Details for: CCL15

Gene ID: 6359

Symbol: CCL15

Ensembl ID: ENSG00000275718

Description: C-C motif chemokine ligand 15

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 12.9504
    Cell Significance Index: -8.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 9.9912
    Cell Significance Index: 350.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 9.9604
    Cell Significance Index: 103.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 7.6548
    Cell Significance Index: 250.6200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 6.5932
    Cell Significance Index: 137.6100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 6.2673
    Cell Significance Index: 123.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 6.2096
    Cell Significance Index: 322.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4310
    Cell Significance Index: -11.8700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 4.0763
    Cell Significance Index: 80.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.4451
    Cell Significance Index: 31.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.8648
    Cell Significance Index: 129.8500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.6984
    Cell Significance Index: 40.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.1930
    Cell Significance Index: 32.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8121
    Cell Significance Index: 52.2100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.6435
    Cell Significance Index: 16.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5361
    Cell Significance Index: 1387.0200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.2075
    Cell Significance Index: 20.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2052
    Cell Significance Index: 26.1100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.8681
    Cell Significance Index: 10.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7166
    Cell Significance Index: 129.1800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.7105
    Cell Significance Index: 7.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6841
    Cell Significance Index: 17.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6760
    Cell Significance Index: 21.6500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6221
    Cell Significance Index: 15.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5079
    Cell Significance Index: 50.2400
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.4938
    Cell Significance Index: 4.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4714
    Cell Significance Index: 10.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2311
    Cell Significance Index: 28.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1902
    Cell Significance Index: 36.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1707
    Cell Significance Index: 17.4400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0879
    Cell Significance Index: 1.0000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0652
    Cell Significance Index: 1.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0576
    Cell Significance Index: 2.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0519
    Cell Significance Index: 6.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0016
    Cell Significance Index: 0.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0002
    Cell Significance Index: 0.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0008
    Cell Significance Index: -0.0300
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0065
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0122
    Cell Significance Index: -9.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0137
    Cell Significance Index: -10.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0158
    Cell Significance Index: -11.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0167
    Cell Significance Index: -0.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0173
    Cell Significance Index: -9.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0235
    Cell Significance Index: -4.7100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0341
    Cell Significance Index: -0.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0361
    Cell Significance Index: -7.1600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0449
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0497
    Cell Significance Index: -8.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0703
    Cell Significance Index: -9.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0858
    Cell Significance Index: -5.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0898
    Cell Significance Index: -2.8600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1073
    Cell Significance Index: -0.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1114
    Cell Significance Index: -2.7800
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.1194
    Cell Significance Index: -0.8400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1196
    Cell Significance Index: -1.8500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1225
    Cell Significance Index: -0.7600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1288
    Cell Significance Index: -2.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1462
    Cell Significance Index: -11.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1627
    Cell Significance Index: -3.7600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1909
    Cell Significance Index: -3.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1909
    Cell Significance Index: -10.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1960
    Cell Significance Index: -4.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2057
    Cell Significance Index: -3.1000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2128
    Cell Significance Index: -4.2700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2382
    Cell Significance Index: -2.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2476
    Cell Significance Index: -9.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2483
    Cell Significance Index: -5.1500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2683
    Cell Significance Index: -2.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2826
    Cell Significance Index: -10.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2875
    Cell Significance Index: -13.5100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3088
    Cell Significance Index: -4.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3110
    Cell Significance Index: -9.1600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3247
    Cell Significance Index: -2.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3248
    Cell Significance Index: -8.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3413
    Cell Significance Index: -11.8600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3727
    Cell Significance Index: -9.3000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3756
    Cell Significance Index: -9.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3929
    Cell Significance Index: -10.7000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4057
    Cell Significance Index: -4.7700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4278
    Cell Significance Index: -7.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4303
    Cell Significance Index: -11.4900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.4673
    Cell Significance Index: -5.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5059
    Cell Significance Index: -12.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5205
    Cell Significance Index: -10.9000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5260
    Cell Significance Index: -8.3500
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.5284
    Cell Significance Index: -5.0700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.5499
    Cell Significance Index: -9.4000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.5716
    Cell Significance Index: -5.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5814
    Cell Significance Index: -9.7300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.5969
    Cell Significance Index: -5.8400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.6022
    Cell Significance Index: -8.6300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.6415
    Cell Significance Index: -10.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6433
    Cell Significance Index: -11.8900
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.6478
    Cell Significance Index: -4.5200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.6484
    Cell Significance Index: -9.4500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6592
    Cell Significance Index: -11.1100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.6618
    Cell Significance Index: -9.0800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.6665
    Cell Significance Index: -9.4700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.6955
    Cell Significance Index: -9.0000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6992
    Cell Significance Index: -10.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCL15 is a small, secreted protein that belongs to the C-C chemokine family. It is primarily expressed in epithelial cells of various organs, including the colon, kidney, and bladder. CCL15 has been shown to be involved in the recruitment and activation of immune cells, such as eosinophils, neutrophils, and lymphocytes, in response to inflammatory stimuli. Its expression is upregulated in several disease states, including inflammatory bowel disease, asthma, and kidney diseases. **Pathways and Functions:** CCL15's primary function is to mediate chemotaxis, the directed migration of cells in response to chemical stimuli. It achieves this by binding to its receptor, CCR1, which is expressed on the surface of various immune cells. The binding of CCL15 to CCR1 triggers a series of downstream signaling events that activate the ERK1/2 cascade, leading to the phosphorylation and activation of various transcription factors. These transcription factors, in turn, regulate the expression of genes involved in inflammation, immune response, and cellular migration. CCL15 has been implicated in the regulation of various cellular processes, including: * Eosinophil chemotaxis: CCL15 is a potent chemoattractant for eosinophils, which play a crucial role in the pathogenesis of allergic diseases, such as asthma. * Lymphocyte chemotaxis: CCL15 has been shown to recruit lymphocytes to sites of inflammation, where they contribute to the immune response. * Monocyte and neutrophil chemotaxis: CCL15 has also been implicated in the recruitment of monocytes and neutrophils to sites of inflammation. **Clinical Significance:** CCL15 has been implicated in the pathogenesis of several diseases, including: * Inflammatory bowel disease (IBD): CCL15 expression is upregulated in the colon of patients with IBD, and its blockade has been shown to reduce inflammation and improve symptoms. * Asthma: CCL15 has been implicated in the recruitment of eosinophils to the airways, where they contribute to the pathogenesis of asthma. * Kidney diseases: CCL15 has been shown to be upregulated in the kidney of patients with kidney diseases, such as diabetic nephropathy. In conclusion, CCL15 is a multifaceted chemokine that plays a critical role in regulating immune responses, inflammation, and cellular migration. Its clinical significance lies in its involvement in various disease states, including IBD, asthma, and kidney diseases. Further research is needed to fully elucidate the mechanisms by which CCL15 regulates immune responses and to explore its therapeutic potential in these diseases.

Genular Protein ID: 439693963

Symbol: CCL15_HUMAN

Name: C-C motif chemokine 15

UniProtKB Accession Codes:

Q16663 B2RU34 E1P651 Q9UM74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 2 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9548457

Title: Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3.

PubMed ID: 9548457

PubMed ID: 9624581

Title: Molecular cloning and functional characterization of human MIP-1 delta, a new C-C chemokine related to mouse CCF-18 and C10.

PubMed ID: 9624581

DOI: 10.1023/a:1020535106684

PubMed ID: 9600961

Title: HCC-2, a human chemokine: gene structure, expression pattern, and biological activity.

PubMed ID: 9600961

DOI: 10.1073/pnas.95.11.6308

PubMed ID: 10213461

Title: Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES.

PubMed ID: 10213461

DOI: 10.1089/107999099314153

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9129202

Title: The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases.

PubMed ID: 9129202

DOI: 10.1002/jlb.61.5.545

PubMed ID: 9558365

Title: Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1.

PubMed ID: 9558365

PubMed ID: 15905581

Title: Proteolytic activation of alternative CCR1 ligands in inflammation.

PubMed ID: 15905581

DOI: 10.4049/jimmunol.174.11.7341

PubMed ID: 10320325

Title: Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype.

PubMed ID: 10320325

DOI: 10.1021/bi990065i

Sequence Information:

  • Length: 113
  • Mass: 12236
  • Checksum: 0BBC31FB696E16C9
  • Sequence:
    • MKVSVAALSC LMLVAVLGSQ AQFTNDAETE LMMSKLPLEN PVVLNSFHFA ADCCTSYISQ 
SIPCSLMKSY FETSSECSKP GVIFLTKKGR QVCAKPSGPG VQDCMKKLKP YSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.