Gene TRGV2 - ENSG00000233306 | NCBI Gene ID: 6974

Details for: TRGV2

Gene ID: 6974

Symbol: TRGV2

Ensembl ID: ENSG00000233306

Description: T cell receptor gamma variable 2

Associated with

Adaptive immune response
(GO:0002250)
External side of plasma membrane
(GO:0009897)
Innate immune response
(GO:0045087)
T cell receptor complex
(GO:0042101)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 869
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7692
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 795
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5335
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.91
Marker Score: 798
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5294
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.85
Marker Score: 1251
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.82
Marker Score: 268
Cell Name: mast cell (CL0000097)
Fold Change: 0.81
Marker Score: 468
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.71
Marker Score: 181
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.7
Marker Score: 1697
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.68
Marker Score: 451
Cell Name: fibroblast (CL0000057)
Fold Change: 0.66
Marker Score: 638
Cell Name: neutrophil (CL0000775)
Fold Change: 0.64
Marker Score: 388
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 481
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.58
Marker Score: 512
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.56
Marker Score: 501
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 234
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.55
Marker Score: 425
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.52
Marker Score: 138
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.47
Marker Score: 761
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.46
Marker Score: 306
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.45
Marker Score: 1257
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.44
Marker Score: 425.5
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.43
Marker Score: 414
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.42
Marker Score: 283.5
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.42
Marker Score: 1317
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.41
Marker Score: 365
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.37
Marker Score: 226
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.37
Marker Score: 519
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.34
Marker Score: 340
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.31
Marker Score: 262
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.28
Marker Score: 554
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.24
Marker Score: 121
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.23
Marker Score: 253.5
Cell Name: B cell (CL0000236)
Fold Change: 0.22
Marker Score: 213
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.2
Marker Score: 116
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.2
Marker Score: 255
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.2
Marker Score: 271
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.2
Marker Score: 442
Cell Name: plasma cell (CL0000786)
Fold Change: 0.19
Marker Score: 216
Cell Name: mature T cell (CL0002419)
Fold Change: 0.18
Marker Score: 1815.5
Cell Name: Unknown (CL0000548)
Fold Change: 0.18
Marker Score: 131
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.14
Marker Score: 44
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 0.13
Marker Score: 30
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.13
Marker Score: 214
Cell Name: platelet (CL0000233)
Fold Change: 0.13
Marker Score: 59
Cell Name: blood cell (CL0000081)
Fold Change: 0.12
Marker Score: 1445
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.12
Marker Score: 222
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.12
Marker Score: 99
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.11
Marker Score: 83
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.11
Marker Score: 40
Cell Name: T cell (CL0000084)
Fold Change: 0.1
Marker Score: 178
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.1
Marker Score: 45
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.09
Marker Score: 31
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.09
Marker Score: 30
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.09
Marker Score: 28
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.09
Marker Score: 30
Cell Name: leukocyte (CL0000738)
Fold Change: 0.09
Marker Score: 49
Cell Name: group 2 innate lymphoid cell (CL0001069)
Fold Change: 0.09
Marker Score: 29
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.08
Marker Score: 47
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.08
Marker Score: 143
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.08
Marker Score: 29
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.08
Marker Score: 87.5
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.08
Marker Score: 4090
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.08
Marker Score: 58
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.08
Marker Score: 55
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.07
Marker Score: 29
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.07
Marker Score: 136
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.07
Marker Score: 28
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.07
Marker Score: 39
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.07
Marker Score: 55
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 0.06
Marker Score: 29
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.06
Marker Score: 31
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.06
Marker Score: 27
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.06
Marker Score: 31
Cell Name: Unknown (CL0000003)
Fold Change: 0.06
Marker Score: 182
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.06
Marker Score: 44
Cell Name: thymocyte (CL0000893)
Fold Change: 0.06
Marker Score: 58
Cell Name: type II NK T cell (CL0000922)
Fold Change: 0.06
Marker Score: 17
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.06
Marker Score: 38
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.05
Marker Score: 30
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.05
Marker Score: 29
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.05
Marker Score: 30
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.05
Marker Score: 29
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.05
Marker Score: 212
Cell Name: naive B cell (CL0000788)
Fold Change: 0.05
Marker Score: 43
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.05
Marker Score: 31
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.05
Marker Score: 32
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.04
Marker Score: 27
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.04
Marker Score: 30
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.04
Marker Score: 32
Cell Name: macrophage (CL0000235)
Fold Change: 0.04
Marker Score: 48
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.04
Marker Score: 30
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 0.04
Marker Score: 25

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Other Information

Description

**Key Characteristics:** 1. **T cell receptor gamma variable 2**: TRGV2 is a gamma variable region of the T cell receptor (TCR) complex, which is essential for recognizing and binding to antigens. 2. **Significant expression**: TRGV2 is expressed in a wide range of cell types, including granulocyte monocyte progenitor cells, goblet cells, and early T lineage precursors. 3. **Adaptive and innate immune responses**: TRGV2 plays a crucial role in both adaptive and innate immune responses, highlighting its importance in maintaining immune homeostasis. 4. **External side of plasma membrane**: TRGV2 is localized to the external side of the plasma membrane, where it interacts with other molecules to facilitate immune responses. **Pathways and Functions:** 1. **Adaptive immune response**: TRGV2 recognizes and binds to antigens, triggering a cascade of signaling events that activate T cells and elicit an adaptive immune response. 2. **Innate immune response**: TRGV2 also participates in the innate immune response by interacting with pattern recognition receptors (PRRs) to recognize pathogen-associated molecular patterns (PAMPs). 3. **T cell receptor complex**: TRGV2 is a component of the TCR complex, which assembles with other TCR chains and co-receptors to form a functional T cell receptor. 4. **Activation of T cells**: TRGV2 plays a critical role in the activation of T cells, including alpha-beta cytotoxic T cells and alpha-beta T cells. **Clinical Significance:** 1. **Autoimmune diseases**: Dysregulation of TRGV2 may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where T cell responses are disrupted. 2. **Cancer**: TRGV2 may play a role in cancer development and progression, particularly in cancers where T cell responses are compromised, such as melanoma and lung cancer. 3. **Infectious diseases**: TRGV2 may be involved in the pathogenesis of infectious diseases, such as HIV and tuberculosis, where T cell responses are critical for controlling infection. 4. **Immunotherapy**: TRGV2 may serve as a target for immunotherapies, such as checkpoint inhibitors, which aim to restore T cell function and enhance anti-tumor responses. In conclusion, TRGV2 is a critical component of the T cell receptor complex, playing a pivotal role in the adaptive and innate immune responses. Its dysregulation may contribute to autoimmune diseases, cancer, and infectious diseases, highlighting the importance of understanding its mechanisms and potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.