Details for: KIF25

Gene ID: 3834

Symbol: KIF25

Ensembl ID: ENSG00000125337

Description: kinesin family member 25

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.42
    Marker Score: 1375
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.3
    Marker Score: 1212
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1512
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.89
    Marker Score: 1512
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.56
    Marker Score: 2958
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4814
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.12
    Marker Score: 470
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.92
    Marker Score: 1028
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.9
    Marker Score: 282
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 511
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.64
    Marker Score: 203.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 387
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 465
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.5
    Marker Score: 1949
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.46
    Marker Score: 807
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.45
    Marker Score: 3018
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 213
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.44
    Marker Score: 887
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.4
    Marker Score: 820
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 102
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.39
    Marker Score: 6097
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.37
    Marker Score: 1501
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 202
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.32
    Marker Score: 145
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.3
    Marker Score: 168
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.28
    Marker Score: 130
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.28
    Marker Score: 354.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.28
    Marker Score: 17111
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.25
    Marker Score: 193
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.25
    Marker Score: 128
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.24
    Marker Score: 127
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.24
    Marker Score: 338
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.21
    Marker Score: 489
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.21
    Marker Score: 854
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 91
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.18
    Marker Score: 65
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.17
    Marker Score: 93.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.16
    Marker Score: 1526
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.16
    Marker Score: 66
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.15
    Marker Score: 362
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.15
    Marker Score: 34
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.15
    Marker Score: 5542
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.15
    Marker Score: 143
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.15
    Marker Score: 61
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.14
    Marker Score: 123
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.14
    Marker Score: 80
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.13
    Marker Score: 1315
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 105
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 143
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.11
    Marker Score: 177
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.11
    Marker Score: 2250
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.11
    Marker Score: 1026
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.11
    Marker Score: 446
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.11
    Marker Score: 413
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 23
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.1
    Marker Score: 49
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 107
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.09
    Marker Score: 117
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.09
    Marker Score: 3479
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.09
    Marker Score: 24

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Other Information

**Key characteristics**: - KIF25 is a microtubule-associated protein (MAP). - It is a key component of the mitotic spindle assembly complex. - It is involved in the establishment of spindle orientation and the segregation of sister chromatids during mitosis. - It is also involved in the regulation of autophagy, centrosome separation, and organelle organization. **Pathways and functions**: - KIF25 is involved in the Atp binding, ATP hydrolysis activity, and Golgi-to-er retrograde traffic pathways. - It is also involved in the factors involved in megakaryocyte development and platelet production pathway. - It is involved in the establishment of spindle orientation and the segregation of sister chromatids during mitosis. - It is also involved in the negative regulation of autophagy and mitotic centrosome separation. **Clinical significance**: - Mutations in KIF25 have been linked to several human diseases, including leukemia, cardiac disease, and developmental disorders. - Targeting KIF25 has emerged as a potential therapeutic strategy for these diseases. **Additional information**: - KIF25 is a highly conserved protein with significant expression in different cell types. - It is a promising target for cancer immunotherapy due to its involvement in cell migration and tumor growth. - Further research is needed to explore the role of KIF25 in human health and disease.

Genular Protein ID: 885628244

Symbol: KIF25_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UIL4 A8K0C3 O94775 Q5SZU9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9925916

Title: Identification, genomic organization, and alternative splicing of KNSL3, a novel human gene encoding a kinesin-like protein.

PubMed ID: 9925916

DOI: 10.1159/000015159

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 22354037

Title: Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.

PubMed ID: 22354037

DOI: 10.1038/emboj.2012.36

PubMed ID: 28263957

Title: The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation.

PubMed ID: 28263957

DOI: 10.1038/ncb3486

Sequence Information:

  • Length: 384
  • Mass: 40686
  • Checksum: 7739D463BCFDB429
  • Sequence:
    • MTWTSGQLQR EKQARPGSGA VLAFPDDKDL RVYGPAESQS AVFGDVCPLL TSLLDGYNVC 
VMAYGQTGSG KSYTMLGRHS DDGPVLPLDP QSDLGIIPRV AEELFRLILE NTSRSPKVEV 
SIVEVYNNDI FDLLAKDSIA AVSGVKREVV TAKDGRTEVA LLASEAVGSA SKLMELVHGG 
LQLRAKHPTL VHADSSRSHL IITVTLTTAS CSDSTADQAC SATLPREQTE AGRAGRSRRA 
SQGALAPQLV PGNPAGHAEQ VQARLQLVDS AGSECVGVSG VTGLALREMA CISRSLAALA 
GVLGALLEHR GHAPYRNSRL THLLQDCLGG DAKLLVILCI SPSQRHLAQT LQGLGFGIRA 
RQVQRGPARK KPPSSQTEGK RRPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.