Details for: ABHD17B

Gene ID: 51104

Symbol: ABHD17B

Ensembl ID: ENSG00000107362

Description: abhydrolase domain containing 17B, depalmitoylase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 167.5397
    Cell Significance Index: -26.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 93.4383
    Cell Significance Index: -23.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.5498
    Cell Significance Index: -26.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4667
    Cell Significance Index: -25.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7840
    Cell Significance Index: -26.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.2446
    Cell Significance Index: -19.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.9569
    Cell Significance Index: -8.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.8030
    Cell Significance Index: 113.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5589
    Cell Significance Index: 80.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.3825
    Cell Significance Index: 16.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3153
    Cell Significance Index: 59.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1008
    Cell Significance Index: 993.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9906
    Cell Significance Index: 198.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9665
    Cell Significance Index: 191.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9502
    Cell Significance Index: 53.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8114
    Cell Significance Index: 48.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7697
    Cell Significance Index: 83.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7596
    Cell Significance Index: 49.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6430
    Cell Significance Index: 104.5800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6230
    Cell Significance Index: 10.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4654
    Cell Significance Index: 6.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4634
    Cell Significance Index: 10.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4096
    Cell Significance Index: 146.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3945
    Cell Significance Index: 27.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3939
    Cell Significance Index: 11.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3673
    Cell Significance Index: 66.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3211
    Cell Significance Index: 222.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3081
    Cell Significance Index: 18.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2930
    Cell Significance Index: 36.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2918
    Cell Significance Index: 7.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2799
    Cell Significance Index: 7.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2613
    Cell Significance Index: 20.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2272
    Cell Significance Index: 6.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2032
    Cell Significance Index: 13.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1780
    Cell Significance Index: 33.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1323
    Cell Significance Index: 72.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1180
    Cell Significance Index: 11.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1137
    Cell Significance Index: 3.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0832
    Cell Significance Index: 36.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0744
    Cell Significance Index: 2.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0593
    Cell Significance Index: 8.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0490
    Cell Significance Index: 0.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0490
    Cell Significance Index: 75.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0397
    Cell Significance Index: 73.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0187
    Cell Significance Index: 0.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0119
    Cell Significance Index: 0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0050
    Cell Significance Index: 3.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0037
    Cell Significance Index: 6.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0021
    Cell Significance Index: -0.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0052
    Cell Significance Index: -7.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0095
    Cell Significance Index: -4.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0127
    Cell Significance Index: -0.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0181
    Cell Significance Index: -0.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0291
    Cell Significance Index: -21.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0303
    Cell Significance Index: -22.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0317
    Cell Significance Index: -23.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0443
    Cell Significance Index: -24.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0446
    Cell Significance Index: -1.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0493
    Cell Significance Index: -7.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0502
    Cell Significance Index: -31.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0592
    Cell Significance Index: -1.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0756
    Cell Significance Index: -21.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0782
    Cell Significance Index: -5.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0913
    Cell Significance Index: -15.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0916
    Cell Significance Index: -10.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0950
    Cell Significance Index: -4.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1208
    Cell Significance Index: -15.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1307
    Cell Significance Index: -13.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1420
    Cell Significance Index: -16.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1430
    Cell Significance Index: -30.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1476
    Cell Significance Index: -7.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1597
    Cell Significance Index: -5.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1944
    Cell Significance Index: -5.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2034
    Cell Significance Index: -23.3000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2039
    Cell Significance Index: -3.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2176
    Cell Significance Index: -16.2200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2197
    Cell Significance Index: -5.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2226
    Cell Significance Index: -6.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2344
    Cell Significance Index: -5.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2431
    Cell Significance Index: -25.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2721
    Cell Significance Index: -12.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3023
    Cell Significance Index: -23.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3188
    Cell Significance Index: -6.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3507
    Cell Significance Index: -18.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3567
    Cell Significance Index: -21.8700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3573
    Cell Significance Index: -3.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3715
    Cell Significance Index: -10.6500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3965
    Cell Significance Index: -8.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4218
    Cell Significance Index: -7.0600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.4263
    Cell Significance Index: -2.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4265
    Cell Significance Index: -7.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4324
    Cell Significance Index: -13.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4371
    Cell Significance Index: -14.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4820
    Cell Significance Index: -10.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5155
    Cell Significance Index: -10.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5381
    Cell Significance Index: -14.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5549
    Cell Significance Index: -19.4400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5717
    Cell Significance Index: -6.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5755
    Cell Significance Index: -11.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5843
    Cell Significance Index: -15.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ABHD17B is a member of the ABHD (abhydrolase domain-containing) family of enzymes, which are involved in the regulation of protein localization and signaling pathways. The ABHD17B protein is a depalmitoylase, which means it catalyzes the removal of palmitoyl groups from proteins. This process is essential for the proper localization and function of proteins, as palmitoylation is a post-translational modification that can affect protein-protein interactions, protein stability, and protein localization. **Pathways and Functions:** ABHD17B is involved in several signaling pathways, including: 1. **Mapk1/mapk3 signaling**: ABHD17B regulates the MAPK signaling pathway, which is involved in cell proliferation, differentiation, and survival. 2. **Raf/map kinase cascade**: ABHD17B is involved in the regulation of the Raf MAPK signaling pathway, which is crucial for the activation of MAPK kinases. 3. **Ras processing**: ABHD17B regulates the processing of Ras proteins, which is essential for the activation of downstream signaling pathways. 4. **Protein localization to synapse**: ABHD17B regulates the localization of proteins to synapses, which is essential for the proper functioning of the nervous system. 5. **Regulation of dendritic spine maintenance**: ABHD17B regulates the maintenance of dendritic spines, which are critical structures for synaptic plasticity and learning. **Clinical Significance:** Dysregulation of ABHD17B has been implicated in various immune-related disorders, including: 1. **Immune cell dysfunction**: ABHD17B is essential for the proper functioning of immune cells, including T cells, B cells, and dendritic cells. Dysregulation of ABHD17B can lead to impaired immune cell function and increased susceptibility to infections. 2. **Autoimmune diseases**: ABHD17B has been implicated in the pathogenesis of autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. 3. **Cancer**: ABHD17B has been identified as a potential oncogene, and its dysregulation has been implicated in the development and progression of various cancers. 4. **Neurological disorders**: ABHD17B has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, ABHD17B is a critical regulator of protein localization and signaling pathways in immune cells. Its dysregulation has been implicated in various immune-related disorders, and further research is needed to fully understand the role of ABHD17B in human health and disease.

Genular Protein ID: 25404827

Symbol: AB17B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5VST6 A8KAJ5 Q5VST7 Q86YB6 Q8IY03 Q9Y377

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 EC 1 EMBL 7 ESTHER 1 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26701913

Title: ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization.

PubMed ID: 26701913

DOI: 10.7554/elife.11306

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 288
  • Mass: 32215
  • Checksum: F315AF711AF532BD
  • Sequence:
    • MNNLSFSELC CLFCCPPCPG KIASKLAFLP PDPTYTLMCD ESGSRWTLHL SERADWQYSS 
REKDAIECFM TRTSKGNRIA CMFVRCSPNA KYTLLFSHGN AVDLGQMSSF YIGLGSRINC 
NIFSYDYSGY GASSGKPTEK NLYADIEAAW LALRTRYGIR PENVIIYGQS IGTVPSVDLA 
ARYESAAVIL HSPLTSGMRV AFPDTKKTYC FDAFPNIDKI SKITSPVLII HGTEDEVIDF 
SHGLALFERC QRPVEPLWVE GAGHNDVELY GQYLERLKQF VSQELVNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.