Details for: MYBPC2

Gene ID: 4606

Symbol: MYBPC2

Ensembl ID: ENSG00000086967

Description: myosin binding protein C2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 6.0483
    Cell Significance Index: 97.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 3.9630
    Cell Significance Index: -1.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 1.6863
    Cell Significance Index: -1.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2839
    Cell Significance Index: -2.8100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 1.2569
    Cell Significance Index: 18.3200
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 1.1770
    Cell Significance Index: 8.6400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.8839
    Cell Significance Index: 7.3100
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7777
    Cell Significance Index: 7.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5789
    Cell Significance Index: 14.8800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.4496
    Cell Significance Index: 10.9700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3144
    Cell Significance Index: 4.5700
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.2647
    Cell Significance Index: 2.0400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.2458
    Cell Significance Index: 2.9100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2215
    Cell Significance Index: 3.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2197
    Cell Significance Index: 4.7600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.1458
    Cell Significance Index: 1.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1243
    Cell Significance Index: 2.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0612
    Cell Significance Index: 1.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0195
    Cell Significance Index: 1.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0150
    Cell Significance Index: 10.3600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0147
    Cell Significance Index: 0.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0123
    Cell Significance Index: 2.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0123
    Cell Significance Index: 2.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0099
    Cell Significance Index: 1.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0086
    Cell Significance Index: 16.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0058
    Cell Significance Index: 8.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0047
    Cell Significance Index: 1.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0046
    Cell Significance Index: 0.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0042
    Cell Significance Index: 0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0036
    Cell Significance Index: 6.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0020
    Cell Significance Index: 2.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0019
    Cell Significance Index: 1.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0016
    Cell Significance Index: -0.1900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0018
    Cell Significance Index: -0.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0018
    Cell Significance Index: -1.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0018
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0025
    Cell Significance Index: -1.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0039
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0046
    Cell Significance Index: -0.5300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0047
    Cell Significance Index: -0.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0081
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0082
    Cell Significance Index: -1.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0086
    Cell Significance Index: -0.2300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0086
    Cell Significance Index: -0.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0094
    Cell Significance Index: -0.9600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0095
    Cell Significance Index: -0.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0103
    Cell Significance Index: -1.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0104
    Cell Significance Index: -1.4300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0113
    Cell Significance Index: -0.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0116
    Cell Significance Index: -0.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0133
    Cell Significance Index: -0.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0137
    Cell Significance Index: -1.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0161
    Cell Significance Index: -1.0800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0169
    Cell Significance Index: -0.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0181
    Cell Significance Index: -1.3900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0188
    Cell Significance Index: -0.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0194
    Cell Significance Index: -1.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0201
    Cell Significance Index: -0.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0212
    Cell Significance Index: -0.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0221
    Cell Significance Index: -0.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0225
    Cell Significance Index: -1.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0240
    Cell Significance Index: -1.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0243
    Cell Significance Index: -1.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0256
    Cell Significance Index: -0.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0260
    Cell Significance Index: -0.8500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0274
    Cell Significance Index: -0.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0282
    Cell Significance Index: -1.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0294
    Cell Significance Index: -1.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0297
    Cell Significance Index: -1.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0303
    Cell Significance Index: -1.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0314
    Cell Significance Index: -0.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0324
    Cell Significance Index: -1.1300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0347
    Cell Significance Index: -0.3000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0347
    Cell Significance Index: -0.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0357
    Cell Significance Index: -0.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0367
    Cell Significance Index: -1.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0368
    Cell Significance Index: -1.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0389
    Cell Significance Index: -0.8400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0389
    Cell Significance Index: -0.7800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0398
    Cell Significance Index: -0.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0415
    Cell Significance Index: -1.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0415
    Cell Significance Index: -1.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0439
    Cell Significance Index: -1.1000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0439
    Cell Significance Index: -0.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0461
    Cell Significance Index: -0.6800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0461
    Cell Significance Index: -0.6400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0467
    Cell Significance Index: -0.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0474
    Cell Significance Index: -1.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0484
    Cell Significance Index: -1.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0494
    Cell Significance Index: -1.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0498
    Cell Significance Index: -1.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0517
    Cell Significance Index: -1.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0522
    Cell Significance Index: -1.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0536
    Cell Significance Index: -1.4300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0537
    Cell Significance Index: -1.1200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0570
    Cell Significance Index: -1.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0573
    Cell Significance Index: -1.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MYBPC2 is a protein-coding gene that encodes myosin binding protein C2, a key component of the sarcomere, the functional unit of striated muscle tissue. This protein is essential for regulating muscle contraction, relaxation, and cell adhesion. The gene is highly expressed in various cell types, including muscle cells, kidney epithelial cells, and immune cells, underscoring its pleiotropic functions. **Pathways and Functions:** MYBPC2 is involved in several critical pathways, including: 1. **Muscle Contraction and Relaxation:** MYBPC2 regulates the interaction between myosin and actin filaments, facilitating muscle contraction and relaxation. 2. **Cell Adhesion:** This protein is crucial for maintaining cell-cell adhesion, particularly in epithelial and endothelial cells. 3. **Sarcomere Organization:** MYBPC2 contributes to the structural organization of the sarcomere, ensuring proper muscle function and integrity. 4. **Actin Binding:** MYBPC2 interacts with actin-binding proteins, modulating the dynamics of actin filaments and muscle contraction. **Clinical Significance:** Dysregulation of MYBPC2 has been implicated in various diseases, including: 1. **Hypertrophic Cardiomyopathy (HCM):** Mutations in MYBPC2 are a common cause of HCM, a leading cause of sudden cardiac death in young athletes. 2. **Muscular Dystrophy:** MYBPC2 mutations have been linked to various forms of muscular dystrophy, including limb-girdle muscular dystrophy and Becker muscular dystrophy. 3. **Kidney Disease:** MYBPC2 has been associated with kidney disease, including focal segmental glomerulosclerosis and nephrotic syndrome. 4. **Neurological Disorders:** MYBPC2 has been implicated in neurological disorders, including autism spectrum disorder and schizophrenia. In conclusion, MYBPC2 is a critical gene that plays a multifaceted role in muscle function, cell adhesion, and structural integrity. Its dysregulation contributes to various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully elucidate the mechanisms underlying MYBPC2-mediated processes and to develop effective therapeutic strategies for related diseases.

Genular Protein ID: 422733368

Symbol: MYPC2_HUMAN

Name: Myosin-binding protein C, fast-type

UniProtKB Accession Codes:

Q14324 A1L4G9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8375400

Title: Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment.

PubMed ID: 8375400

DOI: 10.1111/j.1432-1033.1993.tb18186.x

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1141
  • Mass: 128072
  • Checksum: 91F4B18C4367743A
  • Sequence:
    • MPEAKPAAKK APKGKDAPKG APKEAPPKEA PAEAPKEAPP EDQSPTAEEP TGVFLKKPDS 
VSVETGKDAV VVAKVNGKEL PDKPTIKWFK GKWLELGSKS GARFSFKESH NSASNVYTVE 
LHIGKVVLGD RGYYRLEVKA KDTCDSCGFN IDVEAPRQDA SGQSLESFKR TSEKKSDTAG 
ELDFSGLLKK REVVEEEKKK KKKDDDDLGI PPEIWELLKG AKKSEYEKIA FQYGITDLRG 
MLKRLKKAKV EVKKSAAFTK KLDPAYQVDR GNKIKLMVEI SDPDLTLKWF KNGQEIKPSS 
KYVFENVGKK RILTINKCTL ADDAAYEVAV KDEKCFTELF VKEPPVLIVT PLEDQQVFVG 
DRVEMAVEVS EEGAQVMWMK DGVELTREDS FKARYRFKKD GKRHILIFSD VVQEDRGRYQ 
VITNGGQCEA ELIVEEKQLE VLQDIADLTV KASEQAVFKC EVSDEKVTGK WYKNGVEVRP 
SKRITISHVG RFHKLVIDDV RPEDEGDYTF VPDGYALSLS AKLNFLEIKV EYVPKQEPPK 
IHLDCSGKTS ENAIVVVAGN KLRLDVSITG EPPPVATWLK GDEVFTTTEG RTRIEKRVDC 
SSFVIESAQR EDEGRYTIKV TNPVGEDVAS IFLQVVDVPD PPEAVRITSV GEDWAILVWE 
PPMYDGGKPV TGYLVERKKK GSQRWMKLNF EVFTETTYES TKMIEGILYE MRVFAVNAIG 
VSQPSMNTKP FMPIAPTSEP LHLIVEDVTD TTTTLKWRPP NRIGAGGIDG YLVEYCLEGS 
EEWVPANTEP VERCGFTVKN LPTGARILFR VVGVNIAGRS EPATLAQPVT IREIAEPPKI 
RLPRHLRQTY IRKVGEQLNL VVPFQGKPRP QVVWTKGGAP LDTSRVHVRT SDFDTVFFVR 
QAARSDSGEY ELSVQIENMK DTATIRIRVV EKAGPPINVM VKEVWGTNAL VEWQAPKDDG 
NSEIMGYFVQ KADKKTMEWF NVYERNRHTS CTVSDLIVGN EYYFRVYTEN ICGLSDSPGV 
SKNTARILKT GITFKPFEYK EHDFRMAPKF LTPLIDRVVV AGYSAALNCA VRGHPKPKVV 
WMKNKMEIRE DPKFLITNYQ GVLTLNIRRP SPFDAGTYTC RAVNELGEAL AECKLEVRVP 
Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.