Details for: MSRA

Gene ID: 4482

Symbol: MSRA

Ensembl ID: ENSG00000175806

Description: methionine sulfoxide reductase A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 372.9462
    Cell Significance Index: -58.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 217.5692
    Cell Significance Index: -55.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 124.2262
    Cell Significance Index: -58.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 108.2263
    Cell Significance Index: -55.6700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 87.5679
    Cell Significance Index: -58.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.4388
    Cell Significance Index: -58.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.9068
    Cell Significance Index: -53.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.9086
    Cell Significance Index: -58.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 14.8917
    Cell Significance Index: 255.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.1722
    Cell Significance Index: -26.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 6.3477
    Cell Significance Index: 1826.4100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 5.1101
    Cell Significance Index: 75.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.1703
    Cell Significance Index: 1495.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 3.9165
    Cell Significance Index: 569.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.4747
    Cell Significance Index: 697.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.1423
    Cell Significance Index: 138.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.7485
    Cell Significance Index: 104.0800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.5272
    Cell Significance Index: 42.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8451
    Cell Significance Index: 366.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5246
    Cell Significance Index: 1054.4400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.3122
    Cell Significance Index: 17.5100
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.1291
    Cell Significance Index: 8.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0594
    Cell Significance Index: 63.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9324
    Cell Significance Index: 101.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9200
    Cell Significance Index: 25.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8093
    Cell Significance Index: 62.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6805
    Cell Significance Index: 17.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6275
    Cell Significance Index: 35.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5462
    Cell Significance Index: 88.8400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5035
    Cell Significance Index: 6.2500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.4869
    Cell Significance Index: 6.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4317
    Cell Significance Index: 5.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3851
    Cell Significance Index: 26.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3797
    Cell Significance Index: 68.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3768
    Cell Significance Index: 46.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2823
    Cell Significance Index: 18.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2649
    Cell Significance Index: 239.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2078
    Cell Significance Index: 24.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2041
    Cell Significance Index: 26.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1743
    Cell Significance Index: 328.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1611
    Cell Significance Index: 3.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1574
    Cell Significance Index: 15.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1384
    Cell Significance Index: 255.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1276
    Cell Significance Index: 69.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1137
    Cell Significance Index: 175.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0859
    Cell Significance Index: 16.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0625
    Cell Significance Index: 39.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0598
    Cell Significance Index: 26.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0575
    Cell Significance Index: 2.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0448
    Cell Significance Index: 1.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0049
    Cell Significance Index: 0.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0011
    Cell Significance Index: -0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0013
    Cell Significance Index: -1.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0254
    Cell Significance Index: -1.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0484
    Cell Significance Index: -35.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0523
    Cell Significance Index: -23.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0546
    Cell Significance Index: -41.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0713
    Cell Significance Index: -52.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1042
    Cell Significance Index: -58.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1117
    Cell Significance Index: -69.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1266
    Cell Significance Index: -12.9300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1522
    Cell Significance Index: -3.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1545
    Cell Significance Index: -4.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1610
    Cell Significance Index: -27.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1877
    Cell Significance Index: -25.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1931
    Cell Significance Index: -14.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2062
    Cell Significance Index: -9.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2101
    Cell Significance Index: -6.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2399
    Cell Significance Index: -3.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3093
    Cell Significance Index: -7.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3160
    Cell Significance Index: -66.5600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3381
    Cell Significance Index: -5.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3381
    Cell Significance Index: -23.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3933
    Cell Significance Index: -13.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3977
    Cell Significance Index: -8.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4617
    Cell Significance Index: -5.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4619
    Cell Significance Index: -52.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4773
    Cell Significance Index: -49.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5129
    Cell Significance Index: -40.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5368
    Cell Significance Index: -7.7200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.5716
    Cell Significance Index: -9.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6351
    Cell Significance Index: -12.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6872
    Cell Significance Index: -36.0800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7312
    Cell Significance Index: -15.6300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7581
    Cell Significance Index: -18.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7643
    Cell Significance Index: -38.6300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8007
    Cell Significance Index: -17.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8115
    Cell Significance Index: -25.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8143
    Cell Significance Index: -17.8300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.8228
    Cell Significance Index: -6.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8664
    Cell Significance Index: -30.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9225
    Cell Significance Index: -58.1400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9346
    Cell Significance Index: -19.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9473
    Cell Significance Index: -58.0800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.0132
    Cell Significance Index: -9.6400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.0403
    Cell Significance Index: -13.3400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.0854
    Cell Significance Index: -12.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.1459
    Cell Significance Index: -29.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.1857
    Cell Significance Index: -32.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Oxidative Stress Response:** MSRA plays a critical role in mitigating oxidative damage to proteins caused by reactive oxygen species (ROS). 2. **Protein Repair:** MSRA is essential for the repair of methionine sulfoxide residues in proteins, which can be induced by oxidative stress, UV radiation, or other forms of cellular damage. 3. **Cellular Localization:** MSRA is primarily localized to the cytosol and mitochondria, where it can interact with proteins and other cellular components. 4. **Cell Type-Specific Expression:** MSRA is significantly expressed in various cell types, including neurons, glial cells, and immune cells, suggesting its diverse roles in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Methionine Metabolic Process:** MSRA participates in the methionine metabolic pathway, which involves the conversion of methionine to S-adenosylmethionine (SAMe). 2. **Protein Modification Process:** MSRA is involved in the repair of methionine sulfoxide residues in proteins, which can be induced by oxidative stress or other forms of cellular damage. 3. **Cellular Response to Oxidative Stress:** MSRA plays a critical role in mitigating oxidative damage to proteins caused by ROS, thereby maintaining cellular homeostasis. 4. **Actin Cytoskeleton and Cellular Response to Oxidative Stress:** MSRA is also involved in regulating the actin cytoskeleton and responding to oxidative stress, which can impact cellular signaling and migration. **Clinical Significance:** 1. **Neurodegenerative Diseases:** MSRA has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where oxidative stress and protein damage are thought to play a critical role. 2. **Cancer:** MSRA has been shown to be overexpressed in various types of cancer, suggesting its potential role in tumorigenesis and cancer progression. 3. **Aging and Age-Related Diseases:** MSRA may also play a role in the aging process and age-related diseases, such as atherosclerosis and age-related macular degeneration, where oxidative stress and protein damage are thought to contribute to disease progression. 4. **Pharmacological Interventions:** MSRA inhibitors have been identified as potential therapeutic targets for treating diseases characterized by oxidative stress and protein damage, such as neurodegenerative diseases and cancer. In conclusion, MSRA is a critical enzyme involved in maintaining cellular homeostasis and responding to oxidative stress. Its role in regulating protein repair, cellular localization, and cell type-specific expression suggests its potential involvement in various diseases, including neurodegenerative diseases, cancer, and aging-related diseases. Further research is needed to fully elucidate the function of MSRA and its potential as a therapeutic target.

Genular Protein ID: 526497224

Symbol: MSRA_HUMAN

Name: Mitochondrial peptide methionine sulfoxide reductase

UniProtKB Accession Codes:

Q9UJ68 E9PAS8 Q52TC4 Q549N4 Q66MI7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 18 Ensembl 8 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 Rhea 8 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10452521

Title: Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA).

PubMed ID: 10452521

DOI: 10.1016/s0014-5793(99)00917-5

PubMed ID: 15680232

Title: Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation.

PubMed ID: 15680232

DOI: 10.1016/j.bbapap.2004.09.010

PubMed ID: 16364291

Title: Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina.

PubMed ID: 16364291

DOI: 10.1016/j.exer.2005.10.003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12039877

Title: Mitochondrial targeting of the human peptide methionine sulfoxide reductase (MSRA), an enzyme involved in the repair of oxidized proteins.

PubMed ID: 12039877

DOI: 10.1096/fj.01-0737fje

PubMed ID: 20368336

Title: Dual sites of protein initiation control the localization and myristoylation of methionine sulfoxide reductase A.

PubMed ID: 20368336

DOI: 10.1074/jbc.m110.119701

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25807930

Title: Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

PubMed ID: 25807930

DOI: 10.1002/anie.201500342

Sequence Information:

  • Length: 235
  • Mass: 26132
  • Checksum: B89A9BBBE4D58D90
  • Sequence:
    • MLSATRRACQ LLLLHSLFPV PRMGNSASNI VSPQEALPGR KEQTPVAAKH HVNGNRTVEP 
FPEGTQMAVF GMGCFWGAER KFWVLKGVYS TQVGFAGGYT SNPTYKEVCS EKTGHAEVVR 
VVYQPEHMSF EELLKVFWEN HDPTQGMRQG NDHGTQYRSA IYPTSAKQME AALSSKENYQ 
KVLSEHGFGP ITTDIREGQT FYYAEDYHQQ YLSKNPNGYC GLGGTGVSCP VGIKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.