Details for: NMBR

Gene ID: 4829

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: NMBR

Ensembl ID: ENSG00000135577

Description: neuromedin B receptor

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • ependymal cell CL0000065
    CSI 3.06
    rCSI 6.2%
    PRS 97.59
  • amacrine cell CL0000561
    CSI 2.02
    rCSI 5.85%
    PRS 99.2
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 2.01
    rCSI 3.37%
    PRS 99.03

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [NMBR](/details-gene/4829), or Neuromedin B Receptor, is a protein-coding gene located on chromosome 6q24.1. It encodes a G protein-coupled receptor (GPCR) that functions as the specific receptor for the neuropeptide neuromedin B. As part of the bombesin-like peptide receptor family, [NMBR](/details-gene/4829) is primarily involved in the [neuropeptide signaling pathway](/details-ontology/GO:0007218) and [G alpha (q) signalling events](https://reactome.org/content/detail/R-HSA-416476). **Overall**, expression data indicates that [NMBR](/details-gene/4829) is a significant marker in specific cell types of the central nervous system, including [ependymal cell](/details-cell/CL0000065), [amacrine cell](/details-cell/CL0000561), and [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011). Recent evidence also points to its involvement in the [antiviral innate immune response](/details-ontology/GO:0140374) ([Link](https://doi.org/10.1186/s13567-019-0695-2)), suggesting a dual role in both neuromodulation and immunity. ## Cellular Roles and Expression Landscape The expression profile of [NMBR](/details-gene/4829) highlights its specialized role within the central nervous system. **Overall**, the gene shows its highest significance in [ependymal cell](/details-cell/CL0000065) (CSI: 3.06), which lines the ventricles of the brain and the central canal of the spinal cord. This is followed by high significance in distinct neuronal populations, including [amacrine cell](/details-cell/CL0000561) (CSI: 2.02), a type of interneuron in the retina, and [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 2.01), which is involved in cortical circuitry. The high CSI scores in these specific, yet functionally diverse, neural cell types suggest that [NMBR](/details-gene/4829) is not a pan-neuronal gene but rather serves as a defining functional marker for distinct neuropeptide-responsive circuits. Its established expression in lung carcinoma cells further indicates a potential role in non-neuronal tissues, particularly in pathological contexts ([Link](https://doi.org/10.1016/s0021-9258(18)55129-2)). ## Pathways and Molecular Function Functionally, [NMBR](/details-gene/4829) is annotated as a [neuropeptide receptor activity](/details-ontology/GO:0008188) and more specifically, [bombesin receptor activity](/details-ontology/GO:0004946). As a member of the [Class a/1 (rhodopsin-like receptors)](https://reactome.org/content/detail/R-HSA-373076) superfamily, its activation initiates intracellular signaling cascades primarily through the [G alpha (q) signalling events](https://reactome.org/content/detail/R-HSA-416476) pathway, leading to the activation of phospholipase C. Beyond its role in neuromodulation, [NMBR](/details-gene/4829) is implicated in immune regulation. Gene Ontology annotations include roles in the [antiviral innate immune response](/details-ontology/GO:0140374), [positive regulation of interferon-alpha production](/details-ontology/GO:0032727), and [negative regulation of interleukin-6 production](/details-ontology/GO:0032715). This is supported by research demonstrating its role in the host defense against influenza A virus infection ([Link](https://doi.org/10.1186/s13567-019-0695-2)), suggesting that [NMBR](/details-gene/4829) signaling may link the nervous and immune systems during pathogenic challenges. Other annotated functions include regulation of osteoclast proliferation ([GO:0090290](/details-ontology/GO:0090290)) and respiratory gaseous exchange ([GO:1903942](/details-ontology/GO:1903942)). ## Research Directions The dual functionality of [NMBR](/details-gene/4829) in both specific neural circuits and innate immunity presents several avenues for future investigation. Its highly specific expression pattern within the CNS suggests it could be a key modulator of distinct physiological processes. **Proposed Hypotheses:** 1. Given its high significance in [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011), [NMBR](/details-gene/4829) signaling likely plays a critical role in modulating the activity of inhibitory circuits in the cerebral cortex, potentially fine-tuning cortical network oscillations that are fundamental to cognitive processes. 2. Based on its annotated role in the [antiviral innate immune response](/details-ontology/GO:0140374), [NMBR](/details-gene/4829) expressed on CNS-resident cells, such as ependymal cells or microglia, may function as a sensor or modulator of neuroinflammation during viral encephalitis, linking neuropeptide signaling directly to immune defense within the brain. **Experimental Approach:** To test the second hypothesis, one could utilize an *in vitro* model of the blood-cerebrospinal fluid barrier using primary human [ependymal cell](/details-cell/CL0000065) cultures. Following CRISPR-Cas9-mediated knockout of [NMBR](/details-gene/4829), these cultures could be challenged with a neurotropic virus (e.g., Herpes Simplex Virus 1) or a viral mimetic like poly(I:C). The impact of [NMBR](/details-gene/4829) loss could be quantified by measuring changes in interferon and cytokine (e.g., IL-6) secretion using ELISA, and by assessing viral replication rates via quantitative PCR. This would directly test the receptor's role in the innate immune response of these critical barrier cells. **Therapeutic Potential:** As a G protein-coupled receptor located on the plasma membrane, [NMBR](/details-gene/4829) is an inherently 'druggable' target. Its specific expression in certain neuronal subtypes suggests that selective agonists or antagonists could be developed to treat neurological or psychiatric conditions with minimal off-target effects. Furthermore, its role in the immune response and established presence in some lung cancers ([Link](https://doi.org/10.1016/s0021-9258(18)55129-2)) indicates that targeting [NMBR](/details-gene/4829) via small molecule inhibitors could be a viable therapeutic strategy for certain inflammatory diseases or malignancies.

Genular Protein ID: 1103008596

Symbol: NMBR_HUMAN

Name: Neuromedin-B receptor

UniProtKB Accession Codes:

P28336 E9KL38 Q5VUK8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 1 Ensembl 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1655761

Title: Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.

PubMed ID: 1655761

DOI: 10.1016/s0021-9258(18)55129-2

PubMed ID: 20736409

Title: Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.

PubMed ID: 20736409

DOI: 10.1074/mcp.m110.001719

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 31601264

Title: Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo.

PubMed ID: 31601264

DOI: 10.1186/s13567-019-0695-2

Sequence Information:

  • Length: 390
  • Mass: 43435
  • Checksum: 8BA9AAD4F3B7309F
  • Sequence:
    • MPSKSLSNLS VTTGANESGS VPEGWERDFL PASDGTTTEL VIRCVIPSLY LLIITVGLLG 
NIMLVKIFIT NSAMRSVPNI FISNLAAGDL LLLLTCVPVD ASRYFFDEWM FGKVGCKLIP 
VIQLTSVGVS VFTLTALSAD RYRAIVNPMD MQTSGALLRT CVKAMGIWVV SVLLAVPEAV 
FSEVARISSL DNSSFTACIP YPQTDELHPK IHSVLIFLVY FLIPLAIISI YYYHIAKTLI 
KSAHNLPGEY NEHTKKQMET RKRLAKIVLV FVGCFIFCWF PNHILYMYRS FNYNEIDPSL 
GHMIVTLVAR VLSFGNSCVN PFALYLLSES FRRHFNSQLC CGRKSYQERG TSYLLSSSAV 
RMTSLKSNAK NMVTNSVLLN GHSMKQEMAL