Details for: NMBR

Gene ID: 4829

Symbol: NMBR

Ensembl ID: ENSG00000135577

Description: neuromedin B receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3683
    Cell Significance Index: 8.0700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2333
    Cell Significance Index: 3.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1116
    Cell Significance Index: 77.1900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0950
    Cell Significance Index: 2.3700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0811
    Cell Significance Index: 1.9700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0649
    Cell Significance Index: 0.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0238
    Cell Significance Index: 4.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0192
    Cell Significance Index: 1.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0061
    Cell Significance Index: 1.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0039
    Cell Significance Index: 0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0008
    Cell Significance Index: 1.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0037
    Cell Significance Index: -1.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0046
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0055
    Cell Significance Index: -4.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0061
    Cell Significance Index: -3.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0063
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0066
    Cell Significance Index: -4.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0072
    Cell Significance Index: -3.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0079
    Cell Significance Index: -2.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0142
    Cell Significance Index: -2.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0160
    Cell Significance Index: -2.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0194
    Cell Significance Index: -2.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0197
    Cell Significance Index: -4.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0205
    Cell Significance Index: -3.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0240
    Cell Significance Index: -0.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0288
    Cell Significance Index: -3.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0294
    Cell Significance Index: -3.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0307
    Cell Significance Index: -3.7700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0323
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0334
    Cell Significance Index: -3.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0346
    Cell Significance Index: -0.8900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0364
    Cell Significance Index: -0.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0373
    Cell Significance Index: -2.8600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0393
    Cell Significance Index: -0.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0400
    Cell Significance Index: -0.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0406
    Cell Significance Index: -2.1300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0514
    Cell Significance Index: -0.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0518
    Cell Significance Index: -3.4800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0538
    Cell Significance Index: -0.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0547
    Cell Significance Index: -2.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0606
    Cell Significance Index: -1.9300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0641
    Cell Significance Index: -0.8000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0659
    Cell Significance Index: -1.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0661
    Cell Significance Index: -2.3200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0664
    Cell Significance Index: -1.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0671
    Cell Significance Index: -0.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0681
    Cell Significance Index: -1.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0681
    Cell Significance Index: -2.2300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0691
    Cell Significance Index: -0.8400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0696
    Cell Significance Index: -1.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0732
    Cell Significance Index: -3.2400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0735
    Cell Significance Index: -1.1000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0752
    Cell Significance Index: -2.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0794
    Cell Significance Index: -2.7900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0801
    Cell Significance Index: -1.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0802
    Cell Significance Index: -3.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0815
    Cell Significance Index: -3.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0862
    Cell Significance Index: -2.1500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0895
    Cell Significance Index: -1.7700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0910
    Cell Significance Index: -1.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0968
    Cell Significance Index: -2.7900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0975
    Cell Significance Index: -1.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1001
    Cell Significance Index: -2.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1008
    Cell Significance Index: -2.1400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1024
    Cell Significance Index: -1.7700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1086
    Cell Significance Index: -1.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1091
    Cell Significance Index: -1.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1102
    Cell Significance Index: -2.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1133
    Cell Significance Index: -2.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1168
    Cell Significance Index: -2.9200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1174
    Cell Significance Index: -2.4500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1220
    Cell Significance Index: -1.5400
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1227
    Cell Significance Index: -1.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1233
    Cell Significance Index: -3.5200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1233
    Cell Significance Index: -3.0800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1239
    Cell Significance Index: -1.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1246
    Cell Significance Index: -3.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1266
    Cell Significance Index: -3.3800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1267
    Cell Significance Index: -1.7100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1273
    Cell Significance Index: -2.5900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1275
    Cell Significance Index: -1.7000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1275
    Cell Significance Index: -3.1100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1279
    Cell Significance Index: -1.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1282
    Cell Significance Index: -3.4900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1309
    Cell Significance Index: -2.6100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1328
    Cell Significance Index: -1.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1345
    Cell Significance Index: -2.7900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1353
    Cell Significance Index: -1.4000
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1371
    Cell Significance Index: -1.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1402
    Cell Significance Index: -4.0200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1403
    Cell Significance Index: -1.6500
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1404
    Cell Significance Index: -1.3800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1411
    Cell Significance Index: -1.8300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1437
    Cell Significance Index: -1.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1446
    Cell Significance Index: -3.3400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1466
    Cell Significance Index: -1.1300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1511
    Cell Significance Index: -3.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G-protein coupled receptor (GPCR) structure**: NMBR belongs to the class A/1 (rhodopsin-like receptors) and is characterized by a characteristic seven-transmembrane domain structure. 2. **Wide tissue expression**: NMBR is expressed in various cell types, including blood vessel endothelial cells, retinal cells, plasma cells, and immune cells. 3. **Multifunctional signaling**: NMBR has been implicated in the regulation of immune responses, neurotransmission, and cellular proliferation. 4. **Antiviral innate immune response**: NMBR has been shown to modulate the antiviral innate immune response, suggesting its potential role in protecting against viral infections. **Pathways and Functions:** 1. **Antiviral innate immune response**: NMBR has been shown to regulate the production of interferon-alpha, a key cytokine involved in the antiviral response. 2. **Neurotransmission**: NMBR has been implicated in the regulation of neurotransmission in the retina, suggesting its potential role in visual processing and sensory perception. 3. **Inflammation regulation**: NMBR has been shown to modulate the production of inflammatory cytokines, including interleukin-6, and the proliferation of osteoclasts. 4. **Cell proliferation**: NMBR has been implicated in the regulation of cell proliferation, including the proliferation of osteoclasts and immune cells. 5. **Respiratory gaseous exchange**: NMBR has been shown to regulate respiratory gaseous exchange, suggesting its potential role in modulating respiratory function. **Clinical Significance:** The neuromedin B receptor has been implicated in various diseases, including: 1. **Autoimmune disorders**: NMBR has been shown to regulate the production of inflammatory cytokines, suggesting its potential role in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 2. **Infectious diseases**: NMBR has been implicated in the regulation of the antiviral innate immune response, suggesting its potential role in protecting against viral infections. 3. **Neurological disorders**: NMBR has been shown to regulate neurotransmission in the retina, suggesting its potential role in neurological disorders, such as retinitis pigmentosa and visual impairment. 4. **Respiratory diseases**: NMBR has been implicated in the regulation of respiratory gaseous exchange, suggesting its potential role in respiratory diseases, such as chronic obstructive pulmonary disease (COPD). In conclusion, the neuromedin B receptor is a multifunctional GPCR that plays a critical role in various physiological processes, including the antiviral innate immune response, neurotransmission, and regulation of inflammatory responses. Further research is needed to fully elucidate the role of NMBR in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1103008596

Symbol: NMBR_HUMAN

Name: Neuromedin-B receptor

UniProtKB Accession Codes:

P28336 E9KL38 Q5VUK8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 1 Ensembl 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1655761

Title: Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.

PubMed ID: 1655761

DOI: 10.1016/s0021-9258(18)55129-2

PubMed ID: 20736409

Title: Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.

PubMed ID: 20736409

DOI: 10.1074/mcp.m110.001719

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 31601264

Title: Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo.

PubMed ID: 31601264

DOI: 10.1186/s13567-019-0695-2

Sequence Information:

  • Length: 390
  • Mass: 43435
  • Checksum: 8BA9AAD4F3B7309F
  • Sequence:
    • MPSKSLSNLS VTTGANESGS VPEGWERDFL PASDGTTTEL VIRCVIPSLY LLIITVGLLG 
NIMLVKIFIT NSAMRSVPNI FISNLAAGDL LLLLTCVPVD ASRYFFDEWM FGKVGCKLIP 
VIQLTSVGVS VFTLTALSAD RYRAIVNPMD MQTSGALLRT CVKAMGIWVV SVLLAVPEAV 
FSEVARISSL DNSSFTACIP YPQTDELHPK IHSVLIFLVY FLIPLAIISI YYYHIAKTLI 
KSAHNLPGEY NEHTKKQMET RKRLAKIVLV FVGCFIFCWF PNHILYMYRS FNYNEIDPSL 
GHMIVTLVAR VLSFGNSCVN PFALYLLSES FRRHFNSQLC CGRKSYQERG TSYLLSSSAV 
RMTSLKSNAK NMVTNSVLLN GHSMKQEMAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.