Details for: PRM1

Gene ID: 5619

Symbol: PRM1

Ensembl ID: ENSG00000175646

Description: protamine 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162075
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8278
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6844
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3183
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7550
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3657
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32720
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 741
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.79
    Marker Score: 439
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 405
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.55
    Marker Score: 3665
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.48
    Marker Score: 7560
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.37
    Marker Score: 219
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.35
    Marker Score: 717
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.32
    Marker Score: 991
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3
    Marker Score: 572
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.27
    Marker Score: 426
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.27
    Marker Score: 160
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.21
    Marker Score: 1237
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.13
    Marker Score: 62
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 86
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.07
    Marker Score: 82
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.07
    Marker Score: 47
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 21.5
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.07
    Marker Score: 434
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.04
    Marker Score: 79
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.04
    Marker Score: 36
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.03
    Marker Score: 16.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 23.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.02
    Marker Score: 63
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 20.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 31
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.02
    Marker Score: 45
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.02
    Marker Score: 29
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.01
    Marker Score: 35.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 14.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 23.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0
    Marker Score: 64
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0
    Marker Score: 23
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0
    Marker Score: 23
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0
    Marker Score: 19
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0
    Marker Score: 19
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 18
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0
    Marker Score: 25

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Other Information

## Summary PRM1 is a gene encoding a protein called HSP1_HUMAN (Sperm protamine P1). It is located on chromosome 1 and is approximately 3.1 kb in length. The protein is expressed in a variety of cell types, including glutamatergic neuron, oligodendrocyte precursor cell, microglial cell, blood vessel endothelial cell, neoplastic cell, abnormal cell, absorptive cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, and intestinal crypt stem cell of colon. ## Key characteristics * PRM1 is a member of the HSP1 family of heat shock proteins. * The protein is expressed in high levels in the testes during spermatogenesis. * It is also expressed in other tissues during development. * The protein is a key regulator of spermatogenesis. * It is involved in the condensation of the sperm chromatin and the subsequent formation of the sperm head. ## Pathways and functions * PRM1 is involved in the regulation of spermatogenesis. * It is a key regulator of the process by which the sperm chromatin is condensed into a sperm head. * It is also involved in the formation of the sperm tail. * It is also involved in the regulation of the expression of other genes involved in spermatogenesis. ## Clinical significance * Mutations in PRM1 have been linked to male infertility. * In one study, mutations in PRM1 were found in 13% of azoospermic men. * These mutations were associated with a variety of clinical symptoms, including infertility, low sperm count, and abnormal sperm shape. * The development of new therapies for male infertility is an active area of research, and PRM1 is a promising target for new treatments.

Genular Protein ID: 3021740658

Symbol: HSP1_HUMAN

Name: Sperm protamine P1

UniProtKB Accession Codes:

P04553

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 STRING 1 SignaLink 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2081589

Title: Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered.

PubMed ID: 2081589

DOI: 10.1016/0888-7543(90)90234-l

PubMed ID: 2613245

Title: Chromosomal localization and structure of the human P1 protamine gene.

PubMed ID: 2613245

DOI: 10.1016/0888-7543(89)90036-0

PubMed ID: 3658707

Title: The nucleotide sequence of a human protamine 1 cDNA.

PubMed ID: 3658707

DOI: 10.1093/nar/15.18.7639

PubMed ID: 7983046

Title: Characterization of a human locus in transition.

PubMed ID: 7983046

DOI: 10.1016/s0021-9258(18)47391-7

PubMed ID: 8263493

Title: Direct sequencing of the human protamine P1 gene and application in forensic medicine.

PubMed ID: 8263493

PubMed ID: 10659848

Title: Rapid evolution of male reproductive genes in the descent of man.

PubMed ID: 10659848

DOI: 10.1038/35002070

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4027356

Title: The amino acid sequence of human sperm protamine P1.

PubMed ID: 4027356

DOI: 10.1007/bf01116555

PubMed ID: 3527226

Title: Isolation and amino-acid sequence analysis of human sperm protamines P1 and P2. Occurrence of two forms of protamine P2.

PubMed ID: 3527226

DOI: 10.1515/bchm3.1986.367.1.515

PubMed ID: 10390541

Title: SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1.

PubMed ID: 10390541

DOI: 10.1093/nar/27.14.2972

Sequence Information:

  • Length: 51
  • Mass: 6823
  • Checksum: 4A5C6A92C713C33D
  • Sequence:
    • MARYRCCRSQ SRSRYYRQRQ RSRRRRRRSC QTRRRAMRCC RPRYRPRCRR H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.