Details for: OR3A1

Gene ID: 4994

Symbol: OR3A1

Ensembl ID: ENSG00000180090

Description: olfactory receptor family 3 subfamily A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 8.1611
    Cell Significance Index: -2.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.6870
    Cell Significance Index: -2.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8480
    Cell Significance Index: 20.5400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.5375
    Cell Significance Index: 6.0900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1660
    Cell Significance Index: 2.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0343
    Cell Significance Index: 2.1600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0244
    Cell Significance Index: 0.3500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0111
    Cell Significance Index: 0.1100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0103
    Cell Significance Index: 0.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0075
    Cell Significance Index: 0.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0028
    Cell Significance Index: 0.5700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0027
    Cell Significance Index: 0.0300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0015
    Cell Significance Index: 0.0300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0010
    Cell Significance Index: 0.0200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.0008
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0006
    Cell Significance Index: 0.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0003
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0003
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0006
    Cell Significance Index: -0.1000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0010
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0011
    Cell Significance Index: -0.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0015
    Cell Significance Index: -0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0044
    Cell Significance Index: -1.5900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0051
    Cell Significance Index: -0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0054
    Cell Significance Index: -1.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0057
    Cell Significance Index: -0.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0066
    Cell Significance Index: -1.1900
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0076
    Cell Significance Index: -0.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0079
    Cell Significance Index: -0.3700
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0119
    Cell Significance Index: -0.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0133
    Cell Significance Index: -1.6300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0137
    Cell Significance Index: -0.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0141
    Cell Significance Index: -0.7900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0148
    Cell Significance Index: -0.1500
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0156
    Cell Significance Index: -0.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0186
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0209
    Cell Significance Index: -0.2600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0213
    Cell Significance Index: -0.2800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0214
    Cell Significance Index: -0.2400
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0231
    Cell Significance Index: -0.2300
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0232
    Cell Significance Index: -0.2500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0248
    Cell Significance Index: -0.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0269
    Cell Significance Index: -0.5700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0275
    Cell Significance Index: -0.3000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0287
    Cell Significance Index: -0.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0305
    Cell Significance Index: -0.8300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0309
    Cell Significance Index: -0.3600
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0315
    Cell Significance Index: -0.3100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0317
    Cell Significance Index: -0.3600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0334
    Cell Significance Index: -0.6700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0336
    Cell Significance Index: -0.8400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0337
    Cell Significance Index: -0.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0352
    Cell Significance Index: -0.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0354
    Cell Significance Index: -0.3900
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0356
    Cell Significance Index: -0.4100
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0357
    Cell Significance Index: -0.4000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0386
    Cell Significance Index: -0.5200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0388
    Cell Significance Index: -0.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0394
    Cell Significance Index: -1.1300
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0423
    Cell Significance Index: -0.4100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0439
    Cell Significance Index: -0.6400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0451
    Cell Significance Index: -0.9000
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0456
    Cell Significance Index: -0.4400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0463
    Cell Significance Index: -1.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0463
    Cell Significance Index: -1.1100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0474
    Cell Significance Index: -0.9900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0491
    Cell Significance Index: -1.0000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0506
    Cell Significance Index: -0.4800
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.0516
    Cell Significance Index: -0.4100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0547
    Cell Significance Index: -0.6900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0549
    Cell Significance Index: -1.0800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0561
    Cell Significance Index: -0.8400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0570
    Cell Significance Index: -0.9900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0597
    Cell Significance Index: -1.5200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0604
    Cell Significance Index: -0.3700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0608
    Cell Significance Index: -0.6100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0610
    Cell Significance Index: -0.6600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0616
    Cell Significance Index: -0.9000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0626
    Cell Significance Index: -0.7800
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0630
    Cell Significance Index: -0.3700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0641
    Cell Significance Index: -0.8100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0642
    Cell Significance Index: -0.8900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0643
    Cell Significance Index: -0.8300
  • Cell Name: OFF parasol ganglion cell (CL4033051)
    Fold Change: -0.0645
    Cell Significance Index: -0.8100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0648
    Cell Significance Index: -0.7300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0650
    Cell Significance Index: -0.8200
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0654
    Cell Significance Index: -0.7100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0655
    Cell Significance Index: -0.8300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0655
    Cell Significance Index: -0.7800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0655
    Cell Significance Index: -0.8300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0669
    Cell Significance Index: -0.8300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0698
    Cell Significance Index: -0.9300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0698
    Cell Significance Index: -0.8300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0711
    Cell Significance Index: -0.7800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0714
    Cell Significance Index: -0.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0725
    Cell Significance Index: -1.9400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0729
    Cell Significance Index: -1.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression in Immune Cells:** OR3A1 is significantly expressed in various immune cells, including blood vessel endothelial cells, monocytes, granulocytes, and precursor B cells, suggesting its involvement in immune regulation. 2. **Olfactory Receptor Activity:** OR3A1 is a member of the olfactory receptor family and exhibits olfactory receptor activity, enabling it to detect chemical stimuli involved in sensory perception of smell. 3. **G Protein-Coupled Receptor Signaling:** OR3A1 is a G protein-coupled receptor, which activates downstream signaling pathways upon ligand binding, influencing various cellular processes. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR3A1 detects chemical stimuli involved in sensory perception of smell, contributing to the processing of olfactory information. 2. **Immune Regulation:** OR3A1 is involved in modulating immune responses in immune cells, potentially influencing inflammation, immune cell activation, and immune tolerance. 3. **Signal Transduction:** The activation of OR3A1 by its ligands triggers signal transduction pathways, which regulate various cellular processes, including gene expression, cell proliferation, and differentiation. 4. **G Protein-Coupled Receptor Signaling Pathway:** OR3A1 activates the G protein-coupled receptor signaling pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and survival. **Clinical Significance:** 1. **Olfactory Disorders:** OR3A1 dysfunction may contribute to olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Immune-Related Disorders:** OR3A1's involvement in immune regulation may have implications for immune-related disorders, such as asthma, allergies, and autoimmune diseases. 3. **Cancer Research:** OR3A1's expression in immune cells and its role in signal transduction pathways make it an attractive target for cancer research, particularly in the development of immunotherapies. 4. **Neurological Disorders:** OR3A1's expression in the cerebral cortex and its involvement in sensory perception may have implications for neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the OR3A1 gene is a multifunctional gene that plays a significant role in both sensory perception and immune regulation. Further research is necessary to fully understand the mechanisms underlying OR3A1's functions and its clinical significance.

Genular Protein ID: 3201494993

Symbol: OR3A1_HUMAN

Name: Olfactory receptor 3A1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8647456

Title: Olfactory receptor-encoding genes and pseudogenes are expressed in humans.

PubMed ID: 8647456

DOI: 10.1016/0378-1119(95)00849-7

PubMed ID: 8921386

Title: Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity.

PubMed ID: 8921386

DOI: 10.1006/geno.1996.0536

PubMed ID: 10673334

Title: Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

PubMed ID: 10673334

DOI: 10.1006/geno.1999.6030

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8004088

Title: Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire.

PubMed ID: 8004088

DOI: 10.1093/hmg/3.2.229

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 315
  • Mass: 34609
  • Checksum: DF32977D5EA7D7CA
  • Sequence:
  • MQPESGANGT VIAEFILLGL LEAPGLQPVV FVLFLFAYLV TVRGNLSILA AVLVEPKLHT 
    PMYFFLGNLS VLDVGCISVT VPSMLSRLLS RKRAVPCGAC LTQLFFFHLF VGVDCFLLTA 
    MAYDRFLAIC RPLTYSTRMS QTVQRMLVAA SWACAFTNAL THTVAMSTLN FCGPNVINHF 
    YCDLPQLFQL SCSSTQLNEL LLFAVGFIMA GTPMALIVIS YIHVAAAVLR IRSVEGRKKA 
    FSTCGSHLTV VAIFYGSGIF NYMRLGSTKL SDKDKAVGIF NTVINPMLNP IIYSFRNPDV 
    QSAIWRMLTG RRSLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.