Details for: ITGA2

Gene ID: 3673

Symbol: ITGA2

Ensembl ID: ENSG00000164171

Description: integrin subunit alpha 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.52
    Marker Score: 3119
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.92
    Marker Score: 7138
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.68
    Marker Score: 2114
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.57
    Marker Score: 12648
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.21
    Marker Score: 9200
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.19
    Marker Score: 1218
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.97
    Marker Score: 5641
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.93
    Marker Score: 2032
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.89
    Marker Score: 2142.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.85
    Marker Score: 1427
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.77
    Marker Score: 2609
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.75
    Marker Score: 1191
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.74
    Marker Score: 12977
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.74
    Marker Score: 4158
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.73
    Marker Score: 1200
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.61
    Marker Score: 464.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.55
    Marker Score: 3911
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.47
    Marker Score: 3943
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168246
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.44
    Marker Score: 2044
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.43
    Marker Score: 1784
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.42
    Marker Score: 2516
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.4
    Marker Score: 473
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.34
    Marker Score: 1422
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.32
    Marker Score: 790
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.31
    Marker Score: 1695
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.31
    Marker Score: 1133
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.29
    Marker Score: 1218.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.29
    Marker Score: 11190
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.28
    Marker Score: 498
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.28
    Marker Score: 258
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.2
    Marker Score: 1213
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.19
    Marker Score: 344
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.17
    Marker Score: 975
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.15
    Marker Score: 1267
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.14
    Marker Score: 3934
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.13
    Marker Score: 641
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.13
    Marker Score: 4345
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.1
    Marker Score: 698
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.07
    Marker Score: 252
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.06
    Marker Score: 1010
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.05
    Marker Score: 490.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71783
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48008
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1
    Marker Score: 2024
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.99
    Marker Score: 231
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.99
    Marker Score: 1069
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.95
    Marker Score: 1573
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.94
    Marker Score: 14740
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.93
    Marker Score: 14947
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1486
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.91
    Marker Score: 572
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.91
    Marker Score: 323
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.9
    Marker Score: 1637
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.88
    Marker Score: 1680
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.88
    Marker Score: 384
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5006
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.87
    Marker Score: 211
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.87
    Marker Score: 1978
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.87
    Marker Score: 505
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.87
    Marker Score: 195
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.85
    Marker Score: 500
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.85
    Marker Score: 421
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.85
    Marker Score: 1389
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.84
    Marker Score: 480
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.84
    Marker Score: 1609.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.83
    Marker Score: 7122
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.82
    Marker Score: 1194
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.82
    Marker Score: 409
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.82
    Marker Score: 1866
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 623
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.81
    Marker Score: 780
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.8
    Marker Score: 300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.8
    Marker Score: 10706
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.79
    Marker Score: 191
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.79
    Marker Score: 6941
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.79
    Marker Score: 516
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.78
    Marker Score: 3750
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.77
    Marker Score: 407
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.76
    Marker Score: 509
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.74
    Marker Score: 1750
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.73
    Marker Score: 2718
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 658
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.72
    Marker Score: 835
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.7
    Marker Score: 340
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.68
    Marker Score: 303
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2859.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.67
    Marker Score: 668
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.67
    Marker Score: 4270
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 434

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Other Information

**Key characteristics:** - ITGA2 is a glycoprotein with a molecular weight of approximately 120 kDa. - It is a transmembrane protein that is expressed on the cell surface. - It is a member of the integrin family of cell adhesion molecules. **Pathways and functions:** - ITGA2 is involved in cell adhesion to extracellular matrix proteins, including collagen, fibronectin, and laminin. - It plays a critical role in cell migration by facilitating cell-cell adhesion and guiding cell movement. - ITGA2 is also involved in cell signaling pathways, including those involving met, a receptor tyrosine kinase. - It is expressed in high levels in epithelial cells, where it is involved in cell-cell adhesion, tissue morphogenesis, and tumor progression. **Clinical significance:** - Mutations in ITGA2 have been linked to various human diseases, including prostate cancer, breast cancer, and lung cancer. - Targeting ITGA2 with antibodies or small molecules is a promising therapeutic strategy for these diseases. - ITGA2 is a potential target for the development of novel cancer therapies that inhibit tumor growth and metastasis.

Genular Protein ID: 2884121621

Symbol: ITA2_HUMAN

Name: Integrin alpha-2

UniProtKB Accession Codes:

P17301 Q14595

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 57 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 16 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2545729

Title: The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain.

PubMed ID: 2545729

DOI: 10.1083/jcb.109.1.397

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 8276836

Title: The human alpha 2 integrin gene promoter. Identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expression.

PubMed ID: 8276836

DOI: 10.1016/s0021-9258(17)42373-8

PubMed ID: 8411387

Title: Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2.

PubMed ID: 8411387

DOI: 10.1128/jvi.67.11.6847-6852.1993

PubMed ID: 12941907

Title: Integrin-using rotaviruses bind alpha2beta1 integrin alpha2 I domain via VP4 DGE sequence and recognize alphaXbeta2 and alphaVbeta3 by using VP7 during cell entry.

PubMed ID: 12941907

DOI: 10.1128/jvi.77.18.9969-9978.2003

PubMed ID: 16754960

Title: Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.

PubMed ID: 16754960

DOI: 10.1083/jcb.200509019

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 18804435

Title: Integrin trafficking regulated by Rab21 is necessary for cytokinesis.

PubMed ID: 18804435

DOI: 10.1016/j.devcel.2008.08.001

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 9353312

Title: Crystal structure of the I domain from integrin alpha2beta1.

PubMed ID: 9353312

DOI: 10.1074/jbc.272.45.28512

PubMed ID: 7901236

Title: The human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2).

PubMed ID: 7901236

DOI: 10.1172/jci116849

PubMed ID: 10744142

Title: The impact of the glycoprotein Ia collagen receptor subunit A1648G gene polymorphism on coronary artery disease and acute myocardial infarction.

PubMed ID: 10744142

PubMed ID: 23368983

Title: HPA-5 typing discrepancy reveals an Ile503Leu substitution in platelet GPIa (alpha2 integrin).

PubMed ID: 23368983

DOI: 10.1111/vox.12019

Sequence Information:

  • Length: 1181
  • Mass: 129296
  • Checksum: 06DD2DE59EAB39ED
  • Sequence:
    • MGPERTGAAP LPLLLVLALS QGILNCCLAY NVGLPEAKIF SGPSSEQFGY AVQQFINPKG 
NWLLVGSPWS GFPENRMGDV YKCPVDLSTA TCEKLNLQTS TSIPNVTEMK TNMSLGLILT 
RNMGTGGFLT CGPLWAQQCG NQYYTTGVCS DISPDFQLSA SFSPATQPCP SLIDVVVVCD 
ESNSIYPWDA VKNFLEKFVQ GLDIGPTKTQ VGLIQYANNP RVVFNLNTYK TKEEMIVATS 
QTSQYGGDLT NTFGAIQYAR KYAYSAASGG RRSATKVMVV VTDGESHDGS MLKAVIDQCN 
HDNILRFGIA VLGYLNRNAL DTKNLIKEIK AIASIPTERY FFNVSDEAAL LEKAGTLGEQ 
IFSIEGTVQG GDNFQMEMSQ VGFSADYSSQ NDILMLGAVG AFGWSGTIVQ KTSHGHLIFP 
KQAFDQILQD RNHSSYLGYS VAAISTGEST HFVAGAPRAN YTGQIVLYSV NENGNITVIQ 
AHRGDQIGSY FGSVLCSVDV DKDTITDVLL VGAPMYMSDL KKEEGRVYLF TIKEGILGQH 
QFLEGPEGIE NTRFGSAIAA LSDINMDGFN DVIVGSPLEN QNSGAVYIYN GHQGTIRTKY 
SQKILGSDGA FRSHLQYFGR SLDGYGDLNG DSITDVSIGA FGQVVQLWSQ SIADVAIEAS 
FTPEKITLVN KNAQIILKLC FSAKFRPTKQ NNQVAIVYNI TLDADGFSSR VTSRGLFKEN 
NERCLQKNMV VNQAQSCPEH IIYIQEPSDV VNSLDLRVDI SLENPGTSPA LEAYSETAKV 
FSIPFHKDCG EDGLCISDLV LDVRQIPAAQ EQPFIVSNQN KRLTFSVTLK NKRESAYNTG 
IVVDFSENLF FASFSLPVDG TEVTCQVAAS QKSVACDVGY PALKREQQVT FTINFDFNLQ 
NLQNQASLSF QALSESQEEN KADNLVNLKI PLLYDAEIHL TRSTNINFYE ISSDGNVPSI 
VHSFEDVGPK FIFSLKVTTG SVPVSMATVI IHIPQYTKEK NPLMYLTGVQ TDKAGDISCN 
ADINPLKIGQ TSSSVSFKSE NFRHTKELNC RTASCSNVTC WLKDVHMKGE YFVNVTTRIW 
NGTFASSTFQ TVQLTAAAEI NTYNPEIYVI EDNTVTIPLM IMKPDEKAEV PTGVIIGSII 
AGILLLLALV AILWKLGFFK RKYEKMTKNP DEIDETTELS S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.