Details for: CABP2

Gene ID: 51475

Symbol: CABP2

Ensembl ID: ENSG00000167791

Description: calcium binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 17.9591
    Cell Significance Index: 457.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 6.9435
    Cell Significance Index: 53.5200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 4.5247
    Cell Significance Index: 63.5500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.8429
    Cell Significance Index: 62.2400
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 3.5966
    Cell Significance Index: 20.1700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.6573
    Cell Significance Index: 36.4400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.4793
    Cell Significance Index: 42.3800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.4622
    Cell Significance Index: 31.8600
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.4350
    Cell Significance Index: 18.8900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.3461
    Cell Significance Index: 14.3000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.6119
    Cell Significance Index: 5.3900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.5296
    Cell Significance Index: 6.4200
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: 0.1995
    Cell Significance Index: 2.4500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.1801
    Cell Significance Index: 2.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0810
    Cell Significance Index: 1.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0749
    Cell Significance Index: 4.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0168
    Cell Significance Index: 0.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0150
    Cell Significance Index: 0.7900
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: 0.0093
    Cell Significance Index: 0.1200
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: 0.0048
    Cell Significance Index: 0.0600
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0007
    Cell Significance Index: -0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0048
    Cell Significance Index: -2.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0054
    Cell Significance Index: -2.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0055
    Cell Significance Index: -0.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0062
    Cell Significance Index: -0.3500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0091
    Cell Significance Index: -0.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0092
    Cell Significance Index: -1.8400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0094
    Cell Significance Index: -0.2000
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: giant bipolar cell (CL4033035)
    Fold Change: -0.0111
    Cell Significance Index: -0.1300
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0116
    Cell Significance Index: -0.1300
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0124
    Cell Significance Index: -0.1200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0130
    Cell Significance Index: -0.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0153
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0159
    Cell Significance Index: -2.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0165
    Cell Significance Index: -2.9700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0170
    Cell Significance Index: -0.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0208
    Cell Significance Index: -3.0300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0209
    Cell Significance Index: -0.1100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0229
    Cell Significance Index: -0.2700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0230
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0235
    Cell Significance Index: -2.6900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0236
    Cell Significance Index: -0.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0242
    Cell Significance Index: -2.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0246
    Cell Significance Index: -0.3400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0248
    Cell Significance Index: -0.3600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0249
    Cell Significance Index: -0.4300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0251
    Cell Significance Index: -0.3600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0257
    Cell Significance Index: -0.3000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0282
    Cell Significance Index: -0.3800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0288
    Cell Significance Index: -0.4100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0304
    Cell Significance Index: -0.3900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0304
    Cell Significance Index: -0.3700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0315
    Cell Significance Index: -0.3300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0323
    Cell Significance Index: -0.3200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0326
    Cell Significance Index: -0.4200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0334
    Cell Significance Index: -0.4200
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.0345
    Cell Significance Index: -0.2500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0348
    Cell Significance Index: -0.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0357
    Cell Significance Index: -2.4000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0372
    Cell Significance Index: -0.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0383
    Cell Significance Index: -0.5700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0394
    Cell Significance Index: -0.3700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0400
    Cell Significance Index: -0.4600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0415
    Cell Significance Index: -0.4600
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0489
    Cell Significance Index: -0.3800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0495
    Cell Significance Index: -0.3100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0503
    Cell Significance Index: -0.4400
  • Cell Name: motor neuron (CL0000100)
    Fold Change: -0.0528
    Cell Significance Index: -0.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0538
    Cell Significance Index: -2.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0559
    Cell Significance Index: -1.7800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0560
    Cell Significance Index: -0.7000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0563
    Cell Significance Index: -0.7100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0597
    Cell Significance Index: -0.6500
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0599
    Cell Significance Index: -0.3700
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0602
    Cell Significance Index: -0.6600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0609
    Cell Significance Index: -0.7600
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0618
    Cell Significance Index: -0.4600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0627
    Cell Significance Index: -0.6600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0628
    Cell Significance Index: -0.6800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0630
    Cell Significance Index: -0.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0631
    Cell Significance Index: -2.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0654
    Cell Significance Index: -2.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0671
    Cell Significance Index: -3.0400
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0682
    Cell Significance Index: -0.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0699
    Cell Significance Index: -2.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0718
    Cell Significance Index: -1.7900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0762
    Cell Significance Index: -1.5200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0782
    Cell Significance Index: -1.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0838
    Cell Significance Index: -2.3900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0840
    Cell Significance Index: -0.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0873
    Cell Significance Index: -3.0400
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0883
    Cell Significance Index: -1.1000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0886
    Cell Significance Index: -1.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0919
    Cell Significance Index: -1.9500
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0924
    Cell Significance Index: -1.1600
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0941
    Cell Significance Index: -1.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CABP2 is a calcium-binding protein that interacts with calcium ions, influencing various cellular processes. Its expression is widespread, with significant levels detected in erythrocytes, photoreceptor cells, and neurons. The protein is involved in regulating calcium channels and modulating sensory perception, particularly in the context of sound processing and visual perception. Its involvement in calcium regulation and signal transduction pathways underscores its potential role in maintaining cellular homeostasis. **Pathways and Functions:** CABP2 is involved in several signaling pathways, including: 1. **Calcium channel regulation:** CABP2 interacts with calcium channels, modulating their activity and influencing calcium influx into cells. 2. **Sensory perception:** CABP2 plays a critical role in sensory processing, particularly in the context of sound and visual perception, by regulating calcium channels and modulating signal transduction pathways. 3. **Signal transduction:** CABP2 is involved in signal transduction pathways, influencing cellular responses to various stimuli. 4. **Cellular homeostasis:** CABP2 helps maintain cellular homeostasis by regulating calcium levels and modulating signaling pathways. **Clinical Significance:** CABP2 has significant implications for various neurological and auditory disorders, including: 1. **Hearing loss:** Alterations in CABP2 expression or function may contribute to hearing loss, particularly in the context of sound processing and auditory neuropathy. 2. **Visual disorders:** CABP2 may play a role in visual perception and processing disorders, such as retinitis pigmentosa or age-related macular degeneration. 3. **Neurological disorders:** CABP2 may be involved in various neurological disorders, including epilepsy, Parkinson's disease, and Alzheimer's disease, due to its role in calcium regulation and signal transduction pathways. 4. **Therapeutic potential:** Understanding the functional significance of CABP2 may lead to the development of novel therapeutic strategies targeting its regulation or function, offering new avenues for treating neurological and auditory disorders. In conclusion, CABP2 is a calcium-binding protein involved in regulating calcium channels, modulating sensory perception, and maintaining cellular homeostasis. Its widespread expression in various cell types and involvement in multiple signaling pathways underscore its potential significance in neurological and auditory disorders. Further research is needed to elucidate the functional significance of CABP2 and its potential as a therapeutic target.

Genular Protein ID: 773816482

Symbol: CABP2_HUMAN

Name: Calcium-binding protein 2

UniProtKB Accession Codes:

Q9NPB3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 14 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10625670

Title: Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin.

PubMed ID: 10625670

DOI: 10.1074/jbc.275.2.1247

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 11108966

Title: Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease.

PubMed ID: 11108966

DOI: 10.1016/s0167-4889(00)00099-9

PubMed ID: 19338761

Title: Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8.

PubMed ID: 19338761

DOI: 10.1016/j.bbrc.2009.01.177

PubMed ID: 22981119

Title: A mutation in CABP2, expressed in cochlear hair cells, causes autosomal-recessive hearing impairment.

PubMed ID: 22981119

DOI: 10.1016/j.ajhg.2012.08.018

PubMed ID: 28183797

Title: Ca(2+)-binding protein 2 inhibits Ca(2+)-channel inactivation in mouse inner hair cells.

PubMed ID: 28183797

DOI: 10.1073/pnas.1617533114

Sequence Information:

  • Length: 220
  • Mass: 24482
  • Checksum: 9A0F0E7358A44F3A
  • Sequence:
    • MGNCAKRPWR RGPKDPLQWL GSPPRGSCPS PSSSPKEQGD PAPGVQGYSV LNSLVGPACI 
FLRPSIAATQ LDRELRPEEI EELQVAFQEF DRDRDGYIGC RELGACMRTL GYMPTEMELI 
EISQQISGGK VDFEDFVELM GPKLLAETAD MIGVRELRDA FREFDTNGDG RISVGELRAA 
LKALLGERLS QREVDEILQD VDLNGDGLVD FEEFVRMMSR

Genular Protein ID: 287268554

Symbol: F1T0K2_HUMAN

Name: N/A

UniProtKB Accession Codes:

F1T0K2

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 GO 4 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

Sequence Information:

  • Length: 226
  • Mass: 24639
  • Checksum: 71F1FA4FB765B791
  • Sequence:
    • MVQGPWGTVP SGPGAGALRT PCSGSAPHQG APAPAPAPAP RSRGTPRQAS RATRCSTAWW 
GLPASSCGPA LPPPNSYDRE LRPEEIEELQ VAFQEFDRDR DGYIGCRELG ACMRTLGYMP 
TEMELIEISQ QISGGKVDFE DFVELMGPKL LAETADMIGV RELRDAFREF DTNGDGRISV 
GELRAALKAL LGERLSQREV DEILQDVDLN GDGLVDFEEF VRMMSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.