Details for: SLC22A18AS

Gene ID: 5003

Symbol: SLC22A18AS

Ensembl ID: ENSG00000254827

Description: SLC22A18 antisense RNA

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.4979
    Cell Significance Index: -3.1700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.3820
    Cell Significance Index: 65.6600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 3.1597
    Cell Significance Index: 23.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.7798
    Cell Significance Index: 126.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.5711
    Cell Significance Index: -3.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5317
    Cell Significance Index: 40.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9839
    Cell Significance Index: 107.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9758
    Cell Significance Index: 21.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9244
    Cell Significance Index: 26.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6561
    Cell Significance Index: 17.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6535
    Cell Significance Index: 106.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5459
    Cell Significance Index: 37.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4749
    Cell Significance Index: 15.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3526
    Cell Significance Index: 7.5100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2860
    Cell Significance Index: 4.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2206
    Cell Significance Index: 41.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2004
    Cell Significance Index: 2.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1885
    Cell Significance Index: 21.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1780
    Cell Significance Index: 17.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1507
    Cell Significance Index: 7.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1411
    Cell Significance Index: 127.4400
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.1342
    Cell Significance Index: 1.3700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.1307
    Cell Significance Index: 1.4300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1277
    Cell Significance Index: 1.8900
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.0988
    Cell Significance Index: 0.5800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0830
    Cell Significance Index: 0.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0816
    Cell Significance Index: 2.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0663
    Cell Significance Index: 2.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0440
    Cell Significance Index: 0.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0372
    Cell Significance Index: 7.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0368
    Cell Significance Index: 0.3000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0249
    Cell Significance Index: 0.1900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0199
    Cell Significance Index: 0.1300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0121
    Cell Significance Index: 0.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0088
    Cell Significance Index: 1.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0083
    Cell Significance Index: 3.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0063
    Cell Significance Index: 1.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0052
    Cell Significance Index: 2.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0021
    Cell Significance Index: -2.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0024
    Cell Significance Index: -1.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0031
    Cell Significance Index: -0.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0039
    Cell Significance Index: -0.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0043
    Cell Significance Index: -0.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0047
    Cell Significance Index: -1.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0048
    Cell Significance Index: -3.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0049
    Cell Significance Index: -0.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0049
    Cell Significance Index: -3.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0050
    Cell Significance Index: -1.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0058
    Cell Significance Index: -3.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0058
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0061
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0062
    Cell Significance Index: -0.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0079
    Cell Significance Index: -3.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0098
    Cell Significance Index: -1.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0120
    Cell Significance Index: -0.3100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0129
    Cell Significance Index: -0.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0129
    Cell Significance Index: -0.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0137
    Cell Significance Index: -1.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0165
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0169
    Cell Significance Index: -3.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0185
    Cell Significance Index: -3.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0195
    Cell Significance Index: -2.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0212
    Cell Significance Index: -1.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0220
    Cell Significance Index: -0.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0229
    Cell Significance Index: -1.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0233
    Cell Significance Index: -3.3900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0274
    Cell Significance Index: -0.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0281
    Cell Significance Index: -1.7200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0285
    Cell Significance Index: -0.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0303
    Cell Significance Index: -3.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0360
    Cell Significance Index: -1.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0361
    Cell Significance Index: -4.2600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0368
    Cell Significance Index: -0.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0369
    Cell Significance Index: -2.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0396
    Cell Significance Index: -3.0400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0405
    Cell Significance Index: -3.2100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0447
    Cell Significance Index: -0.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0449
    Cell Significance Index: -2.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0467
    Cell Significance Index: -1.5300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0498
    Cell Significance Index: -0.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0542
    Cell Significance Index: -1.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0547
    Cell Significance Index: -3.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0554
    Cell Significance Index: -3.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0563
    Cell Significance Index: -0.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0588
    Cell Significance Index: -1.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0615
    Cell Significance Index: -3.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0639
    Cell Significance Index: -0.9100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0660
    Cell Significance Index: -0.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0691
    Cell Significance Index: -1.7300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0707
    Cell Significance Index: -0.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0714
    Cell Significance Index: -3.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0725
    Cell Significance Index: -2.3100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0764
    Cell Significance Index: -3.3200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0798
    Cell Significance Index: -0.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0802
    Cell Significance Index: -2.1500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0808
    Cell Significance Index: -1.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0858
    Cell Significance Index: -3.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Antisense RNA**: SLC22A18AS is an antisense RNA, meaning it is transcribed from the opposite DNA strand of the SLC22A18 gene. Antisense RNAs can regulate gene expression by interacting with their sense counterparts, either through RNA-RNA interactions or by influencing epigenetic modifications. 2. **Wide-Ranging Expression**: SLC22A18AS is significantly expressed in various cell types, including respiratory basal cells, enterocytes, renal cells, and immune cells such as mononuclear cells and GABAergic interneurons. This broad expression pattern suggests a critical role in maintaining cellular homeostasis and regulating immune responses. 3. **Cell-Type Specificity**: The expression of SLC22A18AS varies across different cell types, with some cells exhibiting high levels of expression while others show minimal or no expression. This cell-type specificity highlights the potential for SLC22A18AS to play distinct roles in different tissues and organs. **Pathways and Functions:** 1. **Amino Acid Transport**: SLC22A18AS is involved in the regulation of amino acid transport, which is essential for maintaining cellular homeostasis and supporting various cellular processes, including neurotransmitter metabolism and immune responses. 2. **Neurotransmitter Metabolism**: The expression of SLC22A18AS in GABAergic interneurons suggests a role in regulating neurotransmitter metabolism, particularly in the context of the central nervous system. 3. **Immune Regulation**: The expression of SLC22A18AS in immune cells such as mononuclear cells and GABAergic interneurons suggests a potential role in regulating immune responses, including the modulation of immune cell function and cytokine production. **Clinical Significance:** 1. **Neurological Disorders**: The expression of SLC22A18AS in GABAergic interneurons and its potential role in neurotransmitter metabolism suggest a potential link to neurological disorders, such as epilepsy and schizophrenia. 2. **Immunological Disorders**: The expression of SLC22A18AS in immune cells and its potential role in regulating immune responses suggest a potential link to immunological disorders, such as autoimmune diseases and immunodeficiency disorders. 3. **Cancer**: The expression of SLC22A18AS in various cell types, including cancer cells, suggests a potential role in cancer development and progression. **Conclusion:** In conclusion, the SLC22A18AS gene is a complex and multifaceted molecule with a wide range of functions and implications for human health. Further research is needed to fully understand the role of SLC22A18AS in regulating gene expression and function, particularly in the context of immune responses and neurological disorders. As our understanding of this gene continues to evolve, it is likely to shed light on new therapeutic strategies for the treatment of various diseases and disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.