Details for: TAS2R1

Gene ID: 50834

Symbol: TAS2R1

Ensembl ID: ENSG00000169777

Description: taste 2 receptor member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 22.8593
    Cell Significance Index: 370.2400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 6.9218
    Cell Significance Index: 118.3200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.5685
    Cell Significance Index: 141.8800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 5.0101
    Cell Significance Index: 68.7100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.5990
    Cell Significance Index: 33.6300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.2031
    Cell Significance Index: 12.7800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3520
    Cell Significance Index: 5.1100
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.1534
    Cell Significance Index: 1.7900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0781
    Cell Significance Index: 1.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0772
    Cell Significance Index: 5.1900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0621
    Cell Significance Index: 1.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0601
    Cell Significance Index: 3.7900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0483
    Cell Significance Index: 0.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0284
    Cell Significance Index: 3.9000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0255
    Cell Significance Index: 0.3400
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.0182
    Cell Significance Index: 0.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0161
    Cell Significance Index: 0.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0149
    Cell Significance Index: 2.9700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0074
    Cell Significance Index: 0.0900
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.0038
    Cell Significance Index: 0.0400
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.0033
    Cell Significance Index: 0.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0001
    Cell Significance Index: 0.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0001
    Cell Significance Index: -0.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0006
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0017
    Cell Significance Index: -0.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0022
    Cell Significance Index: -0.6300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0028
    Cell Significance Index: -0.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0036
    Cell Significance Index: -0.1700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0038
    Cell Significance Index: -0.0300
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.0043
    Cell Significance Index: -0.0500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0051
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0057
    Cell Significance Index: -0.9700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0059
    Cell Significance Index: -0.0500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0071
    Cell Significance Index: -0.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0075
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0088
    Cell Significance Index: -1.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0093
    Cell Significance Index: -0.2000
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: -0.0116
    Cell Significance Index: -0.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0118
    Cell Significance Index: -1.2100
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0120
    Cell Significance Index: -0.1300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0124
    Cell Significance Index: -0.0900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0131
    Cell Significance Index: -0.1700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0156
    Cell Significance Index: -0.1200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0162
    Cell Significance Index: -0.1700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0164
    Cell Significance Index: -0.1700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0166
    Cell Significance Index: -0.1800
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0175
    Cell Significance Index: -0.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0179
    Cell Significance Index: -0.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0183
    Cell Significance Index: -0.9500
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.0183
    Cell Significance Index: -0.0400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0186
    Cell Significance Index: -0.2200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0198
    Cell Significance Index: -0.2900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0206
    Cell Significance Index: -0.2900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0206
    Cell Significance Index: -0.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0231
    Cell Significance Index: -0.5100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0235
    Cell Significance Index: -0.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0237
    Cell Significance Index: -1.3300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0263
    Cell Significance Index: -0.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0271
    Cell Significance Index: -0.9500
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0272
    Cell Significance Index: -0.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0273
    Cell Significance Index: -0.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0275
    Cell Significance Index: -0.9000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0281
    Cell Significance Index: -0.1800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0309
    Cell Significance Index: -0.7700
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0326
    Cell Significance Index: -0.3500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0348
    Cell Significance Index: -0.3300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0355
    Cell Significance Index: -0.3000
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0360
    Cell Significance Index: -0.4400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0375
    Cell Significance Index: -0.5000
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.0382
    Cell Significance Index: -0.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0390
    Cell Significance Index: -0.8300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0390
    Cell Significance Index: -0.4600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0399
    Cell Significance Index: -0.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0403
    Cell Significance Index: -0.4800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0410
    Cell Significance Index: -0.5400
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0414
    Cell Significance Index: -0.4500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0430
    Cell Significance Index: -0.9300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0434
    Cell Significance Index: -0.5000
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0435
    Cell Significance Index: -0.4500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0440
    Cell Significance Index: -0.5100
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0454
    Cell Significance Index: -0.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0456
    Cell Significance Index: -0.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0461
    Cell Significance Index: -1.2300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0474
    Cell Significance Index: -0.6200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0480
    Cell Significance Index: -0.9500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0485
    Cell Significance Index: -1.0100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0486
    Cell Significance Index: -0.4900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0492
    Cell Significance Index: -0.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0502
    Cell Significance Index: -1.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0506
    Cell Significance Index: -1.4500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0517
    Cell Significance Index: -1.0300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0518
    Cell Significance Index: -1.0200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0549
    Cell Significance Index: -1.3400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0550
    Cell Significance Index: -1.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0560
    Cell Significance Index: -0.6100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0571
    Cell Significance Index: -0.7700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0606
    Cell Significance Index: -0.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Bitter taste receptor**: TAS2R1 is a G protein-coupled receptor (GPCR) that binds to bitter compounds, triggering a signaling cascade that ultimately leads to the perception of bitterness. 2. **Metabotropic receptor**: TAS2R1 is a metabotropic receptor, meaning it uses a second messenger system to transmit signals rather than directly opening ion channels. 3. **High specificity**: TAS2R1 has high specificity for bitter compounds, allowing for the precise detection of these molecules in the mouth and throat. 4. **Dual signaling pathway**: TAS2R1 activates both the Gα(i) signaling pathway and the GPCR downstream signaling pathway, contributing to the complex signaling mechanisms involved in bitter taste perception. **Pathways and Functions** 1. **Gα(i) signaling pathway**: TAS2R1 activates the Gα(i) signaling pathway, which involves the activation of adenylyl cyclase and the production of cyclic AMP (cAMP). cAMP then activates protein kinase A (PKA), leading to the phosphorylation and activation of downstream targets. 2. **GPCR downstream signaling pathway**: TAS2R1 also activates the GPCR downstream signaling pathway, which involves the activation of phospholipase C (PLC) and the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). IP3 and DAG then activate protein kinase C (PKC), leading to the phosphorylation and activation of downstream targets. 3. **Taste perception**: TAS2R1 plays a critical role in the perception of bitter taste, allowing us to detect and avoid toxic compounds that are harmful to our health. **Clinical Significance** 1. **Bitter taste disorders**: Mutations in the TAS2R1 gene have been associated with bitter taste disorders, such as impaired bitter taste perception. 2. **Cancer risk**: Research suggests that individuals with impaired bitter taste perception may be at increased risk of developing certain types of cancer, such as oral and esophageal cancer. 3. **Dietary implications**: TAS2R1 plays a crucial role in the detection of bitter compounds in food, highlighting the importance of bitter taste perception in dietary choices and food safety. In conclusion, TAS2R1 is a vital component of our taste perception system, responsible for detecting bitter compounds and contributing to the complex signaling mechanisms involved in bitter taste perception. Further research into the TAS2R1 gene and its functions will provide valuable insights into the molecular mechanisms underlying taste perception and the clinical implications of impaired bitter taste perception.

Genular Protein ID: 3774922330

Symbol: TA2R1_HUMAN

Name: Taste receptor type 2 member 1

UniProtKB Accession Codes:

Q9NYW7 Q646G8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10761934

Title: A novel family of mammalian taste receptors.

PubMed ID: 10761934

DOI: 10.1016/s0092-8674(00)80705-9

PubMed ID: 15496549

Title: Evolution of bitter taste receptors in humans and apes.

PubMed ID: 15496549

DOI: 10.1093/molbev/msi027

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10761935

Title: T2Rs function as bitter taste receptors.

PubMed ID: 10761935

DOI: 10.1016/s0092-8674(00)80706-0

PubMed ID: 12139982

Title: Receptors for bitter and sweet taste.

PubMed ID: 12139982

DOI: 10.1016/s0959-4388(02)00345-8

PubMed ID: 11696554

Title: Molecular mechanisms of bitter and sweet taste transduction.

PubMed ID: 11696554

DOI: 10.1074/jbc.r100054200

PubMed ID: 12581520

Title: Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

PubMed ID: 12581520

DOI: 10.1016/s0092-8674(03)00071-0

Sequence Information:

  • Length: 299
  • Mass: 34333
  • Checksum: CFB17DD15645392C
  • Sequence:
    • MLESHLIIYF LLAVIQFLLG IFTNGIIVVV NGIDLIKHRK MAPLDLLLSC LAVSRIFLQL 
FIFYVNVIVI FFIEFIMCSA NCAILLFINE LELWLATWLG VFYCAKVASV RHPLFIWLKM 
RISKLVPWMI LGSLLYVSMI CVFHSKYAGF MVPYFLRKFF SQNATIQKED TLAIQIFSFV 
AEFSVPLLIF LFAVLLLIFS LGRHTRQMRN TVAGSRVPGR GAPISALLSI LSFLILYFSH 
CMIKVFLSSL KFHIRRFIFL FFILVIGIYP SGHSLILILG NPKLKQNAKK FLLHSKCCQ

Genular Protein ID: 1618933142

Symbol: Q502V6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q502V6

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 2 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 299
  • Mass: 34289
  • Checksum: 814BE11BFC206C27
  • Sequence:
    • MLESHLIIYF LLAVIQFLLG IFTNGIIVVV NGIDLIKHRK MAPLDLLLSC LAVSRIFLQL 
FIFYVNVIVI FFIEFIMCSA NCAILLFINE LELWLATWLG VFYCAKVASV RHPLFIWLKM 
RISKLVPWMI LGSLLYVSMI CVFHSKYAGF MVPCFLRKFF SQNATIQKED TLAIQIFSFV 
AEFSVPLLIF LFAVLLLIFS LGRHTWQMRN TVAGSRVPGR GAPISALLSI LSFLILYFSH 
CMIKVFLSSL KFHIRRFIFL FFILVIGVYP SGHSLILILG NPKLKQNAKK FLLHSKCCQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.