Details for: KCNJ4

Gene ID: 3761

Symbol: KCNJ4

Ensembl ID: ENSG00000168135

Description: potassium inwardly rectifying channel subfamily J member 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.66
    Marker Score: 3690
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.42
    Marker Score: 2434
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2214
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.73
    Marker Score: 910
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.35
    Marker Score: 563
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19582
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.22
    Marker Score: 1519
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.1
    Marker Score: 7325
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.98
    Marker Score: 1040
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.96
    Marker Score: 1478
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.94
    Marker Score: 624
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.94
    Marker Score: 8087
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5342
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.85
    Marker Score: 1613
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 490
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.78
    Marker Score: 7446
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.75
    Marker Score: 3111
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.74
    Marker Score: 6931
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.73
    Marker Score: 44996
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.7
    Marker Score: 25916
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.7
    Marker Score: 1120
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1312
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.63
    Marker Score: 2425
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 498
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.62
    Marker Score: 1278
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.61
    Marker Score: 675
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.5
    Marker Score: 476
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.49
    Marker Score: 224
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 233
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.47
    Marker Score: 7035
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.41
    Marker Score: 244
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.4
    Marker Score: 1567
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.4
    Marker Score: 178
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.37
    Marker Score: 646
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.36
    Marker Score: 1468
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.36
    Marker Score: 7161
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.36
    Marker Score: 188
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.35
    Marker Score: 209
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.34
    Marker Score: 125
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.28
    Marker Score: 468
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.27
    Marker Score: 87
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 115
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.26
    Marker Score: 151
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.26
    Marker Score: 262
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 73
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.24
    Marker Score: 117
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.22
    Marker Score: 436.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.22
    Marker Score: 168
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.21
    Marker Score: 263
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.21
    Marker Score: 597.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.2
    Marker Score: 90
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.19
    Marker Score: 902
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.19
    Marker Score: 166
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.18
    Marker Score: 112
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.17
    Marker Score: 1324
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.17
    Marker Score: 710
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 393.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.17
    Marker Score: 127
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.17
    Marker Score: 1673
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.16
    Marker Score: 6231
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.16
    Marker Score: 106
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 49
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.14
    Marker Score: 49.5
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 118
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.13
    Marker Score: 47.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.13
    Marker Score: 140
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.11
    Marker Score: 64
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.11
    Marker Score: 103
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.11
    Marker Score: 199
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 123
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.1
    Marker Score: 154.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.09
    Marker Score: 126
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.09
    Marker Score: 161
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.09
    Marker Score: 1966
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.09
    Marker Score: 103
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.08
    Marker Score: 34
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.08
    Marker Score: 245
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.08
    Marker Score: 31

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Other Information

**Key characteristics:** * KCNJ4 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It belongs to the inwardly rectifying potassium channel family, which are important regulators of cellular potassium homeostasis. * KCNJ4 is a tetramer, consisting of four subunits that assemble into a heterodimeric structure. * Each subunit contains a unique transmembrane domain that mediates ion channel gating. * KCNJ4 is a key regulator of cardiac conduction, as it opens upon depolarization of the cardiac membrane, allowing potassium ions to flow into the cell. * In other cell types, KCNJ4 is involved in various cellular processes, including muscle contraction, neurotransmitter signaling, and synaptic transmission. **Pathways and functions:** * Activation of G protein-gated potassium channels by various stimuli, including Gaba and muscarinic cholinesterase. * Activation of GABAB receptors, which are G protein-coupled receptors that are expressed in cardiac muscle. * Inhibition of voltage-gated calcium channels via gbeta/gamma subunits. * Regulation of monoatomic ion transmembrane transport. * Transmission across chemical synapses. **Clinical significance:** * Mutations in KCNJ4 have been linked to several human genetic disorders, including cardiac arrhythmias, epilepsy, and stroke. * KCNJ4 is a potential therapeutic target for these disorders, as it has been shown to be a therapeutic target in animal models of cardiac arrhythmias. * Further research is needed to explore the potential clinical significance of KCNJ4 in humans.

Genular Protein ID: 2237841745

Symbol: KCNJ4_HUMAN

Name: Inward rectifier potassium channel 4

UniProtKB Accession Codes:

P48050 Q14D44

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 ELM 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PIRSF 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8016146

Title: Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus.

PubMed ID: 8016146

DOI: 10.1073/pnas.91.13.6240

PubMed ID: 8034048

Title: Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes.

PubMed ID: 8034048

DOI: 10.1016/0014-5793(94)00612-1

PubMed ID: 8051145

Title: Cloning and expression of a novel human brain inward rectifier potassium channel.

PubMed ID: 8051145

DOI: 10.1016/s0021-9258(17)32016-1

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7576658

Title: Identification and molecular localization of a pH-sensing domain for the inward rectifier potassium channel HIR.

PubMed ID: 7576658

DOI: 10.1016/0896-6273(95)90103-5

PubMed ID: 12032359

Title: Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.

PubMed ID: 12032359

DOI: 10.1073/pnas.102609499

PubMed ID: 19635485

Title: Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1.

PubMed ID: 19635485

DOI: 10.1016/j.jmb.2009.07.060

Sequence Information:

  • Length: 445
  • Mass: 49500
  • Checksum: 893F03365273E8BE
  • Sequence:
    • MHGHSRNGQA HVPRRKRRNR FVKKNGQCNV YFANLSNKSQ RYMADIFTTC VDTRWRYMLM 
IFSAAFLVSW LFFGLLFWCI AFFHGDLEAS PGVPAAGGPA AGGGGAAPVA PKPCIMHVNG 
FLGAFLFSVE TQTTIGYGFR CVTEECPLAV IAVVVQSIVG CVIDSFMIGT IMAKMARPKK 
RAQTLLFSHH AVISVRDGKL CLMWRVGNLR KSHIVEAHVR AQLIKPYMTQ EGEYLPLDQR 
DLNVGYDIGL DRIFLVSPII IVHEIDEDSP LYGMGKEELE SEDFEIVVIL EGMVEATAMT 
TQARSSYLAS EILWGHRFEP VVFEEKSHYK VDYSRFHKTY EVAGTPCCSA RELQESKITV 
LPAPPPPPSA FCYENELALM SQEEEEMEEE AAAAAAVAAG LGLEAGSKEE AGIIRMLEFG 
SHLDLERMQA SLPLDNISYR RESAI

Genular Protein ID: 3857841535

Symbol: Q58F07_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q58F07

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 2 PeptideAtlas 1 Pfam 4 RefSeq 1 RuleBase 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 393
  • Mass: 43989
  • Checksum: 80254FF964FFAA3C
  • Sequence:
    • MHGHSRNGQA HVPRRKRRNR FVKKNGQCNV YFANLSNKSQ RYMADIFTTC VDTRWRYMLM 
IFSAAFLVSW LFFGLLFWCI AFFHGDLEAS PGVPAAGGPA AGGGGAAPVA PKPCIMHVNG 
FLGAFLFSVE TQTTIGYGFR CVTEECPLAV IAVVVQSIVG CVIDSFMIGT IMAKMARPKK 
RAQTLLFSHH AVISVRDGKL CLMWRVGNLR KSHIVEAHVR AQLIKPYMTQ EGEYLPLDQR 
DLNVGYDIGL DRIFLVSPII IVHEIDEDSP LYGMGKEELE SEDFEIVVIL EGMVEATAMT 
TQARSSYLAS EILWGHRFEP VVFEEKSHYK VDYSRFHKTY EVAGTPCCSA RELQESKITV 
LPAPPPPPSA FCYENELALM SQEEEEMEEE AAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.