Details for: PLA2G3

Gene ID: 50487

Symbol: PLA2G3

Ensembl ID: ENSG00000100078

Description: phospholipase A2 group III

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8577
    Cell Significance Index: 20.7800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3477
    Cell Significance Index: 5.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.2770
    Cell Significance Index: 28.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1264
    Cell Significance Index: 1.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0976
    Cell Significance Index: 11.3800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0756
    Cell Significance Index: 0.7800
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.0465
    Cell Significance Index: 0.2000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0180
    Cell Significance Index: 0.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0141
    Cell Significance Index: 10.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0016
    Cell Significance Index: 0.8700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0011
    Cell Significance Index: -0.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0025
    Cell Significance Index: -4.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0029
    Cell Significance Index: -4.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0050
    Cell Significance Index: -2.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0068
    Cell Significance Index: -3.1000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0078
    Cell Significance Index: -0.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0084
    Cell Significance Index: -2.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0103
    Cell Significance Index: -1.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0113
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0115
    Cell Significance Index: -2.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0119
    Cell Significance Index: -2.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0143
    Cell Significance Index: -2.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0151
    Cell Significance Index: -2.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0169
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0177
    Cell Significance Index: -2.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0181
    Cell Significance Index: -2.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0211
    Cell Significance Index: -2.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0311
    Cell Significance Index: -4.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0325
    Cell Significance Index: -2.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0409
    Cell Significance Index: -2.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0412
    Cell Significance Index: -1.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0428
    Cell Significance Index: -1.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0445
    Cell Significance Index: -1.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0450
    Cell Significance Index: -2.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0474
    Cell Significance Index: -2.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0483
    Cell Significance Index: -2.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0507
    Cell Significance Index: -3.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0541
    Cell Significance Index: -3.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0612
    Cell Significance Index: -1.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0684
    Cell Significance Index: -2.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0722
    Cell Significance Index: -2.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0730
    Cell Significance Index: -3.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0760
    Cell Significance Index: -2.4200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0773
    Cell Significance Index: -1.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0781
    Cell Significance Index: -2.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0792
    Cell Significance Index: -2.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0836
    Cell Significance Index: -1.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0849
    Cell Significance Index: -2.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0851
    Cell Significance Index: -2.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0873
    Cell Significance Index: -2.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0879
    Cell Significance Index: -2.5900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0882
    Cell Significance Index: -0.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0892
    Cell Significance Index: -2.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0935
    Cell Significance Index: -2.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0941
    Cell Significance Index: -3.5700
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0944
    Cell Significance Index: -0.8400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0962
    Cell Significance Index: -1.8800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1032
    Cell Significance Index: -1.4500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1039
    Cell Significance Index: -2.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1042
    Cell Significance Index: -2.7400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1073
    Cell Significance Index: -2.1400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1106
    Cell Significance Index: -2.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1127
    Cell Significance Index: -2.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1175
    Cell Significance Index: -2.4600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1241
    Cell Significance Index: -2.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1251
    Cell Significance Index: -2.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1261
    Cell Significance Index: -2.7300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1268
    Cell Significance Index: -3.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1272
    Cell Significance Index: -2.1400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1341
    Cell Significance Index: -0.8900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1351
    Cell Significance Index: -1.6200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1353
    Cell Significance Index: -1.7700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1359
    Cell Significance Index: -3.9000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1364
    Cell Significance Index: -2.9000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1372
    Cell Significance Index: -1.9500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1396
    Cell Significance Index: -2.7600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1410
    Cell Significance Index: -2.8300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1415
    Cell Significance Index: -1.6800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1429
    Cell Significance Index: -2.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1454
    Cell Significance Index: -3.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1460
    Cell Significance Index: -3.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1478
    Cell Significance Index: -3.5500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1479
    Cell Significance Index: -2.9100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1512
    Cell Significance Index: -2.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1609
    Cell Significance Index: -4.3000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1620
    Cell Significance Index: -2.7700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1673
    Cell Significance Index: -2.4700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1693
    Cell Significance Index: -1.4000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1735
    Cell Significance Index: -1.8300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1753
    Cell Significance Index: -2.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1783
    Cell Significance Index: -4.1200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1784
    Cell Significance Index: -2.5000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1794
    Cell Significance Index: -2.7300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1797
    Cell Significance Index: -2.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic activity:** PLA2G3 is a secreted enzyme that catalyzes the hydrolysis of phospholipids into free fatty acids and lysophospholipids. 2. **Cellular localization:** PLA2G3 is expressed in various cell types, including epithelial cells, immune cells, neuronal cells, and cancer cells. 3. **Tissue distribution:** PLA2G3 is highly expressed in tissues involved in immune responses, such as the lungs, liver, and pancreas. 4. **Regulatory mechanisms:** PLA2G3 is regulated by various mechanisms, including negative regulation of gene expression, positive regulation of cytokine production, and regulation of endocytic recycling. **Pathways and Functions:** 1. **Lipid metabolism:** PLA2G3 is involved in the hydrolysis of phospholipids into free fatty acids and lysophospholipids, which are essential for membrane biogenesis and signaling. 2. **Inflammatory response:** PLA2G3 is involved in the production of pro-inflammatory mediators, such as prostaglandins and leukotrienes, which are essential for immune responses. 3. **Cell signaling:** PLA2G3 is involved in the regulation of cell signaling pathways, including the phospholipase A2 pathway, which is involved in the production of eicosanoids. 4. **Immune cell activation:** PLA2G3 is involved in the activation of immune cells, including macrophages and mast cells, which are essential for immune responses. **Clinical Significance:** 1. **Inflammatory disorders:** PLA2G3 is implicated in various inflammatory disorders, including asthma, rheumatoid arthritis, and inflammatory bowel disease. 2. **Cancer:** PLA2G3 is overexpressed in various types of cancer, including breast, lung, and pancreatic cancer. 3. **Neurodegenerative diseases:** PLA2G3 is implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Pharmacological targeting:** PLA2G3 is a potential therapeutic target for the treatment of inflammatory disorders and cancer. In conclusion, PLA2G3 is a critical enzyme in lipid metabolism and inflammatory response, and its dysregulation is implicated in various diseases. Further research is needed to understand the mechanisms of PLA2G3 regulation and its role in disease pathogenesis, and to develop therapeutic strategies targeting this enzyme.

Genular Protein ID: 2582127741

Symbol: PA2G3_HUMAN

Name: Group 3 secretory phospholipase A2

UniProtKB Accession Codes:

Q9NZ20 O95768

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 30 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 10 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10713052

Title: Novel human secreted phospholipase A2 with homology to the group III bee venom enzyme.

PubMed ID: 10713052

DOI: 10.1074/jbc.275.11.7492

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12522102

Title: Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII).

PubMed ID: 12522102

DOI: 10.1074/jbc.m211325200

PubMed ID: 15863501

Title: Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A(2).

PubMed ID: 15863501

DOI: 10.1074/jbc.m502088200

PubMed ID: 17868035

Title: Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival.

PubMed ID: 17868035

DOI: 10.1042/bj20070844

PubMed ID: 18801741

Title: Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.

PubMed ID: 18801741

DOI: 10.1074/jbc.m804628200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20393563

Title: Functional genomic screen for modulators of ciliogenesis and cilium length.

PubMed ID: 20393563

DOI: 10.1038/nature08895

PubMed ID: 23624557

Title: Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.

PubMed ID: 23624557

DOI: 10.1038/ni.2586

PubMed ID: 28947740

Title: Group III phospholipase A2 promotes colitis and colorectal cancer.

PubMed ID: 28947740

DOI: 10.1038/s41598-017-12434-z

Sequence Information:

  • Length: 509
  • Mass: 57167
  • Checksum: ED03BED129B0BC9F
  • Sequence:
    • MGVQAGLFGM LGFLGVALGG SPALRWYRTS CHLTKAVPGN PLGYLSFLAK DAQGLALIHA 
RWDAHRRLQS CSWEDEPELT AAYGALCAHE TAWGSFIHTP GPELQRALAT LQSQWEACRA 
LEESPAGARK KRAAGQSGVP GGGHQREKRG WTMPGTLWCG VGDSAGNSSE LGVFQGPDLC 
CREHDRCPQN ISPLQYNYGI RNYRFHTISH CDCDTRFQQC LQNQHDSISD IVGVAFFNVL 
EIPCFVLEEQ EACVAWYWWG GCRMYGTVPL ARLQPRTFYN ASWSSRATSP TPSSRSPAPP 
KPRQKQHLRK GPPHQKGSKR PSKANTTALQ DPMVSPRLDV APTGLQGPQG GLKPQGARWV 
CRSFRRHLDQ CEHQIGPREI EFQLLNSAQE PLFHCNCTRR LARFLRLHSP PEVTNMLWEL 
LGTTCFKLAP PLDCVEGKNC SRDPRAIRVS ARHLRRLQQR RHQLQDKGTD ERQPWPSEPL 
RGPMSFYNQC LQLTQAARRP DRQQKSWSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.