Details for: RASGRF1

Gene ID: 5923

Symbol: RASGRF1

Ensembl ID: ENSG00000058335

Description: Ras protein specific guanine nucleotide releasing factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 60.7546
    Cell Significance Index: -15.4100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 5.5167
    Cell Significance Index: 68.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.7473
    Cell Significance Index: 78.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1424
    Cell Significance Index: 768.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9347
    Cell Significance Index: 388.1000
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.8396
    Cell Significance Index: 14.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.7317
    Cell Significance Index: -3.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2510
    Cell Significance Index: 865.2600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.2438
    Cell Significance Index: 16.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1570
    Cell Significance Index: 25.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.0334
    Cell Significance Index: 17.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6604
    Cell Significance Index: 44.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4911
    Cell Significance Index: 13.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3956
    Cell Significance Index: 17.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2984
    Cell Significance Index: 11.3000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1574
    Cell Significance Index: 2.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1240
    Cell Significance Index: 93.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0283
    Cell Significance Index: 0.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0247
    Cell Significance Index: 4.9100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.0225
    Cell Significance Index: 0.4700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0133
    Cell Significance Index: 0.3500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0105
    Cell Significance Index: 0.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0061
    Cell Significance Index: 0.2000
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.0057
    Cell Significance Index: 0.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0044
    Cell Significance Index: 2.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0018
    Cell Significance Index: 1.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0017
    Cell Significance Index: 2.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0038
    Cell Significance Index: -2.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0053
    Cell Significance Index: -10.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0057
    Cell Significance Index: -0.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0059
    Cell Significance Index: -9.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0065
    Cell Significance Index: -3.5500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0169
    Cell Significance Index: -0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0183
    Cell Significance Index: -11.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0196
    Cell Significance Index: -3.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0242
    Cell Significance Index: -10.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0271
    Cell Significance Index: -5.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0309
    Cell Significance Index: -5.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0310
    Cell Significance Index: -3.6600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0319
    Cell Significance Index: -0.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0384
    Cell Significance Index: -11.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0503
    Cell Significance Index: -0.7200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0517
    Cell Significance Index: -1.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0629
    Cell Significance Index: -9.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0661
    Cell Significance Index: -0.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0666
    Cell Significance Index: -2.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0753
    Cell Significance Index: -9.2600
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0760
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0823
    Cell Significance Index: -9.4000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0867
    Cell Significance Index: -3.7700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0970
    Cell Significance Index: -1.2100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0995
    Cell Significance Index: -1.1900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0998
    Cell Significance Index: -1.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1027
    Cell Significance Index: -2.0300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1037
    Cell Significance Index: -1.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1053
    Cell Significance Index: -14.4600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1076
    Cell Significance Index: -0.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1094
    Cell Significance Index: -14.1400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1125
    Cell Significance Index: -1.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1256
    Cell Significance Index: -3.5100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1276
    Cell Significance Index: -1.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1329
    Cell Significance Index: -13.5800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1363
    Cell Significance Index: -1.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1409
    Cell Significance Index: -16.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1443
    Cell Significance Index: -16.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1450
    Cell Significance Index: -5.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1463
    Cell Significance Index: -15.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1570
    Cell Significance Index: -12.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1618
    Cell Significance Index: -20.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1669
    Cell Significance Index: -13.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1904
    Cell Significance Index: -14.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1921
    Cell Significance Index: -11.8100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1921
    Cell Significance Index: -3.7800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1958
    Cell Significance Index: -2.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2306
    Cell Significance Index: -14.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2374
    Cell Significance Index: -13.3200
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.2565
    Cell Significance Index: -2.8300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2605
    Cell Significance Index: -5.5700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2649
    Cell Significance Index: -2.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2792
    Cell Significance Index: -17.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2810
    Cell Significance Index: -13.2100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2939
    Cell Significance Index: -2.9600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2948
    Cell Significance Index: -7.0700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2949
    Cell Significance Index: -5.8800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3070
    Cell Significance Index: -4.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3276
    Cell Significance Index: -14.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3349
    Cell Significance Index: -12.3000
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.3382
    Cell Significance Index: -3.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3519
    Cell Significance Index: -8.1300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3525
    Cell Significance Index: -2.9100
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.3530
    Cell Significance Index: -3.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3577
    Cell Significance Index: -12.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3936
    Cell Significance Index: -18.3500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3985
    Cell Significance Index: -6.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3993
    Cell Significance Index: -20.7400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.4087
    Cell Significance Index: -4.4800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.4127
    Cell Significance Index: -3.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4352
    Cell Significance Index: -12.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4374
    Cell Significance Index: -11.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Guanine nucleotide-releasing factor**: RasGRF1 functions as a guanine nucleotide-releasing factor, which is essential for the activation of Ras protein signaling pathways. 2. **Ras protein signaling**: The RasGRF1 gene is involved in the regulation of Ras protein signaling pathways, which are critical for various cellular processes, including growth, differentiation, and survival. 3. **Neuronal specificity**: RasGRF1 is significantly expressed in several types of neurons, including inhibitory interneurons and glutamatergic cortical neurons. 4. **Synaptic plasticity**: The RasGRF1 gene has been implicated in the regulation of synaptic plasticity, which is essential for learning and memory. **Pathways and Functions:** 1. **Activation of gTPase activity**: RasGRF1 activates gTPase activity, which is essential for the regulation of Ras protein signaling pathways. 2. **Activation of NMDA receptors**: RasGRF1 is involved in the activation of NMDA receptors, which are critical for synaptic plasticity and learning. 3. **CREB1 phosphorylation**: The RasGRF1 gene is involved in the phosphorylation of CREB1, a transcription factor that regulates gene expression in response to NMDA receptor activation. 4. **Raf/MapK cascade**: RasGRF1 is involved in the regulation of the Raf/MapK cascade, which is a critical signaling pathway involved in cell growth and differentiation. 5. **Regulation of neuronal synaptic plasticity**: The RasGRF1 gene has been implicated in the regulation of neuronal synaptic plasticity, which is essential for learning and memory. **Clinical Significance:** 1. **Epilepsy**: Mutations in the RasGRF1 gene have been implicated in the development of epilepsy, a neurological disorder characterized by seizures. 2. **Schizophrenia**: The RasGRF1 gene has been implicated in the regulation of synaptic plasticity and has been associated with schizophrenia, a neurological disorder characterized by cognitive and emotional deficits. 3. **Neurodegenerative diseases**: The RasGRF1 gene may play a role in the regulation of synaptic plasticity and has been implicated in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer**: The RasGRF1 gene has been implicated in the regulation of cell growth and differentiation and has been associated with cancer, a group of diseases characterized by uncontrolled cell growth. In conclusion, the RasGRF1 gene is a critical regulator of neuronal signaling and synaptic plasticity, and its dysregulation has been implicated in various neurological disorders, including epilepsy, schizophrenia, and neurodegenerative diseases. Further research is needed to fully understand the role of RasGRF1 in these diseases and to develop novel therapeutic strategies for their treatment.

Genular Protein ID: 1444291004

Symbol: RGRF1_HUMAN

Name: Ras-specific guanine nucleotide-releasing factor 1

UniProtKB Accession Codes:

Q13972 F8VPA5 H0YKF2 J3KQP9 Q16027

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 4 CPTAC 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 GO 19 Gene3D 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7828890

Title: Cloning and analysis of human cDNAs encoding a 140-kDa brain guanine nucleotide-exchange factor, Cdc25GEF, which regulates the function of Ras.

PubMed ID: 7828890

DOI: 10.1016/0378-1119(94)90671-8

PubMed ID: 7684828

Title: Identification of a human guanine nucleotide-releasing factor (H-GRF55) specific for Ras proteins.

PubMed ID: 7684828

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 1379731

Title: Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae.

PubMed ID: 1379731

DOI: 10.1073/pnas.89.15.7100

PubMed ID: 10373510

Title: Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.

PubMed ID: 10373510

DOI: 10.1128/mcb.19.7.4611

PubMed ID: 11389730

Title: Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm.

PubMed ID: 11389730

DOI: 10.1046/j.1432-1327.2001.02230.x

Sequence Information:

  • Length: 1273
  • Mass: 145234
  • Checksum: B629AEAFDC7E500A
  • Sequence:
    • MQKGIRLNDG HVASLGLLAR KDGTRKGYLS KRSSDNTKWQ TKWFALLQNL LFYFESDSSS 
RPSGLYLLEG CVCDRAPSPK PALSAKEPLE KQHYFTVNFS HENQKALELR TEDAKDCDEW 
VAAIAHASYR TLATEHEALM QKYLHLLQIV ETEKTVAKQL RQQIEDGEIE IERLKAEITS 
LLKDNERIQS TQTVAPNDED SDIKKIKKVQ SFLRGWLCRR KWKTIIQDYI RSPHADSMRK 
RNQVVFSMLE AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH 
QIFYQGLKAR ISSWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC KQNRDFDKLL 
KHYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP HEHVERNSLD YAKSKLEELS 
RIMHDEVSET ENIRKNLAIE RMIIEGCEIL LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG 
SLSLKKEGER QCFLFSKHLI ICTRGSGGKL HLTKNGVISL IDCTLLEEPE STEEEAKGSG 
QDIDHLDFKI GVEPKDSPPF TVILVASSRQ EKAAWTSDIS QCVDNIRCNG LMMNAFEENS 
KVTVPQMIKR TREGTREAEM SRSDASLYCD DVDIRFSKTM NSCKVLQIRY ASVERLLERL 
TDLRFLSIDF LNTFLHSYRV FTTAIVVLDK LITIYKKPIS AIPARWLRSL ELLFASGQNN 
KLLYGEPPKS PRATRKFSSP PPLSITKTSS PSRRRKLSLN IPIITGGKAL DLAALSCNSN 
GYTSMYSAMS PFSKATLDTS KLYVSSSFTN KIPDEGDTTP EKPEDPSALS KQSSEVSMRE 
ESDIDQNQSD DGDTETSPTK SPTTPKSVKN KNSSEFPLFS YNNGVVMTSC RELDNNRSAL 
SAASAFAIAT AGANEGTPNK EKYRRMSLAS AGFPPDQRNG DKEFVIRRAA TNRVLNVLRH 
WVSKHSQDFE TNDELKCKVI GFLEEVMHDP ELLTQERKAA ANIIRTLTQE DPGDNQITLE 
EITQMAEGVK AEPFENHSAL EIAEQLTLLD HLVFKKIPYE EFFGQGWMKL EKNERTPYIM 
KTTKHFNDIS NLIASEIIRN EDINARVSAI EKWVAVADIC RCLHNYNAVL EITSSMNRSA 
IFRLKKTWLK VSKQTKALID KLQKLVSSEG RFKNLREALK NCDPPCVPYL GMYLTDLAFI 
EEGTPNYTED GLVNFSKMRM ISHIIREIRQ FQQTAYKIEH QAKVTQYLLD QSFVMDEESL 
YESSLRIEPK LPT

Genular Protein ID: 450700715

Symbol: A8K270_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K270

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 3 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 2 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 868
  • Mass: 98814
  • Checksum: 8A317EE96407F2A6
  • Sequence:
    • MQKGIRLNDG HVASLGLLAR KDGTRKGYLS KRSSDNTKWQ TKWFALLQNL LFYFESDSSS 
RPSGLYLLEG CVCDRAPSPK PALSAKEPLE KQHYFTVNFS HENQKALELR TEDAKDCDEW 
VAAIAHASYR TLATEHEALM QKYLHLLQIV ETEKTVAKQL RQQIEDGEIE IERLKAEITS 
LLKDNERIQS TQTVAPNDED SDIKKIKKVQ SFLRGWLCRR KWKTIIQDYI RSPHADSMRK 
RNQVVFSMLE AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH 
QIFYQGLKAR ISSWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC KQNRDFDKLL 
KHYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP HEHVERNSLD YAKSKLEELS 
RIMHDEVSET ENIRKNLAIE RMIIEGCEIL LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG 
SLSLKKEGER QCFLFSKHLI ICTRGSGGKL HLTKNGVISL IDCTLLEEPE STEEEAKGSG 
QDIDHLDFKI GVEPKDSPPF TVILVASSRQ EKAAWTSDIS QCVDNIRCNG LMMNAFEENS 
KVTVPQMIKR TREGTREAEM SRSDASLYCD DVDIRFSKTM NSCKVLQIRY ASVERLLERL 
TDLRFLSIDF LNTFLHSYRV FTTAIVVLDK LITIYKKPIS AIPARWLRSL ELLFASGQNN 
KLLYGEPPKS PRATRKFSSP PPLSITKTSS PSRRRKLSLN IPIITGGKAL DLAALSCNSN 
GYTSMYSAMS PFSKATLDTS KLYVSSSFTN KIPDEGDTTP EKPEDPSALS KQSSEVSMRE 
ESDIDQNQSD DGDTETSPTK SPTTPKSA

Genular Protein ID: 4042369918

Symbol: Q8IUU5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IUU5

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 3 Gene3D 4 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 10 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 2 SMART 4 SUPFAM 3

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1181
  • Mass: 133905
  • Checksum: A5FE151C4D15F70C
  • Sequence:
    • MQKGIRLNDG HVASLGLLAR KDGTRKGYLS KRSSDNTKWQ TKWFALLQNL LFYFESDSSS 
RPSGLYLLEG CVCDRAPSPK PALSAKEPLE KQHYFTVNFS HENQKALELR TEDAKDCDEW 
VAAIAHASYR TLATEHEALM QKYLHLLQIV ETEKTVAKQL RQQIEDGEIE IERLKAEITS 
LLKDNERIQS TQTVAPNDED SDIKKIKKVQ SFLRGWLCRR KWKTIIQDYI RSPHADSMRK 
RNQVVFSMLE AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH 
QIFYQGLKAR ISSWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC KQNRDFDKLL 
KHYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP HEHVERNSLD YAKSKLEELS 
RIMHDEVSET ENIRKNLAIE RMIIEGCEIL LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG 
SLSLKKEGER QCFLFSKHLI ICTRGSGGKL HLTKNGVISL IDCTLLEEPE STEEEAKGSG 
QDIDHLDFKI GVEPKDSPPF TVILVASSRQ EKAAWTSDIS QCVDNIRCNG LMMNAFEENS 
KVTVPQMIKS DASLYCDDVD IRFSKTMNSC KVLQIRYASV ERLLERLTDL RFLSIDFLNT 
FLHSYRVFTT AIVVLDKLIT IYKKPISAIP ARSLELLFAS GQNNKLLYGE PPKSPRATRK 
FSSPPPLSIT KTSSPSRRRK LSLNIPIITG GKALDLAALS CNSNGYTSMY SAMSPFSKAT 
LDTSKLYVSS SFTNKIPDEG DTTPEKPEDP SALSKQSSEV SMREESDIDQ NQSDDGDTET 
SPTKSPTTPK SVKNKNSSEF PLFSYNNGVV MTSCRELDNN RSALSAASAF AIATAGANEG 
TPNKEKYRRM SLASAGFPPD QRNGDKEFVI RRAATNRVLN VLRHWVSKHS QDFETNDELK 
CKVIGFLEEV MHDPELLTQE RKAAANIIRT LTQEDPGDNQ ITLEEITQMA EGVKAEPFEN 
HSALEIAEQL TLLDHLVFKK IPYEEFFGQG WMKLEKNERT PYIMKTTKHF NDISNLIASE 
IIRNEDINAR VSAIEKWVAV ADICRCLHNY NAVLEITSSM NRSAIFRLKK TWLKVSKQVR 
AGGWHHCLPG AGLGLGQEDP WAGHWASTSG QRTGLRSNTP R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.