2F
- Sequence:
MTTYSDKGAK PERGRFLHFH SVTFWVGNAK QAASFYCSKM GFEPLAYRGL ETGSREVVSH VIKQGKIVFV LSSALNPWNK EMGDHLVKHG DGVKDIAFEV EDCDYIVQKA RERGAKIMRE PWVEQDKFGK VKFAVLQTYG DTTHTLVEKM NYIGQFLPGY EAPAFMDPLL PKLPKCSLEM IDHIVGNQPD QEMVSASEWY LKNLQFHRFW SVDDTQVHTE YSSLRSIVVA NYEESIKMPI NEPAPGKKKS QIQEYVDYNG GAGVQHIALK TEDIITAIRH LRERGLEFLS VPSTYYKQLR EKLKTAKIKV KENIDALEEL KILVDYDEKG YLLQIFTKPV QDRPTLFLEV IQRHNHQGFG AGNFNSLFKA FEEEQNLRGN LTNMETNGVV PGM
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.