Details for: TRGV2

Gene ID: 6974

Symbol: TRGV2

Ensembl ID: ENSG00000233306

Description: T cell receptor gamma variable 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.2762
    Cell Significance Index: 0.7400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2696
    Cell Significance Index: 1.4700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.2170
    Cell Significance Index: 2.2500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.0388
    Cell Significance Index: 0.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0061
    Cell Significance Index: -0.1500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0139
    Cell Significance Index: -0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0148
    Cell Significance Index: -2.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0172
    Cell Significance Index: -3.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0185
    Cell Significance Index: -3.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0226
    Cell Significance Index: -3.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0230
    Cell Significance Index: -3.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0310
    Cell Significance Index: -3.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0327
    Cell Significance Index: -3.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0395
    Cell Significance Index: -1.8600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0511
    Cell Significance Index: -0.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0529
    Cell Significance Index: -3.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0540
    Cell Significance Index: -1.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0544
    Cell Significance Index: -3.6600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0557
    Cell Significance Index: -1.3500
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: -0.0638
    Cell Significance Index: -0.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0657
    Cell Significance Index: -1.7600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0671
    Cell Significance Index: -1.1400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0678
    Cell Significance Index: -0.9300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0759
    Cell Significance Index: -0.7700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0765
    Cell Significance Index: -1.9100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0772
    Cell Significance Index: -1.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0800
    Cell Significance Index: -3.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0801
    Cell Significance Index: -2.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0840
    Cell Significance Index: -2.7500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0885
    Cell Significance Index: -1.0500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0924
    Cell Significance Index: -0.7800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0926
    Cell Significance Index: -0.7200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0934
    Cell Significance Index: -1.1600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0950
    Cell Significance Index: -1.6000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1023
    Cell Significance Index: -0.9700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1080
    Cell Significance Index: -0.9200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1082
    Cell Significance Index: -1.4000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1193
    Cell Significance Index: -1.4100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1226
    Cell Significance Index: -1.8100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1287
    Cell Significance Index: -3.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1326
    Cell Significance Index: -3.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1333
    Cell Significance Index: -2.8800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1351
    Cell Significance Index: -1.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1375
    Cell Significance Index: -2.7600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1400
    Cell Significance Index: -1.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1406
    Cell Significance Index: -2.9900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1443
    Cell Significance Index: -3.5200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1457
    Cell Significance Index: -2.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1480
    Cell Significance Index: -3.4200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1568
    Cell Significance Index: -1.2700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1611
    Cell Significance Index: -2.6100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1632
    Cell Significance Index: -3.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1645
    Cell Significance Index: -2.8400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1653
    Cell Significance Index: -1.7900
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1654
    Cell Significance Index: -1.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1704
    Cell Significance Index: -3.1500
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1753
    Cell Significance Index: -1.7500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1805
    Cell Significance Index: -2.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1840
    Cell Significance Index: -3.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1850
    Cell Significance Index: -3.6100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1852
    Cell Significance Index: -2.0700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1894
    Cell Significance Index: -2.1800
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1895
    Cell Significance Index: -1.4100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1901
    Cell Significance Index: -1.9200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1917
    Cell Significance Index: -2.1600
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1989
    Cell Significance Index: -1.7100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2001
    Cell Significance Index: -3.4200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2052
    Cell Significance Index: -1.6200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2055
    Cell Significance Index: -2.9200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2083
    Cell Significance Index: -2.0300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2083
    Cell Significance Index: -2.2400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2093
    Cell Significance Index: -2.6200
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2099
    Cell Significance Index: -1.7400
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.2124
    Cell Significance Index: -1.8300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2176
    Cell Significance Index: -2.5600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2208
    Cell Significance Index: -2.7900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2215
    Cell Significance Index: -3.2700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2245
    Cell Significance Index: -2.6400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2264
    Cell Significance Index: -3.3000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2280
    Cell Significance Index: -3.4100
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2333
    Cell Significance Index: -1.9500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2358
    Cell Significance Index: -3.2700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2363
    Cell Significance Index: -3.8000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2374
    Cell Significance Index: -3.2600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2374
    Cell Significance Index: -3.6100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2382
    Cell Significance Index: -3.0600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2395
    Cell Significance Index: -2.9900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.2413
    Cell Significance Index: -1.9800
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: -0.2423
    Cell Significance Index: -1.8700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2432
    Cell Significance Index: -3.2000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2433
    Cell Significance Index: -2.9000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2442
    Cell Significance Index: -3.1900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2451
    Cell Significance Index: -3.5200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2467
    Cell Significance Index: -2.6600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2471
    Cell Significance Index: -2.3200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2483
    Cell Significance Index: -3.4800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2484
    Cell Significance Index: -3.2600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2484
    Cell Significance Index: -2.9400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2485
    Cell Significance Index: -2.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2485
    Cell Significance Index: -3.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **T cell receptor gamma variable 2**: TRGV2 is a gamma variable region of the T cell receptor (TCR) complex, which is essential for recognizing and binding to antigens. 2. **Significant expression**: TRGV2 is expressed in a wide range of cell types, including granulocyte monocyte progenitor cells, goblet cells, and early T lineage precursors. 3. **Adaptive and innate immune responses**: TRGV2 plays a crucial role in both adaptive and innate immune responses, highlighting its importance in maintaining immune homeostasis. 4. **External side of plasma membrane**: TRGV2 is localized to the external side of the plasma membrane, where it interacts with other molecules to facilitate immune responses. **Pathways and Functions:** 1. **Adaptive immune response**: TRGV2 recognizes and binds to antigens, triggering a cascade of signaling events that activate T cells and elicit an adaptive immune response. 2. **Innate immune response**: TRGV2 also participates in the innate immune response by interacting with pattern recognition receptors (PRRs) to recognize pathogen-associated molecular patterns (PAMPs). 3. **T cell receptor complex**: TRGV2 is a component of the TCR complex, which assembles with other TCR chains and co-receptors to form a functional T cell receptor. 4. **Activation of T cells**: TRGV2 plays a critical role in the activation of T cells, including alpha-beta cytotoxic T cells and alpha-beta T cells. **Clinical Significance:** 1. **Autoimmune diseases**: Dysregulation of TRGV2 may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where T cell responses are disrupted. 2. **Cancer**: TRGV2 may play a role in cancer development and progression, particularly in cancers where T cell responses are compromised, such as melanoma and lung cancer. 3. **Infectious diseases**: TRGV2 may be involved in the pathogenesis of infectious diseases, such as HIV and tuberculosis, where T cell responses are critical for controlling infection. 4. **Immunotherapy**: TRGV2 may serve as a target for immunotherapies, such as checkpoint inhibitors, which aim to restore T cell function and enhance anti-tumor responses. In conclusion, TRGV2 is a critical component of the T cell receptor complex, playing a pivotal role in the adaptive and innate immune responses. Its dysregulation may contribute to autoimmune diseases, cancer, and infectious diseases, highlighting the importance of understanding its mechanisms and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.