Details for: OR2A1

Gene ID: 346528

Symbol: OR2A1

Ensembl ID: ENSG00000221970

Description: olfactory receptor family 2 subfamily A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.6795
    Cell Significance Index: 79.9900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 3.1393
    Cell Significance Index: 43.0500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 3.0627
    Cell Significance Index: 39.6300
  • Cell Name: mast cell (CL0000097)
    Fold Change: 2.3404
    Cell Significance Index: 30.8000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4305
    Cell Significance Index: 34.6500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3148
    Cell Significance Index: 4.5700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.2402
    Cell Significance Index: 3.8900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2240
    Cell Significance Index: 2.9400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2181
    Cell Significance Index: 3.4600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.0944
    Cell Significance Index: 1.1400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0672
    Cell Significance Index: 0.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0193
    Cell Significance Index: 0.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0154
    Cell Significance Index: 0.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0150
    Cell Significance Index: 0.7800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.0064
    Cell Significance Index: 0.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0032
    Cell Significance Index: 0.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0024
    Cell Significance Index: 0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0015
    Cell Significance Index: 2.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0008
    Cell Significance Index: 1.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0006
    Cell Significance Index: 0.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0000
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0006
    Cell Significance Index: -0.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0006
    Cell Significance Index: -0.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0006
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0008
    Cell Significance Index: -0.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0009
    Cell Significance Index: -0.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0011
    Cell Significance Index: -0.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0011
    Cell Significance Index: -0.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0020
    Cell Significance Index: -0.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0021
    Cell Significance Index: -0.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0023
    Cell Significance Index: -0.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0026
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0034
    Cell Significance Index: -0.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0035
    Cell Significance Index: -0.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0045
    Cell Significance Index: -0.4700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0049
    Cell Significance Index: -0.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0050
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0050
    Cell Significance Index: -0.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0051
    Cell Significance Index: -0.1000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0053
    Cell Significance Index: -0.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0061
    Cell Significance Index: -0.1600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0061
    Cell Significance Index: -0.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0062
    Cell Significance Index: -0.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0080
    Cell Significance Index: -0.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0083
    Cell Significance Index: -0.6400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0088
    Cell Significance Index: -0.1800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0101
    Cell Significance Index: -0.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0107
    Cell Significance Index: -0.1000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0107
    Cell Significance Index: -0.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0110
    Cell Significance Index: -0.3600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0115
    Cell Significance Index: -0.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0116
    Cell Significance Index: -0.3700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0128
    Cell Significance Index: -0.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0132
    Cell Significance Index: -0.5000
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0134
    Cell Significance Index: -0.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0147
    Cell Significance Index: -0.2000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0155
    Cell Significance Index: -0.4900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0159
    Cell Significance Index: -0.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0164
    Cell Significance Index: -0.4700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0166
    Cell Significance Index: -0.2300
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0170
    Cell Significance Index: -0.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0174
    Cell Significance Index: -0.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0184
    Cell Significance Index: -0.3700
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0184
    Cell Significance Index: -0.2000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0186
    Cell Significance Index: -0.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0198
    Cell Significance Index: -0.5200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0198
    Cell Significance Index: -0.2100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0202
    Cell Significance Index: -0.3500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0204
    Cell Significance Index: -0.2800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0206
    Cell Significance Index: -0.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0214
    Cell Significance Index: -0.4200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0218
    Cell Significance Index: -0.4700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0220
    Cell Significance Index: -0.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0220
    Cell Significance Index: -0.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0221
    Cell Significance Index: -0.3700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0225
    Cell Significance Index: -0.1500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0226
    Cell Significance Index: -0.1900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0237
    Cell Significance Index: -0.2700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0241
    Cell Significance Index: -0.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0254
    Cell Significance Index: -0.4700
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0254
    Cell Significance Index: -0.2400
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -0.0264
    Cell Significance Index: -0.2700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0268
    Cell Significance Index: -0.2900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0272
    Cell Significance Index: -0.2400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0276
    Cell Significance Index: -0.2800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0278
    Cell Significance Index: -0.3300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0282
    Cell Significance Index: -0.1300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0282
    Cell Significance Index: -0.2700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0285
    Cell Significance Index: -0.3800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0287
    Cell Significance Index: -0.3700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0292
    Cell Significance Index: -0.3500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0292
    Cell Significance Index: -0.4200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0296
    Cell Significance Index: -0.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0298
    Cell Significance Index: -0.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR2A1 is a G protein-coupled receptor that binds to specific odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **Widespread Expression:** OR2A1 is expressed in various cell types, including those involved in the nervous system, immune system, and hematopoiesis, underscoring its importance in multiple physiological processes. 3. **Cellular Distribution:** OR2A1 is found in cells such as glutamatergic neurons, erythrocytes, megakaryocytes, and hematopoietic stem cells, indicating its involvement in distinct biological pathways. 4. **Signaling Pathways:** OR2A1 is associated with G protein-coupled receptor activity and signaling pathways, including the G protein-coupled receptor signaling pathway and olfactory receptor activity. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR2A1 binds to specific odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **G Protein-Coupled Receptor Activity:** OR2A1 is a G protein-coupled receptor that activates G proteins, leading to the modulation of downstream signaling pathways. 3. **Olfactory Signaling Pathway:** OR2A1 is integral to the olfactory signaling pathway, which is responsible for transmitting sensory information from the nose to the brain. 4. **Regulation of Sensory Perception:** OR2A1 plays a crucial role in modulating sensory perception, including the detection of chemical stimuli and the regulation of olfactory signaling. **Clinical Significance:** 1. **Olfactory Dysfunction:** Alterations in OR2A1 expression or function may contribute to olfactory dysfunction, which can have significant implications for quality of life and cognitive function. 2. **Neurological Disorders:** OR2A1 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, where olfactory dysfunction is a common feature. 3. **Immunological Disorders:** OR2A1 is expressed in immune cells, and alterations in its expression or function may contribute to immunological disorders, such as allergies and asthma. 4. **Cancer:** OR2A1 has been identified as a potential biomarker for certain types of cancer, including lung and breast cancer, where olfactory dysfunction is a common feature. In conclusion, OR2A1 is a multifunctional gene that plays a critical role in sensory perception, immune function, and overall health. Further research is necessary to fully elucidate the mechanisms underlying OR2A1's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2263030873

Symbol: OR2A1_HUMAN

Name: Olfactory receptor 2A1/2A42

UniProtKB Accession Codes:

Q8NGT9 Q6IF44 Q96R46

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 2 Bgee 1 BioGRID-ORCS 2 BioMuta 1 CCDS 2 CDD 1 CTD 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 4 Gene3D 1 GeneCards 2 GeneTree 1 GeneWiki 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 InterPro 3 KEGG 2 MANE-Select 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 2 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 310
  • Mass: 34714
  • Checksum: CE5E0170B025E871
  • Sequence:
    • MGENQTMVTE FLLLGFLLGP RIQMLLFGLF SLFYIFTLLG NGAILGLISL DSRLHTPMYF 
FLSHLAVVDI AYTRNTVPQM LANLLHPAKP ISFAGCMTQT FLCLSFGHSE CLLLVLMSYD 
RYVAICHPLR YSVIMTWRVC ITLAVTSWTC GSLLALAHVV LILRLPFSGP HEINHFFCEI 
LSVLRLACAD TWLNQVVIFA ACVFFLVGPP SLVLVSYSHI LAAILRIQSG EGRRKAFSTC 
SSHLCVVGLF FGSAIIMYMA PKSRHPEEQQ KVFFLFYSFF NPTLNPLIYS LRNGEVKGAL 
RRALGKESHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.