Details for: MMP12

Gene ID: 4321

Symbol: MMP12

Ensembl ID: ENSG00000262406

Description: matrix metallopeptidase 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8308
    Cell Significance Index: 23.8200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5719
    Cell Significance Index: 8.8500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.5365
    Cell Significance Index: 7.2400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.3753
    Cell Significance Index: 5.6200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2124
    Cell Significance Index: 1.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1272
    Cell Significance Index: 6.6100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.0815
    Cell Significance Index: 1.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0559
    Cell Significance Index: 0.8000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0372
    Cell Significance Index: 0.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0305
    Cell Significance Index: 3.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0292
    Cell Significance Index: 0.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0219
    Cell Significance Index: 4.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0193
    Cell Significance Index: 0.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0112
    Cell Significance Index: 20.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0065
    Cell Significance Index: 1.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0003
    Cell Significance Index: 0.4900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0023
    Cell Significance Index: -0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0037
    Cell Significance Index: -4.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0052
    Cell Significance Index: -3.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0054
    Cell Significance Index: -2.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0058
    Cell Significance Index: -4.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0063
    Cell Significance Index: -0.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0080
    Cell Significance Index: -3.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0080
    Cell Significance Index: -4.4900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0104
    Cell Significance Index: -3.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0140
    Cell Significance Index: -2.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0169
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0190
    Cell Significance Index: -3.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0202
    Cell Significance Index: -4.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0222
    Cell Significance Index: -3.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0238
    Cell Significance Index: -3.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0258
    Cell Significance Index: -3.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0273
    Cell Significance Index: -3.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0330
    Cell Significance Index: -0.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0338
    Cell Significance Index: -3.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0360
    Cell Significance Index: -3.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0448
    Cell Significance Index: -5.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0470
    Cell Significance Index: -3.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0586
    Cell Significance Index: -3.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0609
    Cell Significance Index: -2.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0611
    Cell Significance Index: -4.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0612
    Cell Significance Index: -3.7500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0619
    Cell Significance Index: -1.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0689
    Cell Significance Index: -3.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0723
    Cell Significance Index: -2.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0740
    Cell Significance Index: -4.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0772
    Cell Significance Index: -3.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0779
    Cell Significance Index: -1.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0805
    Cell Significance Index: -4.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0876
    Cell Significance Index: -3.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0936
    Cell Significance Index: -2.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0965
    Cell Significance Index: -3.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0992
    Cell Significance Index: -3.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0995
    Cell Significance Index: -4.4000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1127
    Cell Significance Index: -1.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1173
    Cell Significance Index: -4.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1199
    Cell Significance Index: -4.4000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1271
    Cell Significance Index: -3.1700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1294
    Cell Significance Index: -2.5800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1349
    Cell Significance Index: -3.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1381
    Cell Significance Index: -3.9400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1385
    Cell Significance Index: -1.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1386
    Cell Significance Index: -4.8700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1502
    Cell Significance Index: -3.2500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1514
    Cell Significance Index: -3.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1517
    Cell Significance Index: -3.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1525
    Cell Significance Index: -4.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1607
    Cell Significance Index: -4.4900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1619
    Cell Significance Index: -3.2500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1621
    Cell Significance Index: -3.1900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1623
    Cell Significance Index: -3.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1651
    Cell Significance Index: -1.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1656
    Cell Significance Index: -4.2200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1656
    Cell Significance Index: -2.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1661
    Cell Significance Index: -4.2700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1685
    Cell Significance Index: -5.3300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1732
    Cell Significance Index: -4.3200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1732
    Cell Significance Index: -2.5200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1862
    Cell Significance Index: -4.5100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1885
    Cell Significance Index: -3.2600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1893
    Cell Significance Index: -1.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1943
    Cell Significance Index: -5.2900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1947
    Cell Significance Index: -2.7000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1955
    Cell Significance Index: -1.6800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1972
    Cell Significance Index: -4.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2012
    Cell Significance Index: -5.0300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2143
    Cell Significance Index: -5.2300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2155
    Cell Significance Index: -3.6600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2161
    Cell Significance Index: -2.8300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2177
    Cell Significance Index: -2.3900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2191
    Cell Significance Index: -3.6100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2202
    Cell Significance Index: -3.7100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2213
    Cell Significance Index: -3.9100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2223
    Cell Significance Index: -3.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2229
    Cell Significance Index: -3.7300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2303
    Cell Significance Index: -3.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MMP12 is a zinc-dependent endopeptidase that exhibits a broad substrate specificity, cleaving a wide range of ECM proteins, including collagens, elastins, and proteoglycans. Its catalytic activity is characterized by the hydrolysis of peptide bonds, resulting in the degradation of the ECM. MMP12 is also known to interact with various ECM components, including fibronectin, laminin, and collagen, which modulates its activity and regulates its interaction with other ECM proteins. **Pathways and Functions** MMP12 plays a multifaceted role in ECM remodeling and immune response. Its primary function is to degrade the ECM, facilitating tissue repair, wound healing, and immune cell migration. MMP12 is also involved in the regulation of cell proliferation, differentiation, and survival, particularly in the context of inflammation and tissue injury. Furthermore, MMP12 has been shown to interact with various signaling pathways, including the MAPK, NF-κB, and PI3K/AKT pathways, which modulate its activity and regulate its expression. **Clinical Significance** Dysregulation of MMP12 has been implicated in various diseases, including: 1. **Pulmonary fibrosis**: Excessive ECM deposition and remodeling in pulmonary fibrosis can lead to the activation of MMP12, which contributes to disease progression. 2. **Inflammatory disorders**: MMP12 is overexpressed in inflammatory conditions, such as arthritis, asthma, and Crohn's disease, where it promotes ECM degradation and tissue damage. 3. **Cancer**: MMP12 is involved in the degradation of the ECM, facilitating tumor invasion and metastasis. 4. **Wound healing**: MMP12 plays a crucial role in wound healing, where it regulates ECM remodeling and tissue repair. In conclusion, MMP12 is a critical regulator of ECM remodeling and immune response. Its dysregulation has far-reaching consequences, contributing to various diseases. Further research is needed to elucidate the mechanisms underlying MMP12's functions and to explore its potential as a therapeutic target for the treatment of these diseases. **Significantly expressed cells**: Mononuclear phagocyte, granulocyte monocyte progenitor cell, extravillous trophoblast, goblet cell, early T lineage precursor, luminal epithelial cell of mammary gland, absorptive cell, immature innate lymphoid cell, intestinal crypt stem cell of colon, transit amplifying cell **Proteins**: MMP12_HUMAN (Macrophage metalloelastase)

Genular Protein ID: 3864689789

Symbol: MMP12_HUMAN

Name: Macrophage metalloelastase

UniProtKB Accession Codes:

P39900 B2R9X8 B7ZLF6 Q2M1L9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 27 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 17 DrugCentral 1 EC 2 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 32 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 86 PDBsum 86 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8226919

Title: Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.

PubMed ID: 8226919

DOI: 10.1016/s0021-9258(20)80459-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9115292

Title: Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase.

PubMed ID: 9115292

DOI: 10.1074/jbc.272.18.12189

PubMed ID: 11575928

Title: Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure.

PubMed ID: 11575928

DOI: 10.1006/jmbi.2001.4954

PubMed ID: 11575929

Title: Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor.

PubMed ID: 11575929

DOI: 10.1006/jmbi.2001.4953

Sequence Information:

  • Length: 470
  • Mass: 54002
  • Checksum: 8C745EEA8C0EA216
  • Sequence:
    • MKFLLILLLQ ATASGALPLN SSTSLEKNNV LFGERYLEKF YGLEINKLPV TKMKYSGNLM 
KEKIQEMQHF LGLKVTGQLD TSTLEMMHAP RCGVPDVHHF REMPGGPVWR KHYITYRINN 
YTPDMNREDV DYAIRKAFQV WSNVTPLKFS KINTGMADIL VVFARGAHGD FHAFDGKGGI 
LAHAFGPGSG IGGDAHFDED EFWTTHSGGT NLFLTAVHEI GHSLGLGHSS DPKAVMFPTY 
KYVDINTFRL SADDIRGIQS LYGDPKENQR LPNPDNSEPA LCDPNLSFDA VTTVGNKIFF 
FKDRFFWLKV SERPKTSVNL ISSLWPTLPS GIEAAYEIEA RNQVFLFKDD KYWLISNLRP 
EPNYPKSIHS FGFPNFVKKI DAAVFNPRFY RTYFFVDNQY WRYDERRQMM DPGYPKLITK 
NFQGIGPKID AVFYSKNKYY YFFQGSNQFE YDFLLQRITK TLKSNSWFGC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.