Details for: NOX3

Gene ID: 50508

Symbol: NOX3

Ensembl ID: ENSG00000074771

Description: NADPH oxidase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3420
    Cell Significance Index: 3.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2359
    Cell Significance Index: 5.7200
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1535
    Cell Significance Index: 1.5200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0985
    Cell Significance Index: 1.4400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0623
    Cell Significance Index: 1.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0519
    Cell Significance Index: 0.8900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0371
    Cell Significance Index: 0.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0354
    Cell Significance Index: 7.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0157
    Cell Significance Index: 0.4100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0140
    Cell Significance Index: 0.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0080
    Cell Significance Index: 0.5400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0065
    Cell Significance Index: 0.1300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0062
    Cell Significance Index: 0.0600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0057
    Cell Significance Index: 0.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0056
    Cell Significance Index: 0.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0039
    Cell Significance Index: 1.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0036
    Cell Significance Index: 0.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0016
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0019
    Cell Significance Index: -1.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0026
    Cell Significance Index: -1.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0027
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0029
    Cell Significance Index: -2.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0038
    Cell Significance Index: -2.1400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0046
    Cell Significance Index: -0.0500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0065
    Cell Significance Index: -1.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0068
    Cell Significance Index: -0.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0069
    Cell Significance Index: -0.1500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0095
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0102
    Cell Significance Index: -2.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0104
    Cell Significance Index: -1.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0120
    Cell Significance Index: -1.4800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0137
    Cell Significance Index: -0.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0146
    Cell Significance Index: -0.4100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0152
    Cell Significance Index: -0.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0161
    Cell Significance Index: -1.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0176
    Cell Significance Index: -0.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0182
    Cell Significance Index: -1.4000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0214
    Cell Significance Index: -0.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0236
    Cell Significance Index: -0.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0237
    Cell Significance Index: -0.6100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0247
    Cell Significance Index: -0.3000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0277
    Cell Significance Index: -0.2500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0285
    Cell Significance Index: -0.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0293
    Cell Significance Index: -0.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0308
    Cell Significance Index: -1.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0314
    Cell Significance Index: -1.3900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0322
    Cell Significance Index: -0.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0328
    Cell Significance Index: -0.6400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0339
    Cell Significance Index: -0.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0345
    Cell Significance Index: -1.2100
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0346
    Cell Significance Index: -0.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0349
    Cell Significance Index: -1.8200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0353
    Cell Significance Index: -0.4700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0367
    Cell Significance Index: -1.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0371
    Cell Significance Index: -0.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0379
    Cell Significance Index: -1.2400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0379
    Cell Significance Index: -0.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0383
    Cell Significance Index: -1.4500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0384
    Cell Significance Index: -0.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0389
    Cell Significance Index: -1.8300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0397
    Cell Significance Index: -0.5200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0402
    Cell Significance Index: -0.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0418
    Cell Significance Index: -1.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0420
    Cell Significance Index: -2.1200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0422
    Cell Significance Index: -1.0300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0427
    Cell Significance Index: -0.4300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0433
    Cell Significance Index: -0.3300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0441
    Cell Significance Index: -0.6700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0441
    Cell Significance Index: -0.6600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0450
    Cell Significance Index: -0.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0455
    Cell Significance Index: -1.5800
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0457
    Cell Significance Index: -0.4500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0460
    Cell Significance Index: -0.5800
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0460
    Cell Significance Index: -0.2800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0490
    Cell Significance Index: -0.6400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0501
    Cell Significance Index: -1.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0502
    Cell Significance Index: -1.4800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0513
    Cell Significance Index: -0.7300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0521
    Cell Significance Index: -0.7300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0542
    Cell Significance Index: -0.5800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0544
    Cell Significance Index: -1.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0547
    Cell Significance Index: -1.1600
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0552
    Cell Significance Index: -0.6800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0553
    Cell Significance Index: -1.3800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0559
    Cell Significance Index: -0.9400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0574
    Cell Significance Index: -1.2400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0575
    Cell Significance Index: -0.5000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0586
    Cell Significance Index: -0.5300
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0617
    Cell Significance Index: -0.7900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0624
    Cell Significance Index: -0.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0631
    Cell Significance Index: -1.8000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0643
    Cell Significance Index: -0.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0648
    Cell Significance Index: -1.7300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0653
    Cell Significance Index: -0.8800
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0663
    Cell Significance Index: -0.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NOX3 exhibits several distinct characteristics that set it apart from other NADPH oxidases: 1. **Low expression in immune cells**: NOX3 is predominantly expressed in non-immune cells, such as epithelial cells and mesangial cells, which suggests a distinct role in these cell types. 2. **Unique subunit composition**: The NOX3 enzyme is composed of a distinct subunit arrangement, which may influence its specific functions and interactions. 3. **High expression in non-immune tissues**: NOX3 is widely expressed in various non-immune tissues, including the lung, kidney, and brain, indicating its involvement in tissue homeostasis and development. **Pathways and Functions** NOX3 is involved in several cellular pathways, including: 1. **Immune responses**: NOX3 is expressed in immune cells and contributes to the production of ROS, which play a crucial role in immune cell activation and function. 2. **Cellular differentiation**: NOX3 is required for the differentiation of certain cell types, such as granulocytes and epithelial cells. 3. **Tissue homeostasis**: NOX3 is involved in maintaining tissue homeostasis by regulating ROS levels and promoting cellular differentiation and survival. 4. **Signaling pathways**: NOX3 interacts with various signaling pathways, including the Rac1 and Rho GTPase cycles, which regulate cellular functions such as migration, proliferation, and differentiation. **Clinical Significance** NOX3 has been implicated in various diseases and disorders, including: 1. **Atherosclerosis**: NOX3 has been linked to the development of atherosclerosis, a cardiovascular disease characterized by the buildup of plaque in arterial walls. 2. **Diabetes**: NOX3 has been implicated in the pathogenesis of type 2 diabetes, where it contributes to insulin resistance and oxidative stress. 3. **Neurodegenerative diseases**: NOX3 has been linked to neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, where it contributes to oxidative stress and neuronal damage. 4. **Cancer**: NOX3 has been implicated in the development and progression of certain cancers, including lung, breast, and prostate cancer. In conclusion, NOX3 is a multifaceted gene involved in various cellular processes, including immune responses, cellular differentiation, and tissue homeostasis. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of NOX3 in maintaining cellular and tissue homeostasis. Further research is necessary to fully elucidate the functions and clinical significance of NOX3.

Genular Protein ID: 4194176202

Symbol: NOX3_HUMAN

Name: NADPH oxidase 3

UniProtKB Accession Codes:

Q9HBY0 Q9HBJ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 6 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PeroxiBase 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 1 SFLD 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11376945

Title: Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.

PubMed ID: 11376945

DOI: 10.1016/s0378-1119(01)00449-8

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 10974555

Title: NADPH oxidase subunit, gp91phox homologue, preferentially expressed in human colon epithelial cells.

PubMed ID: 10974555

DOI: 10.1016/s0378-1119(00)00258-4

PubMed ID: 15181005

Title: Nox3 regulation by NOXO1, p47phox, and p67phox.

PubMed ID: 15181005

DOI: 10.1074/jbc.m400660200

PubMed ID: 15824103

Title: The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators.

PubMed ID: 15824103

DOI: 10.1074/jbc.m414548200

Sequence Information:

  • Length: 568
  • Mass: 64935
  • Checksum: 10BCD6BEB18D0583
  • Sequence:
    • MMGCWILNEG LSTILVLSWL GINFYLFIDT FYWYEEEESF HYTRVILGST LAWARASALC 
LNFNCMLILI PVSRNLISFI RGTSICCRGP WRRQLDKNLR FHKLVAYGIA VNATIHIVAH 
FFNLERYHWS QSEEAQGLLA ALSKLGNTPN ESYLNPVRTF PTNTTTELLR TIAGVTGLVI 
SLALVLIMTS STEFIRQASY ELFWYTHHVF IVFFLSLAIH GTGRIVRGQT QDSLSLHNIT 
FCRDRYAEWQ TVAQCPVPQF SGKEPSAWKW ILGPVVLYAC ERIIRFWRFQ QEVVITKVVS 
HPSGVLELHM KKRGFKMAPG QYILVQCPAI SSLEWHPFTL TSAPQEDFFS VHIRAAGDWT 
AALLEAFGAE GQALQEPWSL PRLAVDGPFG TALTDVFHYP VCVCVAAGIG VTPFAALLKS 
IWYKCSEAQT PLKLSKVYFY WICRDARAFE WFADLLLSLE TRMSEQGKTH FLSYHIFLTG 
WDENQALHIA LHWDENTDVI TGLKQKTFYG RPNWNNEFKQ IAYNHPSSSI GVFFCGPKAL 
SRTLQKMCHL YSSADPRGVH FYYNKESF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.