Details for: MUC6

Gene ID: 4588

Symbol: MUC6

Ensembl ID: ENSG00000184956

Description: mucin 6, oligomeric mucus/gel-forming

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 10.22
    Marker Score: 32734
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 6.23
    Marker Score: 18178
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.78
    Marker Score: 17142
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.8
    Marker Score: 4600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 4.43
    Marker Score: 5528
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.97
    Marker Score: 11398
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.8
    Marker Score: 32115
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.41
    Marker Score: 9739
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.14
    Marker Score: 7115
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.73
    Marker Score: 1794
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.6
    Marker Score: 668
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170032
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.47
    Marker Score: 775
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.25
    Marker Score: 431
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.21
    Marker Score: 2511
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.11
    Marker Score: 960
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5341
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.83
    Marker Score: 5315
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.83
    Marker Score: 371.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 503
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.76
    Marker Score: 535
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 689
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 575
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.74
    Marker Score: 631
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7
    Marker Score: 1703
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.69
    Marker Score: 1647
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.56
    Marker Score: 326
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.44
    Marker Score: 932
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.43
    Marker Score: 134.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 394
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.39
    Marker Score: 125
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.39
    Marker Score: 624
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.37
    Marker Score: 170.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.36
    Marker Score: 376.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.35
    Marker Score: 1667
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.35
    Marker Score: 197
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.34
    Marker Score: 193
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.33
    Marker Score: 176
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.31
    Marker Score: 228
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.3
    Marker Score: 717.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.28
    Marker Score: 110
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.28
    Marker Score: 706
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.28
    Marker Score: 90
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.28
    Marker Score: 121
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.27
    Marker Score: 1818
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.25
    Marker Score: 242
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.24
    Marker Score: 103
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.24
    Marker Score: 143
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.23
    Marker Score: 120
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 68.5
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.23
    Marker Score: 59
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.22
    Marker Score: 151
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.22
    Marker Score: 233
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.21
    Marker Score: 605
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.21
    Marker Score: 300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.21
    Marker Score: 224
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.21
    Marker Score: 85
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.21
    Marker Score: 66
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.21
    Marker Score: 2755
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.21
    Marker Score: 185
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.2
    Marker Score: 82
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.2
    Marker Score: 220
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2
    Marker Score: 757
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.2
    Marker Score: 191
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.19
    Marker Score: 89
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.19
    Marker Score: 300
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.19
    Marker Score: 38
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.19
    Marker Score: 1659
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.19
    Marker Score: 1125
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.19
    Marker Score: 1935
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.19
    Marker Score: 125
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.18
    Marker Score: 1715
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.18
    Marker Score: 173
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.17
    Marker Score: 240
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.17
    Marker Score: 1036
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.17
    Marker Score: 58
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.17
    Marker Score: 220
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.17
    Marker Score: 282
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.17
    Marker Score: 97
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.16
    Marker Score: 125
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.16
    Marker Score: 52
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.15
    Marker Score: 271

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Other Information

**Key characteristics:** * MUC6 is a highly conserved protein, with a sequence found in mammals, birds, and reptiles. * It is expressed in a wide range of tissues, including epithelial cells, endothelial cells, and immune cells. * MUC6 is a key component of the basal layer of epithelial cells, where it helps to maintain the structural integrity of the tissue. * It is also expressed in the mucus layer of the respiratory tract and the gastrointestinal tract. **Pathways and functions:** * MUC6 is a key component of the ECM, where it helps to assemble and maintain the network of glycoproteins and proteoglycans that hold cells together. * It is involved in cell adhesion, migration, and signaling. * It also plays a role in the regulation of inflammation and cell migration. **Clinical significance:** * Mutations in the MUC6 gene have been linked to several human diseases, including mucocutaneous diseases, corneal diseases, and cancer. * In mucocutaneous diseases, MUC6 mutations can lead to the accumulation of abnormal mucin proteins in the skin, leading to symptoms such as dryness, pain, and inflammation. * In corneal diseases, MUC6 mutations can lead to the formation of abnormal blood-aqueous barriers, which can lead to dry eyes and other eye problems. * In cancer, MUC6 mutations can promote tumor growth and metastasis. **Additional notes:** * MUC6 is a highly glycosylated protein, with a significant proportion of its amino acids containing sugar residues. * It is a member of the C-type lectin receptor (clr) family of cell surface receptors. * Mutations in the MUC6 gene have also been linked to other diseases, including rheumatoid arthritis, psoriasis, and osteoporosis.

Genular Protein ID: 1915647275

Symbol: MUC6_HUMAN

Name: Mucin-6

UniProtKB Accession Codes:

Q6W4X9 O15329 Q14394 Q2TUQ5 Q4L207 Q8N8I1 Q8NAK1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 MANE-Select 1 MEROPS 2 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SAM 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15081123

Title: The complete genomic organization of the human MUC6 and MUC2 mucin genes.

PubMed ID: 15081123

DOI: 10.1016/j.ygeno.2003.11.003

PubMed ID: 7680650

Title: Human gastric mucin. Identification of a unique species by expression cloning.

PubMed ID: 7680650

DOI: 10.1016/s0021-9258(18)53402-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 9195947

Title: The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence.

PubMed ID: 9195947

DOI: 10.1074/jbc.272.26.16398

PubMed ID: 9422745

Title: Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs.

PubMed ID: 9422745

DOI: 10.1074/jbc.273.2.881

PubMed ID: 10209489

Title: The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues.

PubMed ID: 10209489

DOI: 10.1002/(sici)1096-9896(199812)186:4<398::aid-path192>3.0.co;2-x

PubMed ID: 10330458

Title: Expression of the MUC 6 mucin gene in development of the human kidney and male genital ducts.

PubMed ID: 10330458

DOI: 10.1177/002215549904700611

PubMed ID: 11988092

Title: Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution.

PubMed ID: 11988092

DOI: 10.1042/bj3640191

PubMed ID: 15280409

Title: Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation.

PubMed ID: 15280409

DOI: 10.1136/jcp.2003.015487

PubMed ID: 15979574

Title: Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors.

PubMed ID: 15979574

DOI: 10.1016/j.bbrc.2005.06.037

Sequence Information:

  • Length: 2439
  • Mass: 257051
  • Checksum: 4A1A7E6A7C30F895
  • Sequence:
    • MVQRWLLLSC CGALLSAGLA NTSYTSPGLQ RLKDSPQTAP DKGQCSTWGA GHFSTFDHHV 
YDFSGTCNYI FAATCKDAFP TFSVQLRRGP DGSISRIIVE LGASVVTVSE AIISVKDIGV 
ISLPYTSNGL QITPFGQSVR LVAKQLELEL EVVWGPDSHL MVLVERKYMG QMCGLCGNFD 
GKVTNEFVSE EGKFLEPHKF AALQKLDDPG EICTFQDIPS THVRQAQHAR ICTQLLTLVA 
PECSVSKEPF VLSCQADVAA APQPGPQNSS CATLSEYSRQ CSMVGQPVRR WRSPGLCSVG 
QCPANQVYQE CGSACVKTCS NPQHSCSSSC TFGCFCPEGT VLNDLSNNHT CVPVTQCPCV 
LHGAMYAPGE VTIAACQTCR CTLGRWVCTE RPCPGHCSLE GGSFVTTFDA RPYRFHGTCT 
YILLQSPQLP EDGALMAVYD KSGVSHSETS LVAVVYLSRQ DKIVISQDEV VTNNGEAKWL 
PYKTRNITVF RQTSTHLQMA TSFGLELVVQ LRPIFQAYVT VGPQFRGQTR GLCGNFNGDT 
TDDFTTSMGI AEGTASLFVD SWRAGNCPAA LERETDPCSM SQLNKVCAET HCSMLLRTGT 
VFERCHATVN PAPFYKRCVY QACNYEETFP HICAALGDYV HACSLRGVLL WGWRSSVDNC 
TIPCTGNTTF SYNSQACERT CLSLSDRATE CHHSAVPVDG CNCPDGTYLN QKGECVRKAQ 
CPCILEGYKF ILAEQSTVIN GITCHCINGR LSCPQRPQMF LASCQAPKTF KSCSQSSENK 
FGAACAPTCQ MLATGVACVP TKCEPGCVCA EGLYENADGQ CVPPEECPCE FSGVSYPGGA 
ELHTDCRTCS CSRGRWACQQ GTHCPSTCTL YGEGHVITFD GQRFVFDGNC EYILATDVCG 
VNDSQPTFKI LTENVICGNS GVTCSRAIKI FLGGLSVVLA DRNYTVTGEE PHVQLGVTPG 
ALSLVVDISI PGRYNLTLIW NRHMTILIRI ARASQDPLCG LCGNFNGNMK DDFETRSRYV 
ASSELELVNS WKESPLCGDV SFVTDPCSLN AFRRSWAERK CSVINSQTFA TCHSKVYHLP 
YYEACVRDAC GCDSGGDCEC LCDAVAAYAQ ACLDKGVCVD WRTPAFCPIY CGFYNTHTQD 
GHGEYQYTQE ANCTWHYQPC LCPSQPQSVP GSNIEGCYNC SQDEYFDHEE GVCVPCMPPT 
TPQPPTTPQL PTTGSRPTQV WPMTGTSTTI GLLSSTGPSP SSNHTPASPT QTPLLPATLT 
SSKPTASSGE PPRPTTAVTP QATSGLPPTA TLRSTATKPT VTQATTRATA STASPATTST 
AQSTTRTTMT LPTPATSGTS PTLPKSTNQE LPGTTATQTT GPRPTPASTT GPTTPQPGQP 
TRPTATETTQ TRTTTEYTTP QTPHTTHSPP TAGSPVPSTG PVTATSFHAT TTYPTPSHPE 
TTLPTHVPPF STSLVTPSTH TVITPTHAQM ATSASNHSAP TGTIPPPTTL KATGSTHTAP 
PITPTTSGTS QAHSSFSTNK TPTSLHSHTS STHHPEVTPT STTTITPNPT STRTRTPVAH 
TNSATSSRPP PPFTTHSPPT GSSPFSSTGP MTATSFKTTT TYPTPSHPQT TLPTHVPPFS 
TSLVTPSTHT VITPTHAQMA TSASIHSMPT GTIPPPTTLK ATGSTHTAPT MTLTTSGTSQ 
ALSSLNTAKT STSLHSHTSS THHAEATSTS TTNITPNPTS TGTPPMTVTT SGTSQSRSSF 
STAKTSTSLH SHTSSTHHPE VTSTSTTSIT PNHTSTGTRT PVAHTTSATS SRLPTPFTTH 
SPPTGTTPIS STGPVTATSF QTTTTYPTPS HPHTTLPTHV PSFSTSLVTP STHTVIIPTH 
TQMATSASIH SMPTGTIPPP TTIKATGSTH TAPPMTPTTS GTSQSPSSFS TAKTSTSLPY 
HTSSTHHPEV TPTSTTNITP KHTSTGTRTP VAHTTSASSS RLPTPFTTHS PPTGSSPFSS 
TGPMTATSFQ TTTTYPTPSH PQTTLPTHVP PFSTSLVTPS THTVIITTHT QMATSASIHS 
TPTGTVPPPT TLKATGSTHT APPMTVTTSG TSQTHSSFST ATASSSFISS SSWLPQNSSS 
RPPSSPITTQ LPHLSSATTP VSTTNQLSSS FSPSPSAPST VSSYVPSSHS SPQTSSPSVG 
TSSSFVSAPV HSTTLSSGSH SSLSTHPTTA SVSASPLFPS SPAASTTIRA TLPHTISSPF 
TLSALLPIST VTVSPTPSSH LASSTIAFPS TPRTTASTHT APAFSSQSTT SRSTSLTTRV 
PTSGFVSLTS GVTGIPTSPV TNLTTRHPGP TLSPTTRFLT SSLTAHGSTP ASAPVSSLGT 
PTPTSPGVCS VREQQEEITF KGCMANVTVT RCEGACISAA SFNIITQQVD ARCSCCRPLH 
SYEQQLELPC PDPSTPGRRL VLTLQVFSHC VCSSVACGD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.