Details for: TRGV5

Gene ID: 6978

Symbol: TRGV5

Ensembl ID: ENSG00000211697

Description: T cell receptor gamma variable 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.9220
    Cell Significance Index: 2.4700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1522
    Cell Significance Index: 0.8300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0014
    Cell Significance Index: 0.0600
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0027
    Cell Significance Index: -2.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0097
    Cell Significance Index: -1.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0098
    Cell Significance Index: -0.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0101
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0116
    Cell Significance Index: -1.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0119
    Cell Significance Index: -1.6400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0145
    Cell Significance Index: -0.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0180
    Cell Significance Index: -1.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0206
    Cell Significance Index: -0.5500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0214
    Cell Significance Index: -0.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0264
    Cell Significance Index: -1.7000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0321
    Cell Significance Index: -0.4700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0324
    Cell Significance Index: -0.5500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0373
    Cell Significance Index: -0.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0399
    Cell Significance Index: -1.8600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0406
    Cell Significance Index: -0.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0429
    Cell Significance Index: -2.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0496
    Cell Significance Index: -1.5800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0512
    Cell Significance Index: -1.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0601
    Cell Significance Index: -2.0900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0603
    Cell Significance Index: -0.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0654
    Cell Significance Index: -2.4000
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: -0.0655
    Cell Significance Index: -0.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0660
    Cell Significance Index: -1.2200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0704
    Cell Significance Index: -0.8900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0711
    Cell Significance Index: -0.8400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0726
    Cell Significance Index: -1.8100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0751
    Cell Significance Index: -0.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0757
    Cell Significance Index: -2.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0771
    Cell Significance Index: -2.2700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0775
    Cell Significance Index: -0.6600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0781
    Cell Significance Index: -0.7800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0786
    Cell Significance Index: -1.9600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0789
    Cell Significance Index: -2.0100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0791
    Cell Significance Index: -0.8200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0802
    Cell Significance Index: -0.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0802
    Cell Significance Index: -2.1100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0808
    Cell Significance Index: -1.5800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0887
    Cell Significance Index: -0.9000
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0889
    Cell Significance Index: -0.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0895
    Cell Significance Index: -1.9000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0941
    Cell Significance Index: -1.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0952
    Cell Significance Index: -2.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1032
    Cell Significance Index: -2.1600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1068
    Cell Significance Index: -1.7300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1080
    Cell Significance Index: -0.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1086
    Cell Significance Index: -1.8300
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.1096
    Cell Significance Index: -0.8200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1128
    Cell Significance Index: -1.1000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1141
    Cell Significance Index: -1.8300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1160
    Cell Significance Index: -1.6900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1176
    Cell Significance Index: -2.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1191
    Cell Significance Index: -1.4200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1218
    Cell Significance Index: -1.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1219
    Cell Significance Index: -2.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1223
    Cell Significance Index: -3.3300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1228
    Cell Significance Index: -1.3900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1240
    Cell Significance Index: -1.8000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1257
    Cell Significance Index: -1.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1267
    Cell Significance Index: -2.1200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1276
    Cell Significance Index: -1.5000
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1280
    Cell Significance Index: -1.0700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1283
    Cell Significance Index: -1.2000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1288
    Cell Significance Index: -1.4400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1302
    Cell Significance Index: -1.6500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1307
    Cell Significance Index: -1.9300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1308
    Cell Significance Index: -1.9300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1334
    Cell Significance Index: -1.0800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1338
    Cell Significance Index: -1.4300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1345
    Cell Significance Index: -1.4900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1346
    Cell Significance Index: -1.7600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1398
    Cell Significance Index: -1.6600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1399
    Cell Significance Index: -1.9400
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1400
    Cell Significance Index: -1.1600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1415
    Cell Significance Index: -2.0100
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1419
    Cell Significance Index: -1.3900
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1423
    Cell Significance Index: -1.5200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1447
    Cell Significance Index: -1.7100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1449
    Cell Significance Index: -1.8100
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.1450
    Cell Significance Index: -1.4800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1450
    Cell Significance Index: -1.6600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1461
    Cell Significance Index: -1.8900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1477
    Cell Significance Index: -1.7000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1489
    Cell Significance Index: -1.8100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1491
    Cell Significance Index: -1.8000
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1501
    Cell Significance Index: -1.8900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1503
    Cell Significance Index: -1.7300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1504
    Cell Significance Index: -1.4300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1505
    Cell Significance Index: -1.9300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1510
    Cell Significance Index: -1.9400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1513
    Cell Significance Index: -2.0100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1523
    Cell Significance Index: -2.0300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1526
    Cell Significance Index: -1.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Family:** TRGV5 belongs to the TCR gamma family, which is responsible for encoding the gamma chain of the TCR complex. This family consists of 13 gamma chains, each with distinct sequences and functions. 2. **Expression Profile:** TRGV5 is expressed in various cell types, including thymocytes, oligodendrocyte precursor cells, double negative thymocytes, and neutrophil progenitor cells. This widespread expression suggests a critical role in immune cell development and function. 3. **Cell Type Specificity:** The expression of TRGV5 in glutamatergic neurons and GABAergic interneurons highlights its involvement in the central nervous system, where it may contribute to neuronal development and function. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRGV5 plays a crucial role in the adaptive immune response, where it recognizes and responds to antigens presented by major histocompatibility complex (MHC) molecules. The interaction between TRGV5 and MHC molecules triggers a signaling cascade that leads to the activation of T cells. 2. **T Cell Receptor Complex:** TRGV5 is a component of the TCR complex, which is responsible for recognizing and binding to antigens. The TRGV5 gene product forms a heterodimer with other TCR chains, resulting in a functional TCR complex. 3. **Signaling Pathways:** The TRGV5 gene is involved in various signaling pathways, including the activation of protein kinase C (PKC) and the transcriptional regulation of genes involved in immune cell development. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Variations in the TRGV5 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). These disorders result from defective T cell development and function, highlighting the importance of TRGV5 in immune cell development. 2. **Cancer Immunotherapy:** TRGV5 has been identified as a potential target for cancer immunotherapy. The gene product can recognize and bind to tumor antigens, leading to the activation of T cells and the induction of anti-tumor responses. 3. **Neurological Disorders:** The expression of TRGV5 in glutamatergic neurons and GABAergic interneurons suggests its involvement in neurological disorders, such as epilepsy and autism spectrum disorder. Further research is needed to fully understand the role of TRGV5 in these disorders. In conclusion, the TRGV5 gene is a critical component of the adaptive immune system, playing a pivotal role in recognizing and responding to antigens. Its widespread expression in various cell types highlights its importance in immune cell development and function. Further research is needed to fully understand the clinical significance of TRGV5 and its potential applications in immunotherapy and neurological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.