Details for: CCL16

Gene ID: 6360

Symbol: CCL16

Ensembl ID: ENSG00000275152

Description: C-C motif chemokine ligand 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.5542
    Cell Significance Index: 4.1000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.9478
    Cell Significance Index: 13.9900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.5852
    Cell Significance Index: 7.5600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2707
    Cell Significance Index: 4.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2541
    Cell Significance Index: 5.5100
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.2104
    Cell Significance Index: 2.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1206
    Cell Significance Index: 23.9400
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.0921
    Cell Significance Index: 0.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0396
    Cell Significance Index: 2.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0334
    Cell Significance Index: 5.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0294
    Cell Significance Index: 2.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0293
    Cell Significance Index: 0.2700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.0237
    Cell Significance Index: 0.1700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0200
    Cell Significance Index: 0.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0064
    Cell Significance Index: 0.2900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0058
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -1.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0015
    Cell Significance Index: -1.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0020
    Cell Significance Index: -1.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0022
    Cell Significance Index: -1.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0023
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0031
    Cell Significance Index: -0.5300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0034
    Cell Significance Index: -0.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0034
    Cell Significance Index: -1.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0043
    Cell Significance Index: -1.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0050
    Cell Significance Index: -0.2600
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.0053
    Cell Significance Index: -0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0054
    Cell Significance Index: -1.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0063
    Cell Significance Index: -0.0900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0066
    Cell Significance Index: -0.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0089
    Cell Significance Index: -1.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0090
    Cell Significance Index: -1.3100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0094
    Cell Significance Index: -0.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0115
    Cell Significance Index: -1.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0132
    Cell Significance Index: -1.3500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0143
    Cell Significance Index: -0.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0148
    Cell Significance Index: -0.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0163
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0172
    Cell Significance Index: -1.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0173
    Cell Significance Index: -2.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0174
    Cell Significance Index: -0.5000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0199
    Cell Significance Index: -0.3000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0215
    Cell Significance Index: -0.1700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0229
    Cell Significance Index: -0.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0241
    Cell Significance Index: -1.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0278
    Cell Significance Index: -1.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0279
    Cell Significance Index: -1.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0296
    Cell Significance Index: -1.6600
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0302
    Cell Significance Index: -0.3600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0332
    Cell Significance Index: -0.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0364
    Cell Significance Index: -1.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0365
    Cell Significance Index: -1.2800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0407
    Cell Significance Index: -0.6100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0410
    Cell Significance Index: -0.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0412
    Cell Significance Index: -1.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0422
    Cell Significance Index: -1.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0423
    Cell Significance Index: -1.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0440
    Cell Significance Index: -0.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0443
    Cell Significance Index: -1.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0444
    Cell Significance Index: -1.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0470
    Cell Significance Index: -1.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0485
    Cell Significance Index: -1.3900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0535
    Cell Significance Index: -0.7600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0537
    Cell Significance Index: -0.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0541
    Cell Significance Index: -1.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0553
    Cell Significance Index: -1.3400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0561
    Cell Significance Index: -0.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0569
    Cell Significance Index: -1.4200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0569
    Cell Significance Index: -1.4500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0581
    Cell Significance Index: -1.4500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0632
    Cell Significance Index: -1.2600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.0637
    Cell Significance Index: -0.6600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0651
    Cell Significance Index: -2.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0662
    Cell Significance Index: -1.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0662
    Cell Significance Index: -1.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0673
    Cell Significance Index: -1.7700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0674
    Cell Significance Index: -0.7300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0690
    Cell Significance Index: -1.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0692
    Cell Significance Index: -1.7300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0693
    Cell Significance Index: -0.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0717
    Cell Significance Index: -1.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0720
    Cell Significance Index: -2.9500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0725
    Cell Significance Index: -0.6700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0727
    Cell Significance Index: -1.4300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0738
    Cell Significance Index: -1.4600
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.0741
    Cell Significance Index: -0.8300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0757
    Cell Significance Index: -0.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0771
    Cell Significance Index: -1.6000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0779
    Cell Significance Index: -1.9000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0801
    Cell Significance Index: -1.3600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0833
    Cell Significance Index: -1.1400
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0834
    Cell Significance Index: -0.2900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0841
    Cell Significance Index: -0.9500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0844
    Cell Significance Index: -0.4600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0847
    Cell Significance Index: -1.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0848
    Cell Significance Index: -1.9600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0877
    Cell Significance Index: -0.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Chemokine structure**: CCL16 is a small chemokine consisting of 77 amino acids, belonging to the C-C motif family. 2. **Expression pattern**: CCL16 is expressed in various tissues, including the gastrointestinal tract, lymphoid organs, and epithelial cells. 3. **Cellular interactions**: CCL16 interacts with the CCR6 receptor, which is expressed on immune cells, including eosinophils, T cells, and dendritic cells. 4. **Function**: CCL16 promotes the recruitment and activation of immune cells, particularly eosinophils, in response to inflammatory stimuli. **Pathways and Functions:** 1. **Chemotaxis**: CCL16 acts as a chemoattractant, guiding immune cells to sites of inflammation and tissue damage. 2. **Cell-cell signaling**: CCL16 interacts with its receptor, CCR6, to activate downstream signaling pathways that regulate immune cell activation and survival. 3. **Inflammatory response**: CCL16 plays a crucial role in the regulation of the inflammatory response, particularly in the recruitment and activation of eosinophils and T cells. 4. **Gastrointestinal immunity**: CCL16 is expressed in the gastrointestinal tract and plays a role in maintaining the balance between immune responses and tolerance in the gut. **Clinical Significance:** 1. **Inflammatory bowel disease (IBD)**: CCL16 has been implicated in the pathogenesis of IBD, including Crohn's disease and ulcerative colitis, where it promotes the recruitment and activation of immune cells to the gut epithelium. 2. **Allergic diseases**: CCL16 is involved in the pathogenesis of allergic diseases, such as asthma and atopic dermatitis, where it promotes the recruitment of eosinophils and other immune cells to the airways or skin. 3. **Cancer**: CCL16 has been implicated in the progression of certain cancers, including colorectal cancer, where it promotes the recruitment of immune cells to the tumor microenvironment. 4. **Neurological disorders**: CCL16 has been implicated in the pathogenesis of neurological disorders, such as multiple sclerosis and Parkinson's disease, where it promotes the recruitment of immune cells to the central nervous system. In conclusion, CCL16 is a multifaceted chemokine that plays a crucial role in the regulation of immune responses and the pathogenesis of various inflammatory and autoimmune diseases. Further research is needed to fully elucidate the mechanisms by which CCL16 regulates immune responses and to explore its potential as a therapeutic target in human disease.

Genular Protein ID: 1602645769

Symbol: CCL16_HUMAN

Name: C-C motif chemokine 16

UniProtKB Accession Codes:

O15467 Q4KKU0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9596672

Title: Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10.

PubMed ID: 9596672

PubMed ID: 9545580

Title: Isolation of cDNA encoding a novel human CC chemokine NCC-4/LEC.

PubMed ID: 9545580

DOI: 10.1016/s0167-4781(97)00235-2

PubMed ID: 10213461

Title: Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES.

PubMed ID: 10213461

DOI: 10.1089/107999099314153

PubMed ID: 9642106

Title: Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity.

PubMed ID: 9642106

DOI: 10.1006/bbrc.1998.8762

PubMed ID: 10235110

Title: Genomic organization of the genes for human and mouse CC chemokine LEC.

PubMed ID: 10235110

DOI: 10.1089/104454999315330

PubMed ID: 10671294

Title: Cloning, characterization and genomic organization of LCC-1 (scya16), a novel human CC chemokine expressed in liver.

PubMed ID: 10671294

DOI: 10.1006/cyto.1999.0548

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 120
  • Mass: 13600
  • Checksum: 373D73016134D894
  • Sequence:
    • MKVSEAALSL LVLILIITSA SRSQPKVPEW VNTPSTCCLK YYEKVLPRRL VVGYRKALNC 
HLPAIIFVTK RNREVCTNPN DDWVQEYIKD PNLPLLPTRN LSTVKIITAK NGQPQLLNSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.