Details for: NEUROG3

Gene ID: 50674

Symbol: NEUROG3

Ensembl ID: ENSG00000122859

Description: neurogenin 3

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Regulation of beta-cell development
    (R-HSA-186712)
  • Regulation of gene expression in endocrine-committed (neurog3+) progenitor cells
    (R-HSA-210746)
  • Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
    (R-HSA-210744)
  • Axon development
    (GO:0061564)
  • Central nervous system development
    (GO:0007417)
  • Chromatin
    (GO:0000785)
  • Chromatin dna binding
    (GO:0031490)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • E-box binding
    (GO:0070888)
  • Epithelial cell differentiation
    (GO:0030855)
  • Forebrain development
    (GO:0030900)
  • Hindbrain development
    (GO:0030902)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nervous system development
    (GO:0007399)
  • Nucleus
    (GO:0005634)
  • Peripheral nervous system development
    (GO:0007422)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of dendrite morphogenesis
    (GO:0048814)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sensory organ development
    (GO:0007423)
  • Spinal cord development
    (GO:0021510)
  • Transdifferentiation
    (GO:0060290)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.2309
    Cell Significance Index: 198.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.9591
    Cell Significance Index: 94.7800
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 1.1732
    Cell Significance Index: 10.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9961
    Cell Significance Index: 189.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6562
    Cell Significance Index: 13.9800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6457
    Cell Significance Index: 10.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5117
    Cell Significance Index: 50.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4675
    Cell Significance Index: 422.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4542
    Cell Significance Index: 27.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4096
    Cell Significance Index: 44.5500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.3384
    Cell Significance Index: 4.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2987
    Cell Significance Index: 48.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2316
    Cell Significance Index: 16.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.1995
    Cell Significance Index: 42.0200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1681
    Cell Significance Index: 2.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1232
    Cell Significance Index: 14.3600
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.0644
    Cell Significance Index: 0.7100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0404
    Cell Significance Index: 1.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0196
    Cell Significance Index: 0.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0130
    Cell Significance Index: 0.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0121
    Cell Significance Index: 0.3500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0121
    Cell Significance Index: 0.1200
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.0094
    Cell Significance Index: 0.0400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0043
    Cell Significance Index: 0.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0042
    Cell Significance Index: 0.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0037
    Cell Significance Index: 0.0500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0014
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0002
    Cell Significance Index: 0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0010
    Cell Significance Index: -0.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0040
    Cell Significance Index: -0.0600
  • Cell Name: metallothionein-positive alveolar macrophage (CL4033042)
    Fold Change: -0.0053
    Cell Significance Index: -0.0300
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: -0.0055
    Cell Significance Index: -0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0139
    Cell Significance Index: -2.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0148
    Cell Significance Index: -2.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0171
    Cell Significance Index: -2.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0220
    Cell Significance Index: -2.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0227
    Cell Significance Index: -1.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0306
    Cell Significance Index: -0.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0331
    Cell Significance Index: -0.9000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0339
    Cell Significance Index: -0.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0389
    Cell Significance Index: -2.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0436
    Cell Significance Index: -2.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0531
    Cell Significance Index: -2.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0533
    Cell Significance Index: -2.9900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0546
    Cell Significance Index: -0.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0615
    Cell Significance Index: -1.7600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0628
    Cell Significance Index: -0.6800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0769
    Cell Significance Index: -0.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0825
    Cell Significance Index: -2.7000
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0827
    Cell Significance Index: -1.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0889
    Cell Significance Index: -2.3800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0901
    Cell Significance Index: -1.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0935
    Cell Significance Index: -2.9800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0943
    Cell Significance Index: -1.1700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0976
    Cell Significance Index: -1.0300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1044
    Cell Significance Index: -2.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1062
    Cell Significance Index: -3.1200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1143
    Cell Significance Index: -0.7900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1148
    Cell Significance Index: -0.8200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1161
    Cell Significance Index: -2.9000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1173
    Cell Significance Index: -2.3400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1206
    Cell Significance Index: -1.7800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1277
    Cell Significance Index: -1.9400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1299
    Cell Significance Index: -1.3800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1354
    Cell Significance Index: -1.8600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1363
    Cell Significance Index: -2.9500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1363
    Cell Significance Index: -1.8900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1382
    Cell Significance Index: -2.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1391
    Cell Significance Index: -2.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1418
    Cell Significance Index: -3.0100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1447
    Cell Significance Index: -3.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1469
    Cell Significance Index: -2.9500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1470
    Cell Significance Index: -1.3800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1483
    Cell Significance Index: -2.9000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1501
    Cell Significance Index: -2.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1520
    Cell Significance Index: -2.8100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1520
    Cell Significance Index: -2.6200
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1526
    Cell Significance Index: -1.3200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1537
    Cell Significance Index: -1.9200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1557
    Cell Significance Index: -1.9500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1561
    Cell Significance Index: -2.0200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1567
    Cell Significance Index: -2.5200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1574
    Cell Significance Index: -2.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1589
    Cell Significance Index: -2.6600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1602
    Cell Significance Index: -1.4800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1640
    Cell Significance Index: -2.0600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1642
    Cell Significance Index: -2.0800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1662
    Cell Significance Index: -2.3300
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1665
    Cell Significance Index: -1.7600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1682
    Cell Significance Index: -2.5200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1703
    Cell Significance Index: -2.9500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1706
    Cell Significance Index: -2.3900
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1718
    Cell Significance Index: -1.9800
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1734
    Cell Significance Index: -1.9400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1742
    Cell Significance Index: -2.0500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1812
    Cell Significance Index: -2.3700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1812
    Cell Significance Index: -2.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key characteristics** NEUROG3 exhibits several key characteristics that distinguish it from other transcription factors. These include: 1. **Specific tissue expression**: NEUROG3 is specifically expressed in progenitor cells of the pancreas, intestinal epithelium, and peripheral nervous system, suggesting its role in the development and differentiation of these tissues. 2. **Transcriptional activation**: NEUROG3 acts as a transcriptional activator, meaning it increases the expression of target genes that are essential for neuronal and endocrine differentiation. 3. **RNA polymerase II specificity**: NEUROG3 is specific for RNA polymerase II, suggesting its role in regulating the expression of genes that are transcribed by this enzyme. 4. **E-box binding**: NEUROG3 binds to E-box motifs, which are specific DNA sequences that are recognized by transcription factors that regulate the expression of neuronal and endocrine genes. **Pathways and functions** NEUROG3 is involved in several key pathways and functions, including: 1. **Axon development**: NEUROG3 is involved in the development of axons in the peripheral nervous system, regulating the expression of genes that are essential for axon growth and differentiation. 2. **Central nervous system development**: NEUROG3 is involved in the development of the central nervous system, regulating the expression of genes that are essential for neuronal differentiation and development. 3. **Endocrine development**: NEUROG3 is involved in the development of endocrine tissues, regulating the expression of genes that are essential for endocrine cell differentiation and function. 4. **Transdifferentiation**: NEUROG3 is involved in the transdifferentiation of progenitor cells into neuronal or endocrine cells, regulating the expression of genes that are essential for this process. **Clinical significance** The dysregulation of NEUROG3 has been implicated in several diseases, including: 1. **Type 2 diabetes**: NEUROG3 has been shown to play a role in the development of pancreatic beta cells, and its dysregulation has been implicated in the development of type 2 diabetes. 2. **Pancreatic cancer**: NEUROG3 has been shown to play a role in the development of pancreatic cancer, and its dysregulation has been implicated in the progression of this disease. 3. **Neurodevelopmental disorders**: NEUROG3 has been shown to play a role in the development of the central nervous system, and its dysregulation has been implicated in the development of neurodevelopmental disorders such as autism and schizophrenia. In conclusion, NEUROG3 is a transcription factor that plays a crucial role in the development and differentiation of various neural and endocrine tissues. Its dysregulation has been implicated in several diseases, and further research is needed to fully understand its role in human disease.

Genular Protein ID: 3300484274

Symbol: NGN3_HUMAN

Name: Neurogenin-3

UniProtKB Accession Codes:

Q9Y4Z2 Q5VVI0 Q6DJX6 Q9BY24

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16855267

Title: Mutant neurogenin-3 in congenital malabsorptive diarrhea.

PubMed ID: 16855267

DOI: 10.1056/nejmoa054288

Sequence Information:

  • Length: 214
  • Mass: 23077
  • Checksum: 2E80623E46F88B83
  • Sequence:
    • MTPQPSGAPT VQVTRETERS FPRASEDEVT CPTSAPPSPT RTRGNCAEAE EGGCRGAPRK 
LRARRGGRSR PKSELALSKQ RRSRRKKAND RERNRMHNLN SALDALRGVL PTFPDDAKLT 
KIETLRFAHN YIWALTQTLR IADHSLYALE PPAPHCGELG SPGGSPGDWG SLYSPVSQAG 
SLSPAASLEE RPGLLGATFS ACLSPGSLAF SDFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.