Details for: CDK18

Gene ID: 5129

Symbol: CDK18

Ensembl ID: ENSG00000117266

Description: cyclin dependent kinase 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 108.0072
    Cell Significance Index: -16.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 63.1595
    Cell Significance Index: -16.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.2271
    Cell Significance Index: -13.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.5694
    Cell Significance Index: -13.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.6339
    Cell Significance Index: -16.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3870
    Cell Significance Index: -17.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.1451
    Cell Significance Index: 62.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.6914
    Cell Significance Index: 36.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7992
    Cell Significance Index: 38.9800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.4214
    Cell Significance Index: 17.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4164
    Cell Significance Index: 108.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0862
    Cell Significance Index: 31.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0386
    Cell Significance Index: 112.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7384
    Cell Significance Index: 86.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7331
    Cell Significance Index: 33.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7279
    Cell Significance Index: 37.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7074
    Cell Significance Index: 37.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5804
    Cell Significance Index: 16.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4935
    Cell Significance Index: 97.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4770
    Cell Significance Index: 95.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4350
    Cell Significance Index: 30.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3081
    Cell Significance Index: 55.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2714
    Cell Significance Index: 511.0800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2410
    Cell Significance Index: 5.0000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2319
    Cell Significance Index: 3.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2104
    Cell Significance Index: 4.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2012
    Cell Significance Index: 19.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1861
    Cell Significance Index: 6.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1718
    Cell Significance Index: 264.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1516
    Cell Significance Index: 7.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1408
    Cell Significance Index: 259.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1341
    Cell Significance Index: 85.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1191
    Cell Significance Index: 65.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1102
    Cell Significance Index: 13.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1077
    Cell Significance Index: 38.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0936
    Cell Significance Index: 2.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0694
    Cell Significance Index: 1.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0652
    Cell Significance Index: 12.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0452
    Cell Significance Index: 31.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0419
    Cell Significance Index: 57.0200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0406
    Cell Significance Index: 0.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0391
    Cell Significance Index: 35.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0079
    Cell Significance Index: 1.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0026
    Cell Significance Index: -0.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0065
    Cell Significance Index: -2.8600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0112
    Cell Significance Index: -0.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0167
    Cell Significance Index: -7.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0167
    Cell Significance Index: -12.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0181
    Cell Significance Index: -13.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0241
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0242
    Cell Significance Index: -17.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0316
    Cell Significance Index: -17.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0321
    Cell Significance Index: -20.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0461
    Cell Significance Index: -13.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0464
    Cell Significance Index: -0.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0608
    Cell Significance Index: -7.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0618
    Cell Significance Index: -8.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0770
    Cell Significance Index: -4.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0786
    Cell Significance Index: -9.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0819
    Cell Significance Index: -10.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0903
    Cell Significance Index: -19.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1214
    Cell Significance Index: -12.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1392
    Cell Significance Index: -6.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1413
    Cell Significance Index: -7.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1442
    Cell Significance Index: -4.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1464
    Cell Significance Index: -17.2600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1531
    Cell Significance Index: -1.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1593
    Cell Significance Index: -4.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1650
    Cell Significance Index: -4.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1679
    Cell Significance Index: -11.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1809
    Cell Significance Index: -10.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1826
    Cell Significance Index: -14.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1877
    Cell Significance Index: -13.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1940
    Cell Significance Index: -13.7200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2208
    Cell Significance Index: -9.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2217
    Cell Significance Index: -13.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2224
    Cell Significance Index: -13.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2337
    Cell Significance Index: -14.7300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2381
    Cell Significance Index: -2.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2641
    Cell Significance Index: -4.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3140
    Cell Significance Index: -8.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3152
    Cell Significance Index: -13.9400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3166
    Cell Significance Index: -4.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3255
    Cell Significance Index: -11.3100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3319
    Cell Significance Index: -5.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3497
    Cell Significance Index: -17.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3541
    Cell Significance Index: -13.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3577
    Cell Significance Index: -11.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3777
    Cell Significance Index: -13.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3820
    Cell Significance Index: -7.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3846
    Cell Significance Index: -10.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3925
    Cell Significance Index: -11.5600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4137
    Cell Significance Index: -10.3200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.4367
    Cell Significance Index: -3.3600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4379
    Cell Significance Index: -13.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4387
    Cell Significance Index: -12.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4402
    Cell Significance Index: -16.1600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4430
    Cell Significance Index: -7.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4485
    Cell Significance Index: -9.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDK18 is a member of the cyclin-dependent kinase (CDK) family, which plays a crucial role in regulating the cell cycle. Unlike other CDKs, CDK18 lacks a known cyclin binding partner, suggesting that its mechanism of action may differ from other CDKs. Notably, CDK18 is predominantly expressed in the cytoplasm and nucleus, where it may interact with various proteins to regulate cellular processes. Its expression in various tissues suggests that CDK18 may play a role in maintaining tissue homeostasis and regulating cellular differentiation. **Pathways and Functions:** The pathways and functions of CDK18 are not yet fully elucidated. However, based on its expression profile and functional characteristics, several potential pathways can be inferred: 1. **Cell cycle regulation:** CDK18 may play a role in regulating the cell cycle, particularly in the G2/M phase. Its expression in cardiac myocytes and lens epithelial cells suggests that CDK18 may be involved in maintaining tissue-specific cell cycle checkpoints. 2. **Protein phosphorylation:** CDK18 may phosphorylate various proteins, including transcription factors, kinases, and phosphatases, to regulate their activity and cellular processes. 3. **Apoptosis regulation:** CDK18 may also play a role in regulating apoptosis, particularly in response to DNA damage or other forms of cellular stress. **Clinical Significance:** The clinical significance of CDK18 is an area of active research. While its expression in various tissues suggests that CDK18 may play a role in maintaining tissue homeostasis, its dysregulation may contribute to various diseases, including: 1. **Cardiac arrhythmias:** CDK18's expression in cardiac myocytes suggests that it may play a role in regulating cardiac rhythm. Dysregulation of CDK18 may contribute to cardiac arrhythmias, such as atrial fibrillation. 2. **Cataract formation:** CDK18's expression in lens epithelial cells suggests that it may play a role in maintaining lens transparency. Dysregulation of CDK18 may contribute to cataract formation. 3. **Neurodegenerative diseases:** CDK18's expression in oligodendrocytes and other neuronal cells suggests that it may play a role in regulating neuronal function and survival. Dysregulation of CDK18 may contribute to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, CDK18 is a mysterious gene with widespread expression in various tissues. While its functional significance remains unknown, its potential role in regulating cell cycle, protein phosphorylation, and apoptosis suggests that it may contribute to various diseases. Further research is needed to elucidate the mechanisms of CDK18 and its clinical significance.

Genular Protein ID: 3550623284

Symbol: CDK18_HUMAN

Name: Cyclin-dependent kinase 18

UniProtKB Accession Codes:

Q07002 Q5VXQ2 Q6V3A2 Q6V3A3 Q96F90

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 3 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 5 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15019984

Title: Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain.

PubMed ID: 15019984

DOI: 10.1016/j.gene.2003.12.011

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1639063

Title: A family of human cdc2-related protein kinases.

PubMed ID: 1639063

DOI: 10.1002/j.1460-2075.1992.tb05360.x

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 474
  • Mass: 54424
  • Checksum: 43C83A573A595476
  • Sequence:
    • MIMNKMKNFK RRFSLSVPRT ETIEESLAEF TEQFNQLHNR RNENLQLGPL GRDPPQECST 
FSPTDSGEEP GQLSPGVQFQ RRQNQRRFSM EDVSKRLSLP MDIRLPQEFL QKLQMESPDL 
PKPLSRMSRR ASLSDIGFGK LETYVKLDKL GEGTYATVFK GRSKLTENLV ALKEIRLEHE 
EGAPCTAIRE VSLLKNLKHA NIVTLHDLIH TDRSLTLVFE YLDSDLKQYL DHCGNLMSMH 
NVKIFMFQLL RGLAYCHHRK ILHRDLKPQN LLINERGELK LADFGLARAK SVPTKTYSNE 
VVTLWYRPPD VLLGSTEYST PIDMWGVGCI HYEMATGRPL FPGSTVKEEL HLIFRLLGTP 
TEETWPGVTA FSEFRTYSFP CYLPQPLINH APRLDTDGIH LLSSLLLYES KSRMSAEAAL 
SHSYFRSLGE RVHQLEDTAS IFSLKEIQLQ KDPGYRGLAF QQPGRGKNRR QSIF

Genular Protein ID: 589185307

Symbol: Q59G02_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59G02

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 3 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 436
  • Mass: 49724
  • Checksum: C0FE7D1195AEF106
  • Sequence:
    • RLSLLDLQLG PLGRDPPQEC STFSPTDSGE EPGQLSPGVQ FQRRQNQRRF SMEDVSKRLS 
LPMDIRLPQE FLQKLQMESP DLPKPLSRMS RRASLSDIGF GKLETYVKLD KLGEGTYATV 
FKGRSKLTEN LVALKEIRLE HEEGAPCTAI REVSLLKNLK HANIVTLHDL IHTDRSLTLV 
FEYLDSDLKQ YLDHCGNLMS MHNVKIFMFQ LLRGLAYCHH RKILHRDLKP QNLLINERGE 
LKLADFGLAR AKSVPTKTYS NEVVTLWYRP PDVLLGSTEY STPIDMWGVG CIHYEMATGR 
PLFPGSTVKE ELHLIFRLLG TPTEETWPGV TAFSEFRTYS FPCYLPQPLI NHAPRLDTDG 
IHLLSSLLLY ESKSRMSAEA ALSHSYFRSL GERVHQLEDT ASIFSLKEIQ LQKDPGYRGL 
AFQQPGRGKN RRQSIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.