Details for: LMAN1

Gene ID: 3998

Symbol: LMAN1

Ensembl ID: ENSG00000074695

Description: lectin, mannose binding 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 3.08
    Marker Score: 848
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9
    Marker Score: 100354
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.63
    Marker Score: 1498
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 2.53
    Marker Score: 665
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.51
    Marker Score: 5721
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.45
    Marker Score: 6562.5
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.43
    Marker Score: 2071
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.41
    Marker Score: 3307
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.31
    Marker Score: 4089.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3
    Marker Score: 25961
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.3
    Marker Score: 1342
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.28
    Marker Score: 40413
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.26
    Marker Score: 5699
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.25
    Marker Score: 76624
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.21
    Marker Score: 14375
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.18
    Marker Score: 2325
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.13
    Marker Score: 10487
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.13
    Marker Score: 2247
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.11
    Marker Score: 15717
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.03
    Marker Score: 3365.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.01
    Marker Score: 7440
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2
    Marker Score: 566
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.97
    Marker Score: 971.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.96
    Marker Score: 2299
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.96
    Marker Score: 3145.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.93
    Marker Score: 3167
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.93
    Marker Score: 5247.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.91
    Marker Score: 612.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.88
    Marker Score: 2425
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.87
    Marker Score: 1595.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.87
    Marker Score: 778
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.87
    Marker Score: 1894
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.87
    Marker Score: 7332
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.86
    Marker Score: 870
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.86
    Marker Score: 4227
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.85
    Marker Score: 3910
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.84
    Marker Score: 2715
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.84
    Marker Score: 2450
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.83
    Marker Score: 4798
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.83
    Marker Score: 2258
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.82
    Marker Score: 7857
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.82
    Marker Score: 1958
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.81
    Marker Score: 11557.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.8
    Marker Score: 856
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.79
    Marker Score: 15520
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.78
    Marker Score: 23499
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.76
    Marker Score: 767.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.76
    Marker Score: 404
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.75
    Marker Score: 1460
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.74
    Marker Score: 1851
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.74
    Marker Score: 503
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.74
    Marker Score: 1846
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.74
    Marker Score: 3167
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.73
    Marker Score: 17410
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.72
    Marker Score: 1083
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.71
    Marker Score: 943
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.71
    Marker Score: 4166.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.7
    Marker Score: 3552
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.7
    Marker Score: 1073
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.69
    Marker Score: 708
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.69
    Marker Score: 10998
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.68
    Marker Score: 586
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.68
    Marker Score: 1495
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.66
    Marker Score: 1173
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.66
    Marker Score: 1720
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.66
    Marker Score: 2343
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.64
    Marker Score: 1096
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.63
    Marker Score: 407
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.63
    Marker Score: 3258.5
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.62
    Marker Score: 1554
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.62
    Marker Score: 407
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.61
    Marker Score: 398
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.61
    Marker Score: 2014
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.6
    Marker Score: 13789.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.6
    Marker Score: 2537
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.59
    Marker Score: 1088
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.58
    Marker Score: 831
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.57
    Marker Score: 1658
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.56
    Marker Score: 1089
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.56
    Marker Score: 373
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.55
    Marker Score: 2388
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.55
    Marker Score: 9890
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.54
    Marker Score: 792
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.53
    Marker Score: 615
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.51
    Marker Score: 1103
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.51
    Marker Score: 753
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.51
    Marker Score: 1094
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.51
    Marker Score: 1022
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.5
    Marker Score: 1346
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.5
    Marker Score: 480.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.49
    Marker Score: 3550
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.49
    Marker Score: 336
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.49
    Marker Score: 1405
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.49
    Marker Score: 17353
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.49
    Marker Score: 801
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.48
    Marker Score: 2512.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.47
    Marker Score: 546.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.47
    Marker Score: 2785
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.46
    Marker Score: 1469.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.45
    Marker Score: 425

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Other Information

**Key characteristics:** * LMAN1 is a glycoprotein with a molecular weight of approximately 120 kDa. * It is expressed on the surface of a variety of cell types, including immune cells, epithelial cells, and cancer cells. * LMAN1 is a ligand for galectin-9, a cell surface protein that is expressed on activated macrophages and tumor cells. * It is involved in the regulation of cell migration, adhesion, and signaling. **Pathways and functions:** * LMAN1 is involved in the regulation of cell migration by binding to galectin-9 and facilitating its interaction with integrins on the cell surface. * It is also involved in the regulation of adhesion by binding to various extracellular matrix proteins, including collagen and fibronectin. * LMAN1 is involved in signaling by binding to galectin-9 and facilitating the activation of the signaling cascade. * It is also involved in the regulation of cell growth and differentiation. **Clinical significance:** * Mutations in the LMAN1 gene have been linked to a number of human diseases, including cancer, asthma, and rheumatoid arthritis. * LMAN1 is a potential target for cancer immunotherapy. * Inhibition of LMAN1 has been shown to inhibit cancer cell migration and growth. **Additional notes:** * LMAN1 is a highly conserved protein, with a similar protein found in mice and humans. * It is a member of the lectin family of cell adhesion molecules, which are expressed in a variety of cell types. * LMAN1 is a versatile protein that is involved in a variety of cellular processes.

Genular Protein ID: 4192974764

Symbol: LMAN1_HUMAN

Name: Protein ERGIC-53

UniProtKB Accession Codes:

P49257 Q12895 Q8N5I7 Q9UQG1 Q9UQG2 Q9UQG3 Q9UQG4 Q9UQG5 Q9UQG6 Q9UQG7 Q9UQG8 Q9UQG9 Q9UQH0 Q9UQH1 Q9UQH2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 ELM 1 EMBL 24 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 11 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8223692

Title: ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif.

PubMed ID: 8223692

PubMed ID: 7876089

Title: ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells.

PubMed ID: 7876089

DOI: 10.1074/jbc.270.8.3551

PubMed ID: 10090935

Title: ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families.

PubMed ID: 10090935

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8205612

Title: A putative novel class of animal lectins in the secretory pathway homologous to leguminous lectins.

PubMed ID: 8205612

DOI: 10.1016/0092-8674(94)90047-7

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 13130098

Title: ER export of ERGIC-53 is controlled by cooperation of targeting determinants in all three of its domains.

PubMed ID: 13130098

DOI: 10.1242/jcs.00759

PubMed ID: 12717434

Title: Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.

PubMed ID: 12717434

DOI: 10.1038/ng1153

PubMed ID: 16257008

Title: Oligomerization and intracellular localization of the glycoprotein receptor ERGIC-53 is independent of disulfide bonds.

PubMed ID: 16257008

DOI: 10.1016/j.jmb.2005.09.077

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22337587

Title: Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.

PubMed ID: 22337587

DOI: 10.1074/mcp.m111.016444

PubMed ID: 24806965

Title: TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport.

PubMed ID: 24806965

DOI: 10.1242/jcs.136754

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31142615

Title: The E3 ubiquitin ligase MARCH2 regulates ERGIC3-dependent trafficking of secretory proteins.

PubMed ID: 31142615

DOI: 10.1074/jbc.ra119.007435

PubMed ID: 20138881

Title: Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII.

PubMed ID: 20138881

DOI: 10.1016/j.febslet.2010.02.009

PubMed ID: 20142513

Title: Structural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiency.

PubMed ID: 20142513

DOI: 10.1073/pnas.0908526107

PubMed ID: 19787799

Title: A novel missense mutation causing abnormal LMAN1 in a Japanese patient with combined deficiency of factor V and factor VIII.

PubMed ID: 19787799

DOI: 10.1002/ajh.21532

Sequence Information:

  • Length: 510
  • Mass: 57549
  • Checksum: B87EF117C0CD386C
  • Sequence:
    • MAGSRQRGLR ARVRPLFCAL LLSLGRFVRG DGVGGDPAVA LPHRRFEYKY SFKGPHLVQS 
DGTVPFWAHA GNAIPSSDQI RVAPSLKSQR GSVWTKTKAA FENWEVEVTF RVTGRGRIGA 
DGLAIWYAEN QGLEGPVFGS ADLWNGVGIF FDSFDNDGKK NNPAIVIIGN NGQIHYDHQN 
DGASQALASC QRDFRNKPYP VRAKITYYQN TLTVMINNGF TPDKNDYEFC AKVENMIIPA 
QGHFGISAAT GGLADDHDVL SFLTFQLTEP GKEPPTPDKE ISEKEKEKYQ EEFEHFQQEL 
DKKKEEFQKG HPDLQGQPAE EIFESVGDRE LRQVFEGQNR IHLEIKQLNR QLDMILDEQR 
RYVSSLTEEI SKRGAGMPGQ HGQITQQELD TVVKTQHEIL RQVNEMKNSM SETVRLVSGM 
QHPGSAGGVY ETTQHFIDIK EHLHIVKRDI DNLVQRNMPS NEKPKCPELP PFPSCLSTVH 
FIIFVVVQTV LFIGYIMYRS QQEAAAKKFF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.