Details for: SSX2

Gene ID: 6757

Symbol: SSX2

Ensembl ID: ENSG00000241476

Description: SSX family member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0793
    Cell Significance Index: 1.9800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0542
    Cell Significance Index: 0.6900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0160
    Cell Significance Index: 0.4000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0013
    Cell Significance Index: -0.2700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0053
    Cell Significance Index: -0.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0060
    Cell Significance Index: -0.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0084
    Cell Significance Index: -0.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0090
    Cell Significance Index: -0.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0096
    Cell Significance Index: -0.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0102
    Cell Significance Index: -0.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0109
    Cell Significance Index: -0.1300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0120
    Cell Significance Index: -0.2600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0125
    Cell Significance Index: -0.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0134
    Cell Significance Index: -0.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0135
    Cell Significance Index: -0.3800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0162
    Cell Significance Index: -0.2100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0178
    Cell Significance Index: -0.2400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0187
    Cell Significance Index: -0.2000
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.0189
    Cell Significance Index: -0.2100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0195
    Cell Significance Index: -0.2600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0197
    Cell Significance Index: -0.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0208
    Cell Significance Index: -0.3200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0210
    Cell Significance Index: -0.2800
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.0211
    Cell Significance Index: -0.2300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0213
    Cell Significance Index: -0.2800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0216
    Cell Significance Index: -0.2700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0217
    Cell Significance Index: -0.3200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0220
    Cell Significance Index: -0.2700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0226
    Cell Significance Index: -0.2900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0227
    Cell Significance Index: -0.2800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0234
    Cell Significance Index: -0.2800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0244
    Cell Significance Index: -0.2900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0248
    Cell Significance Index: -0.3300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0254
    Cell Significance Index: -0.3000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0275
    Cell Significance Index: -0.2900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0288
    Cell Significance Index: -0.2700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0290
    Cell Significance Index: -0.3800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0293
    Cell Significance Index: -0.3400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0298
    Cell Significance Index: -0.3300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0299
    Cell Significance Index: -0.3400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0303
    Cell Significance Index: -0.2500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0314
    Cell Significance Index: -0.3400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0316
    Cell Significance Index: -0.3000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0317
    Cell Significance Index: -0.3700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0317
    Cell Significance Index: -0.3700
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0318
    Cell Significance Index: -0.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0327
    Cell Significance Index: -0.3100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0338
    Cell Significance Index: -0.2600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0339
    Cell Significance Index: -0.4900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0340
    Cell Significance Index: -0.3000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0343
    Cell Significance Index: -0.3800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0355
    Cell Significance Index: -0.3100
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0359
    Cell Significance Index: -0.3600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0363
    Cell Significance Index: -0.3400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0364
    Cell Significance Index: -0.5000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0381
    Cell Significance Index: -0.4000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0387
    Cell Significance Index: -0.3600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0400
    Cell Significance Index: -0.4500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0411
    Cell Significance Index: -0.2200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0414
    Cell Significance Index: -0.3800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0417
    Cell Significance Index: -0.4900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0435
    Cell Significance Index: -0.5000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0446
    Cell Significance Index: -0.4400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0449
    Cell Significance Index: -0.4600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0470
    Cell Significance Index: -0.3100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0498
    Cell Significance Index: -0.4400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0509
    Cell Significance Index: -0.5800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0522
    Cell Significance Index: -0.3100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0538
    Cell Significance Index: -0.7700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0583
    Cell Significance Index: -0.6000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0599
    Cell Significance Index: -0.5000
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0620
    Cell Significance Index: -0.3300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0699
    Cell Significance Index: -0.4700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0709
    Cell Significance Index: -0.8000
  • Cell Name: contractile cell (CL0000183)
    Fold Change: -0.2782
    Cell Significance Index: -0.5400
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: -0.2840
    Cell Significance Index: -0.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SSX2 is a member of the SSX gene family, which consists of four genes (SSX1, SSX2, SSX3, and SSX4) that are involved in regulating cellular processes. SSX2 is specifically expressed in various cell types, including smooth muscle cells, skin fibroblasts, male germ cells, and T cells. The gene's expression is also observed in lymphoid lineage-restricted progenitor cells, pericytes, and skeletal muscle fibroblasts. SSX2's protein product interacts with various transcription factors and signaling molecules, influencing gene expression and cell signaling pathways. **Pathways and Functions:** SSX2's involvement in multiple cellular processes can be attributed to its interactions with various transcription factors, signaling molecules, and other proteins. Its pathways and functions include: 1. **Regulation of DNA-templated transcription:** SSX2 interacts with transcription factors, such as TFIID and TFIIB, to regulate the expression of genes involved in cell growth, differentiation, and survival. 2. **Cell signaling:** SSX2's protein product interacts with signaling molecules, such as apoptosis regulators and kinases, to modulate cell signaling pathways. 3. **Cell differentiation:** SSX2 plays a role in regulating cell differentiation, particularly in the development of smooth muscle cells and T cells. 4. **Apoptosis:** SSX2's protein product interacts with pro-apoptotic and anti-apoptotic proteins to regulate apoptosis, a process essential for maintaining tissue homeostasis. **Clinical Significance:** SSX2's dysregulation has been implicated in various diseases, including: 1. **Cancer:** Overexpression of SSX2 has been observed in various types of cancer, including prostate, breast, and lung cancer. SSX2's role in regulating cell growth and differentiation suggests that its dysregulation may contribute to tumorigenesis. 2. **Autoimmune disorders:** SSX2's expression in T cells and lymphoid lineage-restricted progenitor cells suggests that it may play a role in regulating immune responses. Dysregulation of SSX2 has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurological disorders:** SSX2's expression in neuronal receptor cells and smooth muscle myoblasts suggests that it may play a role in regulating neuronal function and muscle development. Dysregulation of SSX2 has been implicated in neurological disorders, such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). In conclusion, SSX2 is a multifaceted gene involved in regulating various cellular processes, including transcription, cell signaling, and cell differentiation. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and neurological disorders. Further research is needed to fully understand the role of SSX2 in maintaining tissue homeostasis and its implications in human diseases.

Genular Protein ID: 705995035

Symbol: SSX2_HUMAN

Name: Protein SSX2

UniProtKB Accession Codes:

Q16385 Q16404 Q5JS26 Q96IP7 Q9BU88

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 2 Bgee 1 BindingDB 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 4 CTD 2 ChiTaRS 2 DMDM 1 DNASU 1 DisGeNET 2 EMBL 14 EMDB 1 Ensembl 5 GO 2 GeneCards 2 GeneTree 1 GeneWiki 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 IntAct 1 InterPro 4 KEGG 2 MANE-Select 2 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 6 SMART 1 SMR 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 2 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7539744

Title: Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma.

PubMed ID: 7539744

DOI: 10.1002/j.1460-2075.1995.tb07228.x

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7655467

Title: Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas.

PubMed ID: 7655467

DOI: 10.1093/hmg/4.6.1097

PubMed ID: 7951320

Title: Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma.

PubMed ID: 7951320

DOI: 10.1038/ng0894-502

PubMed ID: 7495284

Title: Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript.

PubMed ID: 7495284

PubMed ID: 12007189

Title: The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP.

PubMed ID: 12007189

DOI: 10.1002/gcc.10073

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 188
  • Mass: 21620
  • Checksum: BF5D18AA5F45B1B1
  • Sequence:
    • MNGDDAFARR PTVGAQIPEK IQKAFDDIAK YFSKEEWEKM KASEKIFYVY MKRKYEAMTK 
LGFKATLPPF MCNKRAEDFQ GNDLDNDPNR GNQVERPQMT FGRLQGISPK IMPKKPAEEG 
NDSEEVPEAS GPQNDGKELC PPGKPTTSEK IHERSGPKRG EHAWTHRLRE RKQLVIYEEI 
SDPEEDDE

Genular Protein ID: 2893855820

Symbol: R9QTR3_HUMAN

Name: N/A

UniProtKB Accession Codes:

R9QTR3

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 2 CTD 2 DNASU 1 DisGeNET 2 EMBL 2 GO 2 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 214
  • Mass: 24695
  • Checksum: B4E6E903C03B92A8
  • Sequence:
    • MNGDDAFARR PTVGAQIPEK IQKAFDDIAK YFSKEEWEKM KASEKIFYVY MKRKYEAMTK 
LGFKATLPPF MCNKRAEDFQ GNDLDNDPNR GNQVERPQMT FGRLQGISPK IMPKKPAEEG 
NDSEEVPEAS GPQNDGKELC PPGKPTTSEK IHERSGNREA QEKEERRGTA HRWSSQNTHN 
IGPKRGEHAW THRLRERKQL VIYEEISDPE EDDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.