Details for: SLC17A1

Gene ID: 6568

Symbol: SLC17A1

Ensembl ID: ENSG00000124568

Description: solute carrier family 17 member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 7.0670
    Cell Significance Index: 248.3300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 6.6095
    Cell Significance Index: 85.5300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 6.1999
    Cell Significance Index: 85.0200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.7037
    Cell Significance Index: 80.4100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.0348
    Cell Significance Index: 17.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2165
    Cell Significance Index: 55.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1855
    Cell Significance Index: 28.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8224
    Cell Significance Index: 163.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7807
    Cell Significance Index: 148.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6680
    Cell Significance Index: 66.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5461
    Cell Significance Index: 493.0500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.4700
    Cell Significance Index: 1.7700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3690
    Cell Significance Index: 6.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3193
    Cell Significance Index: 4.5700
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.3161
    Cell Significance Index: 2.6700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3044
    Cell Significance Index: 4.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2212
    Cell Significance Index: 24.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1901
    Cell Significance Index: 30.9200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.1740
    Cell Significance Index: 1.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1533
    Cell Significance Index: 3.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1296
    Cell Significance Index: 8.9700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.1125
    Cell Significance Index: 1.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1100
    Cell Significance Index: 76.0900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0511
    Cell Significance Index: 0.7700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0416
    Cell Significance Index: 0.7000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0402
    Cell Significance Index: 1.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0357
    Cell Significance Index: 2.1900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0222
    Cell Significance Index: 0.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0208
    Cell Significance Index: 2.4200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0195
    Cell Significance Index: 0.1300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0191
    Cell Significance Index: 0.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0076
    Cell Significance Index: 0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -0.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0009
    Cell Significance Index: -1.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0036
    Cell Significance Index: -2.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0040
    Cell Significance Index: -0.1000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0072
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0077
    Cell Significance Index: -5.6400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0079
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0083
    Cell Significance Index: -5.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0086
    Cell Significance Index: -0.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0090
    Cell Significance Index: -5.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0097
    Cell Significance Index: -0.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0099
    Cell Significance Index: -2.8600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0101
    Cell Significance Index: -0.1300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0102
    Cell Significance Index: -0.1500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0104
    Cell Significance Index: -0.3300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0110
    Cell Significance Index: -0.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0130
    Cell Significance Index: -0.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0143
    Cell Significance Index: -5.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0147
    Cell Significance Index: -2.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0166
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0169
    Cell Significance Index: -1.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0179
    Cell Significance Index: -1.8300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0185
    Cell Significance Index: -0.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0209
    Cell Significance Index: -0.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0218
    Cell Significance Index: -2.2800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0247
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0264
    Cell Significance Index: -4.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0311
    Cell Significance Index: -0.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0318
    Cell Significance Index: -5.7300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0343
    Cell Significance Index: -0.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0381
    Cell Significance Index: -5.5400
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0397
    Cell Significance Index: -0.4500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0411
    Cell Significance Index: -0.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0452
    Cell Significance Index: -1.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0475
    Cell Significance Index: -5.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0500
    Cell Significance Index: -3.0000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0547
    Cell Significance Index: -1.0700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0570
    Cell Significance Index: -1.3900
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0578
    Cell Significance Index: -0.5700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0588
    Cell Significance Index: -0.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0589
    Cell Significance Index: -4.5200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0602
    Cell Significance Index: -0.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0615
    Cell Significance Index: -1.2000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0639
    Cell Significance Index: -0.6400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0668
    Cell Significance Index: -0.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0670
    Cell Significance Index: -5.3100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0692
    Cell Significance Index: -0.4800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0695
    Cell Significance Index: -1.0400
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0738
    Cell Significance Index: -0.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0745
    Cell Significance Index: -4.5800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0779
    Cell Significance Index: -1.0200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0784
    Cell Significance Index: -1.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0805
    Cell Significance Index: -5.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0807
    Cell Significance Index: -4.5300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0857
    Cell Significance Index: -0.7300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0864
    Cell Significance Index: -0.4500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0886
    Cell Significance Index: -1.4300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0907
    Cell Significance Index: -1.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0931
    Cell Significance Index: -1.2700
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0971
    Cell Significance Index: -0.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0976
    Cell Significance Index: -3.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0976
    Cell Significance Index: -1.0100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0995
    Cell Significance Index: -1.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0998
    Cell Significance Index: -4.6900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0998
    Cell Significance Index: -1.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Transporter:** NPT1 is a transmembrane protein that facilitates the transport of phosphate ions (Pi) across cell membranes, playing a critical role in maintaining intracellular phosphate levels. 2. **Sodium-dependent:** NPT1 exhibits sodium-dependent transport activity, meaning that the movement of phosphate ions is coupled with the movement of sodium ions (Na+). 3. **Broad Tissue Expression:** SLC17A1 is expressed in various cell types, including hematopoietic stem cells, epithelial cells, and megakaryocytes, underscoring its widespread importance in phosphate homeostasis. 4. **Regulation of Urate Metabolism:** NPT1 is involved in the regulation of urate metabolism, with implications for the development of gout and other urate-related disorders. **Pathways and Functions:** 1. **Phosphate Transport:** NPT1 mediates the transport of phosphate ions across cell membranes, playing a critical role in maintaining intracellular phosphate levels. 2. **Sodium-Phosphate Symporter Activity:** NPT1 exhibits sodium-phosphate symporter activity, coupling the movement of phosphate ions with the movement of sodium ions. 3. **Urate Metabolic Process:** NPT1 is involved in the regulation of urate metabolism, with implications for the development of gout and other urate-related disorders. 4. **Transport of Inorganic Cations/Anions and Amino Acids/Oligopeptides:** NPT1 is also involved in the transport of inorganic cations, anions, and amino acids/oligopeptides, highlighting its role in maintaining cellular homeostasis. **Clinical Significance:** 1. **Gout and Urate-Related Disorders:** Abnormalities in NPT1 function have been implicated in the development of gout and other urate-related disorders, highlighting the importance of this gene in maintaining phosphate homeostasis. 2. **Phosphate Metabolic Disorders:** Mutations in SLC17A1 have been associated with phosphate metabolic disorders, such as renal phosphate wasting and hyperphosphatemia. 3. **Hematological Disorders:** NPT1 expression has been observed in hematopoietic stem cells, suggesting a potential role in the development of hematological disorders, such as anemia and leukemias. 4. **Cancer and Metastasis:** Aberrant expression of NPT1 has been observed in various types of cancer, including breast, lung, and colon cancer, highlighting the potential role of this gene in cancer development and metastasis. In conclusion, the SLC17A1 gene plays a critical role in maintaining phosphate homeostasis, regulating sodium-phosphate symporter activity, and influencing urate metabolism. Its dysregulation has been implicated in various diseases, including gout, phosphate metabolic disorders, and hematological disorders. Further research is necessary to fully elucidate the mechanisms by which NPT1 regulates phosphate homeostasis and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1363338453

Symbol: NPT1_HUMAN

Name: Sodium-dependent phosphate transport protein 1

UniProtKB Accession Codes:

Q14916 A8K418 O60761 Q13783 Q3MIP5 Q5MJP8 Q5TB83 Q96KL8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8288239

Title: Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23.

PubMed ID: 8288239

DOI: 10.1006/geno.1993.1476

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11704559

Title: Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity.

PubMed ID: 11704559

DOI: 10.1152/ajprenal.0092.2001

PubMed ID: 9545579

Title: Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene.

PubMed ID: 9545579

DOI: 10.1016/s0167-4781(97)00231-5

PubMed ID: 7826357

Title: Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression.

PubMed ID: 7826357

DOI: 10.1042/bj3050081

PubMed ID: 25252215

Title: NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout.

PubMed ID: 25252215

DOI: 10.1002/art.38884

PubMed ID: 27906618

Title: Expression of a human NPT1/SLC17A1 missense variant which increases urate export.

PubMed ID: 27906618

DOI: 10.1080/15257770.2016.1149192

Sequence Information:

  • Length: 467
  • Mass: 51132
  • Checksum: 10FE6C7E202BCFF7
  • Sequence:
    • MQMDNRLPPK KVPGFCSFRY GLSFLVHCCN VIITAQRACL NLTMVVMVNS TDPHGLPNTS 
TKKLLDNIKN PMYNWSPDIQ GIILSSTSYG VIIIQVPVGY FSGIYSTKKM IGFALCLSSV 
LSLLIPPAAG IGVAWVVVCR AVQGAAQGIV ATAQFEIYVK WAPPLERGRL TSMSTSGFLL 
GPFIVLLVTG VICESLGWPM VFYIFGACGC AVCLLWFVLF YDDPKDHPCI SISEKEYITS 
SLVQQVSSSR QSLPIKAILK SLPVWAISTG SFTFFWSHNI MTLYTPMFIN SMLHVNIKEN 
GFLSSLPYLF AWICGNLAGQ LSDFFLTRNI LSVIAVRKLF TAAGFLLPAI FGVCLPYLSS 
TFYSIVIFLI LAGATGSFCL GGVFINGLDI APRYFGFIKA CSTLTGMIGG LIASTLTGLI 
LKQDPESAWF KTFILMAAIN VTGLIFYLIV ATAEIQDWAK EKQHTRL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.