Details for: S100A5

Gene ID: 6276

Symbol: S100A5

Ensembl ID: ENSG00000196420

Description: S100 calcium binding protein A5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 8.9363
    Cell Significance Index: -1.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 5.6378
    Cell Significance Index: -1.4300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.6201
    Cell Significance Index: 39.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6721
    Cell Significance Index: 86.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.1679
    Cell Significance Index: -1.4400
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.9206
    Cell Significance Index: 8.4400
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.3714
    Cell Significance Index: 2.5900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.3520
    Cell Significance Index: 3.7400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.2908
    Cell Significance Index: 3.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1928
    Cell Significance Index: 1.7800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0830
    Cell Significance Index: 1.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0779
    Cell Significance Index: 14.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0758
    Cell Significance Index: 1.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0731
    Cell Significance Index: 8.5200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0696
    Cell Significance Index: 0.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0557
    Cell Significance Index: 0.7600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.0537
    Cell Significance Index: 0.7300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0492
    Cell Significance Index: 0.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0449
    Cell Significance Index: 5.5200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0424
    Cell Significance Index: 0.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0319
    Cell Significance Index: 1.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0267
    Cell Significance Index: 0.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0242
    Cell Significance Index: 0.7100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0213
    Cell Significance Index: 0.1700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.0192
    Cell Significance Index: 0.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0160
    Cell Significance Index: 0.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0134
    Cell Significance Index: 7.3400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0016
    Cell Significance Index: 1.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0015
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0013
    Cell Significance Index: 2.4300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0003
    Cell Significance Index: 0.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0006
    Cell Significance Index: -0.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0007
    Cell Significance Index: -0.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0012
    Cell Significance Index: -0.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0013
    Cell Significance Index: -0.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -1.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0018
    Cell Significance Index: -1.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0030
    Cell Significance Index: -1.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0031
    Cell Significance Index: -0.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0040
    Cell Significance Index: -0.4100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0058
    Cell Significance Index: -0.3800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0060
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0062
    Cell Significance Index: -1.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0063
    Cell Significance Index: -0.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0064
    Cell Significance Index: -1.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0073
    Cell Significance Index: -1.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0074
    Cell Significance Index: -0.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0074
    Cell Significance Index: -0.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0075
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0087
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0092
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0110
    Cell Significance Index: -1.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0124
    Cell Significance Index: -0.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0131
    Cell Significance Index: -1.3600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0144
    Cell Significance Index: -0.1700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0159
    Cell Significance Index: -0.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0165
    Cell Significance Index: -0.5800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0177
    Cell Significance Index: -0.1100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0199
    Cell Significance Index: -0.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0208
    Cell Significance Index: -0.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0210
    Cell Significance Index: -0.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0215
    Cell Significance Index: -1.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0219
    Cell Significance Index: -1.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0230
    Cell Significance Index: -0.5900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0231
    Cell Significance Index: -0.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0246
    Cell Significance Index: -1.3800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0262
    Cell Significance Index: -0.2700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0270
    Cell Significance Index: -0.6700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0271
    Cell Significance Index: -0.2800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0291
    Cell Significance Index: -0.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0292
    Cell Significance Index: -0.7800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0299
    Cell Significance Index: -0.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0303
    Cell Significance Index: -0.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0305
    Cell Significance Index: -1.1200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0320
    Cell Significance Index: -0.3100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0325
    Cell Significance Index: -0.6400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0333
    Cell Significance Index: -0.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0338
    Cell Significance Index: -0.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0339
    Cell Significance Index: -1.0800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0340
    Cell Significance Index: -0.7100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0343
    Cell Significance Index: -0.3900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0351
    Cell Significance Index: -0.5900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0383
    Cell Significance Index: -0.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0385
    Cell Significance Index: -1.2600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0386
    Cell Significance Index: -0.6200
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0388
    Cell Significance Index: -0.4200
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0406
    Cell Significance Index: -0.5000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0408
    Cell Significance Index: -0.7600
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0411
    Cell Significance Index: -0.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0418
    Cell Significance Index: -1.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0422
    Cell Significance Index: -1.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0425
    Cell Significance Index: -0.9300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0432
    Cell Significance Index: -1.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium-binding protein**: S100A5's ability to bind calcium ions is crucial for its function, enabling interactions with various cellular components. 2. **Protein homodimerization activity**: S100A5 can form homodimers, which may contribute to its regulatory functions. 3. **Cellular localization**: S100A5 is expressed in diverse cell types, including early T lineage precursors, cardiac endothelial cells, and intestinal crypt stem cells. 4. **Protein binding**: S100A5 interacts with a range of proteins, influencing cellular processes such as cell growth, differentiation, and survival. **Pathways and Functions:** 1. **Calcium-dependent protein binding**: S100A5's calcium-binding properties enable it to interact with other proteins, influencing cellular processes. 2. **Protein homodimerization activity**: S100A5's ability to form homodimers may contribute to its regulatory functions, including cell growth, differentiation, and survival. 3. **Zinc ion binding**: S100A5's interaction with zinc ions may play a role in its regulatory functions, although the exact mechanisms are unclear. 4. **Neuronal cell body**: S100A5 is involved in regulating neuronal cell body functions, including cell growth, differentiation, and survival. 5. **Nucleus**: S100A5's interaction with the nucleus may influence gene expression, cellular differentiation, and survival. **Clinical Significance:** 1. **Cancer**: S100A5 has been implicated in various cancers, including breast, ovarian, and lung cancers. Its expression levels may serve as a biomarker for cancer diagnosis or prognosis. 2. **Cardiovascular disease**: S100A5's involvement in cardiac endothelial cell function may contribute to the development of cardiovascular disease. 3. **Neurological disorders**: S100A5's interaction with neuronal cell bodies may play a role in neurological disorders, such as Alzheimer's disease or Parkinson's disease. 4. **Immune system regulation**: S100A5's expression in immature innate lymphoid cells may influence immune system regulation and function. In conclusion, S100A5 is a multifaceted protein involved in regulating various cellular processes, including protein-protein interactions, homodimerization, and ion binding. Its clinical significance in disease contexts, including cancer, cardiovascular disease, neurological disorders, and immune system regulation, highlights the importance of further research into this protein.

Genular Protein ID: 1580485520

Symbol: S10A5_HUMAN

Name: Protein S100-A5

UniProtKB Accession Codes:

P33763 Q52LE7 Q5RHS3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 7 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8341667

Title: Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E.

PubMed ID: 8341667

DOI: 10.1073/pnas.90.14.6547

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10882717

Title: Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily.

PubMed ID: 10882717

DOI: 10.1074/jbc.m002260200

PubMed ID: 19536568

Title: Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states.

PubMed ID: 19536568

DOI: 10.1007/s00775-009-0553-1

Sequence Information:

  • Length: 92
  • Mass: 10744
  • Checksum: 49C2B1DAEC481561
  • Sequence:
    • METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKK ELCLGEMKES SIDDLMKSLD 
KNSDQEIDFK EYSVFLTMLC MAYNDFFLED NK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.