Details for: OPRD1

Gene ID: 4985

Symbol: OPRD1

Ensembl ID: ENSG00000116329

Description: opioid receptor delta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2961
    Cell Significance Index: 57.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9621
    Cell Significance Index: 193.0000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.7429
    Cell Significance Index: 9.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6776
    Cell Significance Index: 45.5600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.5214
    Cell Significance Index: 7.5700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.5056
    Cell Significance Index: 6.7400
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.4706
    Cell Significance Index: 3.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.4478
    Cell Significance Index: -0.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.4104
    Cell Significance Index: 8.7100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.3385
    Cell Significance Index: 3.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2827
    Cell Significance Index: 41.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2067
    Cell Significance Index: 33.6300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1988
    Cell Significance Index: 3.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1742
    Cell Significance Index: 10.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1568
    Cell Significance Index: 15.5200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1419
    Cell Significance Index: 1.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1303
    Cell Significance Index: 24.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1095
    Cell Significance Index: 6.7300
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0976
    Cell Significance Index: 1.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0960
    Cell Significance Index: 66.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0789
    Cell Significance Index: 1.6800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0756
    Cell Significance Index: 1.0600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0626
    Cell Significance Index: 0.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0606
    Cell Significance Index: 1.7300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.0522
    Cell Significance Index: 1.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0501
    Cell Significance Index: 17.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0478
    Cell Significance Index: 5.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0396
    Cell Significance Index: 0.9500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0305
    Cell Significance Index: 0.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0284
    Cell Significance Index: 0.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0224
    Cell Significance Index: 4.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0194
    Cell Significance Index: 5.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0119
    Cell Significance Index: 0.3900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.0111
    Cell Significance Index: 0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0011
    Cell Significance Index: -0.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0012
    Cell Significance Index: -2.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0020
    Cell Significance Index: -3.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0043
    Cell Significance Index: -0.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0059
    Cell Significance Index: -3.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0076
    Cell Significance Index: -5.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0078
    Cell Significance Index: -5.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0094
    Cell Significance Index: -4.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0105
    Cell Significance Index: -5.7200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0133
    Cell Significance Index: -0.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0166
    Cell Significance Index: -2.9900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0204
    Cell Significance Index: -0.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0211
    Cell Significance Index: -0.5900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0246
    Cell Significance Index: -0.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0253
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0253
    Cell Significance Index: -4.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0260
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0265
    Cell Significance Index: -5.5800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0369
    Cell Significance Index: -0.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0387
    Cell Significance Index: -4.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0406
    Cell Significance Index: -5.5800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0422
    Cell Significance Index: -0.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0436
    Cell Significance Index: -5.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0454
    Cell Significance Index: -2.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0479
    Cell Significance Index: -5.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0539
    Cell Significance Index: -6.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0539
    Cell Significance Index: -5.6100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0542
    Cell Significance Index: -0.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0561
    Cell Significance Index: -5.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0577
    Cell Significance Index: -1.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0598
    Cell Significance Index: -2.1000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0643
    Cell Significance Index: -0.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0667
    Cell Significance Index: -4.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0695
    Cell Significance Index: -5.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0728
    Cell Significance Index: -3.7800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0750
    Cell Significance Index: -1.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0757
    Cell Significance Index: -5.6400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0786
    Cell Significance Index: -0.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0794
    Cell Significance Index: -2.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0801
    Cell Significance Index: -5.0500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0902
    Cell Significance Index: -0.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0929
    Cell Significance Index: -2.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0970
    Cell Significance Index: -6.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0972
    Cell Significance Index: -3.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0984
    Cell Significance Index: -5.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1002
    Cell Significance Index: -4.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1028
    Cell Significance Index: -2.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1030
    Cell Significance Index: -5.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1123
    Cell Significance Index: -5.2800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1148
    Cell Significance Index: -2.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1161
    Cell Significance Index: -3.1600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1218
    Cell Significance Index: -1.6700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1221
    Cell Significance Index: -5.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1241
    Cell Significance Index: -1.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1309
    Cell Significance Index: -4.5500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1375
    Cell Significance Index: -2.3500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1375
    Cell Significance Index: -3.4400
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1455
    Cell Significance Index: -1.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1523
    Cell Significance Index: -3.8000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1531
    Cell Significance Index: -2.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1550
    Cell Significance Index: -5.6900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1597
    Cell Significance Index: -3.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Expression**: OPRD1 is primarily expressed in hematopoietic stem cells, megakaryocyte-erythroid progenitor cells, and various neuronal populations, including chandelier GABAergic cortical interneurons and L2/3-6 intratelencephalic projecting glutamatergic neurons. 2. **Receptor Structure**: OPRD1 is a G-protein coupled receptor (GPCR) that belongs to the class A/1 rhodopsin-like receptors. It is activated by endogenous opioids, such as enkephalins, and plays a critical role in modulating immune responses and neurological functions. 3. **Signaling Pathways**: OPRD1 is involved in multiple signaling pathways, including adenylate cyclase-inhibiting GPCR signaling, G alpha (i) signaling events, and phospholipase C-activating GPCR signaling. These pathways regulate various cellular processes, including gene expression, calcium ion transport, and mitochondrial membrane potential. **Pathways and Functions:** 1. **Immune Regulation**: OPRD1 plays a significant role in regulating immune responses, particularly in the context of inflammation and tissue injury. It modulates the activity of immune cells, such as T cells and macrophages, and influences the production of cytokines and chemokines. 2. **Neurological Function**: OPRD1 is involved in various neurological processes, including pain modulation, mood regulation, and cognitive function. It interacts with other neurotransmitters and hormones to regulate neuronal activity and synaptic plasticity. 3. **Cellular Response to Hypoxia**: OPRD1 is involved in the cellular response to hypoxia, a condition characterized by reduced oxygen availability. It regulates the expression of genes involved in hypoxia adaptation and survival. 4. **Cytokine Signaling**: OPRD1 modulates cytokine signaling in the immune system, influencing the production of pro-inflammatory and anti-inflammatory cytokines. **Clinical Significance:** 1. **Pain Management**: OPRD1 is a target for pain management, particularly in the context of chronic pain and opioid addiction. Modulating OPRD1 activity may provide novel therapeutic strategies for pain relief. 2. **Immune-Mediated Disorders**: OPRD1 dysregulation has been implicated in various immune-mediated disorders, including multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Targeting OPRD1 may offer new therapeutic opportunities for these conditions. 3. **Neurodegenerative Diseases**: OPRD1 is involved in the pathophysiology of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Modulating OPRD1 activity may provide novel therapeutic strategies for these conditions. In conclusion, the OPRD1 gene is a complex and multifaceted player in the regulation of immune responses and neurological functions. Its dysregulation has been implicated in various diseases, making it a promising target for therapeutic interventions. Further research is needed to fully elucidate the mechanisms of OPRD1 and to explore its potential as a therapeutic target.

Genular Protein ID: 3047740822

Symbol: OPRD_HUMAN

Name: Delta-type opioid receptor

UniProtKB Accession Codes:

P41143 B5B0B8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 50 DrugCentral 1 ELM 1 EMBL 4 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8201839

Title: Identification of a human delta opioid receptor: cloning and expression.

PubMed ID: 8201839

DOI: 10.1016/0024-3205(94)90138-4

PubMed ID: 7808419

Title: The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain.

PubMed ID: 7808419

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 12142540

Title: Modulation of postendocytic sorting of G protein-coupled receptors.

PubMed ID: 12142540

DOI: 10.1126/science.1073308

PubMed ID: 15086532

Title: Identification of a novel family of G protein-coupled receptor associated sorting proteins.

PubMed ID: 15086532

DOI: 10.1111/j.1471-4159.2004.02411.x

PubMed ID: 22184124

Title: Cys-27 variant of human delta-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization.

PubMed ID: 22184124

DOI: 10.1074/jbc.m111.305656

PubMed ID: 22417668

Title: Expression and localization of opioid receptors during the maturation of human oocytes.

PubMed ID: 22417668

DOI: 10.1016/j.rbmo.2012.02.007

PubMed ID: 10982041

Title: Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence.

PubMed ID: 10982041

DOI: 10.1007/s004390000340

PubMed ID: 12847517

Title: Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation.

PubMed ID: 12847517

DOI: 10.1038/nsb950

Sequence Information:

  • Length: 372
  • Mass: 40369
  • Checksum: 9D483FC39BA2BAE4
  • Sequence:
    • MEPAPSAGAE LQPPLFANAS DAYPSACPSA GANASGPPGA RSASSLALAI AITALYSAVC 
AVGLLGNVLV MFGIVRYTKM KTATNIYIFN LALADALATS TLPFQSAKYL METWPFGELL 
CKAVLSIDYY NMFTSIFTLT MMSVDRYIAV CHPVKALDFR TPAKAKLINI CIWVLASGVG 
VPIMVMAVTR PRDGAVVCML QFPSPSWYWD TVTKICVFLF AFVVPILIIT VCYGLMLLRL 
RSVRLLSGSK EKDRSLRRIT RMVLVVVGAF VVCWAPIHIF VIVWTLVDID RRDPLVVAAL 
HLCIALGYAN SSLNPVLYAF LDENFKRCFR QLCRKPCGRP DPSSFSRARE ATARERVTAC 
TPSDGPGGGA AA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.