Details for: KIF25

Gene ID: 3834

Symbol: KIF25

Ensembl ID: ENSG00000125337

Description: kinesin family member 25

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 8.0983
    Cell Significance Index: -3.2900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.8327
    Cell Significance Index: 17.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.9247
    Cell Significance Index: 118.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6121
    Cell Significance Index: 34.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3026
    Cell Significance Index: 41.7200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2814
    Cell Significance Index: 31.0400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.6459
    Cell Significance Index: 10.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5917
    Cell Significance Index: 112.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5037
    Cell Significance Index: 11.0300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.4915
    Cell Significance Index: 6.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4336
    Cell Significance Index: 42.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3869
    Cell Significance Index: 8.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3233
    Cell Significance Index: 291.9100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2724
    Cell Significance Index: 2.1000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2559
    Cell Significance Index: 3.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2356
    Cell Significance Index: 25.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2219
    Cell Significance Index: 36.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1971
    Cell Significance Index: 11.8300
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.1950
    Cell Significance Index: 1.7700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1927
    Cell Significance Index: 2.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1269
    Cell Significance Index: 25.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1137
    Cell Significance Index: 7.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0735
    Cell Significance Index: 9.4200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0711
    Cell Significance Index: 0.8000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0532
    Cell Significance Index: 0.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0471
    Cell Significance Index: 2.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0404
    Cell Significance Index: 14.4800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0322
    Cell Significance Index: 0.3900
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.0157
    Cell Significance Index: 0.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0142
    Cell Significance Index: 2.8100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0140
    Cell Significance Index: 0.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0127
    Cell Significance Index: 2.2900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0056
    Cell Significance Index: 0.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0026
    Cell Significance Index: -1.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0035
    Cell Significance Index: -0.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0041
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0042
    Cell Significance Index: -3.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0044
    Cell Significance Index: -2.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0048
    Cell Significance Index: -3.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0050
    Cell Significance Index: -0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0051
    Cell Significance Index: -3.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0054
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0054
    Cell Significance Index: -3.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0057
    Cell Significance Index: -3.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0058
    Cell Significance Index: -0.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0059
    Cell Significance Index: -2.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0066
    Cell Significance Index: -0.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0069
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0081
    Cell Significance Index: -1.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0083
    Cell Significance Index: -2.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0093
    Cell Significance Index: -0.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0104
    Cell Significance Index: -0.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0111
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0153
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0153
    Cell Significance Index: -3.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0158
    Cell Significance Index: -0.6000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0173
    Cell Significance Index: -0.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0191
    Cell Significance Index: -2.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0194
    Cell Significance Index: -2.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0197
    Cell Significance Index: -1.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0204
    Cell Significance Index: -0.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0220
    Cell Significance Index: -2.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0262
    Cell Significance Index: -3.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0279
    Cell Significance Index: -0.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0299
    Cell Significance Index: -0.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0310
    Cell Significance Index: -3.2300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0345
    Cell Significance Index: -0.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0349
    Cell Significance Index: -0.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0360
    Cell Significance Index: -2.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0372
    Cell Significance Index: -1.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0401
    Cell Significance Index: -1.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0403
    Cell Significance Index: -3.0900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0428
    Cell Significance Index: -0.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0459
    Cell Significance Index: -2.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0465
    Cell Significance Index: -1.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0481
    Cell Significance Index: -2.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0503
    Cell Significance Index: -1.0100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0523
    Cell Significance Index: -1.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0523
    Cell Significance Index: -2.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0541
    Cell Significance Index: -1.7700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0545
    Cell Significance Index: -1.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0562
    Cell Significance Index: -1.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0564
    Cell Significance Index: -1.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0566
    Cell Significance Index: -1.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0595
    Cell Significance Index: -1.5300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0606
    Cell Significance Index: -0.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0620
    Cell Significance Index: -1.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0659
    Cell Significance Index: -1.3800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0685
    Cell Significance Index: -1.2100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0700
    Cell Significance Index: -1.4600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0713
    Cell Significance Index: -1.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0736
    Cell Significance Index: -2.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KIF25 is a member of the kinesin superfamily, which is characterized by its ability to bind microtubules and move along them using ATP hydrolysis. The KIF25 protein is a homotetramer, meaning it consists of four identical subunits, and it exhibits minus-end-directed microtubule motor activity. This suggests that KIF25 is involved in the anterograde transport of cargo along microtubules, from the Golgi apparatus to the plasma membrane or to other organelles. **Pathways and Functions:** KIF25 has been implicated in several cellular pathways, including: 1. **Vesicle-mediated transport:** KIF25 plays a crucial role in the transport of vesicles along microtubules, which is essential for the regulation of cellular processes such as cell signaling, protein secretion, and autophagy. 2. **Organelle organization:** KIF25 has been shown to regulate the organization of organelles within the cell, including the Golgi apparatus and the endoplasmic reticulum. 3. **Autophagy regulation:** KIF25 has been implicated in the regulation of autophagy, a cellular process that involves the degradation and recycling of cellular components. 4. **Microtubule organization:** KIF25 helps to regulate the organization of microtubules within the cell, which is essential for maintaining cell shape and structure. **Clinical Significance:** Dysregulation of KIF25 has been implicated in several human diseases, including: 1. **Hemostasis disorders:** Mutations in the KIF25 gene have been associated with bleeding disorders, such as thrombocytopenia and platelet dysfunction. 2. **Neurodegenerative diseases:** KIF25 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it plays a role in the regulation of microtubule organization and autophagy. 3. **Cancer:** KIF25 has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer, where it may contribute to tumor progression and metastasis. In conclusion, KIF25 is a critical component of the kinesin superfamily that plays a key role in microtubule-based transport and regulation of cellular processes. Its dysregulation has been implicated in several human diseases, highlighting the importance of further research into the functions and mechanisms of KIF25.

Genular Protein ID: 885628244

Symbol: KIF25_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UIL4 A8K0C3 O94775 Q5SZU9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9925916

Title: Identification, genomic organization, and alternative splicing of KNSL3, a novel human gene encoding a kinesin-like protein.

PubMed ID: 9925916

DOI: 10.1159/000015159

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 22354037

Title: Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.

PubMed ID: 22354037

DOI: 10.1038/emboj.2012.36

PubMed ID: 28263957

Title: The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation.

PubMed ID: 28263957

DOI: 10.1038/ncb3486

Sequence Information:

  • Length: 384
  • Mass: 40686
  • Checksum: 7739D463BCFDB429
  • Sequence:
    • MTWTSGQLQR EKQARPGSGA VLAFPDDKDL RVYGPAESQS AVFGDVCPLL TSLLDGYNVC 
VMAYGQTGSG KSYTMLGRHS DDGPVLPLDP QSDLGIIPRV AEELFRLILE NTSRSPKVEV 
SIVEVYNNDI FDLLAKDSIA AVSGVKREVV TAKDGRTEVA LLASEAVGSA SKLMELVHGG 
LQLRAKHPTL VHADSSRSHL IITVTLTTAS CSDSTADQAC SATLPREQTE AGRAGRSRRA 
SQGALAPQLV PGNPAGHAEQ VQARLQLVDS AGSECVGVSG VTGLALREMA CISRSLAALA 
GVLGALLEHR GHAPYRNSRL THLLQDCLGG DAKLLVILCI SPSQRHLAQT LQGLGFGIRA 
RQVQRGPARK KPPSSQTEGK RRPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.