Details for: TAT

Gene ID: 6898

Symbol: TAT

Ensembl ID: ENSG00000198650

Description: tyrosine aminotransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 17.8946
    Cell Significance Index: 47.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 12.3037
    Cell Significance Index: 207.2600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 3.8238
    Cell Significance Index: 22.0200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.5925
    Cell Significance Index: 23.5100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.5771
    Cell Significance Index: 4.2300
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.4760
    Cell Significance Index: 5.1400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.4072
    Cell Significance Index: 8.6600
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.9057
    Cell Significance Index: 7.1500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.7859
    Cell Significance Index: 2.9600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4350
    Cell Significance Index: 6.3400
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.3892
    Cell Significance Index: 3.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3277
    Cell Significance Index: 24.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2451
    Cell Significance Index: 3.5100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1992
    Cell Significance Index: 2.5700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1368
    Cell Significance Index: 1.3000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.1212
    Cell Significance Index: 1.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0641
    Cell Significance Index: 4.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0552
    Cell Significance Index: 10.9600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0359
    Cell Significance Index: 0.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0305
    Cell Significance Index: 5.8100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0293
    Cell Significance Index: 0.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0265
    Cell Significance Index: 1.5900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0244
    Cell Significance Index: 0.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0218
    Cell Significance Index: 2.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0189
    Cell Significance Index: 3.0800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0167
    Cell Significance Index: 0.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0163
    Cell Significance Index: 0.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0151
    Cell Significance Index: 0.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0127
    Cell Significance Index: 0.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0071
    Cell Significance Index: 0.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0030
    Cell Significance Index: 0.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0017
    Cell Significance Index: 0.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0015
    Cell Significance Index: 0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0006
    Cell Significance Index: 1.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0004
    Cell Significance Index: 0.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0003
    Cell Significance Index: 0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0002
    Cell Significance Index: 0.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0003
    Cell Significance Index: -0.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0006
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0008
    Cell Significance Index: -0.6300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0009
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0010
    Cell Significance Index: -0.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0013
    Cell Significance Index: -0.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0020
    Cell Significance Index: -0.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0020
    Cell Significance Index: -0.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0021
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0023
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0028
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0029
    Cell Significance Index: -0.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0032
    Cell Significance Index: -0.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0033
    Cell Significance Index: -0.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0045
    Cell Significance Index: -0.5200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0050
    Cell Significance Index: -0.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0053
    Cell Significance Index: -0.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0067
    Cell Significance Index: -0.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0078
    Cell Significance Index: -0.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0081
    Cell Significance Index: -0.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0083
    Cell Significance Index: -1.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0085
    Cell Significance Index: -1.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0086
    Cell Significance Index: -0.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0106
    Cell Significance Index: -0.1600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0107
    Cell Significance Index: -0.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0109
    Cell Significance Index: -0.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0113
    Cell Significance Index: -0.6400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0114
    Cell Significance Index: -0.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0116
    Cell Significance Index: -0.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0128
    Cell Significance Index: -0.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0128
    Cell Significance Index: -0.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0131
    Cell Significance Index: -1.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0131
    Cell Significance Index: -0.5800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0132
    Cell Significance Index: -0.2100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0164
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0164
    Cell Significance Index: -0.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0169
    Cell Significance Index: -0.6400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0175
    Cell Significance Index: -0.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0181
    Cell Significance Index: -0.5200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0182
    Cell Significance Index: -0.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0185
    Cell Significance Index: -0.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0188
    Cell Significance Index: -0.6000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0188
    Cell Significance Index: -0.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0189
    Cell Significance Index: -0.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0197
    Cell Significance Index: -0.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0210
    Cell Significance Index: -0.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0215
    Cell Significance Index: -0.4700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0225
    Cell Significance Index: -0.3000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0228
    Cell Significance Index: -0.5700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0238
    Cell Significance Index: -0.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0241
    Cell Significance Index: -0.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0249
    Cell Significance Index: -0.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0252
    Cell Significance Index: -0.6300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0253
    Cell Significance Index: -0.2700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0255
    Cell Significance Index: -0.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0255
    Cell Significance Index: -0.6700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0256
    Cell Significance Index: -0.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Substrate specificity:** TAT exhibits high specificity for the amino group transfer from tyrosine to α-ketoglutarate, producing L-tyrosine and 2-oxoglutarate. 2. **Coenzyme dependence:** TAT requires pyridoxal phosphate (PLP) as a coenzyme for its catalytic activity. 3. **Tissue distribution:** TAT is primarily expressed in the liver (periportal, midzonal, and centrilobular regions), small intestine (colon goblet cells, intestinal crypt stem cells, and enterocytes), and immune cells (inflammatory macrophages). 4. **Regulatory mechanisms:** TAT expression is modulated by various factors, including hormonal stimuli (e.g., dexamethasone) and oxidative stress. **Pathways and Functions:** 1. **Tyrosine catabolism:** TAT is the primary enzyme responsible for the breakdown of tyrosine, which is then converted into L-tyrosine and 2-oxoglutarate. 2. **Amino acid metabolism:** TAT participates in the metabolism of various amino acids, including phenylalanine, tyrosine, and glutamate. 3. **2-Oxoglutarate metabolic process:** TAT is involved in the 2-oxoglutarate metabolic process, which is crucial for energy production, biosynthesis, and nitrogen metabolism. 4. **Biosynthetic process:** TAT contributes to the biosynthesis of various compounds, including neurotransmitters, hormones, and amino acid derivatives. **Clinical Significance:** 1. **Tyrosinemia:** Mutations in the TAT gene have been associated with tyrosinemia, a genetic disorder characterized by elevated levels of tyrosine in the blood and tissues. 2. **Neurological disorders:** Abnormal TAT activity has been linked to various neurological disorders, including Parkinson's disease, schizophrenia, and autism spectrum disorder. 3. **Cancer:** TAT expression is often upregulated in cancer cells, contributing to their growth, survival, and metastasis. 4. **Inflammatory diseases:** TAT is involved in the regulation of immune responses, and its dysregulation has been implicated in various inflammatory diseases, including rheumatoid arthritis and atherosclerosis. In conclusion, tyrosine aminotransferase (TAT) is a vital enzyme that plays a crucial role in amino acid metabolism, energy production, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding TAT's functions and pathways in maintaining human health.

Genular Protein ID: 3754986553

Symbol: ATTY_HUMAN

Name: Tyrosine aminotransferase

UniProtKB Accession Codes:

P17735 B2R8I1 D3DWS2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 2 EMBL 16 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1973834

Title: Isolation and characterization of the human tyrosine aminotransferase gene.

PubMed ID: 1973834

DOI: 10.1093/nar/18.13.3853

PubMed ID: 7908801

Title: Nucleotide sequence of the human tyrosine aminotransferase gene.

PubMed ID: 7908801

PubMed ID: 7999802

Title: Cloning and expression of human tyrosine aminotransferase cDNA.

PubMed ID: 7999802

DOI: 10.1016/0167-4781(94)00191-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16640556

Title: The narrow substrate specificity of human tyrosine aminotransferase -- the enzyme deficient in tyrosinemia type II.

PubMed ID: 16640556

DOI: 10.1111/j.1742-4658.2006.05202.x

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 1357662

Title: Point mutations in the tyrosine aminotransferase gene in tyrosinemia type II.

PubMed ID: 1357662

DOI: 10.1073/pnas.89.19.9297

Sequence Information:

  • Length: 454
  • Mass: 50399
  • Checksum: 82B5B24F3B2CE489
  • Sequence:
    • MDPYMIQMSS KGNLPSILDV HVNVGGRSSV PGKMKGRKAR WSVRPSDMAK KTFNPIRAIV 
DNMKVKPNPN KTMISLSIGD PTVFGNLPTD PEVTQAMKDA LDSGKYNGYA PSIGFLSSRE 
EIASYYHCPE APLEAKDVIL TSGCSQAIDL CLAVLANPGQ NILVPRPGFS LYKTLAESMG 
IEVKLYNLLP EKSWEIDLKQ LEYLIDEKTA CLIVNNPSNP CGSVFSKRHL QKILAVAARQ 
CVPILADEIY GDMVFSDCKY EPLATLSTDV PILSCGGLAK RWLVPGWRLG WILIHDRRDI 
FGNEIRDGLV KLSQRILGPC TIVQGALKSI LCRTPGEFYH NTLSFLKSNA DLCYGALAAI 
PGLRPVRPSG AMYLMVGIEM EHFPEFENDV EFTERLVAEQ SVHCLPATCF EYPNFIRVVI 
TVPEVMMLEA CSRIQEFCEQ HYHCAEGSQE ECDK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.