Details for: PSG11

Gene ID: 5680

Symbol: PSG11

Ensembl ID: ENSG00000243130

Description: pregnancy specific beta-1-glycoprotein 11

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glial cell (CL0000125)
    Fold Change: 10.54
    Marker Score: 11592.5
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 9.35
    Marker Score: 29945.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 8.3
    Marker Score: 11507
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 7.36
    Marker Score: 9182
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 6.01
    Marker Score: 17818
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.98
    Marker Score: 11435
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.49
    Marker Score: 2504
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.86
    Marker Score: 1784
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.48
    Marker Score: 4220
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71839
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48063
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.58
    Marker Score: 188
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.31
    Marker Score: 4879
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3
    Marker Score: 567
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.19
    Marker Score: 1607
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.18
    Marker Score: 369
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.18
    Marker Score: 104
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.17
    Marker Score: 91
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.17
    Marker Score: 47
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.17
    Marker Score: 71
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1
    Marker Score: 866
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.1
    Marker Score: 48
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.1
    Marker Score: 151
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.09
    Marker Score: 5767
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.08
    Marker Score: 781
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 163
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 84
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 58
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.07
    Marker Score: 269
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.06
    Marker Score: 53
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.06
    Marker Score: 49
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.06
    Marker Score: 56
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.05
    Marker Score: 230
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 61
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.05
    Marker Score: 10
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.05
    Marker Score: 468
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.04
    Marker Score: 45
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 49
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.04
    Marker Score: 396
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.04
    Marker Score: 533
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.03
    Marker Score: 75
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.03
    Marker Score: 37
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.03
    Marker Score: 178
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.03
    Marker Score: 7
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 52
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.02
    Marker Score: 83
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.02
    Marker Score: 163
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.02
    Marker Score: 36
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.02
    Marker Score: 374
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.02
    Marker Score: 31
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.02
    Marker Score: 52
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.02
    Marker Score: 679
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.02
    Marker Score: 233
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 15

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Other Information

**Key characteristics:** * PSG11 is a glycoprotein with a molecular weight of approximately 110 kDa. * It is expressed in a variety of cell types, including glial cells, amacrine cells, Mueller cells, retinal ganglion cells, OFF-bipolar cells, retinal cone cells, blood vessel endothelial cells, retina horizontal cells, and retinal rod cells. * PSG11 is a key regulator of vascular permeability and cell migration. * It is involved in the regulation of hemostasis and homophilic cell-cell adhesion. **Pathways and functions:** * PSG11 is involved in the regulation of blood flow by interacting with the integrin-beta1 (ITGB1) receptor. * It is expressed on the surface of blood vessel endothelial cells and is involved in the regulation of vascular permeability. * It also plays a role in cell migration by interacting with the integrin-beta1 (ITGB1) receptor. * PSG11 is also involved in the regulation of hemostasis by interacting with von Willebrand factor. * It is a key regulator of cell-cell adhesion by interacting with the plasma membrane cell adhesion molecules (PCAMs). **Clinical significance:** * Mutations in the PSG11 gene have been linked to a number of human diseases, including infertility, premature labor, and placental abruption. * PSG11 is a potential therapeutic target for diseases such as infertility, preterm labor, and placental abruption.

Genular Protein ID: 1577374985

Symbol: PSG11_HUMAN

Name: Pregnancy-specific beta-1-glycoprotein 11

UniProtKB Accession Codes:

Q9UQ72 Q13179 Q15242 Q8WW91 Q9UNE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1840485

Title: Cloning and expression of a new pregnancy-specific beta-1-glycoprotein member.

PubMed ID: 1840485

DOI: 10.1016/0006-291x(91)90461-f

PubMed ID: 7794280

Title: Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants.

PubMed ID: 7794280

DOI: 10.1006/bbrc.1995.1862

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 335
  • Mass: 37146
  • Checksum: 4C58685C2CA0FF29
  • Sequence:
    • MGPLSAPPCT EHIKWKGLLL TALLLNFWNL PTTAQVMIEA QPPKVSEGKD VLLLVHNLPQ 
NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET VYSNASLLIQ NVTREDAGSY 
TLHIIKRGDG TRGVTGYFTF TLYLETPKPS ISSSNLNPRE AMETVILTCN PETPDASYLW 
WMNGQSLPMT HRMQLSETNR TLFLFGVTKY TAGPYECEIW NSGSASRSDP VTLNLLHGPD 
LPRIFPSVTS YYSGENLDLS CFANSNPPAQ YSWTINGKFQ LSGQKLFIPQ ITPKHNGLYA 
CSARNSATGE ESSTSLTIRV IAPPGLGTFA FNNPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.