Details for: HTR6

Gene ID: 3362

Symbol: HTR6

Ensembl ID: ENSG00000158748

Description: 5-hydroxytryptamine receptor 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.9410
    Cell Significance Index: 11.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4909
    Cell Significance Index: 7.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3988
    Cell Significance Index: 17.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3473
    Cell Significance Index: 13.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0670
    Cell Significance Index: 13.4500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0379
    Cell Significance Index: 0.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0278
    Cell Significance Index: 19.2600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0237
    Cell Significance Index: 0.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0178
    Cell Significance Index: 1.2000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0098
    Cell Significance Index: 0.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0060
    Cell Significance Index: 0.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0047
    Cell Significance Index: 1.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0037
    Cell Significance Index: 0.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0010
    Cell Significance Index: -1.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0019
    Cell Significance Index: -1.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0023
    Cell Significance Index: -1.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0025
    Cell Significance Index: -0.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0028
    Cell Significance Index: -1.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0030
    Cell Significance Index: -0.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0031
    Cell Significance Index: -1.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0051
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0055
    Cell Significance Index: -0.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0067
    Cell Significance Index: -0.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0071
    Cell Significance Index: -1.0300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0084
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0084
    Cell Significance Index: -1.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0088
    Cell Significance Index: -0.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0097
    Cell Significance Index: -0.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0099
    Cell Significance Index: -1.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0105
    Cell Significance Index: -1.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0108
    Cell Significance Index: -1.1000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0111
    Cell Significance Index: -0.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0114
    Cell Significance Index: -0.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0127
    Cell Significance Index: -1.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0127
    Cell Significance Index: -1.5000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0131
    Cell Significance Index: -0.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0144
    Cell Significance Index: -0.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0144
    Cell Significance Index: -0.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0147
    Cell Significance Index: -0.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0151
    Cell Significance Index: -0.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0154
    Cell Significance Index: -0.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0155
    Cell Significance Index: -0.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0162
    Cell Significance Index: -1.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0187
    Cell Significance Index: -0.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0196
    Cell Significance Index: -0.8900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0202
    Cell Significance Index: -0.5000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0211
    Cell Significance Index: -0.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0216
    Cell Significance Index: -0.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0216
    Cell Significance Index: -1.2100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0221
    Cell Significance Index: -0.9000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0223
    Cell Significance Index: -0.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0236
    Cell Significance Index: -1.1100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0247
    Cell Significance Index: -0.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0273
    Cell Significance Index: -0.6600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0281
    Cell Significance Index: -0.4100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0329
    Cell Significance Index: -0.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0353
    Cell Significance Index: -1.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0358
    Cell Significance Index: -0.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0371
    Cell Significance Index: -0.7700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0372
    Cell Significance Index: -0.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0374
    Cell Significance Index: -0.8100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0378
    Cell Significance Index: -0.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0385
    Cell Significance Index: -1.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0405
    Cell Significance Index: -1.0400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0408
    Cell Significance Index: -1.0200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0412
    Cell Significance Index: -0.8900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0417
    Cell Significance Index: -0.8200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0417
    Cell Significance Index: -0.8700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0425
    Cell Significance Index: -0.8300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0430
    Cell Significance Index: -0.9200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0435
    Cell Significance Index: -0.5600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0435
    Cell Significance Index: -0.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0467
    Cell Significance Index: -1.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0471
    Cell Significance Index: -1.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0475
    Cell Significance Index: -1.2500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0482
    Cell Significance Index: -0.6500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0488
    Cell Significance Index: -0.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0502
    Cell Significance Index: -1.4800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0511
    Cell Significance Index: -0.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0524
    Cell Significance Index: -1.3100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0529
    Cell Significance Index: -0.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0539
    Cell Significance Index: -1.4400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0541
    Cell Significance Index: -1.3200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0545
    Cell Significance Index: -0.7700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0574
    Cell Significance Index: -0.9300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0577
    Cell Significance Index: -1.1500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0585
    Cell Significance Index: -1.4900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0593
    Cell Significance Index: -1.0300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0598
    Cell Significance Index: -0.6000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0610
    Cell Significance Index: -0.8000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0620
    Cell Significance Index: -0.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0631
    Cell Significance Index: -1.3200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0652
    Cell Significance Index: -0.6200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0655
    Cell Significance Index: -0.9800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0664
    Cell Significance Index: -0.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serotonin Binding:** HTR6 is specifically activated by serotonin (5-HT), a neurotransmitter involved in mood regulation, appetite, and sleep. 2. **G Protein-Coupled Receptor (GPCR) Structure:** HTR6 belongs to the GPCR family, characterized by a seven-transmembrane domain structure, which allows for ligand binding and signal transduction. 3. **Diverse Tissue Expression:** HTR6 is expressed in various cell types, including progenitor cells, endothelial cells, plasma cells, goblet cells, pericytes, and GABAergic interneurons, highlighting its broad functional scope. 4. **Positive Regulation of TOR Signaling:** HTR6 activates the mechanistic target of rapamycin (mTOR) signaling pathway, which regulates cell growth, proliferation, and autophagy. **Pathways and Functions:** 1. **Serotonin Signaling:** HTR6 mediates serotonin's effects on the brain, influencing mood, cognition, and appetite. 2. **Immune Modulation:** HTR6 regulates immune responses, including the production of cytokines and the activation of immune cells, such as T cells and macrophages. 3. **Neurotransmitter Release:** HTR6 modulates the release of neurotransmitters, including serotonin, dopamine, and acetylcholine, which are involved in various physiological processes. 4. **Cell Migration and Proliferation:** HTR6 regulates cell migration, proliferation, and differentiation, particularly in the context of cancer and neurological disorders. 5. **Signaling by GPCRs:** HTR6 is a representative of the GPCR family, which plays a crucial role in transducing signals from external stimuli to intracellular responses. **Clinical Significance:** 1. **Mood Disorders:** HTR6 has been implicated in the pathophysiology of mood disorders, including depression and anxiety, where serotonin dysregulation is a common feature. 2. **Neurodegenerative Diseases:** HTR6 has been linked to neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, where serotonin signaling is disrupted. 3. **Cancer:** HTR6 has been identified as a potential target for cancer therapy, as its activation can promote cell proliferation and survival. 4. **Inflammation:** HTR6 regulates immune responses, including inflammation, which is a key feature of various diseases, including cardiovascular disease and autoimmune disorders. 5. **Neurological Disorders:** HTR6 has been implicated in neurological disorders, including epilepsy, where serotonin signaling is disrupted. In conclusion, HTR6 is a multifunctional receptor with diverse roles in the immune system, neurotransmission, and cellular behavior. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying HTR6 function and its potential as a therapeutic target.

Genular Protein ID: 1787485165

Symbol: 5HT6R_HUMAN

Name: N/A

UniProtKB Accession Codes:

P50406 Q13640 Q5TGZ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 32 DrugCentral 1 EMBL 7 EMDB 2 Ensembl 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8522988

Title: Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor.

PubMed ID: 8522988

DOI: 10.1046/j.1471-4159.1996.66010047.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7656980

Title: Expression of serotonin receptor mRNAs in blood vessels.

PubMed ID: 7656980

DOI: 10.1016/0014-5793(95)00828-w

PubMed ID: 23027611

Title: 5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.

PubMed ID: 23027611

DOI: 10.1002/emmm.201201410

PubMed ID: 35714614

Title: GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.

PubMed ID: 35714614

DOI: 10.1016/j.molcel.2022.05.031

PubMed ID: 36989299

Title: Structural insights into constitutive activity of 5-HT6 receptor.

PubMed ID: 36989299

DOI: 10.1073/pnas.2209917120

PubMed ID: 37327704

Title: Structural insight into the selective agonist ST1936 binding of serotonin receptor 5-HT6.

PubMed ID: 37327704

DOI: 10.1016/j.bbrc.2023.05.126

Sequence Information:

  • Length: 440
  • Mass: 46954
  • Checksum: C888F47650C1D2EF
  • Sequence:
    • MVPEPGPTAN STPAWGAGPP SAPGGSGWVA AALCVVIALT AAANSLLIAL ICTQPALRNT 
SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL LWTAFDVMCC SASILNLCLI 
SLDRYLLILS PLRYKLRMTP LRALALVLGA WSLAALASFL PLLLGWHELG HARPPVPGQC 
RLLASLPFVL VASGLTFFLP SGAICFTYCR ILLAARKQAV QVASLTTGMA SQASETLQVP 
RTPRPGVESA DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIV QAVCDCISPG 
LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCPRC PRERQASLAS PSLRTSHSGP 
RPGLSLQQVL PLPLPPDSDS DSDAGSGGSS GLRLTAQLLL PGEATQDPPL PTRAAAAVNF 
FNIDPAEPEL RPHPLGIPTN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.