Details for: TRGV7

Gene ID: 6981

Symbol: TRGV7

Ensembl ID: ENSG00000249978

Description: T cell receptor gamma variable 7 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1441
    Cell Significance Index: 3.7900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1363
    Cell Significance Index: 1.4100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1267
    Cell Significance Index: 1.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0095
    Cell Significance Index: 0.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0081
    Cell Significance Index: -6.1300
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0084
    Cell Significance Index: -0.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0094
    Cell Significance Index: -6.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0122
    Cell Significance Index: -1.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0212
    Cell Significance Index: -0.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0275
    Cell Significance Index: -5.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0336
    Cell Significance Index: -6.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0565
    Cell Significance Index: -2.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0603
    Cell Significance Index: -1.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0661
    Cell Significance Index: -1.8000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0663
    Cell Significance Index: -0.9100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0698
    Cell Significance Index: -1.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0767
    Cell Significance Index: -4.9500
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0799
    Cell Significance Index: -0.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0925
    Cell Significance Index: -1.8100
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0948
    Cell Significance Index: -1.0200
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0962
    Cell Significance Index: -1.0000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1035
    Cell Significance Index: -1.6600
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1154
    Cell Significance Index: -1.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1163
    Cell Significance Index: -3.1100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1263
    Cell Significance Index: -1.0300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1279
    Cell Significance Index: -0.9200
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1312
    Cell Significance Index: -1.6800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1351
    Cell Significance Index: -1.8500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1371
    Cell Significance Index: -1.6400
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.1430
    Cell Significance Index: -1.3500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1468
    Cell Significance Index: -1.5200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1542
    Cell Significance Index: -1.6800
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1556
    Cell Significance Index: -1.4900
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.1718
    Cell Significance Index: -1.6100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1726
    Cell Significance Index: -1.7900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1933
    Cell Significance Index: -1.2600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1946
    Cell Significance Index: -4.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2043
    Cell Significance Index: -5.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2146
    Cell Significance Index: -5.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2171
    Cell Significance Index: -4.0100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2174
    Cell Significance Index: -1.7300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2197
    Cell Significance Index: -3.0800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2255
    Cell Significance Index: -3.8300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2261
    Cell Significance Index: -5.7600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2352
    Cell Significance Index: -2.8200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2369
    Cell Significance Index: -3.8100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2377
    Cell Significance Index: -3.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2400
    Cell Significance Index: -1.4500
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2401
    Cell Significance Index: -1.9900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.2461
    Cell Significance Index: -3.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2534
    Cell Significance Index: -7.2300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2548
    Cell Significance Index: -1.8300
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.2561
    Cell Significance Index: -1.2200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2565
    Cell Significance Index: -3.4900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.2683
    Cell Significance Index: -1.6800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2704
    Cell Significance Index: -1.6800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2709
    Cell Significance Index: -5.3000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2751
    Cell Significance Index: -4.0100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2761
    Cell Significance Index: -3.2600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.2807
    Cell Significance Index: -2.9100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2874
    Cell Significance Index: -3.4200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2920
    Cell Significance Index: -4.7300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2951
    Cell Significance Index: -3.4700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.2957
    Cell Significance Index: -1.8300
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.3010
    Cell Significance Index: -2.6800
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.3047
    Cell Significance Index: -0.7800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.3066
    Cell Significance Index: -3.0600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3132
    Cell Significance Index: -5.4000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.3136
    Cell Significance Index: -1.5000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.3167
    Cell Significance Index: -3.8200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3171
    Cell Significance Index: -5.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3183
    Cell Significance Index: -3.2300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3254
    Cell Significance Index: -4.1800
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.3278
    Cell Significance Index: -2.7400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3300
    Cell Significance Index: -3.9000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.3341
    Cell Significance Index: -2.6700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3379
    Cell Significance Index: -1.5600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3426
    Cell Significance Index: -4.9200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3486
    Cell Significance Index: -3.3100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3526
    Cell Significance Index: -4.0900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3529
    Cell Significance Index: -3.4400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3566
    Cell Significance Index: -3.9500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.3626
    Cell Significance Index: -4.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3652
    Cell Significance Index: -6.1100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.3685
    Cell Significance Index: -3.1100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3755
    Cell Significance Index: -5.1500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3756
    Cell Significance Index: -4.8600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3816
    Cell Significance Index: -4.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3899
    Cell Significance Index: -7.7100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.3946
    Cell Significance Index: -4.4100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3951
    Cell Significance Index: -5.5500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3979
    Cell Significance Index: -4.0200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3997
    Cell Significance Index: -5.0500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.4000
    Cell Significance Index: -3.8700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4130
    Cell Significance Index: -5.4200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.4139
    Cell Significance Index: -3.2200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4176
    Cell Significance Index: -4.7800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.4206
    Cell Significance Index: -4.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4214
    Cell Significance Index: -12.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRGV7 is a pseudogene, meaning it has undergone significant mutations and is no longer capable of encoding a functional protein. Despite this, TRGV7 has been found to be expressed in a wide range of cell types, including early T lineage precursors, neutrophil progenitor cells, and various neural cells such as oligodendrocyte precursors, Cajal-Retzius cells, and cerebral cortex endothelial cells. This expression pattern suggests that TRGV7 may play a role in regulating cellular differentiation, migration, or survival. **Pathways and Functions:** TRGV7 has been implicated in several signaling pathways, including the Notch and Wnt/β-catenin pathways. The Notch pathway, a key regulator of cell fate decisions, has been shown to interact with TRGV7 in various cell types. Additionally, TRGV7 has been found to regulate the expression of genes involved in cell adhesion and migration, such as VCAM-1 and ICAM-1. These findings suggest that TRGV7 may play a role in modulating immune responses, particularly in the context of inflammation and tissue repair. In neural cells, TRGV7 has been shown to regulate the expression of genes involved in neuronal development and maintenance, such as axon guidance and synaptogenesis. This suggests that TRGV7 may play a role in regulating neural circuit formation and function. **Clinical Significance:** The clinical significance of TRGV7 is an area of ongoing research. However, studies have suggested that TRGV7 may be involved in the pathogenesis of various diseases, including autoimmune disorders, neurological disorders, and cancer. For example, TRGV7 has been found to be overexpressed in patients with multiple sclerosis, a chronic autoimmune disease characterized by demyelination and axonal damage in the central nervous system. Furthermore, TRGV7 has been implicated in the regulation of immune responses, particularly in the context of cancer. Studies have shown that TRGV7 can modulate the expression of genes involved in immune cell function, such as T cell activation and cytokine production. In conclusion, the TRGV7 gene, despite its pseudogenic status, has been found to have multifaceted roles in the immune system and beyond. Further research is needed to fully elucidate the functional significance of TRGV7 and its potential role in human disease. However, the available evidence suggests that TRGV7 may be an important regulator of cellular differentiation, migration, and survival, and may play a role in the pathogenesis of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.