Details for: SERPINB10

Gene ID: 5273

Symbol: SERPINB10

Ensembl ID: ENSG00000242550

Description: serpin family B member 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 11.2507
    Cell Significance Index: -1.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.8600
    Cell Significance Index: -1.7400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 3.3857
    Cell Significance Index: 49.1600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.0666
    Cell Significance Index: 13.7100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 1.7098
    Cell Significance Index: 24.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.4112
    Cell Significance Index: -1.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.2527
    Cell Significance Index: 33.5100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.7519
    Cell Significance Index: 4.8000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.5458
    Cell Significance Index: 7.6600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.5251
    Cell Significance Index: 7.5200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.3790
    Cell Significance Index: 3.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0792
    Cell Significance Index: 1.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0568
    Cell Significance Index: 1.0500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0512
    Cell Significance Index: 0.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0232
    Cell Significance Index: 0.2400
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.0070
    Cell Significance Index: 0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0013
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0017
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0026
    Cell Significance Index: -1.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0026
    Cell Significance Index: -1.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0030
    Cell Significance Index: -1.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0039
    Cell Significance Index: -1.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0045
    Cell Significance Index: -0.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0051
    Cell Significance Index: -1.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0061
    Cell Significance Index: -0.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0063
    Cell Significance Index: -1.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0070
    Cell Significance Index: -1.4100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0071
    Cell Significance Index: -0.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0088
    Cell Significance Index: -1.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0102
    Cell Significance Index: -0.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0111
    Cell Significance Index: -1.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0122
    Cell Significance Index: -0.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0132
    Cell Significance Index: -1.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0149
    Cell Significance Index: -1.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0154
    Cell Significance Index: -0.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0160
    Cell Significance Index: -1.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0214
    Cell Significance Index: -1.1100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0231
    Cell Significance Index: -0.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0272
    Cell Significance Index: -0.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0297
    Cell Significance Index: -0.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0314
    Cell Significance Index: -2.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0314
    Cell Significance Index: -1.7600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0343
    Cell Significance Index: -0.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0347
    Cell Significance Index: -1.6300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0348
    Cell Significance Index: -0.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0373
    Cell Significance Index: -1.3700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0379
    Cell Significance Index: -0.5400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0396
    Cell Significance Index: -0.9900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0404
    Cell Significance Index: -0.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0409
    Cell Significance Index: -1.8100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0417
    Cell Significance Index: -1.8100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0422
    Cell Significance Index: -0.2800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0469
    Cell Significance Index: -0.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0473
    Cell Significance Index: -1.7900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0480
    Cell Significance Index: -0.7700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0491
    Cell Significance Index: -1.7200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0501
    Cell Significance Index: -0.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0507
    Cell Significance Index: -1.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0512
    Cell Significance Index: -1.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0516
    Cell Significance Index: -1.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0555
    Cell Significance Index: -1.5900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0564
    Cell Significance Index: -0.8300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0567
    Cell Significance Index: -0.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0575
    Cell Significance Index: -1.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0608
    Cell Significance Index: -1.6300
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: -0.0617
    Cell Significance Index: -0.4700
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0627
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0628
    Cell Significance Index: -0.7900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0661
    Cell Significance Index: -1.0700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0667
    Cell Significance Index: -1.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0671
    Cell Significance Index: -1.6800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0674
    Cell Significance Index: -0.7200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0679
    Cell Significance Index: -1.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0681
    Cell Significance Index: -1.1400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0685
    Cell Significance Index: -1.7500
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0702
    Cell Significance Index: -0.5800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0706
    Cell Significance Index: -0.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0719
    Cell Significance Index: -1.9200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0726
    Cell Significance Index: -0.9400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0740
    Cell Significance Index: -0.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0753
    Cell Significance Index: -2.1500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0779
    Cell Significance Index: -1.9000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0794
    Cell Significance Index: -0.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0801
    Cell Significance Index: -1.7000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0805
    Cell Significance Index: -1.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0819
    Cell Significance Index: -1.7700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0828
    Cell Significance Index: -1.6300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0830
    Cell Significance Index: -1.9900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0854
    Cell Significance Index: -1.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0855
    Cell Significance Index: -1.6900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0861
    Cell Significance Index: -0.9700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0861
    Cell Significance Index: -0.9200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0881
    Cell Significance Index: -1.3000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0904
    Cell Significance Index: -1.0400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0912
    Cell Significance Index: -1.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SerpinB10 is a small, secreted protein that belongs to the serpin family of protease inhibitors. It is primarily expressed in cells of the immune system, including lymphocytes, dendritic cells, and neutrophils. SerpinB10 is characterized by its ability to inhibit serine proteases, such as trypsin and chymotrypsin, which are involved in various cellular processes, including inflammation and cell signaling. The protein's structure consists of a beta-sheet fold, which allows it to bind to serine proteases and prevent their enzymatic activity. **Pathways and Functions:** SerpinB10 plays a crucial role in regulating immune responses, particularly in the context of inflammation and tissue repair. Its primary function is to inhibit serine proteases, which are involved in the activation of inflammatory cascades and the degradation of extracellular matrix components. By modulating the activity of these proteases, SerpinB10 helps to maintain tissue homeostasis and prevent excessive inflammation. In addition to its role in immune responses, SerpinB10 is also involved in various cellular processes, including: 1. **Negative regulation of endopeptidase activity**: SerpinB10 inhibits the activity of serine proteases, which are involved in the degradation of proteins and the activation of signaling pathways. 2. **Neutrophil degranulation**: SerpinB10 modulates the activity of neutrophil granules, which are involved in the release of inflammatory mediators and the degradation of extracellular matrix components. 3. **Innate immune system**: SerpinB10 is expressed in cells of the innate immune system, including dendritic cells and neutrophils, and plays a critical role in regulating immune responses. **Clinical Significance:** Dysregulation of SerpinB10 has been implicated in various immune-related disorders, including: 1. **Inflammatory diseases**: SerpinB10 has been shown to play a critical role in regulating inflammation and tissue repair, and its dysregulation has been implicated in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis and asthma. 2. **Autoimmune disorders**: SerpinB10 has been shown to regulate the activity of immune cells, including T cells and dendritic cells, and its dysregulation has been implicated in the pathogenesis of autoimmune disorders, such as multiple sclerosis and type 1 diabetes. 3. **Cancer**: SerpinB10 has been shown to regulate the activity of proteases involved in tumor growth and metastasis, and its dysregulation has been implicated in the pathogenesis of various cancers, including breast cancer and lung cancer. In conclusion, SerpinB10 is a critical regulator of immune responses and cellular homeostasis, and its dysregulation has been implicated in various immune-related disorders. Further studies are needed to fully understand the role of SerpinB10 in immune regulation and its potential as a therapeutic target for immune-related diseases.

Genular Protein ID: 2347538642

Symbol: SPB10_HUMAN

Name: Serpin B10

UniProtKB Accession Codes:

P48595 Q4VAX4 Q4VAX7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7592909

Title: Molecular cloning of bomapin (protease inhibitor 10), a novel human serpin that is expressed specifically in the bone marrow.

PubMed ID: 7592909

DOI: 10.1074/jbc.270.45.26754

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10196205

Title: Identification of a nuclear targeting domain in the insertion between helices C and D in protease inhibitor-10.

PubMed ID: 10196205

DOI: 10.1074/jbc.274.16.11194

PubMed ID: 10871600

Title: Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence for the formation of intracellular high M(r) protease inhibitor 10-containing complexes.

PubMed ID: 10871600

DOI: 10.1074/jbc.c000389200

PubMed ID: 20433722

Title: Bomapin is a redox-sensitive nuclear serpin that affects responsiveness of myeloid progenitor cells to growth environment.

PubMed ID: 20433722

DOI: 10.1186/1471-2121-11-30

Sequence Information:

  • Length: 397
  • Mass: 45403
  • Checksum: 8CE01246867154DF
  • Sequence:
    • MDSLATSINQ FALELSKKLA ESAQGKNIFF SSWSISTSLT IVYLGAKGTT AAQMAQVLQF 
NRDQGVKCDP ESEKKRKMEF NLSNSEEIHS DFQTLISEIL KPNDDYLLKT ANAIYGEKTY 
AFHNKYLEDM KTYFGAEPQP VNFVEASDQI RKDINSWVER QTEGKIQNLL PDDSVDSTTR 
MILVNALYFK GIWEHQFLVQ NTTEKPFRIN ETTSKPVQMM FMKKKLHIFH IEKPKAVGLQ 
LYYKSRDLSL LILLPEDING LEQLEKAITY EKLNEWTSAD MMELYEVQLH LPKFKLEDSY 
DLKSTLSSMG MSDAFSQSKA DFSGMSSARN LFLSNVFHKA FVEINEQGTE AAAGSGSEID 
IRIRVPSIEF NANHPFLFFI RHNKTNTILF YGRLCSP

Genular Protein ID: 4182937235

Symbol: B2RC45_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RC45

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 6 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 397
  • Mass: 45316
  • Checksum: 2723DB369ECAAC6F
  • Sequence:
    • MDSLATSINQ FALELSKKLA ESAQGKNIFF SSWSISTSLT MVYLGAKGTT AAQMAQVLQF 
NRDQGVKCDP ESEKKRKMEF NLSNSEEIHS DFQTLISETL KPNDDYLLKT ANAIYGEKTY 
AFHNKYLEDM KTYFGAEPQS VNFVEASDQI RKDINSWVER QTEGKIQNLL PDDSVDSTTR 
MILVNALYFK GIWEHQFLVQ NTTEKPFRIN ETTSKPVQMT FMKKKLHIFH IEKPKAVGLQ 
LYYKSCDLSL LILLPEDING LEQLEKAITY EKLNEWTSAD MMELYEVQLH LPKFKLEDSY 
DLKSTLSSMG MSDAFSQSKA DFSGMSSARN LFLSNVFHKA FVEINEQGTE AAAGSGSEID 
IRIRVPSIEF NANHPFLFFI RHNKTNTILF YGRLCSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.