Details for: PSG11

Gene ID: 5680

Symbol: PSG11

Ensembl ID: ENSG00000243130

Description: pregnancy specific beta-1-glycoprotein 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3446
    Cell Significance Index: 32.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1412
    Cell Significance Index: 2.4200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0789
    Cell Significance Index: 0.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0629
    Cell Significance Index: 1.6800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0600
    Cell Significance Index: 0.5700
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: 0.0592
    Cell Significance Index: 0.7200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0360
    Cell Significance Index: 0.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0261
    Cell Significance Index: 5.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0170
    Cell Significance Index: 2.9100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0169
    Cell Significance Index: 0.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0050
    Cell Significance Index: 1.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0049
    Cell Significance Index: 1.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0019
    Cell Significance Index: 3.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0014
    Cell Significance Index: 2.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0010
    Cell Significance Index: 1.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0002
    Cell Significance Index: 0.2400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0016
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0031
    Cell Significance Index: -1.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0038
    Cell Significance Index: -2.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0039
    Cell Significance Index: -1.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0045
    Cell Significance Index: -0.1700
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0083
    Cell Significance Index: -0.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0103
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0104
    Cell Significance Index: -1.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0108
    Cell Significance Index: -2.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0112
    Cell Significance Index: -0.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0117
    Cell Significance Index: -2.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0133
    Cell Significance Index: -1.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0136
    Cell Significance Index: -0.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0139
    Cell Significance Index: -1.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0145
    Cell Significance Index: -1.1100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0156
    Cell Significance Index: -0.2000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0157
    Cell Significance Index: -0.1300
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0177
    Cell Significance Index: -0.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0178
    Cell Significance Index: -2.1900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0198
    Cell Significance Index: -0.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0217
    Cell Significance Index: -2.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0220
    Cell Significance Index: -1.0300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0243
    Cell Significance Index: -0.2300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0246
    Cell Significance Index: -0.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0274
    Cell Significance Index: -0.7900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0289
    Cell Significance Index: -0.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0294
    Cell Significance Index: -1.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0308
    Cell Significance Index: -0.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0321
    Cell Significance Index: -1.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0328
    Cell Significance Index: -1.8400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0362
    Cell Significance Index: -1.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0365
    Cell Significance Index: -1.8500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0375
    Cell Significance Index: -0.8100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0419
    Cell Significance Index: -0.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0450
    Cell Significance Index: -1.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0462
    Cell Significance Index: -2.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0478
    Cell Significance Index: -0.9600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0503
    Cell Significance Index: -0.6000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0514
    Cell Significance Index: -0.5600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0554
    Cell Significance Index: -0.6000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0569
    Cell Significance Index: -0.8300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0581
    Cell Significance Index: -1.4500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0611
    Cell Significance Index: -1.4900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0655
    Cell Significance Index: -2.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0659
    Cell Significance Index: -1.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0662
    Cell Significance Index: -1.9500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0665
    Cell Significance Index: -1.6600
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0672
    Cell Significance Index: -0.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0681
    Cell Significance Index: -1.3300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0703
    Cell Significance Index: -1.3900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0712
    Cell Significance Index: -0.7800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0714
    Cell Significance Index: -1.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0716
    Cell Significance Index: -1.5200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0765
    Cell Significance Index: -1.1000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0765
    Cell Significance Index: -1.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0776
    Cell Significance Index: -2.0800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0776
    Cell Significance Index: -1.6200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0793
    Cell Significance Index: -1.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0795
    Cell Significance Index: -1.7400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0826
    Cell Significance Index: -1.0400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0832
    Cell Significance Index: -1.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0834
    Cell Significance Index: -2.3900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0849
    Cell Significance Index: -1.0600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0884
    Cell Significance Index: -1.2700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0887
    Cell Significance Index: -2.2600
  • Cell Name: diffuse bipolar 3a cell (CL4033029)
    Fold Change: -0.0898
    Cell Significance Index: -1.0800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0925
    Cell Significance Index: -1.6000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0948
    Cell Significance Index: -1.8900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0948
    Cell Significance Index: -1.5300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0975
    Cell Significance Index: -1.3000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0982
    Cell Significance Index: -1.2300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0985
    Cell Significance Index: -1.5800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0994
    Cell Significance Index: -1.3400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0999
    Cell Significance Index: -1.5200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1030
    Cell Significance Index: -0.8400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1039
    Cell Significance Index: -1.2900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1043
    Cell Significance Index: -1.2700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1054
    Cell Significance Index: -2.0600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1073
    Cell Significance Index: -1.3600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1097
    Cell Significance Index: -1.4800
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: -0.1108
    Cell Significance Index: -1.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PSG11 is a glycoprotein that belongs to the beta-1-glycoprotein family. It is characterized by its unique structure and expression pattern, which distinguishes it from other glycoproteins. PSG11 is specifically expressed during pregnancy and is also found in non-pregnant individuals, where it plays a role in maintaining tissue homeostasis. The gene is highly conserved across species, suggesting its evolutionary importance. **Pathways and Functions:** PSG11 is involved in several cellular pathways, including: 1. **Cell surface interactions at the vascular wall:** PSG11 is expressed on endothelial cells and plays a role in regulating blood vessel formation and maintenance. 2. **Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules:** PSG11 interacts with other cell surface molecules to facilitate cell-cell adhesion and tissue organization. 3. **Extracellular region:** PSG11 is secreted into the extracellular environment, where it can interact with other molecules and influence cellular behavior. 4. **Female pregnancy:** PSG11 is specifically expressed during pregnancy and plays a role in maintaining fetal development and placental function. 5. **Hemostasis:** PSG11 is involved in regulating blood clotting and preventing excessive bleeding. **Functions:** The functions of PSG11 are multifaceted and involve: 1. **Cell signaling:** PSG11 can interact with other molecules to regulate cellular signaling pathways. 2. **Cell adhesion:** PSG11 facilitates cell-cell adhesion and tissue organization. 3. **Immune response:** PSG11 may play a role in regulating immune responses, particularly during pregnancy. 4. **Tissue homeostasis:** PSG11 helps maintain tissue homeostasis and prevent disease. **Clinical Significance:** PSG11 has significant clinical implications, particularly in the context of pregnancy and vascular diseases. Abnormal expression of PSG11 has been linked to: 1. **Pregnancy complications:** PSG11 dysregulation may contribute to pregnancy-related complications, such as preeclampsia and placental insufficiency. 2. **Vascular diseases:** PSG11 may play a role in the development of vascular diseases, such as atherosclerosis and stroke. 3. **Neurological disorders:** PSG11 dysregulation has been linked to neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, PSG11 is a multifaceted gene that plays a crucial role in various cellular processes, including cell signaling, cell adhesion, and immune response. Its clinical significance has been increasingly recognized, particularly in the context of pregnancy and vascular diseases. Further research is needed to fully elucidate the functions and clinical implications of PSG11.

Genular Protein ID: 1577374985

Symbol: PSG11_HUMAN

Name: Pregnancy-specific beta-1-glycoprotein 11

UniProtKB Accession Codes:

Q9UQ72 Q13179 Q15242 Q8WW91 Q9UNE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1840485

Title: Cloning and expression of a new pregnancy-specific beta-1-glycoprotein member.

PubMed ID: 1840485

DOI: 10.1016/0006-291x(91)90461-f

PubMed ID: 7794280

Title: Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants.

PubMed ID: 7794280

DOI: 10.1006/bbrc.1995.1862

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 335
  • Mass: 37146
  • Checksum: 4C58685C2CA0FF29
  • Sequence:
    • MGPLSAPPCT EHIKWKGLLL TALLLNFWNL PTTAQVMIEA QPPKVSEGKD VLLLVHNLPQ 
NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET VYSNASLLIQ NVTREDAGSY 
TLHIIKRGDG TRGVTGYFTF TLYLETPKPS ISSSNLNPRE AMETVILTCN PETPDASYLW 
WMNGQSLPMT HRMQLSETNR TLFLFGVTKY TAGPYECEIW NSGSASRSDP VTLNLLHGPD 
LPRIFPSVTS YYSGENLDLS CFANSNPPAQ YSWTINGKFQ LSGQKLFIPQ ITPKHNGLYA 
CSARNSATGE ESSTSLTIRV IAPPGLGTFA FNNPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.