Details for: TLR8

Gene ID: 51311

Symbol: TLR8

Ensembl ID: ENSG00000101916

Description: toll like receptor 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 29.1234
    Cell Significance Index: -4.5300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 8.2623
    Cell Significance Index: -4.2500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 5.0012
    Cell Significance Index: 72.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.6741
    Cell Significance Index: -4.5300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.0967
    Cell Significance Index: 47.9100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6769
    Cell Significance Index: 12.5100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0160
    Cell Significance Index: 0.1300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0037
    Cell Significance Index: 0.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0013
    Cell Significance Index: -0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0035
    Cell Significance Index: -6.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0042
    Cell Significance Index: -6.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0045
    Cell Significance Index: -0.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0049
    Cell Significance Index: -6.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0055
    Cell Significance Index: -3.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0059
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0099
    Cell Significance Index: -4.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0125
    Cell Significance Index: -3.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0191
    Cell Significance Index: -3.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0202
    Cell Significance Index: -3.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0229
    Cell Significance Index: -4.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0233
    Cell Significance Index: -4.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0260
    Cell Significance Index: -3.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0275
    Cell Significance Index: -4.7000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0276
    Cell Significance Index: -1.2000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0311
    Cell Significance Index: -0.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0313
    Cell Significance Index: -3.8500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0324
    Cell Significance Index: -0.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0343
    Cell Significance Index: -4.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0364
    Cell Significance Index: -4.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0406
    Cell Significance Index: -4.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0433
    Cell Significance Index: -4.5100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0521
    Cell Significance Index: -0.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0620
    Cell Significance Index: -3.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0639
    Cell Significance Index: -4.1300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0662
    Cell Significance Index: -1.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0678
    Cell Significance Index: -3.1900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0681
    Cell Significance Index: -0.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0692
    Cell Significance Index: -5.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0726
    Cell Significance Index: -4.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0780
    Cell Significance Index: -4.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0802
    Cell Significance Index: -5.3900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0875
    Cell Significance Index: -1.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0900
    Cell Significance Index: -2.4500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0905
    Cell Significance Index: -1.0700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1079
    Cell Significance Index: -2.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1101
    Cell Significance Index: -5.7200
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1104
    Cell Significance Index: -1.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1118
    Cell Significance Index: -2.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1119
    Cell Significance Index: -5.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1284
    Cell Significance Index: -5.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1324
    Cell Significance Index: -3.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1342
    Cell Significance Index: -4.7000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1438
    Cell Significance Index: -2.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1440
    Cell Significance Index: -4.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1457
    Cell Significance Index: -4.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1468
    Cell Significance Index: -5.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1471
    Cell Significance Index: -5.4000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1482
    Cell Significance Index: -2.0800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1500
    Cell Significance Index: -1.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1538
    Cell Significance Index: -4.9000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1548
    Cell Significance Index: -1.5800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1633
    Cell Significance Index: -1.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1702
    Cell Significance Index: -4.5600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1703
    Cell Significance Index: -4.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1714
    Cell Significance Index: -2.4600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1775
    Cell Significance Index: -2.4300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1776
    Cell Significance Index: -4.4300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1803
    Cell Significance Index: -2.9200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1803
    Cell Significance Index: -3.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1824
    Cell Significance Index: -4.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1855
    Cell Significance Index: -4.7400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1898
    Cell Significance Index: -5.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1902
    Cell Significance Index: -4.1700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1903
    Cell Significance Index: -1.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1935
    Cell Significance Index: -4.6400
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.1948
    Cell Significance Index: -1.8200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1974
    Cell Significance Index: -4.9300
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.2000
    Cell Significance Index: -2.3800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2010
    Cell Significance Index: -2.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2016
    Cell Significance Index: -5.0300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2040
    Cell Significance Index: -2.6400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2070
    Cell Significance Index: -2.4400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2086
    Cell Significance Index: -2.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2158
    Cell Significance Index: -4.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2170
    Cell Significance Index: -6.2200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2170
    Cell Significance Index: -2.3800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2186
    Cell Significance Index: -2.5700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2188
    Cell Significance Index: -3.5100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2199
    Cell Significance Index: -2.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2222
    Cell Significance Index: -4.8000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2257
    Cell Significance Index: -4.7100
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2276
    Cell Significance Index: -1.9900
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2281
    Cell Significance Index: -2.5200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2296
    Cell Significance Index: -4.6100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2331
    Cell Significance Index: -4.6100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2343
    Cell Significance Index: -2.9600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2384
    Cell Significance Index: -4.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2406
    Cell Significance Index: -4.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TLR8 exhibits several key characteristics that enable it to recognize viral infections: 1. **Recognition of ssRNA viruses**: TLR8 is specifically activated by ssRNA viruses, including SARS-CoV-2. 2. **Expression on various cell types**: TLR8 is expressed on myeloid leukocytes, epithelial cells, and immune cells, allowing it to recognize viral infections from multiple cell types. 3. **Activation of NF-κB**: TLR8 signaling leads to the activation of NF-κB, a transcription factor that regulates the expression of pro-inflammatory cytokines. 4. **Pro-inflammatory cytokine production**: TLR8 activation results in the production of pro-inflammatory cytokines, including IL-6, IL-8, and TNF-α, which modulate the immune response. **Pathways and Functions** The TLR8 signaling pathway involves several key steps: 1. **Ligand recognition**: TLR8 recognizes ssRNA viruses, leading to the activation of the receptor. 2. **Activation of NF-κB**: The activation of NF-κB is a critical step in the TLR8 signaling pathway, as it regulates the expression of pro-inflammatory cytokines. 3. **Production of pro-inflammatory cytokines**: The activation of NF-κB leads to the production of pro-inflammatory cytokines, which modulate the immune response. 4. **Innate immune response**: TLR8 activation triggers an innate immune response, which involves the production of pro-inflammatory cytokines and the activation of immune cells. **Clinical Significance** TLR8 plays a critical role in the recognition of viral infections, including SARS-CoV-2. Its activation leads to the production of pro-inflammatory cytokines, which modulate the immune response. The clinical significance of TLR8 lies in its potential as a therapeutic target for the treatment of viral infections. Additionally, its expression on various cell types makes it a potential target for the development of vaccines and immunotherapies. In conclusion, TLR8 is a critical Toll-Like Receptor that plays a pivotal role in the recognition of viral infections. Its activation leads to the production of pro-inflammatory cytokines, which modulate the immune response. The clinical significance of TLR8 lies in its potential as a therapeutic target for the treatment of viral infections, and its expression on various cell types makes it a potential target for the development of vaccines and immunotherapies. **References** * [Insert references to relevant studies and publications on TLR8] **Future Directions** Future research should focus on the following areas: 1. **Characterization of TLR8 expression and function**: Further studies are needed to fully understand the expression and function of TLR8 on various cell types. 2. **Investigation of TLR8 as a therapeutic target**: Research should be conducted to investigate the potential of TLR8 as a therapeutic target for the treatment of viral infections. 3. **Development of vaccines and immunotherapies**: The expression of TLR8 on various cell types makes it a potential target for the development of vaccines and immunotherapies. By continued research in these areas, we can better understand the role of TLR8 in the recognition of viral infections and develop effective therapeutic strategies to combat viral diseases.

Genular Protein ID: 774377800

Symbol: TLR8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NR97 B3Y654 D1CS70 D1CS76 Q495P4 Q6UXL6 Q9NYG9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 19 Ensembl 2 EvolutionaryTrace 1 GO 32 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 36 PDBsum 36 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 4 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11022119

Title: Three novel mammalian Toll-like receptors: gene structure, expression, and evolution.

PubMed ID: 11022119

PubMed ID: 11022120

Title: Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9.

PubMed ID: 11022120

PubMed ID: 18810425

Title: Natural selection in the TLR-related genes in the course of primate evolution.

PubMed ID: 18810425

DOI: 10.1007/s00251-008-0332-0

PubMed ID: 19924287

Title: The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes.

PubMed ID: 19924287

DOI: 10.1371/journal.pone.0007803

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16737960

Title: TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and MEKK3-dependent.

PubMed ID: 16737960

DOI: 10.1074/jbc.m512908200

PubMed ID: 17932028

Title: Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.

PubMed ID: 17932028

DOI: 10.1074/jbc.m707682200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 25297876

Title: Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells.

PubMed ID: 25297876

DOI: 10.4049/jimmunol.1401375

PubMed ID: 31385713

Title: Toll-Like Receptor 8 Stability is Regulated by Ring Finger 216 in response to circulating MicroRNAs.

PubMed ID: 31385713

DOI: 10.1165/rcmb.2018-0373oc

PubMed ID: 31778653

Title: TLR8 Is a Sensor of RNase T2 Degradation Products.

PubMed ID: 31778653

DOI: 10.1016/j.cell.2019.11.001

PubMed ID: 32433612

Title: TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.

PubMed ID: 32433612

DOI: 10.1038/s41586-020-2282-0

PubMed ID: 33718825

Title: SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway.

PubMed ID: 33718825

DOI: 10.1016/j.isci.2021.102295

PubMed ID: 23520111

Title: Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands.

PubMed ID: 23520111

DOI: 10.1126/science.1229159

PubMed ID: 25599397

Title: Toll-like receptor 8 senses degradation products of single-stranded RNA.

PubMed ID: 25599397

DOI: 10.1038/nsmb.2943

PubMed ID: 26929371

Title: Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8.

PubMed ID: 26929371

DOI: 10.1073/pnas.1516000113

PubMed ID: 29155428

Title: Small-molecule inhibition of TLR8 through stabilization of its resting state.

PubMed ID: 29155428

DOI: 10.1038/nchembio.2518

PubMed ID: 33512449

Title: Immunodeficiency and bone marrow failure with mosaic and germline TLR8 gain of function.

PubMed ID: 33512449

DOI: 10.1182/blood.2020009620

PubMed ID: 34981838

Title: TLR8/TLR7 dysregulation due to a novel TLR8 mutation causes severe autoimmune hemolytic anemia and autoinflammation in identical twins.

PubMed ID: 34981838

DOI: 10.1002/ajh.26452

Sequence Information:

  • Length: 1041
  • Mass: 119828
  • Checksum: 39A38B60629291C8
  • Sequence:
    • MENMFLQSSM LTCIFLLISG SCELCAEENF SRSYPCDEKK QNDSVIAECS NRRLQEVPQT 
VGKYVTELDL SDNFITHITN ESFQGLQNLT KINLNHNPNV QHQNGNPGIQ SNGLNITDGA 
FLNLKNLREL LLEDNQLPQI PSGLPESLTE LSLIQNNIYN ITKEGISRLI NLKNLYLAWN 
CYFNKVCEKT NIEDGVFETL TNLELLSLSF NSLSHVPPKL PSSLRKLFLS NTQIKYISEE 
DFKGLINLTL LDLSGNCPRC FNAPFPCVPC DGGASINIDR FAFQNLTQLR YLNLSSTSLR 
KINAAWFKNM PHLKVLDLEF NYLVGEIASG AFLTMLPRLE ILDLSFNYIK GSYPQHINIS 
RNFSKLLSLR ALHLRGYVFQ ELREDDFQPL MQLPNLSTIN LGINFIKQID FKLFQNFSNL 
EIIYLSENRI SPLVKDTRQS YANSSSFQRH IRKRRSTDFE FDPHSNFYHF TRPLIKPQCA 
AYGKALDLSL NSIFFIGPNQ FENLPDIACL NLSANSNAQV LSGTEFSAIP HVKYLDLTNN 
RLDFDNASAL TELSDLEVLD LSYNSHYFRI AGVTHHLEFI QNFTNLKVLN LSHNNIYTLT 
DKYNLESKSL VELVFSGNRL DILWNDDDNR YISIFKGLKN LTRLDLSLNR LKHIPNEAFL 
NLPASLTELH INDNMLKFFN WTLLQQFPRL ELLDLRGNKL LFLTDSLSDF TSSLRTLLLS 
HNRISHLPSG FLSEVSSLKH LDLSSNLLKT INKSALETKT TTKLSMLELH GNPFECTCDI 
GDFRRWMDEH LNVKIPRLVD VICASPGDQR GKSIVSLELT TCVSDVTAVI LFFFTFFITT 
MVMLAALAHH LFYWDVWFIY NVCLAKVKGY RSLSTSQTFY DAYISYDTKD ASVTDWVINE 
LRYHLEESRD KNVLLCLEER DWDPGLAIID NLMQSINQSK KTVFVLTKKY AKSWNFKTAF 
YLALQRLMDE NMDVIIFILL EPVLQHSQYL RLRQRICKSS ILQWPDNPKA EGLFWQTLRN 
VVLTENDSRY NNMYVDSIKQ Y

Genular Protein ID: 13196698

Symbol: A0AA49X8T4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0AA49X8T4

Database IDs:

ARBA 10 CTD 1 EMBL 2 GO 5 Gene3D 2 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PROSITE 3 Pfam 2 RefSeq 3 SAM 1 SMART 4 SMR 1 SUPFAM 3

Sequence Information:

  • Length: 1059
  • Mass: 121764
  • Checksum: 27803D560E09D7BF
  • Sequence:
    • MKESSLQNSS CSLGKETKKE NMFLQSSMLT CIFLLISGSC ELCAEENFSR SYPCDEKKQN 
DSVIAECSNR RLQEVPQTVG KYVTELDLSD NFITHITNES FQGLQNLTKI NLNHNPNVQH 
QNGNPGIQSN GLNITDGAFL NLKNLRELLL EDNQLPQIPS GLPESLTELS LIQNNIYNIT 
KEGISRLINL KNLYLAWNCY FNKVCEKTNI EDGVFETLTN LELLSLSFNS LSHVPPKLPS 
SLRKLFLSNT QIKYISEEDF KGLINLTLLD LSGNCPRCFN APFPCVPCDG GASINIDRFA 
FQNLTQLRYL NLSSTSLRKI NAAWFKNMPH LKVLDLEFNY LVGEIASGAF LTMLPRLEIL 
DLSFNYIKGS YPQHINISRN FSKLLSLRAL HLRGYVFQEL REDDFQPLMQ LPNLSTINLG 
INFIKQIDFK LFQNFSNLEI IYLSENRISP LVKDTRQSYA NSSSFQRHIR KRRSTDFEFD 
PHSNFYHFTR PLIKPQCAAY GKALDLSLNS IFFIGPNQFE NLPDIACLNL SANSNAQVLS 
GTEFSAIPHV KYLDLTNNRL DFDNASALTE LSDLEVLDLS YNSHYFRIAG VTHHLEFIQN 
FTNLKVLNLS HNNIYTLTDK YNLESKSLVE LVFSGNRLDI LWNDDDNRYI SIFKGLKNLT 
RLDLSLNRLK HIPNEAFLNL PASLTELHIN DNMLKFFNWT LLQQFPRLEL LDLRGNKLLF 
LTDSLSDFTS SLRTLLLSHN RISHLPSGFL SEVSSLKHLD LSSNLLKTIN KSALETKTTT 
KLSMLELHGN PFECTCDIGD FRRWMDEHLN VKIPRLVDVI CASPGDQRGK SIVSLELTTC 
VSDVTAVILF FFTFFITTMV MLAALAHHLF YWDVWFIYNV CLAKVKGYRS LSTSQTFYDA 
YISYDTKDAS VTDWVINELR YHLEESRDKN VLLCLEERDW DPGLAIIDNL MQSINQSKKT 
VFVLTKKYAK SWNFKTAFYL ALQRLMDENM DVIIFILLEP VLQHSQYLRL RQRICKSSIL 
QWPDNPKAEG LFWQTLRNVV LTENDSRYNN MYVDSIKQY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.