Details for: PI3

Gene ID: 5266

Symbol: PI3

Ensembl ID: ENSG00000124102

Description: peptidase inhibitor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 7.5282
    Cell Significance Index: 64.6900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.0883
    Cell Significance Index: -18.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9723
    Cell Significance Index: -13.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 2.3227
    Cell Significance Index: 24.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.2815
    Cell Significance Index: 78.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8733
    Cell Significance Index: 112.8300
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.6907
    Cell Significance Index: 3.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5172
    Cell Significance Index: 98.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4175
    Cell Significance Index: 19.4700
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.3605
    Cell Significance Index: 2.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3318
    Cell Significance Index: 15.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3259
    Cell Significance Index: 14.7700
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 0.2828
    Cell Significance Index: 1.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2567
    Cell Significance Index: 29.9200
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.2474
    Cell Significance Index: 1.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2390
    Cell Significance Index: 14.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2337
    Cell Significance Index: 6.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1557
    Cell Significance Index: 140.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1154
    Cell Significance Index: 12.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1101
    Cell Significance Index: 10.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1004
    Cell Significance Index: 1.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0727
    Cell Significance Index: 39.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0711
    Cell Significance Index: 11.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0692
    Cell Significance Index: 52.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0557
    Cell Significance Index: 34.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0400
    Cell Significance Index: 2.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0345
    Cell Significance Index: 2.3900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0078
    Cell Significance Index: 0.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0064
    Cell Significance Index: 1.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0056
    Cell Significance Index: 0.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0057
    Cell Significance Index: -4.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0079
    Cell Significance Index: -4.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0104
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0125
    Cell Significance Index: -2.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0140
    Cell Significance Index: -0.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0212
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0229
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0284
    Cell Significance Index: -5.9800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0411
    Cell Significance Index: -0.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0423
    Cell Significance Index: -12.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0568
    Cell Significance Index: -11.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0653
    Cell Significance Index: -13.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0661
    Cell Significance Index: -7.5400
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0707
    Cell Significance Index: -0.6300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0769
    Cell Significance Index: -1.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0847
    Cell Significance Index: -11.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0987
    Cell Significance Index: -12.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1029
    Cell Significance Index: -10.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1095
    Cell Significance Index: -12.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1097
    Cell Significance Index: -5.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1343
    Cell Significance Index: -4.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1392
    Cell Significance Index: -2.9700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1716
    Cell Significance Index: -3.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2167
    Cell Significance Index: -7.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2302
    Cell Significance Index: -6.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2614
    Cell Significance Index: -14.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2625
    Cell Significance Index: -2.9800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2811
    Cell Significance Index: -7.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3240
    Cell Significance Index: -14.3300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3403
    Cell Significance Index: -3.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3560
    Cell Significance Index: -12.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3580
    Cell Significance Index: -9.5600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.3740
    Cell Significance Index: -2.3200
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.3822
    Cell Significance Index: -2.9100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3860
    Cell Significance Index: -4.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3976
    Cell Significance Index: -11.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4026
    Cell Significance Index: -13.1800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.4067
    Cell Significance Index: -2.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4127
    Cell Significance Index: -11.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4161
    Cell Significance Index: -11.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4247
    Cell Significance Index: -12.5100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4407
    Cell Significance Index: -10.9900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.4498
    Cell Significance Index: -4.6400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4810
    Cell Significance Index: -8.5000
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.4844
    Cell Significance Index: -3.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4850
    Cell Significance Index: -12.3900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5008
    Cell Significance Index: -12.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5135
    Cell Significance Index: -9.4900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5547
    Cell Significance Index: -9.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5581
    Cell Significance Index: -15.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5660
    Cell Significance Index: -13.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5990
    Cell Significance Index: -10.0300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.6048
    Cell Significance Index: -7.6600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.6112
    Cell Significance Index: -8.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6165
    Cell Significance Index: -13.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6186
    Cell Significance Index: -13.1300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.6209
    Cell Significance Index: -9.0200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6294
    Cell Significance Index: -13.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6545
    Cell Significance Index: -13.1400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.6569
    Cell Significance Index: -7.9900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.6584
    Cell Significance Index: -13.1300
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.6618
    Cell Significance Index: -4.0900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.6715
    Cell Significance Index: -10.8800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.6775
    Cell Significance Index: -6.9100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6878
    Cell Significance Index: -13.6000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.6918
    Cell Significance Index: -9.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine-type endopeptidase inhibitor activity**: Elafin inhibits the activity of serine proteases, which are involved in the degradation of peptides and proteins. 2. **Widespread tissue expression**: Elafin is expressed in various tissues, including the skin, respiratory, gastrointestinal tracts, and mammary glands. 3. **Antimicrobial peptide regulation**: Elafin modulates the activity of antimicrobial peptides, which are essential for innate immune response against pathogens. 4. **Peptidase cross-linking activity**: Elafin has been shown to cross-link peptides, which is essential for maintaining tissue structure and integrity. 5. **Inhibition of endopeptidase activity**: Elafin inhibits the activity of endopeptidases, which are enzymes involved in the degradation of peptides and proteins. **Pathways and Functions:** 1. **Antibacterial humoral response**: Elafin modulates the activity of antimicrobial peptides, which are essential for innate immune response against pathogens. 2. **Innate immune response**: Elafin regulates the activity of serine proteases, which are involved in the degradation of peptides and proteins, thereby modulating innate immune response. 3. **Keratinization**: Elafin is involved in the regulation of keratinocyte differentiation and the formation of the cornified envelope, which is essential for skin homeostasis. 4. **Peptide cross-linking**: Elafin has been shown to cross-link peptides, which is essential for maintaining tissue structure and integrity. 5. **Endopeptidase inhibition**: Elafin inhibits the activity of endopeptidases, which are enzymes involved in the degradation of peptides and proteins. **Clinical Significance:** 1. **Dermatological disorders**: Elafin has been implicated in various dermatological disorders, including psoriasis, atopic dermatitis, and epidermolysis bullosa. 2. **Respiratory diseases**: Elafin has been shown to play a role in regulating immune responses in respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD). 3. **Cancer**: Elafin has been implicated in the regulation of proteolytic activity in cancer cells, which may contribute to tumor progression and metastasis. 4. **Infectious diseases**: Elafin has been shown to play a role in regulating immune responses against pathogens, which may contribute to the development of antimicrobial therapies. In conclusion, Elafin is a crucial protein that plays a significant role in regulating various physiological and pathological processes. Its involvement in immune response, skin homeostasis, and tissue structure maintenance highlights its importance in maintaining overall health. Further research is needed to fully understand the mechanisms of Elafin and its potential as a therapeutic target in various diseases.

Genular Protein ID: 789948385

Symbol: ELAF_HUMAN

Name: Elafin

UniProtKB Accession Codes:

P19957 E1P618 Q6FG74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PDB 3 PDBsum 3 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1339270

Title: Primary structure of the human elafin precursor preproelafin deduced from the nucleotide sequence of its gene and the presence of unique repetitive sequences in the prosegment.

PubMed ID: 1339270

DOI: 10.1016/s0006-291x(05)80981-7

PubMed ID: 7685029

Title: SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking.

PubMed ID: 7685029

DOI: 10.1016/s0021-9258(19)50303-9

PubMed ID: 8476637

Title: Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions.

PubMed ID: 8476637

DOI: 10.1165/ajrcmb/8.4.439

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2394696

Title: Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence.

PubMed ID: 2394696

DOI: 10.1016/s0021-9258(18)77182-2

PubMed ID: 2039600

Title: Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor.

PubMed ID: 2039600

DOI: 10.1515/bchm3.1991.372.1.13

PubMed ID: 1536690

Title: Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions. Evidence of sequence homology and immunological cross-reactivity.

PubMed ID: 1536690

DOI: 10.1515/bchm3.1992.373.1.27

PubMed ID: 2001428

Title: Skin-derived antileukoproteinase (SKALP), an elastase inhibitor from human keratinocytes. Purification and biochemical properties.

PubMed ID: 2001428

DOI: 10.1016/0925-4439(91)90053-c

PubMed ID: 8794736

Title: Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9-A resolution.

PubMed ID: 8794736

DOI: 10.1021/bi960900l

PubMed ID: 9171290

Title: Solution structure of R-elafin, a specific inhibitor of elastase.

PubMed ID: 9171290

DOI: 10.1006/jmbi.1997.0983

PubMed ID: 29483648

Title: Screening, large-scale production and structure-based classification of cystine-dense peptides.

PubMed ID: 29483648

DOI: 10.1038/s41594-018-0033-9

Sequence Information:

  • Length: 117
  • Mass: 12270
  • Checksum: A51D46257E5B03EF
  • Sequence:
    • MRASSFLIVV VFLIAGTLVL EAAVTGVPVK GQDTVKGRVP FNGQDPVKGQ VSVKGQDKVK 
AQEPVKGPVS TKPGSCPIIL IRCAMLNPPN RCLKDTDCPG IKKCCEGSCG MACFVPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.