Details for: KCNJ4

Gene ID: 3761

Symbol: KCNJ4

Ensembl ID: ENSG00000168135

Description: potassium inwardly rectifying channel subfamily J member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.1079
    Cell Significance Index: 60.7700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.4898
    Cell Significance Index: 42.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 1.5422
    Cell Significance Index: 22.0900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7501
    Cell Significance Index: 18.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6636
    Cell Significance Index: 133.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4972
    Cell Significance Index: 33.4300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.4051
    Cell Significance Index: 5.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3629
    Cell Significance Index: 10.3600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2867
    Cell Significance Index: 3.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2780
    Cell Significance Index: 99.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2473
    Cell Significance Index: 10.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1944
    Cell Significance Index: 7.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1698
    Cell Significance Index: 117.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0829
    Cell Significance Index: 1.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0784
    Cell Significance Index: 6.0200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0711
    Cell Significance Index: 1.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0007
    Cell Significance Index: -0.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0041
    Cell Significance Index: -6.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0052
    Cell Significance Index: -7.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0114
    Cell Significance Index: -8.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0120
    Cell Significance Index: -7.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0132
    Cell Significance Index: -7.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0157
    Cell Significance Index: -7.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0174
    Cell Significance Index: -2.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0228
    Cell Significance Index: -6.5500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0231
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0334
    Cell Significance Index: -5.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0352
    Cell Significance Index: -6.9900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0356
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0392
    Cell Significance Index: -8.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0415
    Cell Significance Index: -7.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0471
    Cell Significance Index: -1.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0484
    Cell Significance Index: -7.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0517
    Cell Significance Index: -7.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0519
    Cell Significance Index: -2.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0557
    Cell Significance Index: -1.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0571
    Cell Significance Index: -3.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0604
    Cell Significance Index: -3.7100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0634
    Cell Significance Index: -0.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0652
    Cell Significance Index: -6.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0731
    Cell Significance Index: -8.3800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0756
    Cell Significance Index: -3.2900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0824
    Cell Significance Index: -1.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0893
    Cell Significance Index: -3.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0901
    Cell Significance Index: -1.3300
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0991
    Cell Significance Index: -1.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1030
    Cell Significance Index: -2.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1040
    Cell Significance Index: -2.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1155
    Cell Significance Index: -2.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1164
    Cell Significance Index: -2.9900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1174
    Cell Significance Index: -1.3700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1198
    Cell Significance Index: -2.5000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1255
    Cell Significance Index: -1.1900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1533
    Cell Significance Index: -1.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1589
    Cell Significance Index: -7.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1701
    Cell Significance Index: -7.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1773
    Cell Significance Index: -3.5600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2145
    Cell Significance Index: -2.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2204
    Cell Significance Index: -6.3500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2208
    Cell Significance Index: -5.6300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2227
    Cell Significance Index: -7.0500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2272
    Cell Significance Index: -2.9800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2363
    Cell Significance Index: -4.6500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2403
    Cell Significance Index: -3.1100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2437
    Cell Significance Index: -4.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2494
    Cell Significance Index: -7.1500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2540
    Cell Significance Index: -2.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2632
    Cell Significance Index: -4.5100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2639
    Cell Significance Index: -5.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2808
    Cell Significance Index: -8.2700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2820
    Cell Significance Index: -6.8800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2821
    Cell Significance Index: -3.5600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2880
    Cell Significance Index: -3.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2890
    Cell Significance Index: -7.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2924
    Cell Significance Index: -7.8400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2995
    Cell Significance Index: -3.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3031
    Cell Significance Index: -8.0900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3031
    Cell Significance Index: -4.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3051
    Cell Significance Index: -7.0500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3061
    Cell Significance Index: -6.3500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3119
    Cell Significance Index: -4.0000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3181
    Cell Significance Index: -5.5000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3345
    Cell Significance Index: -4.0000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3359
    Cell Significance Index: -7.1800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.3359
    Cell Significance Index: -4.0600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3372
    Cell Significance Index: -5.1300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3377
    Cell Significance Index: -4.3800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.3421
    Cell Significance Index: -3.7500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3534
    Cell Significance Index: -4.4700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3537
    Cell Significance Index: -4.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3654
    Cell Significance Index: -8.0000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3750
    Cell Significance Index: -5.0600
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.3761
    Cell Significance Index: -3.8000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3819
    Cell Significance Index: -5.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3851
    Cell Significance Index: -8.0600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3893
    Cell Significance Index: -6.4200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.3901
    Cell Significance Index: -3.4600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.3915
    Cell Significance Index: -2.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Inwardly rectifying potassium channel**: KCNJ4 encodes for an inwardly rectifying potassium channel, which is characterized by its ability to allow potassium ions to flow into the cell while limiting potassium ion flow out of the cell. 2. **Subfamily J member**: KCNJ4 belongs to the inwardly rectifying potassium channel subfamily J, which is a group of channels that are involved in maintaining cellular homeostasis. 3. **GABA receptor activation**: KCNJ4 is involved in the activation of GABA receptors, which are critical for regulating neuronal excitability and synaptic transmission. 4. **Cytoplasmic vesicle membrane**: KCNJ4 is also localized to the cytoplasmic vesicle membrane, where it plays a role in regulating monoatomic ion transmembrane transport. **Pathways and Functions** 1. **Activation of GABA receptors**: KCNJ4 is involved in the activation of GABA receptors, which regulate neuronal excitability and synaptic transmission. 2. **Activation of G protein-gated potassium channels**: KCNJ4 is also involved in the activation of G protein-gated potassium channels, which play a critical role in regulating cellular excitability. 3. **Inhibition of voltage-gated Ca2+ channels**: KCNJ4 inhibits the activity of voltage-gated Ca2+ channels via Gβγ subunits, which regulates muscle contraction and neuronal excitability. 4. **Regulation of monoatomic ion transmembrane transport**: KCNJ4 is involved in regulating monoatomic ion transmembrane transport across cellular membranes. **Clinical Significance** 1. **Neurological disorders**: KCNJ4 has been implicated in various neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder. 2. **Cardiac conduction disorders**: KCNJ4 has also been implicated in cardiac conduction disorders, including long QT syndrome and atrial fibrillation. 3. **Muscular dystrophy**: KCNJ4 has been linked to muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 4. **Blood vessel endothelial cell function**: KCNJ4 plays a critical role in regulating blood vessel endothelial cell function, which is essential for maintaining vascular tone and blood pressure. In conclusion, KCNJ4 is a critical gene that plays a significant role in maintaining cellular homeostasis and regulating various cellular processes, including muscle contraction, neuronal system function, and regulation of monoatomic ion transmembrane transport. Its dysregulation has been implicated in various neurological and cardiac disorders, highlighting the importance of further research into the function and clinical significance of this gene.

Genular Protein ID: 2237841745

Symbol: KCNJ4_HUMAN

Name: Inward rectifier potassium channel 4

UniProtKB Accession Codes:

P48050 Q14D44

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 ELM 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8016146

Title: Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus.

PubMed ID: 8016146

DOI: 10.1073/pnas.91.13.6240

PubMed ID: 8034048

Title: Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes.

PubMed ID: 8034048

DOI: 10.1016/0014-5793(94)00612-1

PubMed ID: 8051145

Title: Cloning and expression of a novel human brain inward rectifier potassium channel.

PubMed ID: 8051145

DOI: 10.1016/s0021-9258(17)32016-1

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7576658

Title: Identification and molecular localization of a pH-sensing domain for the inward rectifier potassium channel HIR.

PubMed ID: 7576658

DOI: 10.1016/0896-6273(95)90103-5

PubMed ID: 12032359

Title: Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.

PubMed ID: 12032359

DOI: 10.1073/pnas.102609499

PubMed ID: 19635485

Title: Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1.

PubMed ID: 19635485

DOI: 10.1016/j.jmb.2009.07.060

Sequence Information:

  • Length: 445
  • Mass: 49500
  • Checksum: 893F03365273E8BE
  • Sequence:
    • MHGHSRNGQA HVPRRKRRNR FVKKNGQCNV YFANLSNKSQ RYMADIFTTC VDTRWRYMLM 
IFSAAFLVSW LFFGLLFWCI AFFHGDLEAS PGVPAAGGPA AGGGGAAPVA PKPCIMHVNG 
FLGAFLFSVE TQTTIGYGFR CVTEECPLAV IAVVVQSIVG CVIDSFMIGT IMAKMARPKK 
RAQTLLFSHH AVISVRDGKL CLMWRVGNLR KSHIVEAHVR AQLIKPYMTQ EGEYLPLDQR 
DLNVGYDIGL DRIFLVSPII IVHEIDEDSP LYGMGKEELE SEDFEIVVIL EGMVEATAMT 
TQARSSYLAS EILWGHRFEP VVFEEKSHYK VDYSRFHKTY EVAGTPCCSA RELQESKITV 
LPAPPPPPSA FCYENELALM SQEEEEMEEE AAAAAAVAAG LGLEAGSKEE AGIIRMLEFG 
SHLDLERMQA SLPLDNISYR RESAI

Genular Protein ID: 3857841535

Symbol: Q58F07_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q58F07

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 2 PeptideAtlas 1 Pfam 4 RefSeq 1 RuleBase 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 393
  • Mass: 43989
  • Checksum: 80254FF964FFAA3C
  • Sequence:
    • MHGHSRNGQA HVPRRKRRNR FVKKNGQCNV YFANLSNKSQ RYMADIFTTC VDTRWRYMLM 
IFSAAFLVSW LFFGLLFWCI AFFHGDLEAS PGVPAAGGPA AGGGGAAPVA PKPCIMHVNG 
FLGAFLFSVE TQTTIGYGFR CVTEECPLAV IAVVVQSIVG CVIDSFMIGT IMAKMARPKK 
RAQTLLFSHH AVISVRDGKL CLMWRVGNLR KSHIVEAHVR AQLIKPYMTQ EGEYLPLDQR 
DLNVGYDIGL DRIFLVSPII IVHEIDEDSP LYGMGKEELE SEDFEIVVIL EGMVEATAMT 
TQARSSYLAS EILWGHRFEP VVFEEKSHYK VDYSRFHKTY EVAGTPCCSA RELQESKITV 
LPAPPPPPSA FCYENELALM SQEEEEMEEE AAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.